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Impact of Taping the Upper Mask Edge on Ocular Surface Stability and Dry Eye Symptoms.

Am J Ophthalmol 2022 Jan 13. Epub 2022 Jan 13.

Cornea, Cataract and Refractive Surgery Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Purpose: To evaluate the impact of taping the upper mask edge on ocular surface stability, dry eye symptomology and tear osmolarity in N95 mask users.

Design: Prospective interventional before-and-after study.

Methods: Fifty eyes of 50 healthcare workers regularly using N95 masks were included. Read More

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January 2022

Epidemiological investigation, extraesophageal symptoms and risk factors of gastroesophageal reflux disease in Kashgar, Xinjiang, China.

Am J Transl Res 2021 15;13(12):14186-14194. Epub 2021 Dec 15.

Second Department of General Surgery, The First People's Hospital of Kashgar Prefecture Kashgar, Xinjiang, China.

Objective: To explore the incidence, distribution characteristics and related symptoms of gastroesophageal reflux disease (GERD) as well as its related risk factors in Kashgar, Xinjiang.

Methods: From March 2020 to October 2020, a questionnaire survey was conducted among 5,080 permanent residents aged 18-80 years in Kashgar using cluster sampling and stratified sampling methods. The content included basic information, accompanying symptoms and diseases, living, customs and eating habits, and Gastroesophageal Reflux Disease Questionnaire score, Results: The prevalence of GERD in Kashgar was 23. Read More

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December 2021

Short-term clinical outcomes of onasemnogene abeparvovec treatment for spinal muscular atrophy.

Brain Dev 2022 Jan 12. Epub 2022 Jan 12.

Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Introduction: Spinal muscular atrophy (SMA) is a degenerative neuromuscular disorder long recognized as the most common genetic cause of infantile mortality described so far. However, the emergence of some innovative therapies, such as nusinersen and onasemnogene abeparvovec (AVXS-101), have made it possible to change the disease course of SMA.

Methods: In this study, five SMA type 1 and one SMA type 2 patients who received AVXS-101 were enrolled (7-24 months of age when administered). Read More

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January 2022

Hyperpolypharmacy and Frailty in Kidney Transplant Recipients.

Transplant Proc 2022 Jan 12. Epub 2022 Jan 12.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: Kidney transplant recipients (KTRs) take multiple medications including immunosuppressants every day. Although polypharmacy is associated with frailty, the situation remains unknown in KTRs. The aim of the present study is to investigate the association between hyperpolypharmacy and frailty in KTRs. Read More

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January 2022

Preclusion of methemoglobinemia caused by nitrate drugs in diabetics and nondiabetics: Possible role of Vitamin C.

Blood Cells Mol Dis 2022 Jan 5;94:102643. Epub 2022 Jan 5.

Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata 700009, India. Electronic address:

The drugs containing nitrates like isosorbide dinitrate, isosorbide mononitrate and glyceryl trinitrate, etc., trigger the oxidation of hemoglobin which is manifested in the pathological disorder named methemoglobinemia. It was considered interesting to investigate the preventive roles of vitamin C towards the toxic effects of nitrate containing drugs used for the treatment of angina. Read More

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January 2022

Spectral dependency of the human pupillary light reflex. Influences of pre-adaptation and chronotype.

PLoS One 2022 12;17(1):e0253030. Epub 2022 Jan 12.

Institute of Medical Psychology, Ludwig-Maximilians-Universität, Munich, Germany.

Non-visual photoreceptors (ipRGCs) and rods both exert a strong influence on the human pupil, yet pupil models regularly use cone-derived sensitivity as their basis. This inconsistency is further exacerbated by the fact that circadian effects can modulate the wavelength sensitivity. We assessed the pupillary reaction to narrowband light stimuli in the mesopic range. Read More

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January 2022

Genetic Clues on Implantable Cardioverter-Defibrillator Placement in Young-Age Hypertrophic Cardiomyopathy: A Case Report of Novel Mutation and Literature Review.

Front Cardiovasc Med 2021 23;8:810291. Epub 2021 Dec 23.

Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Hypertrophic cardiomyopathy (HCM) is the second most common cardiomyopathy in childhood with a life-threatening risk. Implantable cardioverter-defibrillator (ICD) placement is recommended for early prevention if there are two or more clinical risk factors. Pediatric patients with HCM are at a higher risk of sudden cardiac death (SCD), but there are limited reports on indications for ICD implantation in children. Read More

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December 2021

Culturing partial denitrification biofilm in side stream incubator with ordinary activated sludge as inoculum: One step closer to mainstream Anammox upgrade.

Bioresour Technol 2022 Jan 6;347:126679. Epub 2022 Jan 6.

School of Environmental Science and Engineering, Qingdao University, Qingdao 266071, PR China. Electronic address:

Recently, adding carriers into anoxic zone is proposed for mainstream Anammox upgrade, which relied on the denitrifiers responsible for partial denitrification (PD) to generate essential nitrite for Anammox bacteria. Still, their low abundance in the naturally formed biofilm leads to insufficient nitrite supply. This study investigated the sequential culturing of PD biofilm. Read More

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January 2022

Incidence of postoperative week 1 management changes after resident-performed phacoemulsification cataract surgery.

BMC Ophthalmol 2022 Jan 8;22(1):15. Epub 2022 Jan 8.

Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: The goal of this study was to investigate the incidence of departures from routine care at the postoperative week 1 (POW1) visit following uneventful resident-performed cataract surgery in asymptomatic patients who had a normal postoperative day 1 (POD1) examination.

Methods: A retrospective chart review of phacoemulsification surgeries performed by the senior resident class at Montefiore Medical Center between June 20, 2018 and April 1, 2019 was performed. The most recent preoperative visit note, operative report, POD1 visit note, and POW1 visit note were evaluated and variables were recorded. Read More

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January 2022

Training of airway management for anesthesia teams - Measurement of transfer into daily work routine by questionnaire.

J Med Educ Curric Dev 2021 Jan-Dec;8:23821205211063363. Epub 2021 Dec 20.

Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Theory: Problems in airway management are rare in anesthesia but when they occur, they have serious consequences for the patient. For this reason, training is recommended for professionals involved in anesthetic care. Here we investigated, if a newly developed technical/ non-technical hybrid airway training would be relevant for daily practice in a tertiary referral hospital. Read More

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December 2021

Rapid and sensitive point-of-care detection of Leptospira by RPA-CRISPR/Cas12a targeting lipL32.

PLoS Negl Trop Dis 2022 Jan 6;16(1):e0010112. Epub 2022 Jan 6.

Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: One of the key barriers preventing rapid diagnosis of leptospirosis is the lack of available sensitive point-of-care testing. This study aimed to develop and validate a clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 12a (CRISPR/Cas12a) platform combined with isothermal amplification to detect leptospires from extracted patient DNA samples.

Methodology/principal Findings: A Recombinase Polymerase Amplification (RPA)-CRISPR/Cas12a-fluorescence assay was designed to detect the lipL32 gene of pathogenic Leptospira spp. Read More

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January 2022

Sodium selenate as a disease-modifying treatment for mild-moderate Alzheimer's disease: an open-label extension study.

BMJ Neurol Open 2021 16;3(2):e000223. Epub 2021 Dec 16.

Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.

Introduction: Sodium selenate is a potential disease-modifying treatment for Alzheimer's disease (AD) which reduces hyperphosphorylated tau through activation of the protein phosphatase 2A enzyme. We have shown sodium selenate to be safe and well tolerated in a 24-week, phase 2a double-blind placebo-controlled randomised controlled trial (RCT), also reporting sodium selenate reduced neurodegeneration on diffusion-weighted MRI. This study assessed the safety and tolerability of chronic sodium selenate treatment (up to 23 months) in patients with AD who had been enrolled in the RCT. Read More

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December 2021

Leiomyosarcoma of the splenic vein with a history of bilateral retinoblastoma: A case report and review of the literature.

Mol Clin Oncol 2022 Feb 16;16(2):35. Epub 2021 Dec 16.

Department of Gastroenterology, Toranomon Hospital, Tokyo 105-8470, Japan.

Diagnosing leiomyosarcomas of the splenic vein is challenging, and a treatment strategy has not yet been established for this condition. We herein report the case of a 45-year-old female patient with a history of retinoblastoma who underwent pancreatosplenectomy for a primary leiomyosarcoma originating from the splenic vein and transcatheter arterial chemoembolization for metastatic hepatic lesions observed 5 months postoperatively. An initial medical check-up using abdominal ultrasound revealed a 40-mm mass behind the pancreatic tail. Read More

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February 2022

Potential value of home square-stepping exercises for inactive older adults: an exploratory case study.

BMC Geriatr 2022 Jan 3;22(1):14. Epub 2022 Jan 3.

Faculty of Kinesiology, University of New Brunswick, 90 MacKay Dr, Fredericton, NB, E3B 5A3, Canada.

Background: Most older adults do not engage in regular physical activity. However, more research on options to partake in regular exercise in this population by reducing barriers and enhancing enablers while still reaching benefits is needed.

Methods: Using embedded mixed methods, 10 inactive older adults over the age of 65 completed a 3-week square-stepping exercise intervention to help overcome the initial barriers and activate initial enablers to perform regular exercise. Read More

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January 2022

Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer's Disease and Type 2 Diabetes.

Front Aging Neurosci 2021 16;13:741923. Epub 2021 Dec 16.

Division of Physiology, School of Medicine, Universidad de Cádiz, Cádiz, Spain.

Alzheimer's disease is the most common form of dementia, and epidemiological studies support that type 2 diabetes (T2D) is a major contributor. The relationship between both diseases and the fact that Alzheimer's disease (AD) does not have a successful treatment support the study on antidiabetic drugs limiting or slowing down brain complications in AD. Among these, liraglutide (LRGT), a glucagon-like peptide-1 agonist, is currently being tested in patients with AD in the Evaluating Liraglutide in Alzheimer's Disease (ELAD) clinical trial. Read More

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December 2021

PAZ domain is critical for spermatogenesis in chicken.

Anim Biotechnol 2021 Dec 31:1-10. Epub 2021 Dec 31.

College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Piwi-like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation, embryogenesis, growth, and development. We aimed to unravel the function of PIWIL1 and its Piwi/Argonaute/Zwille (PAZ) domain in chicken embryogenesis. The expression of PIWI1 at different stages of spermatogenesis was analyzed by quantitative reverse transcription polymerase chain reaction (RT-qPCR) and the PAZ domain was mutated based on its 3D structure model using the clustered regularly interspaced short palindromic repeats Cas9 (CRISPR/Cas9) technology. Read More

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December 2021

No additional benefit of prescribing a very low-protein diet in patients with advanced Chronic Kidney Disease under regular nephrology care: a pragmatic, randomized, controlled trial.

Am J Clin Nutr 2021 Dec 30. Epub 2021 Dec 30.

Division of Nephrology, University of Campania "Luigi Vanvitelli", Naples.

Background: Whether very low-protein diet supplemented with ketoanalogs (sVLPD), compared to standard low-protein diet (LPD), improves outcomes in chronic kidney disease (CKD) patients under stable nephrology care is undefined.

Objective: To compare the effectiveness of sVLPD vs LPD in patients regularly seen in tertiary nephrology care.

Methods: Participants were CKD patients stage 4-5, followed for at least six months, randomized to receive sVLPD or LPD (0. Read More

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December 2021

Oral Hygiene Status in Rheumatoid Arthritis Patients and Related Factors.

Mediterr J Rheumatol 2021 Sep 30;32(3):249-255. Epub 2021 Sep 30.

Rheumatology B Department, El Ayachi Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.

Objectives: To evaluate oral hygiene status in Rheumatoid arthritis (RA) patients, to analyse possible related factors, and to investigate the role of the rheumatologist in information about importance of adequate oral hygiene status in RA patients.

Methods: A cross-sectional study that included 100 consecutive RA patients (89% female, mean age 46.7 ± 11. Read More

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September 2021

Impact of autoantibodies against the M2-muscarinic acetylcholine receptor on clinical outcomes in peripartum cardiomyopathy patients with standard treatment.

BMC Cardiovasc Disord 2021 12 28;21(1):619. Epub 2021 Dec 28.

Department of Cardiology, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, 8# Gong-Ti South Road, Chaoyang District, Beijing, 100020, China.

Objectives: To evaluate the impact of autoantibodies against the M2-muscarinic receptor (anti-M2-R) on the clinical outcomes of patients receiving the standard treatment for peripartum cardiomyopathy (PPCM).

Methods: A total of 107 PPCM patients who received standard heart failure (HF) treatment between January 1998 and June 2020 were enrolled in this study. According to anti-M2-R reactivity, they were classified into negative (n = 59) and positive (n = 48) groups, denoted as the anti-M2-R (-) and anti-M2-R (+) groups. Read More

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December 2021

Replacing meat with alternative plant-based products (RE-MAP): a randomized controlled trial of a multicomponent behavioral intervention to reduce meat consumption.

Am J Clin Nutr 2021 Dec 27. Epub 2021 Dec 27.

University of Oxford, Nuffield Department of Primary Care Health Sciences, Radcliffe Primary Care Building, Woodstock Rd, Oxford OX2 6GG.

Background: Reducing meat consumption could protect the environment and human health.

Objectives: We tested the impact of a behavioral intervention to reduce meat consumption.

Design: Adult volunteers who regularly consumed meat, were recruited from the general public and randomized 1:1 to an intervention or control condition. Read More

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December 2021

Wine Spoilage Control: Impact of Saccharomycin on and Its Conjugated Effect with Sulfur Dioxide.

Microorganisms 2021 Dec 7;9(12). Epub 2021 Dec 7.

Unit of Bioenergy and Biorefinery, LNEG, Estrada do Paço do Lumiar, 22, 1649-038 Lisboa, Portugal.

The yeast is one of the most dangerous wine contaminants due to the production of phenolic off-flavors such as 4-ethylphenol. This microbial hazard is regularly tackled by addition of sulfur dioxide (SO). Nevertheless, is frequently found at low levels (ca 10 cells/mL) in finished wines. Read More

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December 2021

Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys.

Reprod Toxicol 2021 Dec 21;108:28-34. Epub 2021 Dec 21.

Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany.

Knowledge of the impacts of the anti-CD20 monoclonal antibody ofatumumab on the developing immune system is limited. This study examined the effects of intravenous ofatumumab on pregnancy, parturition, and lactation, and on pre- and postnatal survival and development in cynomolgus monkeys, an established model for developmental toxicity assessment. Pregnant cynomolgus monkeys (n = 42) were randomized to receive vehicle only (control group; n = 14), low-dose ofatumumab (n = 14), or high-dose ofatumumab (n = 14). Read More

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December 2021

Prevalence and Appropriateness of Antipsychotic Prescribing in an Italian Prison: Is Everything Always Really Overprescribed?

J Clin Psychopharmacol 2022 Jan-Feb 01;42(1):31-36

From the Department of Mental Health and Pathological Addictions, Azienda USL di Parma, Parma, Italy.

Purpose/background: Although the prevalence of mental disorders in prisoners is known to be higher than in the general population, less is known about the antipsychotic (AP) prescribing rate in jail. The aim of this research was to investigate prevalence and appropriateness of AP prescription in an Italian prison to expand our understanding on this crucial area of clinical-forensic practice.

Methods/procedures: A cross-sectional (census day) design was used among male adults in the Parma Penitentiary Institutes (PPI). Read More

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December 2021

EFFECT OF ADDING HOME-BASED MODERATE-INTENSITY EXERCISE ON METABOLIC FUNCTIONS IN OLDER ADULTS WITH NON-COMMUNICABLE DISEASES WHO REGULARLY PERFORM GYM-BASED MODERATE-INTENSITY EXERCISE.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(2):226-233

Toyooka Hospital Hidaka Medical Center - Department of Internal Medicine, Toyooka, Japan.

Context: Physical activity is important for the management of metabolic functions; however, little is known whether performing home-based moderate-intensity exercise (MIE) obtains further improvement on metabolic functions in adults with non-communicable diseases (NCDs) who already perform regular gym-based MIE.

Objective: The purpose of this study was to examine the effect of adding home-based MIE on metabolic functions in older adults with NCDs who have regularly performed gym-based MIE.

Design: This was a single-center randomized controlled study. Read More

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December 2021

Effects of the higher concentrate ratio on the production performance, ruminal fermentation, and morphological structure in male cattle-yaks.

Vet Med Sci 2021 Dec 17. Epub 2021 Dec 17.

Animal Nutrition Institute, Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

Background: The present study evaluated the effects of the different concentrate-to-forage ratio on the parameters of production, ruminal fermentation, blood biochemical indices, and ruminal epithelial morphological structure of the male cattle-yaks.

Methods: Eight male cattle-yaks (280 ± 10 kg of body weight) were randomly divided into the high concentrate (HighC, 70% concentrate feeds on a dry matter basis) and low concentrate (LowC, 50% concentrate feeds on a dry matter basis) groups. All the animals were regularly provided rations twice a day at 08:00 and 16:00 h and had free access to water. Read More

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December 2021

Mepolizumab Is an Effective Option in Severe Eosinophilic Asthma Regardless of Baseline Features: Single-Center Real-Life Data.

Int Arch Allergy Immunol 2021 Dec 14:1-13. Epub 2021 Dec 14.

Division of Immunology and Allergic Diseases, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.

Background: Mepolizumab has been approved as a treatment option for severe eosinophilic asthma (SEA) patients in our country. We aimed to evaluate the clinical and functional efficacy of mepolizumab in this group of patients in real life as well as the response rates to mepolizumab and the possible factors affecting the response.

Methods: The study was a retrospective chart review of patients with SEA treated with mepolizumab. Read More

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December 2021

The effect of creep feed composition and form on pre- and post-weaning growth performance of pigs and the utilization of low-complexity nursery diets.

Transl Anim Sci 2021 Oct 10;5(4):txab211. Epub 2021 Nov 10.

Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada.

Fifty-six litters from first-parity sows standardized to 12 piglets were used to determine the effects of creep feed composition and form on pre- and post-weaning pig growth performance and the utilization of low-complexity nursery diets. At 5 days of age, litters (initial body weight [BW] 2.31 ± 0. Read More

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October 2021

Six Months of Inspiratory Muscle Training to Lower Blood Pressure and Improve Endothelial Function in Middle-Aged and Older Adults With Above-Normal Blood Pressure and Obstructive Sleep Apnea: Protocol for the CHART Clinical Trial.

Front Cardiovasc Med 2021 24;8:760203. Epub 2021 Nov 24.

Arizona Respiratory Neurophysiology Laboratory, Department of Physiology, University of Arizona, Tucson, AZ, United States.

Cardiovascular disease is a major global health concern and prevalence is high in adults with obstructive sleep apnea (OSA). Lowering blood pressure (BP) can greatly reduce cardiovascular disease risk and physical activity is routinely prescribed to achieve this goal. Unfortunately, many adults with OSA suffer from fatigue, daytime sleepiness, and exercise intolerance-due to poor sleep quality and nocturnal hypoxemia-and have difficulty initiating and maintaining an exercise program. Read More

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November 2021

Lifestyle Modification Using a Wearable Biometric Ring and Guided Feedback Improve Sleep and Exercise Behaviors: A 12-Month Randomized, Placebo-Controlled Study.

Front Physiol 2021 25;12:777874. Epub 2021 Nov 25.

Airway & Exercise Physiology Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.

Wearable biometric monitoring devices (WBMD) show promise as a cutting edge means to improve health and prevent disease through increasing accountability. By regularly providing real-time quantitative data regarding activity, sleep quality, and recovery, users may become more aware of the impact that their lifestyle has on their health. The purpose of this study was to examine the efficacy of a biometric tracking ring on improving sleep quality and increasing physical fitness over a one-year period. Read More

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November 2021

Correlation between Symptom Burden and Perceived Distress in Advanced Head and Neck Cancer: A Prospective Observational Study.

Indian J Palliat Care 2021 Jul-Sep;27(3):419-425. Epub 2021 Nov 24.

Department of Pain and Palliative Medicine, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Objectives: Head and neck cancer (HNC) account for major cancer burden in the Indian population. Patients often present with a diversity of distressing physical and psychological symptoms, significantly affecting their quality of life. This study aims to determine the correlation between symptom cluster and perceived distress in such patients. Read More

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November 2021