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Rinsing with Statherin-Derived Peptide Alters the Proteome of the Acquired Enamel Pellicle.

Caries Res 2021 24;55(4):333-340. Epub 2021 Jun 24.

Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.

Changes in the proteomic profile of the acquired enamel pellicle (AEP) formed for 3 min or 2 h after rinsing with a peptide containing the 15 N-terminal residues of statherin, with serines 2 and 3 phosphorylated (StatpSpS), were evaluated. Nine volunteers participated in 2 consecutive days. Each day, after professional tooth cleaning, they rinsed for 1 min with 10 mL of phosphate buffer containing 1. Read More

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Clinical efficacy and safety of Janus kinase inhibitors for COVID-19: A systematic review and meta-analysis of randomized controlled trials.

Int Immunopharmacol 2021 Jul 31;99:108027. Epub 2021 Jul 31.

Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan. Electronic address:

Objectives: This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to investigate the clinical efficacy and safety of Janus kinase (JAK) inhibitors for COVID-19 patients.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to July 12, 2021. Read More

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Improved spectrophotometric method for nitrite determination in processed foods and dietary exposure assessment for Korean children and adolescents.

Food Chem 2021 Jul 19;367:130628. Epub 2021 Jul 19.

Food Additives and Packaging Division, National Institute of Food and Drug Safety Evaluation, Cheongju 28159, Republic of Korea. Electronic address:

A spectrophotometric method based on diazo-coupling reaction for nitrite analysis was established and validated, including inter-laboratory validation, linearity, accuracy, precision, the limit of detection (LOD) and limit of quantification (LOQ). The time-saving and high-recovery method was established by examining the filtration step, colorimetric process and concentration range of the calibration curve. This method showed good linearity (r > 0. Read More

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Safety and efficacy of a novel barrier film to prevent intrauterine adhesion formation after hysteroscopic myomectomy: The PREG1 clinical trial.

J Minim Invasive Gynecol 2021 Jul 31. Epub 2021 Jul 31.

Bicêtre hospital, Department of Obstetrics and Gynaecology, Le Kremlin Bicêtre, France.

Objective: To evaluate the safety and potential efficacy of a novel degradable polymer film (DPF), designed to act as a 7-day barrier to prevent intrauterine adhesions (IUAs), post hysteroscopic myomectomy.

Design: A prospective single arm, first-in-human clinical study.

Setting: Multicenter study involving 6 centers in France, Belgium and the Netherlands Patients: Women ≥40 years with no plans to conceive who qualified for hysteroscopic myomectomy (at least one 10 millimeter type 0, 1 or 2 myoma) and had a sounded length of the uterine cavity (fundus to exocervix) ranging between 6 - 9 cm, were considered eligible for the study. Read More

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IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity.

J Mol Cell Cardiol 2021 Jul 31. Epub 2021 Jul 31.

Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States of America; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

Neonatal heart regeneration depends on proliferation of pre-existing cardiomyocytes, yet the mechanisms driving regeneration and cardiomyocyte proliferation are not comprehensively understood. We recently reported that the anti-inflammatory cytokine, interleukin 13 (IL13), promotes neonatal cardiac regeneration; however, the signaling pathway and cell types mediating this regenerative response remain unknown. Here, we hypothesized that expression of the type II heterodimer receptor for IL13, comprised of IL4Rα and IL13Rα1, expressed directly on cardiomyocytes mediates cardiomyocyte cell cycle and heart regeneration in neonatal mice. Read More

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Short-term outcomes of robot-assisted versus thoracoscopic-assisted minimally invasive esophagectomy.

Ann Thorac Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, China. Electronic address:

Background: Robot-assisted (RA) and thoracoscopic-assisted (TA) minimally invasive esophagectomy (MIE) are surgical techniques for the treatment of esophageal cancer. This study aims to compare short-term outcomes of RAMIE to TAMIE.

Methods: We conducted a single-center retrospective analysis between January 2016 and December 2019, including 1012 consecutive patients who underwent MIE, 437 in the RAMIE group and 575 in the TAMIE group. Read More

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Coagulation disorders in patients with severe hemophagocytic lymphohistiocytosis.

PLoS One 2021 3;16(8):e0251216. Epub 2021 Aug 3.

AP-HP, Medical ICU, Hôpital Saint-Louis, Paris, France.

Background: Coagulation disorders are common in patients with hemophagocytic lymphohistiocytosis (HLH), associated with an increased risk of bleeding and death. We aim to investigate coagulation disorders and their outcome implications in critically ill patients with HLH.

Methods: We prospectively evaluated 47 critically ill patients with HLH (median age of 54 years [42-67]) between April 2015 and December 2018. Read More

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Delayed RT-PCR Time-To-Positivity in an adult with SARS-CoV-2 Infection.

J Infect Dev Ctries 2021 Jul 31;15(7):913-917. Epub 2021 Jul 31.

Coronavirus Disease 2019 (COVID-19) Task Force, Kramat Jati Regional General Hospital, Jakarta, Indonesia.

Early diagnosis is among the crucial measures to control the spread of SARS-CoV-2 infection. To date, reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for COVID-19 testing, but various factors can affect its performance leading to false negative results. Hereby we present a patient with a high clinical suspicion for COVID-19 and had multiple negative RT-PCR results over 5 days. Read More

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A longitudinal analysis of smoke-free laws and smoking initiation disparities among young adults in the United States.

Addiction 2021 Aug 3. Epub 2021 Aug 3.

Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Background And Aims: Tobacco control policies may differentially impact smoking initiation across sociodemographic groups. We measured longitudinal associations between exposure to smoke-free laws in grade 12 (modal age 18) and patterns of smoking initiation in the U.S. Read More

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Short-term outcomes and healthcare resource utilization following incisional hernia repair with synthetic mesh in patients with Crohn's disease.

Hernia 2021 Aug 3. Epub 2021 Aug 3.

Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.

Purpose: While the use of synthetic mesh for incisional hernia repair reduces recurrence rates, little evidence exists regarding the impact of this practice on the disease burden of a Crohn's patient. We aimed to describe the post-operative outcomes and healthcare resource utilization following incisional hernia repair with synthetic mesh in patients with Crohn's disease.

Methods: A retrospective review of adult patients with Crohn's disease who underwent elective open incisional hernia repair with extra-peritoneal synthetic mesh from 2014 to 2018 at a single large academic hospital with surgeons specializing in hernia repair was conducted. Read More

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Efficient synthesis of bepotastine and cloperastine intermediates using engineered alcohol dehydrogenase with a hydrophobic pocket.

Appl Microbiol Biotechnol 2021 Aug 3. Epub 2021 Aug 3.

Microbial Pharmacology Laboratory, Shanghai University of Medicine & Health sciences, 279 Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.

(S)-4-Chlorophenylpyridylmethanol and (R)-4-chlorobenzhydrol are key pharmaceutical intermediates for the synthesis of bepotastine and cloperastine, respectively. However, the biocatalytic approach to prepare these bulky diaryl ketones remains challenging because of the low activity of naturally occurring alcohol dehydrogenases (ADH). In the present study, ADH seq5, which has an adequate binding pocket volume and accepts bulky diaryl ketones, was further engineered with a binding pocket of increased hydrophobicity. Read More

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Association of Dose Tapering With Overdose or Mental Health Crisis Among Patients Prescribed Long-term Opioids.

JAMA 2021 Aug;326(5):411-419

Department of Family and Community Medicine, University of California, Davis, Sacramento.

Importance: Opioid-related mortality and national prescribing guidelines have led to tapering of doses among patients prescribed long-term opioid therapy for chronic pain. There is limited information about risks related to tapering, including overdose and mental health crisis.

Objective: To assess whether there are associations between opioid dose tapering and rates of overdose and mental health crisis among patients prescribed stable, long-term, higher-dose opioids. Read More

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More than a decade of real-world experience of pegvisomant for acromegaly: ACROSTUDY.

Eur J Endocrinol 2021 Aug 1. Epub 2021 Aug 1.

R Salvatori, Division of Endocrinology, Diabetes, and Metabolism and Pituitary Center, Johns Hopkins University, Baltimore, United States.

Objective: To report the final long-term safety and efficacy analyses of patients with acromegaly treated with pegvisomant from the ACROSTUDY.

Design: Global (15 countries), multicentre, non-interventional study (2004-2017).

Methods: The complete ACROSTUDY cohort comprised patients with acromegaly, who were being treated with pegvisomant (PEGV) prior to the study or at enrolment. Read More

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Stress Reduction Through Mindfulness Meditation in Student Registered Nurse Anesthetists.

AANA J 2021 Aug;89(4):284-289

is an assistant professor at the University of Cincinnati College of Nursing.

Student registered nurse anesthetists (SRNAs) experience high levels of stress related to the level of difficulty and time commitment associated with an integrated Doctor of Nursing Practice anesthesia program. Although some degree of stress is necessary for motivation, unmanaged stress can contribute to illness, dissatisfaction, and substance use. A search of the literature showed that mindfulness meditation training reduces stress and improves academic performance in graduate student populations. Read More

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Unraveling Congener-Specific Transfer of Non-Dioxin-Like Polychlorinated Biphenyls (ndl-PCBs) from Feed into Chicken Meat.

Environ Sci Technol 2021 Aug 3. Epub 2021 Aug 3.

Department Safety in the Food Chain, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.

Non-dioxin-like polychlorinated biphenyls (ndl-PCBs) are a subclass of persistent bioaccumulative pollutants able to enter the food chain. We investigated the transfer of ndl-PCBs from contaminated feed into meat and liver of fattening chickens. A total of 48 chicks were divided into five treatment and one control groups. Read More

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Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest?

Crit Care Med 2021 Aug 4. Epub 2021 Aug 4.

Department of Emergency Medicine, National Taiwan University Medical College and Hospital, Taipei, Taiwan. Department of Internal Medicine (Cardiology Division), National Taiwan University Medical College and Hospital, Taipei, Taiwan.

Objectives: To evaluate whether the recommended observation period of 7 days for cardiac arrest survivors is sufficient for conscious recovery and to identify the variables associated with eventual neurologic recovery among patients with delayed awakening.

Design: A retrospective cohort study.

Setting: A single tertiary medical center. Read More

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Studying Microtemporal, Within-Person Processes of Diet, Physical Activity, and Related Factors Using the APPetite-Mobile-App: Feasibility, Usability, and Validation Study.

J Med Internet Res 2021 Jul 5;23(7):e25850. Epub 2021 Jul 5.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.

Background: Diet and physical activity (PA) have a major impact on physical and mental health. However, there is a lack of effective strategies for sustaining these health-protective behaviors. A shift to a microtemporal, within-person approach is needed to capture dynamic processes underlying eating behavior and PA, as they change rapidly across minutes or hours and differ among individuals. Read More

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An International, Multicenter Retrospective Observational Study to Assess Technical Success and Clinical Outcomes of Patients Treated with an Endovascular Aneurysm Sealing Device for Type III Endoleak.

J Endovasc Ther 2021 Aug 3:15266028211031933. Epub 2021 Aug 3.

Department of Vascular Surgery, Rijnstate, Arnhem, The Netherlands.

Introduction: Type III endoleaks post-endovascular aortic aneurysm repair (EVAR) warrant treatment because they increase pressure within the aneurysm sac leading to increased rupture risk. The treatment may be difficult with regular endovascular devices. Endovascular aneurysm sealing (EVAS) might provide a treatment option for type III endoleaks, especially if located near the flow divider. Read More

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Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta.

Alcohol Clin Exp Res 2021 Aug 2. Epub 2021 Aug 2.

School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.

Background: Maternal choline supplementation in rats can ameliorate specific neurological and behavioral abnormalities caused by alcohol exposure during pregnancy. We aimed to test whether choline supplementation could ameliorate fetal growth restriction and molecular changes in the placenta associated with periconceptional ethanol exposure in the rat.

Methods: Sprague-Dawley dams were given either 12. Read More

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Children with SARS-CoV-2 in the National COVID Cohort Collaborative (N3C).

medRxiv 2021 Jul 23. Epub 2021 Jul 23.

Importance: SARS-CoV-2.

Objective: To determine the characteristics, changes over time, outcomes, and severity risk factors of SARS-CoV-2 affected children within the National COVID Cohort Collaborative (N3C).

Design: Prospective cohort study of patient encounters with end dates before May 27th, 2021. Read More

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What is new in computer vision and artificial intelligence in medical image analysis applications.

Quant Imaging Med Surg 2021 Aug;11(8):3830-3853

Centro de Estudios en Computación Avanzada, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.

Computer vision and artificial intelligence applications in medicine are becoming increasingly important day by day, especially in the field of image technology. In this paper we cover different artificial intelligence advances that tackle some of the most important worldwide medical problems such as cardiology, cancer, dermatology, neurodegenerative disorders, respiratory problems, and gastroenterology. We show how both areas have resulted in a large variety of methods that range from enhancement, detection, segmentation and characterizations of anatomical structures and lesions to complete systems that automatically identify and classify several diseases in order to aid clinical diagnosis and treatment. Read More

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Fungal osteitis of the axial aspect of the mid body of the medial proximal sesamoid bone in a horse.

Can Vet J 2021 Aug;62(8):867-871

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

The satisfactory outcome of fungal osteitis in an 8-year-old American Quarter Horse is described. The horse was admitted with a grade 4 out of 5 lameness and exhibited metacarpophalangeal synovial effusion, indicative of a mild suppurative inflammation. Results of initial radiographic and ultrasonographic examination were unremarkable. Read More

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Mueller matrix imaging for collagen scoring in mice model of pregnancy.

Sci Rep 2021 Aug 2;11(1):15621. Epub 2021 Aug 2.

LPICM, CNRS, Ecole polytechnique, IP Paris, 91128, Palaiseau, France.

Preterm birth risk is associated with early softening of the uterine cervix in pregnancy due to the accelerated remodeling of collagen extracellular matrix. Studies of mice model of pregnancy were performed with an imaging Mueller polarimeter at different time points of pregnancy to find polarimetric parameters for collagen scoring. Mueller matrix images of the unstained sections of mice uterine cervices were taken at day 6 and day 18 of 19-days gestation period and at different spatial locations through the cervices. Read More

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Structure of the master regulator Rns reveals an inhibitor of enterotoxigenic Escherichia coli virulence regulons.

Sci Rep 2021 Aug 2;11(1):15663. Epub 2021 Aug 2.

Department of Chemistry, Dartmouth College, Hanover, NH, USA.

Enteric infections caused by the gram-negative bacteria enterotoxigenic Escherichia coli (ETEC), Vibrio cholerae, Shigella flexneri, and Salmonella enterica are among the most common and affect billions of people each year. These bacteria control expression of virulence factors using a network of transcriptional regulators, some of which are modulated by small molecules as has been shown for ToxT, an AraC family member from V. cholerae. Read More

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The neutralizing antibody response post COVID-19 vaccination in patients with myeloma is highly dependent on the type of anti-myeloma treatment.

Blood Cancer J 2021 Aug 2;11(8):138. Epub 2021 Aug 2.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Recent data suggest a suboptimal antibody response to COVID-19 vaccination in patients with hematological malignancies. Neutralizing antibodies (NAbs) against SARS-CoV-2 were evaluated in 276 patients with plasma cell neoplasms after vaccination with either the BNT162b2 or the AZD1222 vaccine, on days 1 (before the first vaccine shot), 22, and 50. Patients with MM (n = 213), SMM (n = 38), and MGUS (n = 25) and 226 healthy controls were enrolled in the study (NCT04743388). Read More

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Maternal and Paternal Depression Symptoms During NICU Stay and Transition Home.

Pediatrics 2021 Aug 18;148(2). Epub 2021 Jun 18.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Objective: To examine the trajectory and risk factors of depression symptoms among parents from NICU admission to 30 days postdischarge. We hypothesized depression symptom scores would decrease from admission and then increase from discharge to 30 days.

Methods: Prospective longitudinal cohort study of premature infants in NICU. Read More

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Myopia incidence and lifestyle changes among school children during the COVID-19 pandemic: a population-based prospective study.

Br J Ophthalmol 2021 Aug 2. Epub 2021 Aug 2.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Background: The impacts of social restrictions for COVID-19 on children's vision and lifestyle remain unknown.

Aims: To investigate myopia incidence, spherical equivalent refraction (SER) and lifestyle changes among schoolchildren during the COVID-19 pandemic.

Methods: Two separate longitudinal cohorts of children aged 6-8 years in Hong Kong were included. Read More

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Chief Resident Indirect Supervision in Training Safety Study: Is a Chief Resident General Surgery Service Safe for Patients?

J Surg Educ 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgery, University of Kansas School of Medicine-Wichita, Wichita, Kansas. Electronic address:

Objective: There has been concern expressed amongst the medical educational community regarding the readiness of general surgery residents in the United States to be competent practicing attendings upon graduation and that limited autonomy may be a contributing factor to this unpreparedness. The purpose of this study was to evaluate an RRC-accredited general surgery residency chief resident acute care surgery service with indirect supervision of cases in terms of safety and outcomes compared to traditional general surgeon cases with direct supervision. The study focused on common general surgical procedures, specifically cholecystectomies, appendectomies, and inguinal and ventral hernia repairs. Read More

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