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Uptake and translocation of nano/microplastics by rice seedlings: Evidence from a hydroponic experiment.

J Hazard Mater 2021 Jul 21;421:126700. Epub 2021 Jul 21.

College of Environment and Safety Engineering, Qingdao University of Science and Technology, Qingdao, Shandong Province 266042, PR China. Electronic address:

Microplastics (MPs) are emerging contaminants in terrestrial systems that cause diverse impacts on plants. However, little is known about whether MPs especially micro-sized MPs can be accumulated and translocated in plants particularly food crops. Hereby, a hydroponic experiment was conducted to verify whether nano-sized (80 nm) and micro-sized (1 µm) fluorescently labeled polystyrene (PS) microspheres can enter rice roots and translocate to aerial parts. Read More

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Management of nasal myiasis and type 2 diabetes mellitus: A rare case and review article.

Int J Surg Case Rep 2021 Jul 26;85:106244. Epub 2021 Jul 26.

Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: Nasal myiasis is a nasal infestation caused by house fly larvae (maggot). It's a rare condition with only a few reported cases and no treatment consensus.

Case Presentation: A 54-year-old woman was admitted to the emergency unit with a complaint of larvae found in the left nasal cavity and bloody nasal discharge for 2 days. Read More

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Post-embolization outcomes of splenic artery pseudoaneurysms: A single-center experience.

Clin Imaging 2021 Jul 26;80:160-166. Epub 2021 Jul 26.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL, USA. Electronic address:

Purpose: Splenic artery pseudoaneurysms (PSA) are relatively rare but associated with high mortality/morbidity when presenting acutely. Embolization has emerged as the treatment of choice. We aim to evaluate the outcomes of embolization for the treatment of splenic artery PSAs. Read More

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Impact of the COVID-19 pandemic on acute inpatient psychiatric units in Spain.

Psychiatry Res 2021 Jul 24;304:114136. Epub 2021 Jul 24.

Department of Psychiatry, University Hospital Ramón y Cajal, Madrid, Spain.

Patients with more severe mental health symptoms are treated in acute inpatient psychiatric units (AIPUs), but the functioning of these units throughout Spain has been challenged by the COVID-19 pandemic. We therefore conducted a descriptive, cross-sectional study to assess the situation. An online survey was distributed to all hospitals with AIPUs in Spain and made accessible for 28 days. Read More

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The meaningful change threshold as measured by the 16-item quick inventory of depressive symptomatology in adults with treatment-resistant major depressive and bipolar disorder receiving intravenous ketamine.

J Affect Disord 2021 Jul 20;294:592-596. Epub 2021 Jul 20.

Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada; Canadian Rapid Treatment Center of Excellence, Mississauga, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Objective: .To identify a meaningful change threshold (MCT) in depression outcomes in adults with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) receiving intravenous ketamine treatment at a community-based mood disorders center.

Method: . Read More

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Do clinical criteria based on PROMIS outcomes identify acceptable symptoms and function for patients with musculoskeletal problems.

Musculoskelet Sci Pract 2021 Jul 5;55:102423. Epub 2021 Jul 5.

George Fox University, Newberg, OR, USA.

Background: Understanding how symptoms influence patient judgements of their health informs providers where to direct care. Patient reported physical outcomes (physical function, pain interference) and self-efficacy of symptom management (SEsm)) predict a patient's health state (i.e. Read More

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2,6-Dimethoxy-1,4-benzoquinone increases skeletal muscle mass and performance by regulating AKT/mTOR signaling and mitochondrial function.

Phytomedicine 2021 Jul 10;91:153658. Epub 2021 Jul 10.

Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, South Korea; Division of Food Biotechnology, University of Science and Technology, Daejeon 34113, South Korea. Electronic address:

Background: 2,6-Dimethoxy-1,4-benzoquinone (DMBQ), a natural phytochemical present in fermented wheat germ, has been reported to exert anti-cancer, anti-inflammatory, and anti-adipogenic effects. However, the effect of DMBQ on muscle hypertrophy and myoblast differentiation has not been elucidated.

Purpose: We investigated the effect of DMBQ on skeletal muscle mass and muscle function and then determined the possible mechanism of DMBQ. Read More

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Impact of a computerized physician order entry (CPOE)-based antibiotic stewardship intervention on the treatment duration for pneumonia and COPD exacerbations.

Respir Med 2021 Jul 24;186:106546. Epub 2021 Jul 24.

Department of Respiratory Medicine, Evangelische Lungenklinik, Berlin, Germany.

Background: In hospitalized patients, the duration of antibiotic therapy for uncomplicated pneumonia is often longer than recommended in clinical guidelines. Consequences include increased risk of Clostridioides difficile infection and the emergence of antibiotic resistance. Reducing the duration of antibiotic therapy is an important goal of antibiotic stewardship (ABS) programs. Read More

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Determination of the optimum digestible isoleucine to lysine ratios for male Yield Plus × Ross 708 broilers between 1.0 and 4.0 kg body weight utilizing growth performance and carcass characteristics.

Poult Sci 2021 Jun 5;100(9):101307. Epub 2021 Jun 5.

Department of Poultry Science, Auburn University, Auburn, AL 36849. Electronic address:

Three experiments (Exp) were conducted to determine optimal digestible Ile to Lys ratios for male Yield Plus × Ross 708 broilers from approximately 1.0 to 4.0 kg BW. Read More

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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) : Series of 49 French pediatric cases.

J Allergy Clin Immunol Pract 2021 Jul 28. Epub 2021 Jul 28.

Service de Dermatologie, Hôtel Dieu, Centre Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse drug reaction. It can be difficult to diagnose, even more so among children, since symptoms may mimic other commonly encountered pediatric conditions.

Objective: To describe clinical and laboratory features of DRESS syndrome in the pediatric population (≤ 18 years of age), establish causative agents and treatment modalities. Read More

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Single and combined effects of microplastics, pyrethroid and food resources on the life-history traits and microbiome of Chironomus riparius.

Environ Pollut 2021 Jul 26;289:117848. Epub 2021 Jul 26.

Department of Ecology and Genetics, Section of Animal Ecology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, 75236, Uppsala, Sweden.

There is growing evidence of widespread contamination of freshwater ecosystems with microplastics. However, the effects of chronic microplastic ingestion and its interaction with other pollutants and stress factors on the life-history traits and the host-microbiome of aquatic invertebrates are not well understood. This study investigates the effects of exposure to sediment spiked with 1 μm polystyrene-based latex microplastic spheres, an environmentally realistic concentration of a pyrethroid pesticide (esfenvalerate), and a combination of both treatments on the life-history traits of the benthic-dwelling invertebrate, Chironomus riparius and its microbial community. Read More

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Herpesvirus reactivation during severe COVID-19 and high rate of immune defect.

Infect Dis Now 2021 Jul 28. Epub 2021 Jul 28.

Service de médecine intensive et de réanimation médicale, hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010 Paris, France; Université de Paris, ECSTRA team, UMR 1153, Center of Epidemiology and Biostatistics, INSERM, Paris, France.

Objective: We assessed herpesvirus reactivation in severe SARS-CoV-2 infection.

Methods: Retrospective study including consecutive patients admitted to an onco-hematology intensive care unit (ICU) for severe COVID-19. Replication of EBV, CMV, and HSV was evaluated. Read More

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Effects of Ankle Continuous Passive Motion on Soleus Hypertonia in Individuals with Cerebral Palsy: A Case Series.

Biomed J 2021 Jul 28. Epub 2021 Jul 28.

School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, No.259, Wen-hua 1st Rd., Guishan Dist., Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, No.5, Fuhsing Str., Guishan Dist., Taoyuan, Taiwan. Electronic address:

Background: Continuous passive motion device (CPM) provides repetitive movement over extended periods of time for those who have low functional ability. The purpose of this research was to evaluate the effects of a four-week program of continuous passive motion of the ankle joint on the changes in soleus hypertonia in individuals with cerebral palsy who suffered from life-long hypertonia.

Material And Methods: A single group, repeated-measures study was conducted. Read More

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Accelerated theta burst stimulation for the treatment of depression: A randomised controlled trial.

Brain Stimul 2021 Jul 28. Epub 2021 Jul 28.

Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Department of Psychiatry, Monash University, Camberwell, Victoria, Australia.

Introduction: Theta burst pattern repetitive transcranial magnetic stimulation (TBS) is increasingly applied to treat depression. TBS's brevity is well-suited to application in accelerated schedules. Sizeable trials of accelerated TBS are lacking; and optimal TBS parameters such as stimulation intensity are not established. Read More

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Dural Tear Does Not Increase the Rate of Venous Thromboembolic Disease in Patients Undergoing Elective Lumbar Decompression with Instrumented Fusion.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, University of Maryland Medical Center, Baltimore, MD. Electronic address:

Objective: Evaluate if dural tears (DT) are an indirect risk factor for venous thromboembolic disease through increased recumbency in patients undergoing elective lumbar decompression and instrumented fusion.

Methods: A retrospective cohort study of consecutive patients undergoing elective lumbar decompression and instrumented fusion at a single institution between 2016 and 2019. Patients were divided into cohorts: those who sustained a dural tear and those who did not. Read More

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Extracellular Matrix Remodeling precedes Atrial Fibrillation. Results of the PREDICT-AF trial.

Heart Rhythm 2021 Jul 28. Epub 2021 Jul 28.

Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address:

Background: To which extent atrial remodeling occurs prior to atrial fibrillation (AF) is unknown.

Objective: The PREDICT-AF study investigated such subclinical remodeling, that may be used for risk stratification and AF prevention.

Methods: Patients (n=150) without a history of AF with a CHADS-VASc score ≥2 at increased risk of developing AF, were included. Read More

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Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fiber system that simulates human plasma and epithelial lining fluid pharmacokinetics.

Clin Microbiol Infect 2021 Jul 28. Epub 2021 Jul 28.

Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.

Objectives: Mycobacterium avium complex (MAC) bacteria can cause chronic pulmonary disease (PD). Current treatment regimens of azithromycin, ethambutol and rifampicin have culture conversion rates of around 65%. Dynamic, pre-clinical models to assess the efficacy of treatment regimens are important to guide clinical trial development. Read More

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Investigating immune responses of the house cricket, Acheta domesticus to pathogenic Eschericia coli K1.

Microbes Infect 2021 Jul 28:104876. Epub 2021 Jul 28.

Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, Selangor, Malaysia; Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Background: Insects models are excellent models of the innate immune system, as they are free from the influences of the vertebrate adaptive immunity. Crickets are hemimetabolous insects belonging to the order Orthopteran order that have not been as extensively characterized as other holometabolous insects, and may provide new insights to the insect immune responses. In this study, we aim to characterize the innate immune responses of the common house cricket, Acheta domesticus in response to a human pathogenic bacterium E. Read More

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Association of public health interventions and COVID-19 incidence in Vietnam, January to December 2020.

Int J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, ACT, Australia; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Background: Vietnam implemented various public health interventions such as contact tracing and testing, mandatory quarantine, and lockdowns in response to COVID-19. However, the effects of these measures on the epidemic remain unclear.

Methods: We described public health interventions in relation to COVID-19 incidence. Read More

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Effect of combined exposure to silica nanoparticles and cadmium chloride on female zebrafish ovaries.

Environ Toxicol Pharmacol 2021 Jul 28:103720. Epub 2021 Jul 28.

University of Science and Technology of China, Hefei, 230026, People's Republic of China; CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou, 215163, People's Republic of China. Electronic address:

Silica nanoparticles (SiNPs) and cadmium chloride (CdCl) are two important environmental pollutants. In previous research, found that SiNPs in zebrafish larvae can amplify the cardiovascular damage caused by cadmium. Whether SiNPs in the ovaries can amplify the adverse effects of cadmium on the zebrafish ovaries is worth studying problem. Read More

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Korean red ginseng alleviate depressive disorder by improving astrocyte gap junction function.

J Ethnopharmacol 2021 Jul 28:114466. Epub 2021 Jul 28.

Institute for Brain Research and Rehabilitation (IBRR), South China Normal University (SCNU), Guangzhou, 510631, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Hunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208 Hunan, China; DME Center, Clinical Pharmacology Institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Ethnopharmacological Relevance: Korean red ginseng (KRG), a processed product of Panax ginseng C. A. Mey, show significant anti-depressive effect in clinic. Read More

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The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - a randomized proof of concept study.

Neurosci Lett 2021 Jul 28:136146. Epub 2021 Jul 28.

Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

Introduction: Current treatments for cocaine use disorder (CUD) are not very effective and better treatments are needed. This study investigates the effectiveness of a combined intervention that targets the assumed underlying glutamate pathology in cocaine users. To this end, the combined effects of N-acetylcysteine (NAC) and working memory (WM) training on glutamate concentrations in the dorsal and rostral ACC were investigated in a randomized, double-blind placebo-controlled design. Read More

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Rare-earth nanoparticles induce depression, anxiety-like behavior, and memory impairment in mice.

Food Chem Toxicol 2021 Jul 28:112442. Epub 2021 Jul 28.

Department of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, 350100, China.

Rare-earth nanoparticles have been widely studied for disease diagnosis, in vivo optical imaging, biosensing, and drug delivery. However, the effects of rare-earth nanoparticles on a central nervous system remain unclear. Here, we report that the continuous exposure to rare-earth nanoparticles in mice can cause behavioral alterations including cognitive deficits, anxiety, and depression-like behavior. Read More

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Pufferfish poisoning from Arothron stellatus: The first confirmed case in India with exact species identification.

Toxicon 2021 Jul 28. Epub 2021 Jul 28.

ICAR-Central Institute of Fisheries Technology, Cochin-682 029, Kerala, India.

A puffer fish poisoning case was reported from the coastal city of Veraval in the Gujarat state of India with patient reporting symptoms of giddiness, vertigo, aphasia and heaviness of head following consumption of cooked fish. Treatment was purely symptomatic and supportive. The patient was discharged from the hospital in a stable condition after 4 days. Read More

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The relationship between diabetes and surgical site infection following coronary artery bypass graft surgery in current-era models of care.

J Hosp Infect 2021 Jul 28. Epub 2021 Jul 28.

Department of Diabetes and Endocrinology, Royal Melbourne Hospital; Department of Medicine, Royal Melbourne Hospital, University of Melbourne.

Background: Although diabetes is a recognised risk factor for post-operative infections, the seminal Portland Diabetic Project studies in cardiac surgery demonstrated intravenous insulin infusions following open-cardiac surgery achieved near normal glycaemia and decreased deep sternal wound infection to similar rates to those without diabetes.

Aim: We sought to examine a contemporary cohort of patients undergoing coronary artery bypass graft surgery (CABGS) to evaluate the relationship between diabetes, hyperglycaemia and risk of surgical site infection (SSI) in current-era models of care.

Methods: Consecutive patients who underwent CABGS between 2016 and 2018 were identified through a state-wide data repository for healthcare-associated infections. Read More

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Has COVID-19 lockdown improved glycaemic control in pediatric patients with type 1 diabetes? An analysis of continuous glucose monitoring metrics.

Diabetes Res Clin Pract 2021 Jul 28:108988. Epub 2021 Jul 28.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.

Aims: Our observational study aimed to evaluate the impact of the lockdown period due to 2019 Coronavirus disease pandemic on glycaemic control in a cohort of paediatric patients with type 1 diabetes (T1D).

Methods: Eighty-five patients with T1D aged 5-18 years using continuous glucose monitoring (CGM) systems were enrolled. Demographic and clinical data, including glucose metrics generated by CGM-specific web-based cloud platforms, were collected in three different periods (pre-lockdown phase, lockdown phase, and post-lockdown phase) of 90 days each and were statistically analysed. Read More

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Ninety-Day Readmission After Open Surgical Repair of Stanford Type A Aortic Dissection.

Ann Thorac Surg 2021 Jul 28. Epub 2021 Jul 28.

Michael E. DeBakey Department of Surgery, Division of General Surgery, Baylor College of Medicine, Houston, Texas; Michael E. DeBakey Department of Surgery, Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, Texas; CHI St Luke's Health-Baylor St Luke's Medical Center, Houston, Texas; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Texas. Electronic address:

Background: Investigations into readmissions after surgical repair of acute Stanford Type A aortic dissection (TAAD) remain scarce. We analyzed potential risk factors for readmission after TAAD.

Methods: The 2013-2014 United States Nationwide Readmissions Database was queried for TAAD index hospitalizations and 90-day readmissions indicated by diagnostic and procedural codes. Read More

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Neonatal morbidity and mortality by mode of delivery in very preterm neonates.

Am J Obstet Gynecol 2021 Jul 28. Epub 2021 Jul 28.

Washington University in St. Louis, Division of Maternal Fetal Medicine; Hadassah University Medical Center, Jerusalem, Israel.

Background: The safest mode of delivery for very preterm infants is an ongoing topic of debate. There are many reasons for cesarean delivery (CD) in extremely preterm and very preterm infants, including labor, fetal distress, maternal indications, and malpresentation.

Objectives: This study aimed to determine whether CD is associated with significantly improved neonatal morbidity. Read More

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Incidence of ocular hypertension in patients receiving intravitreal anti-VEGF injections: comparing filtered drug in plastic silicone-free syringes to nonfiltered drug in silicone-lined insulin plastic syringes.

Can J Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

From the Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, B.C.. Electronic address:

Objective: To examine the difference in incidence of ocular hypertension (OHT) following the introduction of filtered anti-vascular endothelial growth factor (anti-VEGF) medication in silicone-free syringes.

Design: Retrospective cohort study.

Methods: A retrospective review of consecutive treatment-naive patients receiving intravitreal anti-VEGF injections in a group practice was performed. Read More

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Performance evaluation of an automated SARS-CoV-2 Ag test for the diagnosis of COVID-19 infection on nasopharyngeal swabs.

Clin Chem Lab Med 2021 Jul 30. Epub 2021 Jul 30.

Université de Lorraine, CNRS, LCPME, Nancy, France.

Objectives: The detection of SARS-CoV-2 in infected people is a key tool to help in controlling COVID-19 pandemic. Like rapid antigenic tests, automated antigen tests, that present the advantage of a higher throughput flow, may be of interest. The LIAISON SARS-CoV-2 Ag test was evaluated for the quantification of SARS-CoV-2 nucleocapsid antigen in nasopharyngeal swabs by comparison to RT-PCR. Read More

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