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Outcomes following open radical cystectomy: an 11-year Christchurch experience.

N Z Med J 2021 Jul 30;134(1539):63-73. Epub 2021 Jul 30.

Statistician, University of Otago, Christchurch, New Zealand.

Background: Radical cystectomy (RC) remains the standard approach to treating muscle invasive bladder cancer. Despite improvements in surgical and anaesthetic care, morbidity and mortality remain high. In the United Kingdom, centralisation has improved outcomes following RC. Read More

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Escalating morphine dosage fails to elicit conditioned analgesia in a preclinical chronic neuropathic pain model.

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

School of Medical Sciences (Neuroscience) and the Brain and Mind Centre, The University of Sydney, New South Wales, Australia.

Many people with chronic pain escalate their opioid dosage to counteract tolerance effects. A treatment regimen consisting of placebos admixed with opioids has been suggested as a possible therapeutic option that could reduce the harm of long-term opioid use. However, the analgesic efficacy of such a regimen requires further investigation before widespread adoption. Read More

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COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series.

Int J Infect Dis 2021 Jul 5;109:160-167. Epub 2021 Jul 5.

Ministry of Home Affairs, Office of the State Forensic Pathologist, Nationalist Road, Lusaka, Zambia; University Teaching Hospitals, Department of Pathology and Microbiology, Nationalist Road, Lusaka, Zambia.

Background: Data from Africa regarding sudden and unexpected COVID-19 community deaths and underlying pathological, demographic, and co-morbidity features require definition.

Methods: We performed a case series of COVID-19-related deaths seen at Forensic Post-Mortem examination of sudden and unexpected Community Deaths in Lusaka, Zambia, Africa. Whole-body Post-Mortem examinations were performed according to Standard Operating Procedures. Read More

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Induction Therapy With Antithymocyte Globulin and Delayed Calcineurin Inhibitor Initiation for Renal Protection in Liver Transplantation: A Multicenter Randomized Controlled Phase II-B Trial.

Transplantation 2021 Jul 27. Epub 2021 Jul 27.

Digestive Disease and Surgery Institute, Transplant Center, Cleveland Clinic, Cleveland, OH. Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH. Transplant Center, Cleveland Clinic Weston, Weston, FL. Division of Transplantation Surgery, Medical College of Wisconsin, Milwaukee, WI. Transplantation Institute, University of Chicago Medicine, Chicago, IL.

Background: Calcineurin inhibitor (CNI) based immunosuppression in liver transplantation (LTx) is associated with acute and chronic deterioration of kidney function. Delaying CNI initiation by using induction rabbit anti-thymocyte globulin (rATG) may provide kidneys with adequate time to recover from a perioperative insult reducing the risk of early post-LTx renal deterioration.

Methods: This was an open-label, multicenter, randomized controlled clinical trial comparing use of induction rATG with delayed CNI initiation (day-10) against upfront CNI commencement (SOC; standard of care) in those patients deemed at standard risk of postoperative renal dysfunction following LTx. Read More

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First report of Cnidium officinale as a natural host plant of Apple stem grooving virus in South Korea.

Plant Dis 2021 Jul 28. Epub 2021 Jul 28.

Rural Development Administration, National Institute of Horticultural & Herbal Sciences, 30,Subong-ro, Gwonseon-gu, Suwon-si, Gyeonggi-do, Suwon, Korea (the Republic of), 441-440.

Cnidium officinale is a perennial plant in the family Apiaceae. It is native to China and cultivated in China, Japan, and Korea for its roots for medicinal purposes. In August 2019, 63 C. Read More

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Allograft discard risk index for heart transplantation.

Clin Transplant 2021 Jul 28. Epub 2021 Jul 28.

Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

The number of patients awaiting heart transplantation (HTx) substantially exceeds the number of donor hearts transplanted each year, yet nearly 65% of eligible donor hearts are discarded rather than transplanted. Deceased organ donors listed within the UNOS Deceased Donor Database between 2010 and 2020 were reviewed. Those greater than 10 years old and consented for heart donation were included and randomly separated into training (n = 48,435) and validation (n = 24,217) cohorts. Read More

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Low-temperature flow-synthesis-assisted urethane-grafted zinc oxide-based dental composites: physical, mechanical, and antibacterial responses.

J Mater Sci Mater Med 2021 Jul 28;32(8):87. Epub 2021 Jul 28.

Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, 46000, Pakistan.

A novel way was adopted to graft zinc oxide (ZnO) with urethane-modified dimethacrylate (UDMA) in order to utilize them as reinforcing agents in resin-based dental composites. Experimental novel composites were synthesized having UDMA-grafted and nongrafted ZnO, at a concentration of 0 wt.%, 5 wt. Read More

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Turn on, Tune in, and Drop out: Predictors of Attrition in a Prospective Observational Cohort Study on Psychedelic Use.

J Med Internet Res 2021 Jul 28;23(7):e25973. Epub 2021 Jul 28.

Centre for Psychedelic Research, Imperial College London, London, United Kingdom.

Background: The resurgence of research and public interest in the positive psychological effects of psychedelics, together with advancements in digital data collection techniques, have brought forth a new type of research design, which involves prospectively gathering large-scale naturalistic data from psychedelic users; that is, before and after the use of a psychedelic compound. A methodological limitation of such studies is their high attrition rate, particularly owing to participants who stop responding after initial study enrollment. Importantly, study dropout can introduce systematic biases that may affect the interpretability of results. Read More

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Stamina-Enhancing Effects of Human Adipose-Derived Stem Cells.

Cell Transplant 2021 Jan-Dec;30:9636897211035409

Department of Biology Education, Korea National University of Education, Cheongju, Korea.

Stamina-enhancing effects of human adipose derived stem cells (hADSCs) were investigated in young Sprague-Dawley rats. Ten-day-old male rats were transplanted intravenously (IV) or intracerebroventricularly (ICV) with hADSCs (1 × 10 cells/rat), and physical activity was measured by locomotor activity and rota-rod performance at post-natal day (PND) 14, 20, 30, and 40, as well as a forced swimming test at PND 41. hADSCs injection increased the moving time in locomotor activity, the latency in rota-rod performance, and the maximum swimming time. Read More

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Hospice Enrollment, Future Hospitalization, and Future Costs Among Racially and Ethnically Diverse Patients Who Received Palliative Care Consultation.

Am J Hosp Palliat Care 2021 Jul 28:10499091211034383. Epub 2021 Jul 28.

NewCourtland Center for Transitions and Health, University of Pennsylvania School of Nursing, Philadelphia, PA, USA.

Background: Palliative care consultation to discuss goals-of-care ("PCC") may mitigate end-of-life care disparities.

Objective: To compare hospitalization and cost outcomes by race and ethnicity among PCC patients; identify predictors of hospice discharge and post-discharge hospitalization utilization and costs.

Methods: This secondary analysis of a retrospective cohort study assessed hospice discharge, do-not-resuscitate status, 30-day readmissions, days hospitalized, ICU care, any hospitalization cost, and total costs for hospitalization with PCC and hospitalization(s) post-discharge among 1,306 Black/African American, Latinx, White, and Other race PCC patients at a United States academic hospital. Read More

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Norwood With Obstructed Total Anomalous Pulmonary Venous Connection and Tracheoesophageal Fistula Repair: Operating Room Delivery.

JACC Case Rep 2020 May 20;2(5):732-733. Epub 2020 May 20.

Cincinnati Children's Hospital Medical Center, Heart Institute, Cincinnati, Ohio.

A baby boy with prenatally diagnosed hypoplastic left heart syndrome variant with obstructed veins was born in the operating room (OR) and underwent emergent Norwood operation and repair of obstructed infra-diaphragmatic total anomalous pulmonary venous connection. Post-operatively, esophageal atresia with tracheoesophageal fistula was identified and repaired on day of life 11. The patient is thriving at 22 months of age. Read More

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TandemHeart-Assisted Balloon Aortic Valvuloplasty for Acute Transcatheter Aortic Valve Replacement Thrombosis.

JACC Case Rep 2020 Mar 18;2(3):437-439. Epub 2020 Mar 18.

Department of Cardiology, Division of Medicine, University of Washington Medical Center, Seattle, Washington.

The patient in this report had a catastrophic case of transcatheter aortic valve replacement-related valve thrombosis manifesting within 1 month of valve implantation that was complicated by acute heart failure and cardiogenic shock. Anticoagulation and thrombolytic agents were not successful, and the patient was treated with TandemHeart (Cardiac Assist, Pittsburgh, Pennsylvania)-supported balloon aortic valvuloplasty and cerebral embolic protection. (). Read More

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Isolated Chylopericardium in an Infant With Hypoplastic Left Heart Syndrome.

JACC Case Rep 2020 Nov 18;2(13):2115-2119. Epub 2020 Nov 18.

Pediatric Services, University Health System, San Antonio, Texas.

Isolated chylopericardium is an exceedingly rare complication in any age group. Review of the limited published case series shows the most common cause of isolated chylopericardium to be cardiac surgery. We present a case of isolated chylopericardium after a bidirectional Glenn procedure in an infant with hypoplastic left heart syndrome. Read More

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November 2020

Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism in the Third Trimester of Pregnancy.

JACC Case Rep 2020 Oct 21;2(12):1899-1904. Epub 2020 Oct 21.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, School of Medicine, San Francisco, California.

A 37-year-old woman presented with chest pain and shortness of breath in the third trimester of pregnancy. Diagnostic imaging demonstrated a saddle pulmonary embolism, severe impairment of right ventricular function, and an extensive deep venous thrombus. She underwent catheter-directed thrombolysis with tissue plasminogen activator and delivered a healthy infant at term. Read More

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October 2020

Percutaneous Management of a Contained Annular Rupture Occurring With Self-Expanding Transcatheter Aortic Valve Replacement.

JACC Case Rep 2020 Oct 21;2(12):1852-1858. Epub 2020 Oct 21.

CardioVascular Institute, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts.

Annular rupture is a rare catastrophic event during transcatheter aortic valve replacement, often life threatening and requiring emergent surgical repair. We describe, herein, a case of contained annular rupture successfully managed percutaneously with coiling and polymer injection. This is a novel technique to manage this complication. Read More

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October 2020

Williams Syndrome and Neonatal Cardiac Surgery for Congenital Single Ventricle.

JACC Case Rep 2020 Sep 12;2(11):1716-1719. Epub 2020 Aug 12.

Dr. C.C. and Mabel L. Criss Heart Center, Children's Hospital and Medical Center, Omaha, Nebraska.

Williams syndrome (WS) is an arteriopathic derangement associated with supravalvular aortic stenosis and branch pulmonary stenosis. We describe double-outlet right ventricle with mitral atresia and aortic arch hypoplasia in an infant with WS. This case demonstrates the difficulty in managing patients with WS with complex cardiac defects. Read More

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September 2020

The Dynamic Evolution of Aortic Intramural Hematoma.

JACC Case Rep 2019 Dec 9;1(4):560-563. Epub 2019 Oct 9.

Cardiology and Aortic Centre, Royal Brompton Hospital and Harefield NHS Foundation Trust, Imperial College London, London, United Kingdom.

A 64-year-old man was admitted for crushing chest pain. Computed tomography revealed an aortic intramural hematoma, with progression to a penetrating aortic ulcer on day 7 and aortic dissection on day 30. The patient was treated with strict blood pressure control and thoracic endovascular aortic repair. Read More

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December 2019

A post hoc comparison of levodopa-carbidopa intestinal gel daytime monotherapy vs polytherapy safety and efficacy in patients with advanced Parkinson's disease: Results from 6 phase 3/3b open-label studies.

Clin Park Relat Disord 2020 11;2:25-34. Epub 2019 Dec 11.

Department of Neurology, Wake Forest School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA.

Introduction: As Parkinson's disease (PD) progresses, the number/frequency of PD medications tend to increase, which is correlated with decreased patient compliance and suboptimal control of PD symptoms. We investigated efficacy and safety of levodopa-carbidopa intestinal gel (LCIG) daytime monotherapy (with or without nighttime oral levodopa-carbidopa) compared with polytherapy (LCIG with ≥1 adjunctive PD therapy) in advanced PD patients.

Methods: This post hoc descriptive study compared LCIG stable daytime monotherapy with LCIG stable polytherapy in all six phase 3/3b open-label studies from both US and international sites; because of study design variability, pooling data for comparison was not appropriate. Read More

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December 2019

Health Care Workers and Patients as Trojan Horses: a COVID19 ward outbreak.

2020 Sep 4;2(3):100073. Epub 2020 Jul 4.

Public Health Wales Microbiology Department, 8 Eaton Cres, Sketty, Swansea, SA2 8QA, UK.

Background: Transmission in healthcare settings can result in significant infections in healthcare workers and patients. Understanding infection dynamics has important implications for methods employed in hospitals to prevent nosocomial transmission events.

Methods: In this case series report we describe a cluster of COVID-19 (Coronavirus disease 2019) in a tertiary care university hospital, in the early phases of the epidemic, after hospital visiting had been stopped and when the UK lockdown was in place. Read More

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September 2020

Evaluation of Saccharin and Resveratrol as Extrinsic Markers of Small-Quantity Lipid-Based Nutrient Supplement Consumption in Healthy Women.

Curr Dev Nutr 2021 Jul 6;5(7):nzab089. Epub 2021 Jul 6.

Institute for Global Nutrition, Department of Nutrition, University of California, Davis, Davis, CA, USA.

Background: Dietary supplements, like small-quantity lipid-based nutrient supplements (SQ-LNS), are used in intervention programs to prevent undernutrition among women and young children in low-income countries. An objective marker is needed to track consumption of supplements to evaluate the effectiveness of these programs.

Objective: The aim of this study was to evaluate saccharin and resveratrol as potential adherence markers for tracking recent consumption of a single serving of SQ-LNS in women. Read More

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Inhibition of Melanosis in Whiteleg Shrimp () during Refrigerated Storage Using Extracts of Different Avocado ( Mill.) By-Products.

Prev Nutr Food Sci 2021 Jun;26(2):209-218

Research Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials, Ho Chi Minh 70000, Viet Nam.

Melanosis in shrimp usually leads to reduction in its shelf life and quality, which causes a significant loss in economic value of shrimp products. This study reports potential applications of nine ethanolic extracts of by-products, i.e. Read More

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Right-sided patent ductus arteriosus with bovine aortic arch, tetralogy of Fallot, dextrocardia and situs inversus.

J Surg Case Rep 2021 Jul 23;2021(7):rjab307. Epub 2021 Jul 23.

Department of Anesthesia, School of Medical Sciences, Health Campus, Universiti Sains Malaysia Kubang Kerian, Kelantan, Malaysia.

A neonate with cyanosis at birth was found to have a rare type of tetralogy of Fallot. Echocardiography showed dextrocardia, left aortic arch with constricting and tortuous patent ductus arteriosus (PDA). Computed tomography angiography thorax revealed visceroatrial situs inversus, mirror image dextrocardia, tetralogy anatomy and tortuous right PDA arising from bovine brachiocephalic artery. Read More

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Molecular and morphometric changes in the small intestine during hot and cold exposure in thermally manipulated broiler chickens.

Vet World 2021 Jun 15;14(6):1511-1528. Epub 2021 Jun 15.

Department of Applied Biological Sciences, Faculty of Science and Art, Jordan University of Science and Technology, Jordan.

Background And Aim: Thermal stress (hot or cold) is one of many environmental stressors that severely affects the health of broiler chickens. One negative effect of thermal stress is the disruption of the intestinal barrier function in broiler chickens. This study aimed to evaluate the effect of thermal manipulation (TM) on the small intestine in terms of histomorphometry as well as junctional, heat-shock, and immune response gene expression during post-hatch exposure to thermal stress. Read More

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Higher cumulative fluid follows a pancreaticoduodenectomy as a single modifiable factor for post-operative pancreatic fistula: Risk factor analysis.

Asian J Surg 2021 Jul 24. Epub 2021 Jul 24.

Division of Hepatobiliary and pancreatic surgery, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Background: Postoperative pancreatic fistula (POPF) is one of the major complications after pancreaticoduodenectomy. There have been many studies into the risk factors determining POPF. Some studies have reported a higher peri-operative fluid balance associated with POPF, however, the pertinent findings remain controversial. Read More

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Hydroxychloroquine and Azithromycin Combination in The Management of COVID-19 Infection: Safety and Effectiveness Challenges.

Curr Drug Saf 2021 Jul 27. Epub 2021 Jul 27.

Critical Care Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.

Background: The treatment of COVID-19 disease remains a dilemma so far because there is no approved therapy for it. This study aimed to evaluate the use of hydroxychloroquine and azithromycin combination in treatment.

Objective: This study was carried out to determine the safety and effectiveness of hydroxychloroquine and azithromycin combination in COVID 19 patients. Read More

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National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?

J Am Heart Assoc 2021 Jul 28:e019655. Epub 2021 Jul 28.

Department of Medicine University of Wisconsin Hospital and Clinics Madison WI.

Background It is unclear whether the recent increase in the number of heart transplants performed annually in the United States is only because of higher availability of donors and if it affected recipients' survival. Methods and Results We examined characteristics of donors and recipients from 2008 to 2012 (n=11 654) and 2013 to 2017 (n=14 556) and compared them with 2003 to 2007 (n=10 869). Cox models examined 30-day and 1-year risk of recipients' death post transplant. Read More

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CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.

Redox Biol 2021 Jul 17;46:102067. Epub 2021 Jul 17.

Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, Taiwan; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address:

Traumatic brain injury (TBI) is a prevalent head injury worldwide which increases the risk of neurodegenerative diseases. Increased reactive oxygen species (ROS) and inflammatory chemokines after TBI induces secondary effects which damage neurons. Targeting NADPH oxidase or increasing redox systems are ways to reduce ROS and damage. Read More

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Evaluation of targeted bupivacaine, bupivacaine-lidocaine-epinephrine, dexamethasone, and meloxicam for reducing acute postoperative pain in cats undergoing routine ovariohysterectomy.

Top Companion Anim Med 2021 Jul 24:100564. Epub 2021 Jul 24.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

This study compared bupivacaine (BUP), bupivacaine-lidocaine-epinephrine (BLE), dexamethasone (DEX), and meloxicam (MEL) targeted at specific, potentially painful sites for reducing acute postoperative pain in cats undergoing elective ovariohysterectomy. One hundred fifty-one cats were included in a prospective, randomized, double-blinded clinical trial. Anesthesia consisted of a standardized protocol including buprenorphine, ketamine, dexmedetomidine, and isoflurane. Read More

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A randomized controlled trial of the effect of post-operative hand exercise training on arteriovenous fistula maturation in patients with chronic kidney disease.

J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Objective: Immature arteriovenous fistula (AVF) is a critical problem in chronic kidney disease (CKD) patients after creation. Exercise with 30% maximum voluntary contraction (MVC) encourages vascular functions in other populations. It is unknown which exercise type is superior on maturation in CKD population. Read More

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