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Increased Relative Functional Gain and Improved Stroke Outcomes: A Linked Registry Study of the Impact of Rehabilitation.

J Stroke Cerebrovasc Dis 2021 Jul 30;30(10):106015. Epub 2021 Jul 30.

Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia; Translational Public Health and Evaluation Division, Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Level 3 Hudson Institute Building, 27-31 Wright Street, Clayton, VIC 3168, Australia. Electronic address:

Objectives: It is unclear how acute care influences patient outcomes in those who receive rehabilitation. We aimed to determine the associations between acute stroke therapies, outcomes during inpatient rehabilitation and self-reported outcomes at 90-180 days after stroke.

Materials And Methods: Patient-level data from adults with acute stroke registered in the Australian Stroke Clinical Registry (AuSCR, 2014-2017) were linked with data from the Australasian Rehabilitation Outcomes Centre (AROC). Read More

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Transfusion Guidelines in Adult Spine Surgery: A Systematic Review and Critical Summary of Currently Available Evidence.

Spine J 2021 Jul 30. Epub 2021 Jul 30.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, TX, USA 75235; University of Texas Southwestern Medical Center, Spine Center, Dallas, TX, USA 75235.

Background Context: Red blood cell transfusion can be associated with complications in medical and surgical patients. Acute anemia in ambulatory patients undergoing surgery can also impede wound healing and independent self-care. Current transfusion threshold guidelines are still based on evidence derived from critically-ill intensive care unit medical patients and may not apply to spine surgery candidates. Read More

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Characterization of Pericarditis Following Allogeneic Hematopoietic Cell Transplant.

Transplant Cell Ther 2021 Jul 30. Epub 2021 Jul 30.

Blood and Marrow Transplant and Cellular Therapy Program, Abramson Cancer Center and the Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Pericarditis is an uncommon cardiac complication following allogeneic hematopoietic transplant (alloHCT) with limited data characterizing incidence, presentation, and management. The etiology of pericarditis in this setting is poorly understood, and may include conditioning-related toxicity, infection, or graft-versus-host disease (GVHD).

Objective: The objective of this study was to characterize the clinical presentation, management and outcomes of post alloHCT pericarditis observed at a single center. Read More

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Intramuscular insulin-like growth factor-1 gene therapy modulates reactive microglia after traumatic brain injury.

Brain Res Bull 2021 Jul 30. Epub 2021 Jul 30.

Universidad Nacional de La Plata, Facultad de Ciencias Médicas, Buenos Aires, Argentina; Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP-CONICET), La Plata, Argentina. Electronic address:

Reactive gliosis is a key feature and an important pathophysiological mechanism underlying chronic neurodegeneration following traumatic brain injury (TBI). In this study, we have explored the effects of intramuscular IGF-1 gene therapy on reactive gliosis and functional outcome after an injury of the cerebral cortex. Young adult male rats were intramuscularly injected with a recombinant adenoviral construct harboring the cDNA of human IGF-1 (RAd-IGF1), with a control vector expressing green fluorescent protein (RAd-GFP) or PBS as control. Read More

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De novo sequencing and analysis of the transcriptome of two highbush blueberry (Vaccinium corymbosum L.) cultivars 'Bluecrop' and 'Legacy' at harvest and following post-harvest storage.

PLoS One 2021 2;16(8):e0255139. Epub 2021 Aug 2.

Unit of Computational Biology, Research and Innovation Centre, Fondazione Edmund Mach (FEM), San Michele all'Adige, Italy.

Fruit firmness and in particular the individual components of texture and moisture loss, are considered the key quality traits when describing blueberry fruit quality, and whilst these traits are genetically regulated, the mechanisms governing their control are not clearly understood. In this investigation, RNAseq was performed on fruits of two blueberry cultivars with very different storage properties, 'Bluecrop' and 'Legacy', at harvest, three weeks storage in a non-modified environment at 4 °C and after three weeks storage at 4 °C followed by three days at 21 °C, with the aim of understanding the transcriptional changes that occur during storage in cultivars with very different post-harvest fruit quality. De novo assemblies of the transcriptomes of the two cultivars were performed separately and a total of 39,335 and 41,896 unigenes for 'Bluecrop' and 'Legacy' respectively were resolved. Read More

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Assessing the severity of laparotomy and partial hepatectomy in male rats-A multimodal approach.

PLoS One 2021 2;16(8):e0255175. Epub 2021 Aug 2.

Institute for Laboratory Animal Science & Experimental Surgery, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

This study assessed the postoperative severity after three different visceral surgical interventions in rats by using objective parameters pertaining to various disciplines. The objective was to evaluate whether the degree of severity increases with the invasiveness of the intervention and whether this is in accordance with the EU Directive 2010/63. 136 adult male WistarHan rats were assigned to three groups: Sham-laparotomy (Sham) [7 days post-surgical survival time]; 50% partial hepatectomy (PH); 70% PH [PH groups with 1, 3, or 7 days post-surgical survival times]. Read More

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Recovery of from feed using different enrichment media.

J Environ Sci Health B 2021 Aug 2:1-7. Epub 2021 Aug 2.

Anitox Corp, Lawrenceville, Georgia, USA.

Studies were conducted to investigate the recovery of from feed. The impact of feed moisture, water activity, pH, number of background microflora and the use of different antibiotic supplements in enrichment broth (CEB) on recovery were evaluated in five studies. Broiler starter feed was inoculated with 10 -10 cfu of /g and stored at 24 °C and 43% RH. Read More

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Clinical Outcomes Following Regionalization of Gastric Cancer Care in a US Integrated Health Care System.

J Clin Oncol 2021 Aug 2:JCO2100480. Epub 2021 Aug 2.

The Permanente Medical Group, Gastric Surgery, Northern California, Oakland, CA.

Purpose: In 2016, Kaiser Permanente Northern California regionalized gastric cancer care, introducing a regional comprehensive multidisciplinary care team, standardizing staging and chemotherapy, and implementing laparoscopic gastrectomy and D2 lymphadenectomy for patients eligible for curative-intent surgery. This study evaluated the effect of regionalization on outcomes.

Methods: The retrospective cohort study included gastric cancer cases diagnosed from January 2010 to May 2018. Read More

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Identification of Efficacious Vaccines Against Contemporary North American H7 Avian Influenza Viruses.

Avian Dis 2021 Mar;65(1):113-121

Exotic and Emerging Avian Viral Diseases Unit, US National Poultry Research Center, USDA-Agricultural Research Service, Athens, GA 30605.

Five vaccines, including four inactivated, whole-virus water-in-oil adjuvanted vaccines and a commercial nonreplicating alphavirus-vectored RNA particle (RP) vaccine were evaluated in chickens for their ability to provide protection against challenge with a recent H7 highly pathogenic avian influenza virus (AIV) from the United States (A/turkey/IN/1403-1/2016 H7N8). One of the inactivated vaccines and the RP vaccine were prepared with A/turkey/IN/16-01571-6/2016 H7N8 low pathogenic AIV (LPAIV; TK/IN/16), which is identical to the challenge virus, except for the proteolytic cleavage site of the hemagglutinin protein. The remaining three inactivated vaccines were prepared with other North American H7 LPAIVs. Read More

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Performance of a 50-gene next generation sequencing panel with post-centrifuge supernatant cytology fluid in non-small-cell lung cancer.

Diagn Cytopathol 2021 Aug 2. Epub 2021 Aug 2.

Department of Pathology, University of New Mexico Hospital, Albuquerque, New Mexico, USA.

Background: Liquid based cytology (LBC) specimens are increasingly utilized for molecular analysis, as results are comparable to molecular analysis performed on traditional specimens (biopsy or cell block). However, there are few studies demonstrating the long-term viability of DNA in LBC samples.

Methods: In this study, a 50-gene next generation sequencing (NGS) panel was performed on DNA isolated from post-centrifuged supernatant LBC samples of cases of non-small-cell lung carcinoma. Read More

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Integration of RNA-seq and RNAi reveals the contribution of znuA gene to the pathogenicity of Pseudomonas plecoglossicida and to the immune response of Epinephelus coioides.

J Fish Dis 2021 Aug 2. Epub 2021 Aug 2.

Fisheries College, Jimei University, Xiamen, China.

Pseudomonas plecoglossicida is an important pathogen in aquaculture and causes serious economic losses. Our previous study indicated that znuA gene might play an important role in the pathogenicity of P. plecoglossicida. Read More

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The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b (slc3a1/slc7a9).

Fish Physiol Biochem 2021 Aug 2. Epub 2021 Aug 2.

Department of Biological Sciences, University of Bergen, Postbox 7803, N-5020, Bergen, Norway.

System b absorbs lysine, arginine, ornithine, and cystine, as well as some (large) neutral amino acids in the mammalian kidney and intestine. It is a heteromeric amino acid transporter made of the heavy subunit SLC3A1/rBAT and the light subunit SLC7A9/bAT. Mutations in these two genes can cause cystinuria in mammals. Read More

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Involvement of the optic pathway and outcome of visual function in patients with neurohypophyseal germ cell tumor.

Acta Neurochir (Wien) 2021 Aug 2. Epub 2021 Aug 2.

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Patients with neurohypophyseal germ cell tumors (GCTs) typically present with visual problems. Hence, this study aimed to assess optic pathway involvement based on clinical and radiological findings and to validate the outcome of visual function.

Methods: A total of 16 patients with newly diagnosed neurohypophyseal GCTs who were treated at the University of Tsukuba Hospital between 2000 and 2020 were included in this study. Read More

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Multimodal treatment of colorectal postsurgical leaks: long-term results of the over-thescope clip (OTSC) application.

Minerva Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of General Surgery, Istituto Clinico Humanitas Mater Domini, Castellanza, Varese, Italy.

Background: Post-surgical anastomotic colorectal leaks often require a surgical second look with a definite morbidity and the risk of delaying adjuvant treatment. The aim of this study is to analyse the long-term results of the endoscopic closure of colorectal leak following low anterior resection (LAR) using the over-the-scope (Ovesco™) clip.

Methods: Patients who were submitted to endoscopic closure of a colorectal leak of maximum 2 cm with an Ovesco™ clip following LAR from 2016 to 2018 were enrolled in this retrospective single-center study (Humanitas Mater Domini Clinical Institute, Italy). Read More

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Preoperative biopsy for suspected adenocarcinoma of the pancreatic head; yield and complications.

Minerva Surg 2021 Aug 2. Epub 2021 Aug 2.

Division of Surgery, Department of General Surgery B, Tel-Aviv Sourasky Medical Center, The Nikolas & Elizabeth Shlezak Fund for Experimental Surgery, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Histologic confirmation before pancreaticoduodenectomy (PD) for suspected pancreatic cancer is often performed. We assessed the yield of preoperative biopsy in these patients in light of the associated complications.

Methods: We retrospectively evaluated 216 patients that underwent PD for suspected carcinoma (CA) between 2012 and 2018. Read More

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Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant.

J Neurochem 2021 Aug 2. Epub 2021 Aug 2.

Department of Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine.

Studies have verified that Fragile X mental retardation protein (FMRP), an RNA-binding protein, plays a potential role in the pathogenesis of formalin- and (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced abnormal pain sensations. However, the role of FMRP in inflammatory pain has not been reported. Here, we showed an increase in FMRP expression in the spinal dorsal horn (SDH) in a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA). Read More

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Management of Neurocysticercosis in Children: Association of Child Neurology Consensus Guidelines.

Indian Pediatr 2021 Aug 2. Epub 2021 Aug 2.

Pediatric Neurology and Neurodevelopment, Medanta the Medicity, Gurugram, Haryana. Correspondence to: Prof Pratibha Singhi, Professor and Chief, Pediatric Neurology and Neurodevelopment, Medanta the Medicity, Gurugram, India.

Justification: Neurocysticercosis is a significant problem in India and other developing countries. but several aspects of this disease have no clear, practical guidelines. There is a need for, pragmatic guidelines, summarizing the available evidence, and filling in the gaps in evidence with expert advice to manage children with neurocysticercosis. Read More

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A phase I/II trial of brentuximab vedotin plus rituximab as frontline therapy for patients with immunosuppression-associated CD30+ and/or EBV + lymphomas.

Leuk Lymphoma 2021 Aug 2:1-8. Epub 2021 Aug 2.

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Treatment strategies for post-transplant lymphoproliferative disorders (PTLD) consist of response-adapted risk-stratified methods using immunosuppression reduction, immunotherapy, and chemotherapy. We investigated the efficacy of Brentuximab vedotin given concurrently with Rituximab (BV + R) once weekly for four weeks, followed by optional consolidation, and up to one year of maintenance. Among 20 assessable patients, BV + R therapy resulted in an overall response rate of 75% (95% CI 51 to 91,  = 0. Read More

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Role of multimodal anaesthetic in post-operative analgesic requirement for robotic assisted radical prostatectomy.

Urologia 2021 Aug 2:3915603211031869. Epub 2021 Aug 2.

Department of Anaesthesia and Critical care, New Cross Hospital, Wolverhampton, UK.

Purpose: Robotic assisted laparoscopic radical prostatectomy (RARP) is considered as standard of care for surgical management of localised prostate cancer. Procedure specific postoperative pain management (PROSPECT) guidelines are available for open radical prostatectomy. There is a lack of evidence for optimal pain management protocol in patients undergoing robotic radical prostatectomy. Read More

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Differential responses in EPA and fucoxanthin production by the marine diatom Stauroneis sp. under varying cultivation conditions.

Biotechnol Prog 2021 Aug 1. Epub 2021 Aug 1.

School of Science, Department of Environmental Science, Centre for Environmental Research, Sustainability and Innovation, Institute of Technology Sligo, Sligo, Ireland.

There has been an increasing drive towards better valorising raw biological materials in the context of the sustainability of bio-based industries and the circular economy. As such, microalgae hold the ability to biosynthesise valuable metabolites, which are sought after within the bioenergy, pharmaceuticals, cosmetics or nutrition sectors. Owing to their bioactivities, the xanthophyll pigment fucoxanthin and the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) have fostered increasing interests in terms of sustainably refining them from natural sources, such as microalgae. Read More

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Differential cardiotoxic electrocardiographic response to doxorubicin treatment in conscious versus anesthetized mice.

Physiol Rep 2021 Aug;9(15):e14987

Department of Biomedical Engineering, The George Washington University, Washington, DC, USA.

Introduction: Doxorubicin (DOX), an anticancer drug used in chemotherapy, causes significant cardiotoxicity. This study aimed to investigate the effects of DOX on mouse cardiac electrophysiology, in conscious versus anesthetized state.

Methods: Male and female C57BL/6 mice were injected with saline, 20 or 30 mg/kg DOX. Read More

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Effects of early exercise training on the severity of autonomic dysreflexia following incomplete spinal cord injury in rodents.

Physiol Rep 2021 Aug;9(15):e14969

Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.

Hemodynamic instability and cardiovascular (CV) dysfunction are hallmarks of patients living with cervical and high thoracic spinal cord injuries (SCI). Individuals experience bouts of autonomic dysreflexia (AD) and persistent hypotension which hamper the activities of daily living. Despite the widespread use of exercise training to improve health and CV function after SCI, little is known about how different training modalities impact hemodynamic stability and severity of AD in a model of incomplete SCI. Read More

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Plasma, platelet and red blood cell transfusion ratios for life-threatening non-traumatic haemorrhage in medical and post-surgical patients: An observational study.

Vox Sang 2021 Aug 1. Epub 2021 Aug 1.

Patient Blood Management Program, Mayo Clinic, Rochester, Minnesota, USA.

Background And Objectives: Despite the broad utilization of component-based transfusion strategies that aim to reconstitute whole blood during acute traumatic haemorrhage, data for haemorrhage occurring outside of trauma and surgery are limited.

Methods: This is an observational cohort study of adults experiencing critical non-traumatic, non-intraoperative haemorrhage during hospitalization at an academic medical centre from 2011 to 2015. The primary goal was to evaluate differences in plasma and platelet to red blood cell (RBC) transfusion ratios across patient demographic, clinical and laboratory characteristics. Read More

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Serum antibody response to BNT162b2 after natural SARS-CoV-2 infection.

Eur J Clin Invest 2021 Aug 1:e13632. Epub 2021 Aug 1.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Background: There is preliminary evidence that individuals with previous SARS-CoV-2 infections exhibit a more pronounced antibody response. However, these assumptions have not yet been supported by data obtained through various CE-marked tests. This study aimed to close this gap. Read More

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Genetic Characteristics and Pathogenicity of a Novel Porcine Deltacoronavirus Southeast Asia-Like Strain Found in China.

Front Vet Sci 2021 16;8:701612. Epub 2021 Jul 16.

College of Animal Science and Technology, Guangxi University, Nanning, China.

Farmers involved in the lucrative pork trading business between China and Southeast Asian countries should be aware of a recently discovered novel porcine deltacoronavirus (PDCoV) in Guangxi province, China. A PDCoV strain, CHN/GX/1468B/2017, was isolated from the small intestinal contents of piglets with diarrhea from this region, with a titer of 1 × 10 TCID/mL on LLC-PK cells. The full-length genome sequence consists of 25,399 nt as determined by next-generation sequencing and this was deposited in the GenBank (accession number MN025260. Read More

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Peri-procedural Trans-esophageal Echocardiographic Sizing of the Native Left Ventricular Outflow Tract During Edwards INTUITY Valve Implantation.

Front Cardiovasc Med 2021 15;8:690752. Epub 2021 Jul 15.

Division of Cardiothoracic Surgery, Prince of Wales Hospital, Shatin, Hong Kong.

The Edwards INTUITY rapid deployment valve was anchored on the left ventricular outflow tract (LVOT) by radial force akin to transcatheter balloon-expandable valves. This design feature facilitates minimally invasive and complex procedures but comes at the price of compressing the atrioventricular conduction bundle and potential requirement for pacemaker implantation. A retrospective observational study was conducted on 30 consecutive patients who received the INTUITY valve at our institution from August 2018 to January 2021. Read More

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Hb Levels and Sex Differences in Relation to Short-Term Outcomes in Patients With Acute Myocardial Infarction.

Front Cardiovasc Med 2021 16;8:653351. Epub 2021 Jul 16.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Women had worse outcomes after acute myocardial infarction (AMI), and physiologically, women had lower hemoglobin values. We examined whether there were sex-related differences in the relationship between hemoglobin levels and adverse outcomes in patients with acute myocardial infarction. We conducted a analysis of data from the Acute Coronary Syndrome Quality Improvement in Kerala (ACS-QUIK) Study. Read More

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A New Precision Minimally Invasive Method of Glial Scar Simulation in the Rat Spinal Cord Using Cryoapplication.

Front Surg 2021 15;8:607551. Epub 2021 Jul 15.

Department of Clinical Neurosciences, NCL-Neuromed Institute of Neurosciences, Rome, Italy.

According to the World Health Organization, every year worldwide up to 500,000 people suffer a spinal cord injury (SCI). Various animal biomodels are essential for searching for novel protocols and therapeutic approaches for SCI treatment. We have developed an original model of post-traumatic spinal cord glial scarring in rats through cryoapplication. Read More

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Nerve Suture Combined With ADSCs Injection Under Real-Time and Dynamic NIR-II Fluorescence Imaging in Peripheral Nerve Regeneration .

Front Chem 2021 14;9:676928. Epub 2021 Jul 14.

Department of Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Peripheral nerve injury gives rise to devastating conditions including neural dysfunction, unbearable pain and even paralysis. The therapeutic effect of current treatment for peripheral nerve injury is unsatisfactory, resulting in slow nerve regeneration and incomplete recovery of neural function. In this study, nerve suture combined with ADSCs injection was adopted in rat model of sciatic nerve injury. Read More

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A New Target Organ of Chronic Infection: The Intestine.

Front Cell Infect Microbiol 2021 14;11:687499. Epub 2021 Jul 14.

Biosciences and Physiopathology Program, Universidade Estadual de Maringá, Maringá, Brazil.

is one of the main causes of cutaneous leishmaniasis in the Americas. This species presents genetic polymorphism that can cause destructive lesions in oral, nasal, and oropharyngeal tracts. In a previous study, the parasite caused several histopathological changes to hamster ileums. Read More

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