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Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment.

Res Vet Sci 2021 Sep 10;140:242-250. Epub 2021 Sep 10.

Graduate Program in Environmental and Experimental Pathology, University Paulista, Rua Doutor Bacelar, 1212, 4th Floor, São Paulo, SP, 04026-002, Brazil; Department of Veterinary Medicine, University Cruzeiro do Sul, Avenida Tenente, Laudelino Ferreira do Amaral, 700, São Paulo, SP, 08060-000, Brazil. Electronic address:

Doxorubicin (DOX) is known to cause cognitive impairments in patients submitted to long-term chemotherapy (deficits also known as chemobrain). Therefore, there is an urgent need for therapeutic strategies capable of returning cancer survivors back to their previous quality of life. The present study investigated whether resveratrol (RSV) or curcumin (CUR) administration could affect mnemonic function and brain morphological changes following DOX administration in rats. Read More

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September 2021

Positive and negative affect are associated with salivary cortisol in the everyday life of older adults: A quantitative synthesis of four aging studies.

Psychoneuroendocrinology 2021 Aug 30;133:105403. Epub 2021 Aug 30.

Department of Psychology, The University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada; Centre for Hip Health and Mobility, The University of British Columbia, 2635 Laurel St, Vancouver, BC V5Z 1M9, Canada.

Research on time-fluctuating links between positive affect and cortisol is inconsistent and mostly based on young to middle-aged samples. The current project investigated how moment-to-moment changes in positive and negative affect are associated with moment-to-moment changes in cortisol levels in older adults' daily lives and whether those associations are moderated by differences in health status (as indicated by the number of comorbidities). Affect and cortisol data collected in four separately conducted momentary assessment studies with parallel protocols were pooled to obtain a sample of N=476 individuals aged 56-88 years (M=71. Read More

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Postoperative Pain after Clitoral Reconstruction in Women with Female Genital Mutilation: an evaluation of practices.

J Gynecol Obstet Hum Reprod 2021 Sep 15:102230. Epub 2021 Sep 15.

Service de Gynécologie-Obstétrique, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75010 Paris.

Introduction: More than 200 million women and girls have undergone genital mutilation. Clitoral reconstruction (CR) can improve the quality of life of some of them, but is accompanied by significant postoperative pain.

Objective: Assess and describe the management of postoperative pain after CR, and the practices among specialists in different countries. Read More

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September 2021

Onset of nutrient consumption during early life stage digestive system development of two tuna species (Thunnus orientalis and Thunnus albacares).

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 15:111075. Epub 2021 Sep 15.

Shirahama Experimental Station, Fisheries Laboratory, Kindai University, 3153 Shirahama, Nishimuro, Wakayama 649-2211, Japan.

To specify the timing of exogenous nutrient consumption in the larvae of two commercially important tuna species, the Pacific bluefin tuna (PBF) Thunnus orientalis and the yellowfin tuna (YFT) Thunnus albacares, the gene expressions of peptide transporter 1 (PEPT1) were examined. The mRNA expressions of PEPT1 first occurred at 2 days post hatching (dph) in PBF larvae and 3 dph for the YFT, and PEPT1 was found to only be expressed in the intestinal tract. The histological changes of the digestive tract of the YFT larvae were observed and compared to PBF larvae from a previous study. Read More

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September 2021

Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life.

Reprod Toxicol 2021 Sep 15. Epub 2021 Sep 15.

Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States. Electronic address:

Adverse environmental stress exposure at critical perinatal stages can alter cardiovascular development, which could persist into adulthood and develop a cardiovascular dysfunctional phenotype late in life. However, the underlying molecular mechanisms remain largely unknown. The present study provided a direct evidence that DNA methylation is a key epigenetic mechanism contributing to the developmental origins of adult cardiovascular disease. Read More

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September 2021

Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring.

Life Sci 2021 Sep 15:119960. Epub 2021 Sep 15.

Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.

Aims: Sertraline (SE) is one of the most prescribed medications for treating gestational depression, anxiety and stress. However, little is known about its effects on nervous-system development in offspring. Therefore, this study investigated the somatic, reflex and neurobehavioral development of rats exposed to SE during pregnancy, associated or not with stress. Read More

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September 2021

Busulfan impairs blood-testis barrier and spermatogenesis by increasing noncollagenous 1 domain peptide via matrix metalloproteinase 9.

Andrology 2021 Sep 18. Epub 2021 Sep 18.

Department of Biochemistry and Molecular Biology, College of Life Science, China Medical University, Shen Yang, 110122, China.

Backgrounds: Sterility induced by anti-cancer treatments has caused significant concern, yet the mechanism and treatment exploration are little for male infertility after cancer therapy. Busulfan (BU), the antineoplastic that widely applied before bone marrow transplantation, was known to induce male reproductive disorder.

Objectives: To investigate the effect of busulfan on blood-testis barrier (BTB) function in adult rats and determine whether noncollagenous 1 (NC1) domain peptide, the biologically active fragment proteolyzed from the collagen α3 chain (IV) by matrix metalloproteinase 9 (MMP-9), was involved during this process. Read More

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September 2021

Improving respiratory muscle strength and health status in burn patients: a randomized controlled trial.

Qual Life Res 2021 Sep 17. Epub 2021 Sep 17.

Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Pulmonary complications are among the major disadvantages of burns. The present study aimed to determine the effect of inspiratory muscle training on respiratory muscle strength and health status in burned patients.

Methods: The current randomized clinical trial was conducted on 64 burned patients in Burn Center of Imam Reza Hospital, Mashhad, Iran. Read More

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September 2021

DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis.

Sci Rep 2021 Sep 17;11(1):18532. Epub 2021 Sep 17.

Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Leydig cells in the testes produce testosterone in the presence of gonadotropins. Therefore, male testosterone levels must oscillate within a healthy spectrum, given that elevated testosterone levels augment the risk of cardiovascular disorders. We observed that the expression of death-associated protein-like 1 (DAPL1), which is involved in the early stages of epithelial differentiation and apoptosis, is considerably higher in the testes of sexually mature mice than in other tissues. Read More

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September 2021

Mothers' cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring.

Sci Rep 2021 Sep 17;11(1):18573. Epub 2021 Sep 17.

Laboratory of Neurobiology, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wojska Polskiego 71C, 60-625, Poznan, Poland.

"Western diet" containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Read More

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September 2021

Colonization and Development of the Fecal Microflora of South China Tiger Cubs (Panthera tigris amoyensis) by Sequencing of the 16S rRNA Gene.

Microb Physiol 2021 Sep 14:1-12. Epub 2021 Sep 14.

College of Life Science, Longyan University, Longyan, China.

Postnatal colonization and development of the gut microbiota is linked to health and growth. A comprehensive understanding of the postnatal compositional changes and development of the microbial community is helpful to understand the gut health and improve the survival rate of South China tiger cubs (Panthera tigris amoyensis). Fecal samples from three tiger cubs were collected on the day of birth in 2018 (June 17-21 [G0], July 18 [G1], July 31 [G2], and August 7 [G3]). Read More

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September 2021

Hierarchical chromatin features reveal the toxin production in Bungarus multicinctus.

Chin Med 2021 Sep 17;16(1):90. Epub 2021 Sep 17.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Background: Bungarus multicinctus, from which a classical Chinese medicine is produced, is known as the most venomous land snake in the world, but the chromatin organization and transcription factor activity during venom replenishment progress have not been explored yet. This study aimed to determine the roles of chromatin structure in toxin activity via bioinformatics and experimental validation.

Methods: Chromosome conformation capture (Hi-C) analysis was used to examine interactions among chromosomes and identify different scales of chromatin during envenomation in B. Read More

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September 2021

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.

Crit Care 2021 Sep 17;25(1):341. Epub 2021 Sep 17.

Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Objective: Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity.

Design: Prospective cohort study with independent replication cohort. Read More

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September 2021

Women empowerment and minimum daily meal frequency among infants and young children in Ghana: analysis of Ghana demographic and health survey.

BMC Public Health 2021 Sep 17;21(1):1700. Epub 2021 Sep 17.

Department of Population and Health, University of Cape Coast, Cape Coast, Ghana.

Background: The nutritional quality of food has an important impact on the health and well-being of families, especially children whose bodies need to grow, develop and reach their full physical and mental potential. Traditionally, women in Ghana provide care and nourishment for their children and families if they have the means to do so or if they are financially, legally and socially empowered. Women's empowerment is not only important for women's human rights, but also improves nutrition and health outcomes of both mothers and their children. Read More

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September 2021

A Single-cell Transcriptome Atlas of Cashmere Goat Hair Follicle Morphogenesis.

Genomics Proteomics Bioinformatics 2021 Sep 14. Epub 2021 Sep 14.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China. Electronic address:

Cashmere, also known as soft gold, is produced from the secondary hair follicles (SHFs) of cashmere goats. The number of SHFs determines the yield and quality of cashmere, therefore, it is of interest to investigate the transcriptional profiles present during cashmere goat hair follicle development. However, mechanisms underlying this development remain largely unexplored and studies regarding hair follicle development mostly use a murine research model. Read More

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September 2021

Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog.

Theriogenology 2021 Aug 15;175:100-110. Epub 2021 Aug 15.

Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary; ATRC Aurigon Ltd., Dunakeszi, Hungary.

The role of anti-Müllerian hormone (AMH) and insulin-like peptide 3 (INSL3) in male infertility is not fully understood. We used the downregulated testis as a model of gonadotropin-dependent infertility. Serum testosterone and AMH concentrations were studied in five adult male Beagles implanted (day 0) with 4. Read More

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Blood cancer care in a resource limited setting during the Covid-19 outbreak; a single center experience from Sri Lanka.

PLoS One 2021 17;16(9):e0256941. Epub 2021 Sep 17.

Sir John Kotelawala Defence University, Werahera, Colombo, Sri Lanka.

Background: The Covid-19 pandemic has caused significant morbidity and mortality among patients with cancer. Most countries employed measures to prevent spread of Covid-19 infection which include shielding, quarantine, lockdown, travel restrictions, physical distancing and the use of personal protective equipment. This study was carried out to assess the change in patient attendance and the efficacy of newly implemented strategies to mitigate the impact of Covid-19 on services at the Lanka Hospital Blood Cancer Centre (LHBCC) in Colombo, Sri Lanka. Read More

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September 2021

Cost-effectiveness of a Digital Health Intervention for Acute Myocardial Infarction Recovery.

Med Care 2021 Sep 17. Epub 2021 Sep 17.

Johns Hopkins Bloomberg School of Public Health Johns Hopkins University School of Nursing Digital Health Innovation Laboratory, Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine Johns Hopkins University School of Medicine, Baltimore, MD Department of Pharmaceutical & Health Economics, School of Pharmacy, University of Southern California Leonard D. Schaeffer Center for Health Economics & Policy, University of Southern California, Los Angeles, CA Dimock Center Johns Hopkins University Whiting School of Engineering, Baltimore, MD Massachusetts General Hospital, Boston, MA Reading Hospital, West Reading, PA Harvard Medical School, Boston, MA Johns Hopkins University Krieger School of Arts and Sciences Johns Hopkins Health System, Baltimore, MD.

Background: Acute myocardial infarction (AMI) is a common cause of hospital admissions, readmissions, and mortality worldwide. Digital health interventions (DHIs) that promote self-management, adherence to guideline-directed therapy, and cardiovascular risk reduction may improve health outcomes in this population. The "Corrie" DHI consists of a smartphone application, smartwatch, and wireless blood pressure monitor to support medication tracking, education, vital signs monitoring, and care coordination. Read More

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September 2021

Social factors and the prevalence of social isolation in a population-based adult cohort.

Soc Psychiatry Psychiatr Epidemiol 2021 Sep 17. Epub 2021 Sep 17.

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany.

Purpose: Social isolation has negative effects on physical and brain health across the lifespan. However, the prevalence of social isolation, specifically with regard to sociodemographic and socioeconomic factors, is not well known.

Methods: Database was the Leipzig population-based study of adults (LIFE-Adult Study, n = 10,000). Read More

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September 2021

Reappraisal of the historical myopia epidemic in native Arctic communities.

Ophthalmic Physiol Opt 2021 Sep 17. Epub 2021 Sep 17.

Dr Iribarren Eye Consultants, Buenos Aires, Argentina.

Purpose: This study was developed to explain the extraordinary rise in myopia prevalence beginning after 1950 in Indigenous Arctic communities considering recent findings about the risk factors for school myopia development. Myopia prevalence changed drastically from a historical low of less than 3% to more than 50% in new generations of young adults following the Second World War. At that time, this increase was attributed to concurrent alterations in the environment and way of life which occurred in an aggressive programme of de-culturalization and re-acculturation through residential school programmes that introduced mental, emotional and physical stressors. Read More

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September 2021

High heritability of telomere length and low heritability of telomere shortening in wild birds.

Mol Ecol 2021 Sep 17. Epub 2021 Sep 17.

Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747AG, Groningen, The Netherlands.

Telomere length and telomere shortening predict survival in many organisms. This raises the question of the contribution of genetic and environmental effects to variation in these traits, which is still poorly known, particularly for telomere shortening. We used experimental (cross-fostering) and statistical (quantitative genetic 'animal' models) means to disentangle and estimate genetic and environmental contributions to telomere length variation in pedigreed free-living jackdaws (Corvus monedula). Read More

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September 2021

Efficacy of Naoxueshu in acute spontaneous intracerebral hemorrhage: a multicenter observational study.

Neurol Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Objective: To evaluate the efficacy and safety outcome and related risk factors of Naoxueshu in the treatment of acute SICH.

Methods: Two hundred twenty patients were enrolled in this study. Diagnosis of SICH was based on neuroimaging. Read More

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September 2021

Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study.

Transl Androl Urol 2021 Aug;10(8):3432-3439

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: To perform a prospective, randomized, single center study to investigate the efficacy of combined use of curcumin, an anti-inflammatory agent, with the best standard management (BSM, tamsulosin and finasteride) in benign prostatic hyperplasia (BPH) patients.

Methods: One hundred and twenty-two consecutive patients were randomized to receive tamsulosin 0.2 mg, finasteride 5 mg, and curcumin 2,250 mg once a day (curcumin + BSM group, n=61) versus tamsulosin 0. Read More

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Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.

ACS Med Chem Lett 2021 Sep 16;12(9):1405-1412. Epub 2021 Aug 16.

FIOCRUZ, Instituto Oswaldo Cruz, Laboratório de Bioquímica de Tripanosomatídeos, Rio de Janeiro, RJ, Brazil.

5-Nitro-furan nitrones () and 5-nitro-thiophene nitrones () were synthesized in one step. Compounds - had the most potent leishmanicidal activity against intracellular amastigote forms of and (from 0.019 to 2. Read More

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September 2021

Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants.

Front Psychiatry 2021 31;12:709559. Epub 2021 Aug 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.

More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, are implicated in behavioral and molecular consequences of chronic alcohol use, making the NMDAR a promising target for novel pharmacotherapeutics. Ethanol exposure upregulates Fyn, a protein tyrosine kinase that indirectly modulates NMDAR signaling by phosphorylating the NR2B subunit. Read More

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Low lung function, sudden cardiac death and non-fatal coronary events in the general population.

BMJ Open Respir Res 2021 Sep;8(1)

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Background: Many of those who suffer from a first acute coronary event (CE) die suddenly during the day of the event, most of them die outside hospital. Poor lung function is a strong predictor of future cardiac events; however, it is unknown whether the pattern of lung function impairment differs for the prediction of sudden cardiac death (SCD) versus non-fatal CEs. We examined measures of lung function in relation to future SCD and non-fatal CE in a population-based study. Read More

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September 2021

Study protocol for yoga-based lifestyle intervention for healthy ageing phenotype in the older adults (yHAP): a two-armed, waitlist randomised controlled trial with multiple primary outcomes.

BMJ Open 2021 Sep 16;11(9):e051209. Epub 2021 Sep 16.

Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India.

Introduction: The conceptualisation of healthy ageing phenotype (HAP) and the availability of a tentative panel for HAP biomarkers raise the need to test the efficacy of potential interventions to promote health in older adults. This study protocol reports the methodology for a 24-week programme to explore the holistic influence of the yoga-based intervention on the (bio)markers of HAP.

Methods And Analysis: The study is a two-armed, randomised waitlist controlled trial with blinded outcome assessors and multiple primary outcomes. Read More

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September 2021

Cost-effectiveness of the adherence with recommendations for clinical monitoring of patients with diabetes.

Nutr Metab Cardiovasc Dis 2021 Jul 28. Epub 2021 Jul 28.

National Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy; Center of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy.

Background And Aims: To validate a set of indicators for monitoring the quality of care of patients with diabetes in 'real-life' practice through its relationship with measurable clinical outcomes and healthcare costs.

Methods And Results: A population-based cohort study was carried out by including the 20,635 patients, residents in the Lombardy Region (Italy), who in the year 2012 were newly taken-in-care for diabetes. Adherence with clinical recommendations (i. Read More

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Effects of 30 days of ketogenic diet on body composition, muscle strength, muscle area, metabolism, and performance in semi-professional soccer players.

J Int Soc Sports Nutr 2021 Sep 16;18(1):62. Epub 2021 Sep 16.

Department of Biomedical Sciences, University of Padua, Via Marzolo, 3, 35131, Padua, Italy.

Background: A ketogenic diet (KD) is a nutritional approach, usually adopted for weight loss, that restricts daily carbohydrates under 30 g/day. KD showed contradictory results on sport performance, whilst no data are available on team sports. We sought to investigate the influence of a KD on different parameters in semi-professional soccer players. Read More

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September 2021

The role of transport and telecommunications technology in the development of the Scottish Highlands and Islands Medical Service: a historical perspective.

Rural Remote Health 2021 Sep 17;21(3):6560. Epub 2021 Sep 17.

Centre for Rural Health, Institute of Applied Health Sciences, University of Aberdeen, Inverness, Scotland IV2 3JH, UK

The Highlands and Islands Medical Service (HIMS) was introduced across the Scottish Highlands and Islands region after the publication of the Dewar Report in 1913. It was the first state-funded medical service in the UK and one of the first in the world. The Dewar Committee recommended the establishment of HIMS following research into healthcare provision in the region, concluding that there was insufficient provision. Read More

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September 2021