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Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.

Hepatology 2021 Sep 25. Epub 2021 Sep 25.

Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background And Aims: Acute liver failure (ALF) is characterized by significant changes in the hemostatic system and by systemic inflammation. The formation of neutrophil extracellular traps (NETs), in which an activated neutrophil expels its DNA, histones and granular enzymes, such as myeloperoxidase (MPO), has been associated with immune-mediated and thrombotic diseases. We hypothesized that formation of NETs in patients with ALF contributes to progression of disease. Read More

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September 2021

YouTube as a source of information on COVID-19 vaccination in rheumatic diseases.

Rheumatol Int 2021 Sep 25. Epub 2021 Sep 25.

Physiotherapy and Rehabilitation Application and Research Center, Hasan Kalyoncu University, Gaziantep, Turkey.

As the most well-known and popular video-sharing platform around the world, YouTube is an influential tool for the dissemination of health-related information. In addition, considering the increase in obtaining information from internet-based sources in pandemic conditions, YouTube has become more important in the presentation of information related to COVID-19. Therefore, the aim of this study was to evaluate videos related to COVID-19 vaccination in rheumatic diseases (RD) on YouTube. Read More

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September 2021

Effects of repeated manganese treatment on proton magnetic resonance spectra of the globus pallidus in rat brain.

NMR Biomed 2021 Sep 25:e4617. Epub 2021 Sep 25.

State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, China.

Excessive manganese is neurotoxic, which means that it can affect the concentrations of metabolite in H MRS. In addition, manganese is paramagnetic and it may influence the relaxation times of the metabolite. The aim of this study is to assess the sensitivity of the metabolite relaxation properties and concentrations to exogenous manganese deposition in the globus pallidus (GP) of rat brain after repeated manganese injection. Read More

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September 2021

Centrally Administered Neuropeptide-S Alleviates Gastrointestinal Dysmotility Induced by Neonatal Maternal Separation.

Neurogastroenterol Motil 2021 Sep 24:e14269. Epub 2021 Sep 24.

Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Background: Neuropeptide-S (NPS) regulates autonomic outflow, stress response, and gastrointestinal (GI) motor functions. This study aimed to investigate the effects of NPS on GI dysmotility induced by neonatal maternal separation (MS).

Methods: MS was conducted by isolating newborn pups from dams from postnatal day 1 to day 14. Read More

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September 2021

Therapeutic potential of Ferula foetida(Bunge) Regel on gastric ulcer model in rats.

Environ Sci Pollut Res Int 2021 Sep 24. Epub 2021 Sep 24.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.

The plant Ferula foetida(Bunge) Regel (FFBR) has a long history in Asian traditional medicine. This study aimed to evaluate the ulcer healing potential of FFBR umbel ethanolic extract on acetic acid-induced chronic gastric ulcer in rats. First, the gastric ulcer model was imitated by serosal application of acetic acid in male Wistar rats. Read More

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September 2021

Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions.

Prog Brain Res 2021 13;265:385-406. Epub 2021 Aug 13.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Nanoparticles affect blood-brain barrier (BBB) and brain edema formation resulting in sensory-motor dysfunction. Exposure of Mn nanoparticles from industrial sources in humans could target basal ganglia resulting in Parkinson's disease. In present investigation, Mn exposure on brain pathology in a rat model was examined. Read More

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Normalization of Peri-Arteriovenous Malformation Hemodynamics Prior to Direct Microsurgery: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona, USA.

Arteriovenous malformations (AVMs) are highly complex vascular lesions characterized by abnormal connections between arteries and an intervening nidus. Definitive and safe treatment of AVMs may require the combination of multiple treatment modalities to address the various complex features of the AVM.1 Endovascular embolization can be used as an adjuvant to surgery in order to control deep feeders, reduce flow, and address high-risk features such as aneurysms. Read More

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September 2021

Effect of Added Free Water to Enteral Tube Feeds in Children Receiving Commercial Blends.

J Pediatr Gastroenterol Nutr 2021 Sep 22. Epub 2021 Sep 22.

Aerodigestive Center, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Hepatology & Nutrition, Boston Children's Hospital, Boston, MA.

Objectives: To determine the impact of free water administration on clinical outcomes in medically complex patients, based on the hypothesis that patients receiving more thin liquids have worse outcomes related to increased risk of gastroesophageal reflux.

Methods: This was a retrospective chart review of children initiated on commercial blenderized tube feedings from 2010 to 2019. The percentage of gastrostomy intake that was a thin liquid was determined, with thin liquids including free water or thin formula based on the International Dysphagia Diet Stardardization Initiative (IDDSI) framework. Read More

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September 2021

Gluten and fructan intake and their associations with gastrointestinal symptoms in irritable bowel syndrome: A food diary study.

Clin Nutr 2021 Sep 9;40(10):5365-5372. Epub 2021 Sep 9.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background & Aims: Wheat contains several components, including gluten and fructan, that may be associated with gastrointestinal symptoms (GI) in irritable bowel syndrome (IBS). The aims of the study were to determine the average daily intake of gluten, investigate the association of gluten and GI symptoms, as well as the association between fructan and GI symptoms in IBS subjects.

Methods: We assessed dietary intake, including total energy, and calculated average gluten and fructan intake in this 4-day food diary study. Read More

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September 2021

Polysubstance use among national samples of in-school adolescents in Tonga and Vanuatu.

Asian J Psychiatr 2021 Sep 21;65:102819. Epub 2021 Sep 21.

Department of Research Administration and Development, University of Limpopo, Polokwane, South Africa; ASEAN Institute for Health Development, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, Thailand.

The study aimed to provide estimates on current polysubstance use among adolescents in Tonga and Vanuatu. Cross-sectional and national school health survey data were analyzed from 5028 adolescents (mean age 15.4 years) in Tonga and Vanuatu in 2016-2017. Read More

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September 2021

Tracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs.

J Trace Elem Med Biol 2021 Sep 13;68:126856. Epub 2021 Sep 13.

Departmento de Dentística, Endodontia e Materiais Odontológicos, Faculdade de Odontologia de Bauru, FOB/USP, Bauru, Brazil.

Background: This study aimed to track the toxic ions released by MTA Fillapex, BioRoot RCS, and an experimental tricalcium silicate-based sealer (CEO) into local and distant tissues as well as to investigate their potential adverse effects. In addition, the chemical constituents of the sealers were also evaluated. The main components of the dry powders, pastes, and mixed sealers were characterized. Read More

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September 2021

Regulation of maternal behavior, social isolation responses, and postpartum estrus by steroid hormones and vaginocervical stimulation in sheep.

Horm Behav 2021 Sep 21;136:105061. Epub 2021 Sep 21.

Centro de Investigación en Reproducción Animal, CINVESTAV-Universidad Autónoma de Tlaxcala, Mexico.

Periparturient ewes display several activities in addition to maternal behavior per se. They isolate themselves from the flock and, contrary to other mammals, do not show postpartum estrus. We investigated the possibility of a common hormonal control of maternal behavior, prepartum social isolation responses, and absence of postpartum estrus. Read More

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September 2021

A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model.

Ann Plast Surg 2021 Oct;87(4):421-426

From the Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, Orange.

Background: Burns are devastating injuries, carry significant morbidity, and require long-term treatment or multiple reconstructive procedures. Wound healing and secondary insults caused by burn wound conversion are amendable to therapeutic intervention, where ischemia has been cited as one of the major factors (Dermatol Surg. 2008;34:1159-1169). Read More

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October 2021

Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms.

J Pharm Pharm Sci 2021 ;24:484-487

Department of Congenital Heart Surgery and Organ Transplantation, New Children's Hospital, University of Helsinki, Finland.

Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients.  We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Read More

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January 2021

A Phase 1b Trial of Prexasertib in Combination with Standard-of-Care Agents in Advanced or Metastatic Cancer.

Target Oncol 2021 Sep 24. Epub 2021 Sep 24.

Sarah Cannon Research Institute, Nashville, TN, USA.

Background: The checkpoint kinase 1 (CHK1) inhibitor prexasertib exhibited modest monotherapy antitumor activity in prior trials, suggesting that combination with chemotherapy or other targeted agents may be needed to maximize efficacy.

Objectives: The aim of this study was to determine the recommended phase II dose and schedule of prexasertib in combination with either cisplatin, cetuximab, pemetrexed, or 5-fluorouracil in patients with advanced and/or metastatic cancer, and to summarize preliminary antitumor activity of these combinations.

Patients And Methods: This phase Ib, nonrandomized, open-label study comprised dose-escalation phase(s) with multiple sub-arms evaluating different prexasertib-drug combinations: Part A, prexasertib + cisplatin (n = 63); Part B, prexasertib + cetuximab (n = 41); Part C, prexasertib + pemetrexed (n = 3); Part D, prexasertib + 5-fluorouracil (n =8). Read More

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September 2021

Early Post-operative Feeding: An Investigation of Early Functional Outcomes for Oral Cancer Patients Treated with Surgical Resection and Free Flap Reconstruction.

Dysphagia 2021 Sep 24. Epub 2021 Sep 24.

Therapies Department, The Royal Marsden NHS Foundation Trust, London, UK.

Traditionally patients can remain nil by mouth (NBM) for up to 12 days after oral tumour resection with free flap reconstruction to reduce the risk of flap dehiscence, poor healing and fistulae. The literature reports that patients could on average remain an inpatient for up to 20 days post-surgery. An evaluation of the impact of a defined early oral feeding protocol was undertaken investigating functional outcomes and complications rates. Read More

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September 2021

Afterload-related cardiac performance predicts prognosis in critical ill patients with sepsis: A prospective observational pilot study.

Medicine (Baltimore) 2021 Sep;100(38):e27235

Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, People's Republic of China.

Abstract: To investigate the usefulness of afterload-related cardiac performance (ACP) for assessing cardiac impairment and predicting prognosis in septic patients.Adult patients with sepsis in the intensive care unit were included. Cardiac output, cardiac index, cardiac power index, and ACP were calculated at the time of admission (D0) and 48-72 h after admission (D3). Read More

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September 2021

Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study.

Neural Regen Res 2022 May;17(5):1051-1058

Department of Neurological Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.

Repetitive transcranial magnetic stimulation (rTMS) has been shown to effectively improve impaired swallowing in Parkinson's disease (PD) patients with dysphagia. However, little is known about how rTMS affects the corresponding brain regions in this patient group. In this case-control study, we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy, Capital Medical University. Read More

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A major outbreak of COVID-19 at aresidential care home.

Dan Med J 2021 Sep 23;68(10). Epub 2021 Sep 23.

Introduction SARS-CoV-2 outbreaks at care homes are associated with a high morbidity and mortality. We aimed to study the molecular epidemiology of a major care home outbreak in Denmark. Methods After a staff member had been tested positive on 16 November 2020, a bundle approach programme was initiated including frequent surveillance screenings of residents and staff, isolation and cohorting procedures. Read More

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September 2021

Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study.

Hum Reprod Open 2021 7;2021(4):hoab032. Epub 2021 Aug 7.

Department of Obstetrics and Gynecology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Study Question: Does lifestyle intervention consisting of an energy-restricted diet, enhancement of physical activity and motivational counseling prior to IVF improve embryo utilization rate (EUR) and cumulative live birth rate (CLBR) in women with obesity?

Summary Answer: A 6-month lifestyle intervention preceding IVF improved neither EUR nor CLBR in women with obesity in the first IVF treatment cycle where at least one oocyte was retrieved.

What Is Known Already: A randomized controlled trial (RCT) evaluating the efficacy of a low caloric liquid formula diet (LCD) preceding IVF in women with obesity was unable to demonstrate an effect of LCD on embryo quality and live birth rate: in this study, only one fresh embryo transfer (ET) or, in case of freeze-all strategy, the first transfer with frozen-thawed embryos was reported. We hypothesized that any effect on embryo quality of a lifestyle intervention in women with obesity undergoing IVF treatment is better revealed by EUR and CLBR after transfer of all fresh and frozen-thawed embryos. Read More

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Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy.

Front Neurol 2021 7;12:708957. Epub 2021 Sep 7.

Department of Neurological Surgery, University of California, Davis, Sacramento, CA, United States.

Over one-third of patients with temporal lobe epilepsy are refractory to medication. In addition, anti-epileptic drugs often exacerbate cognitive comorbidities. Neuromodulation is an FDA treatment for refractory epilepsy, but patients often wait >20 years for a surgical referral for resection or neuromodulation. Read More

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September 2021

Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study.

Front Pharmacol 2021 7;12:620635. Epub 2021 Sep 7.

Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect using urinary excretion of the prostacyclin metabolite 6-keto-prostaglandin F1α. Fifteen healthy male volunteers were studied in an open-label randomized controlled parallel group study. Read More

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September 2021

Effect of Restricted Feeding on Metabolic Health and Sleep-Wake Rhythms in Aging Mice.

Front Neurosci 2021 7;15:745227. Epub 2021 Sep 7.

Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Aging, an irreversible and unavoidable physiological process in all organisms, is often accompanied by obesity, diabetes, cardiovascular diseases, sleep disorders, and fatigue. Thus, older adults are more likely to experience metabolic symptoms and sleep disturbances than are younger adults. Restricted feeding (RF) is a dietary regimen aimed at improving metabolic health and extending longevity, as well as reorganizing sleep-wake cycles. Read More

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September 2021

Radiology Reporting Errors: Learning from Report Addenda.

Indian J Radiol Imaging 2021 Apr 12;31(2):333-344. Epub 2021 Aug 12.

Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.

The addition of new information to a completed radiology report in the form of an "addendum" conveys a variety of information, ranging from less significant typographical errors to serious omissions and misinterpretations. Understanding the reasons for errors and their clinical implications will lead to better clinical governance and radiology practice. This article assesses the common reasons which lead to addenda generation to completed reports and their clinical implications. Read More

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Follicular dynamics during the pre-ovulatory and subsequent first follicular wave stages affect the pregnancy outcome in Japanese Black cows.

J Reprod Dev 2021 Sep 24. Epub 2021 Sep 24.

Cooperative Graduate School of Veterinary Medicine, Iwate University, Iwate 020-8550, Japan.

The diameters of the pre-ovulatory follicles (PF) and the largest follicle during the subsequent first follicular wave (W1LF), and plasma estradiol-17β (E) concentrations were monitored on Days 0, 1, 3, 5, and 7 (ovulation = Day 1). Pregnancy was diagnosed on Day 30. Cows were classified into two groups according to the location of the dominant follicle ipsilateral (IG) or contralateral (CG) to the corpus luteum on Day 7. Read More

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September 2021

Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory.

Proc Natl Acad Sci U S A 2021 09;118(39)

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3QU, United Kingdom;

Light provides the primary signal for entraining circadian rhythms to the day/night cycle. In addition to rods and cones, the retina contains a small population of photosensitive retinal ganglion cells (pRGCs) expressing the photopigment melanopsin (OPN4). Concerns have been raised that exposure to dim artificial lighting in the evening (DLE) may perturb circadian rhythms and sleep patterns, and OPN4 is presumed to mediate these effects. Read More

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September 2021

Prehospital major incident management: how do training and real-life situations relate? A qualitative study.

BMJ Open 2021 Sep 23;11(9):e048792. Epub 2021 Sep 23.

Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Objective: To explore the relationship between preparations and real-life experiences among prehospital major incident commanders.

Design: An explorative, qualitative design was used.

Setting: Prehospital major incidents in Sweden. Read More

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September 2021

User experiences and perceptions of health wearables: an exploratory study in Cambodia.

Glob Health Res Policy 2021 Sep 23;6(1):33. Epub 2021 Sep 23.

Centre for Global Chronic Conditions, London School of Hygiene and Tropical Medicine, London, UK.

Background: In many low- and middle-income countries (LMICs), health system capacities to address the burden of non-communicable diseases (NCDs) are often inadequate. In these countries, wearable health technologies such as smartbands and smartwatches could be used as part of public health programmes to improve the monitoring, prevention, and control of NCDs. Considering this potential, the purpose of this study was to explore user experiences and perceptions of a health wearable in Cambodia. Read More

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September 2021

A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age.

Immun Ageing 2021 Sep 23;18(1):37. Epub 2021 Sep 23.

Department of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Ave, RC2, Mail Stop #8620, CO, 80045, Aurora, USA.

Background: There are currently > 600 million people over the age of 65 globally and this number is expected to double by the year 2050. Alcohol use among this population is on the rise, which is concerning as aging is associated with increased risk for a number of chronic illnesses. As most studies investigating the effects of alcohol have focused on young/middle-aged populations, there is a dearth of information regarding the consequences of alcohol use in older consumers. Read More

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September 2021

Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways.

Eur J Pharmacol 2021 Sep 20:174495. Epub 2021 Sep 20.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, PR China. Electronic address:

Tetrahydrocurcumin (THC) is an essential metabolite of curcumin, a major active component of the Curcuma species, which have been used traditionally for the treatment of cardiovascular diseases. The PI3K/AKT/mTOR signaling pathways serve a vital role during myocardial ischemia-reperfusion (MI/R) injury. The aim of the present study was to investigate the cardioprotective potential and mechanism of THC. Read More

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September 2021