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Intravenous immunoglobulin for corticosteroid-resistant intestinal Henoch-Schönlein purpura: worth a controlled trial against corticosteroids?

Rheumatology (Oxford) 2021 Aug;60(8):3868-3871

Pediatrics and Pediatric Emergency Unit, The Children Hospital, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Objectives: Henoch-Schönlein purpura (HScP) may present in children with severe, occasionally refractory, gastrointestinal (GI) involvement. The use of corticosteroids (CSs) is commonplace in the management of the disease, but to date no standardized protocol is available and, although rare, resistance to CS therapy may be challenging to clinicians. IVIG has been proposed as an effective alternative to CSs, but to date no controlled trial has been conducted to ascertain their real efficacy. Read More

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Behavioral Nudges Increase COVID-19 Vaccinations.

Nature 2021 Aug 2. Epub 2021 Aug 2.

Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Enhancing vaccine uptake is a critical public health challenge. Overcoming vaccine hesitancy and failure to follow-through on vaccination intentions requires effective communication strategies. We present two sequential randomized controlled trials (RCTs) to test the impact of behavioral interventions on COVID-19 vaccine uptake. Read More

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Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18.

Biochem Biophys Res Commun 2021 Jul 29;572:35-40. Epub 2021 Jul 29.

Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Biomedical Sciences, Ohio University, Athens, OH, 45701, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA. Electronic address:

Expression of Regulated endocrine specific protein 18 (Resp18) is localized in numerous tissues and cell types; however, its exact cellular function is unknown. We previously showed that targeted disruption of the Resp18 locus in the Dahl SS (SS) rat (Resp18) results in higher blood pressure (BP), increased renal fibrosis, increased urinary protein excretion, and decreased mean survival time following a chronic (6 weeks) 2% high salt (HS) diet compared with the SS rat. Based on this prominent renal injury phenotype, we hypothesized that targeted disruption of Resp18 in the SS rat promotes an early onset hypertensive-signaling event through altered signatures of the renal transcriptome in response to HS. Read More

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High-flow nasal oxygen (HFNO) for patients with Covid-19 outside intensive care units.

Respir Med 2021 Jul 28;187:106554. Epub 2021 Jul 28.

Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden; Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.

Introduction: High-flow nasal oxygen (HFNO) has traditionally only been used in intensive care units (ICU) especially in acute respiratory distress syndrome (ARDS).

Methods: We studied the use of HFNO at Södersjukhuset, Stockholm, in patients with moderate to severe ARDS related to Covid-19 as well as its benefits both for patients and to offload the ICU. The patients were observed with frequent controls to assess the need of ICU in case of deterioration. Read More

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Sustained-release modeling of clove essential oil in brine to improve the shelf life of Iranian white cheese by bioactive electrospun zein.

Int J Food Microbiol 2021 Jul 24;355:109337. Epub 2021 Jul 24.

Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), km 12 Mashhad-Quchan Highway, P.O. Box: 91895-157-356, Mashhad, Iran. Electronic address:

In this study, the sustained-release of clove essential oil (CEO) loaded into the structure of electrospun zein was used as a biopreservative to extend the shelf life of Iranian white cheese. CEO was loaded at levels of 5, 7.5, and 10% w/w in the structure of electrospun nanofibers. Read More

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Effects of three essential oils and their nano-emulsions on Listeria monocytogenes and Shigella flexneri in Egyptian Talaga cheese.

Int J Food Microbiol 2021 Jul 27;355:109334. Epub 2021 Jul 27.

Certified Food Lab, Animal Health Research Institute, Agriculture Research Center, Egypt.

Talaga cheese is a soft Egyptian cheese that has been associated with foodborne pathogens such as Listeria monocytogenes and Shigella flexneri. Essential oils (EOs) play a pivotal role in sustainably controlling foodborne diseases and as a potential preservative in soft cheeses. However, limited data is available comparing the antibacterial activity of EOs and their nano-emulsions (NEs) when inoculated into Talaga cheese. Read More

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First report on embryonic and larval development of 2n/3n mosaic sterlet.

Animal 2021 Jul 30;15(9):100317. Epub 2021 Jul 30.

Department of Ichthyology and Aquaculture, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

Mosaicism is frequently observed in aquaculture practices, and it adversely affects the production as well as the restoration programme of the sturgeon. The purpose of the present study was the induction of 2n/3n mosaic in sterlet, Acipenser ruthenus L., and compare their embryonic and larval development with diploid control sterlet. Read More

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Effects of oxygen concentration during incubation and broiler breeder age on embryonic heat production, chicken development, and 7-day performance.

Animal 2021 Jul 30;15(9):100323. Epub 2021 Jul 30.

Adaptation Physiology Group, Wageningen University and Research, P.O. Box 338, 6700 AH Wageningen, the Netherlands.

Older breeder flocks produce eggs with a relatively larger yolk and thereby a higher nutrient availability than young breeder flocks. To optimise nutrient utilisation and embryonic development throughout incubation and posthatch period, embryos originating from older breeder flocks may require a higher oxygen availability. The current study investigated effects of broiler breeder flock age and incubational oxygen concentration on embryonic metabolism and chicken development until 7-day posthatch. Read More

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Temporal changes of microbial community structure and nitrogen cycling processes during the aerobic degradation of phenanthrene.

Chemosphere 2021 Jul 28;286(Pt 2):131709. Epub 2021 Jul 28.

Key Laboratory of Three Gorges Reservoir Region's Eco-environment, Ministry of Education, Chongqing University, Chongqing, 400045, China; State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing, 400044, People's Republic of China.

Phenanthrene (PHE) is frequently detected in worldwide soils. But it is still not clear that how the microbial community succession happens and the nitrogen-cycling processes alter during PHE degradation. In this study, the temporal changes of soil microbial community composition and nitrogen-cycling processes during the biodegradation of PHE (12 μg g) were explored. Read More

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The joint adverse effects of aged nanoscale plastic debris and their co-occurring benzo[α]pyrene in freshwater mussel (Anodonta anatina).

Sci Total Environ 2021 Jul 21;798:149196. Epub 2021 Jul 21.

Department of Environmental & Biological Sciences, University of Eastern Finland, PO Box 111, FI80101 Joensuu, Finland.

Although the presence of small-scale plastics, including nanoscale plastic debris (NPD, size <1 μm), is expected in the environment, our understanding of their potential uptake and biodistribution in organisms is still limited. This mostly is because of the limitations in analytical techniques to characterize NPD in organisms' bodies. Moreover, it is still debatable whether aged NPD can sorb and transfer chemicals into organisms. Read More

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Reverse osmosis concentrate treatment by microbubble ozonation-biological activated carbon process: Organics removal performance and environmental impact assessment.

Sci Total Environ 2021 Jul 28;798:149289. Epub 2021 Jul 28.

National University of Singapore, Sembcorp-NUS Corporate Laboratory c/o FoE, Block E1A, #04-01, 1 Engineering Drive 2, 117576, Singapore; Department of Civil & Environmental Engineering, Faculty of Engineering, National University of Singapore, Block E1A, #07-01, 1 Engineering Drive 2, 117576, Singapore. Electronic address:

Reverse osmosis (RO) is being used in many water reclamation facilities to produce high quality water that can be reused for different purposes. As a part of the RO process, a reject stream is produced as the reverse osmosis concentrate (ROC), which contains elevated levels of contaminants compared to the source water. Effective treatment and safe disposal of ROC via cost-effective means is very challenging. Read More

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Increased Relative Functional Gain and Improved Stroke Outcomes: A Linked Registry Study of the Impact of Rehabilitation.

J Stroke Cerebrovasc Dis 2021 Jul 30;30(10):106015. Epub 2021 Jul 30.

Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia; Translational Public Health and Evaluation Division, Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Level 3 Hudson Institute Building, 27-31 Wright Street, Clayton, VIC 3168, Australia. Electronic address:

Objectives: It is unclear how acute care influences patient outcomes in those who receive rehabilitation. We aimed to determine the associations between acute stroke therapies, outcomes during inpatient rehabilitation and self-reported outcomes at 90-180 days after stroke.

Materials And Methods: Patient-level data from adults with acute stroke registered in the Australian Stroke Clinical Registry (AuSCR, 2014-2017) were linked with data from the Australasian Rehabilitation Outcomes Centre (AROC). Read More

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Molecular mechanisms underlying responses of the Antarctic coral Malacobelemnon daytoni to ocean acidification.

Mar Environ Res 2021 Jul 24;170:105430. Epub 2021 Jul 24.

Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales.,Cátedra de Ecología Marina, Av. Vélez Sarsfield 299, X5000JJC, Córdoba, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Diversidad y Ecología Animal (IDEA), Ecosistemas Marinos Polares, Av. Vélez Sarsfield 299, X5000JJC, Córdoba, Argentina. Electronic address:

Benthic organisms of the Southern Ocean are particularly vulnerable to ocean acidification (OA), as they inhabit cold waters where calcite-aragonite saturation states are naturally low. OA most strongly affects animals with calcium carbonate skeletons or shells, such as corals and mollusks. We exposed the abundant cold-water coral Malacobelemnon daytoni from an Antarctic fjord to low pH seawater (LpH) (7. Read More

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Steroid profiling by UHPLC-MS/MS in dried blood spots collected from healthy women with and without testosterone gel administration.

J Pharm Biomed Anal 2021 Jul 26;204:114280. Epub 2021 Jul 26.

Swiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne and Geneva, Lausanne University Hospital and University of Lausanne, Switzerland.

The quantification of a large panel of endogenous steroids in serum by LC-MS/MS represents a powerful clinical tool for the screening or diagnosis of diverse endocrine disorders. This approach has also demonstrated excellent sensitivity for the detection of testosterone misuse in the anti-doping field, especially in female athlete population. In both situations, the use of dried blood spots (DBS) could provide a viable alternative to invasive venous blood collection. Read More

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Gender Differences in Insurance, Surgical Admissions and Outcomes at a Kenyan Referral Hospital.

J Surg Res 2021 Jul 30;268:199-208. Epub 2021 Jul 30.

Department of General Surgery, Indiana University School of Medicine, Indianapolis, IND; Moi University, Kesses, Eldoret, Kenya.

Introduction: Gender is an important factor in determining access to healthcare resources. Women face additional barriers, especially in low- and middle-income countries. Surgical costs can be devastating, which can exacerbate engendered disparities. Read More

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Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae.

Aquat Toxicol 2021 Jul 24;238:105926. Epub 2021 Jul 24.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200292, China. Electronic address:

Perfluorooctanoic acid (PFOA) is known as an environmental endocrine disruptor and has developmental neurotoxicity that could be associated with behavior changes in human and animal studies. Previous studies have shown that PFOA might affect the dopaminergic nervous system. However, the mode of action underlying the effects of PFOA remains poorly understood. Read More

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Fed-in-situ biological reduction treatment of food waste via high-temperature-resistant oil degrading microbial consortium.

Bioresour Technol 2021 Jul 22;340:125635. Epub 2021 Jul 22.

Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou 310014, PR China; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China.

This study aims to construct a high-temperature-resistant microbial consortium to effectively degrade oily food waste by Fed-in-situ biological reduction treatment (FBRT). Oil degrading bacteria were screened under thermophilic conditions of mineral salt medium with increased oil content. The oil degradation and emulsification ability of each stain was evaluated and their synergetic improvement was further confirmed. Read More

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Improving stability of mainstream Anammox in an innovative two-stage process for advanced nitrogen removal from mature landfill leachate.

Bioresour Technol 2021 Jul 21;340:125617. Epub 2021 Jul 21.

China Architecture Design and Research Group, Beijing 100044, PR China. Electronic address:

This study presents an innovative mainstream Anammox based on multiple NO-N supplement pathways to treat actual mature landfill leachate over 180 days. Desirable effluent quality of 11.8 mg/L total nitrogen (TN) and nitrogen removal efficiency of 98. Read More

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Valorization of waste cabbage leaves by postharvest photochemical treatments monitored with a non-destructive fluorescence-based sensor.

J Photochem Photobiol B 2021 Jul 20;222:112263. Epub 2021 Jul 20.

Research Institute of Horticulture, Konstytucji 3 Maja 1/3, Skierniewice, Poland.

The biosynthesis of polyphenolic compounds in cabbage waste, outer green leaves of white head cabbage (Brassica oleracea L. var. capitata subvar. Read More

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Biofilm formation of Ancylobacter sp. TS-1 on different granular materials and its ability for chemolithoautotrophic As(III)-oxidation at high concentrations.

J Hazard Mater 2021 Jul 27;421:126733. Epub 2021 Jul 27.

Departamento de Ingeniería Hidráulica y Ambiental, Pontificia Universidad Católica de Chile, Santiago, Chile; CEDEUS, Centro de Desarrollo Urbano Sustentable, Chile. Electronic address:

The oxidation of arsenic (As) is a key step in its removal from water, and biological oxidation may provide a cost-effective and sustainable method. The biofilm-formation ability of Ancylobacter sp. TS-1, a novel chemolithoautotrophic As oxidizer, was studied for four materials: polypropylene, graphite, sand, and zeolite. Read More

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Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold.

Phytochemistry 2021 Jul 30;190:112887. Epub 2021 Jul 30.

Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia. Electronic address:

Chemical studies of the aerial parts of the Australian desert plant Eremophila microtheca afforded the targeted and known diterpenoid scaffolds, 3,7,8-trihydroxyserrulat-14-en-19-oic acid and 3-acetoxy-7,8-dihydroxyserrulat-14-en-19-oic acid. The most abundant serrulatane scaffold was converted to the poly-methyl derivatives, 3-hydroxy-7,8-dimethoxyserrulat-14-en-19-oic acid methyl ester and 3,7,8-trimethoxyserrulat-14-en-19-oic acid methyl ester using simple and rapid methylation conditions consisting of DMSO, NaOH and MeI at room temperature. Subsequently a 12-membered amide library was synthesised by reacting the methylated scaffolds with a diverse series of commercial primary amines. Read More

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Porous gelatin microspheres for controlled drug delivery with high hemostatic efficacy.

Colloids Surf B Biointerfaces 2021 Jul 28;207:112013. Epub 2021 Jul 28.

Orthopaedic Oncology Center, Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Effective hemostasis and antibacterial efficacy for extensive trauma in a warzone and civilian accidents are important for reducing mortalities and serious complications. Gelatin has been widely used as a hemostatic agent and has the potential for use in drug delivery systems. To enhance its hemostatic efficiency and create conducive conditions for sustained drug release, we developed Vancomycin-impregnated porous gelatin microspheres (Van-MS) by introducing the porous structure into gelatin. Read More

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Heterologous expression and biophysical characterization of a mesophilic tannase following manganese nanoparticle immobilization.

Colloids Surf B Biointerfaces 2021 Jul 29;207:112011. Epub 2021 Jul 29.

Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

In the current study, we analyzed the efficacy of manganese oxide nanoparticle (MnNP)-water dispersion as an immobilization matrix for bacterial tannase. The tannase-secreting Bacillus subtilis strain NJKL.tan. Read More

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Rutin promotes activation and reduces apoptosis of primordial follicles by regulating Akt phosphorylation after in vitro culture of ovine ovarian tissue.

Theriogenology 2021 Jul 26;173:64-72. Epub 2021 Jul 26.

Nucleus of Biotechnology Applied to Ovarian Follicle Development, Federal University of São Francisco Valley, Petrolina, PE, Brazil. Electronic address:

The aims of this study were to analyze the effects of different concentrations of rutin on primordial follicle survival and development after in vitro culture of sheep ovarian tissue, and to verify the possible involvement of the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway in the rutin actions. Ovarian fragments were fixed for histological analysis (fresh control) or cultured in α-minimum essential medium alone (α-MEM: control medium) or in α-MEMsupplemented with different concentrations of rutin (0.1; 1 or 10 μg/mL) for 7 days. Read More

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Transfusion Guidelines in Adult Spine Surgery: A Systematic Review and Critical Summary of Currently Available Evidence.

Spine J 2021 Jul 30. Epub 2021 Jul 30.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, TX, USA 75235; University of Texas Southwestern Medical Center, Spine Center, Dallas, TX, USA 75235.

Background Context: Red blood cell transfusion can be associated with complications in medical and surgical patients. Acute anemia in ambulatory patients undergoing surgery can also impede wound healing and independent self-care. Current transfusion threshold guidelines are still based on evidence derived from critically-ill intensive care unit medical patients and may not apply to spine surgery candidates. Read More

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Characterization of Pericarditis Following Allogeneic Hematopoietic Cell Transplant.

Transplant Cell Ther 2021 Jul 30. Epub 2021 Jul 30.

Blood and Marrow Transplant and Cellular Therapy Program, Abramson Cancer Center and the Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Pericarditis is an uncommon cardiac complication following allogeneic hematopoietic transplant (alloHCT) with limited data characterizing incidence, presentation, and management. The etiology of pericarditis in this setting is poorly understood, and may include conditioning-related toxicity, infection, or graft-versus-host disease (GVHD).

Objective: The objective of this study was to characterize the clinical presentation, management and outcomes of post alloHCT pericarditis observed at a single center. Read More

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Proneurogenic and neuroprotective effect of a multi strain probiotic mixture in a mouse model of acute inflammation: involvement of the gut-brain axis.

Pharmacol Res 2021 Jul 30:105795. Epub 2021 Jul 30.

Institute of Biochemistry and Cell Biology, IBBC, CNR, Monterotondo, Rome, Italy. Electronic address:

Neuroinflammation can severely affect brain homeostasis and adult hippocampal neurogenesis with detrimental effects on cognitive processes. Brain and gut are intimately connected via the "gut-brain axis", a bidirectional communication system, and the administration of live bacteria (probiotics) has been shown to represent an intriguing approach for the prevention or even the cure of several diseases. In the present study we evaluated the putative neuroprotective effect of 15-days consumption of a multi-strain probiotic formulation based on food-associated strains and human gut bacteria at the dose of 10 CFU/mouse/day in a mouse model of acute inflammation, induced by an intraperitoneal single injection of LPS (0. Read More

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Differential protein expression due to Se deficiency and Se toxicity in rat liver.

J Nutr Biochem 2021 Jul 30:108831. Epub 2021 Jul 30.

The Florey Institute of Neuroscience and Mental Health, CRC for Mental Health, University of Melbourne, Australia; Department of Biochemistry, Emory School of Medicine, Atlanta, GA, USA; Department of Neurology, Emory School of Medicine, Atlanta, GA, USA. Electronic address:

There is a U-shaped dose-response between selenium (Se) status and health outcomes, but underlying metabolic processes are unclear. This study aims to identify candidate proteins in liver regulated by dietary Se, ranging from deficiency to toxic. Male rats (n=4) were fed graded Se concentrations as selenite for 28 days. Read More

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Intramuscular insulin-like growth factor-1 gene therapy modulates reactive microglia after traumatic brain injury.

Brain Res Bull 2021 Jul 30. Epub 2021 Jul 30.

Universidad Nacional de La Plata, Facultad de Ciencias Médicas, Buenos Aires, Argentina; Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP-CONICET), La Plata, Argentina. Electronic address:

Reactive gliosis is a key feature and an important pathophysiological mechanism underlying chronic neurodegeneration following traumatic brain injury (TBI). In this study, we have explored the effects of intramuscular IGF-1 gene therapy on reactive gliosis and functional outcome after an injury of the cerebral cortex. Young adult male rats were intramuscularly injected with a recombinant adenoviral construct harboring the cDNA of human IGF-1 (RAd-IGF1), with a control vector expressing green fluorescent protein (RAd-GFP) or PBS as control. Read More

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Astaxanthin-s-allyl cysteine diester against high glucose-induced neuronal toxicity in vitro and diabetes-associated cognitive decline in vivo: Effect on p53, oxidative stress and mitochondrial function.

Neurotoxicology 2021 Jul 30. Epub 2021 Jul 30.

Department of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, India. Electronic address:

Neuroprotective effect of astaxanthin-s-allyl cysteine diester (AST-SAC) against high glucose (HG)-induced oxidative stress in in vitro and cognitive decline under diabetes conditions in in vivo has been explored. Pretreatment of AST-SAC (5, 10 and 15 μM) dose-dependently preserved the neuronal cells (SH-SY5Y) viability against HG toxicity through i) decreasing oxidative stress [decreasing reactive oxygen species generation and increasing endogenous antioxidants level]; ii) protecting mitochondrial function [oxidative phosphorylation (OXPHOS) complexes activity and mitochondrial membrane potential (MMP)]; and iii) decreasing p53 level thereby subsequently decreasing the level apoptotic marker proteins. Male Spraque-Dawley rats were orally administered AST-SAC (1 mg/kg/day) for 45 days in streptozotocin-induced diabetes mellitus (DM) rats. Read More

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