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Incidence, associated risk factors, and the ideal mode of delivery following preterm labour between 24 to 28 weeks of gestation in a low resource setting.

PLoS One 2021 22;16(7):e0254801. Epub 2021 Jul 22.

University of Manchester, Manchester, United Kingdom.

Background: Preterm labour, between 24 to 28 weeks of gestation, remains prevalent in low resource settings. There is evidence of improved survival after 24 weeks though the ideal mode of delivery remains unclear. There are no clear management protocols to guide patient management. Read More

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New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors.

Avicenna J Phytomed 2021 Jul-Aug;11(4):367-379

Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Objective: Farnesoid-X-activated receptors (FXR) are key modulators of liver regeneration. Milk thistle and Chicory are known as potent protective remedies in several liver disorders. The objective of this work was to examine the role of in the hepato-healing properties of milk thistle (MTE) and chicory extracts (CE) in a rat model of acetaminophen-induced hepatotoxicity. Read More

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January 2020

Impact of home blood pressure variability on cardiovascular outcome in patients with arterial stiffness: Results of the J-HOP study.

J Clin Hypertens (Greenwich) 2021 Jul 20. Epub 2021 Jul 20.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.

This study sought to investigate whether the relation between increased blood pressure (BP) variability and increased arterial stiffness confers a risk for cardiovascular disease (CVD) events. We analyzed 2648 patients from a practitioner-based population (mean ± SD age 64.9 ± 11. Read More

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No increased injury incidence in the German Bundesliga after the SARS-CoV-2 virus lockdown.

Arch Orthop Trauma Surg 2021 Jul 20. Epub 2021 Jul 20.

Institute of Sports and Preventive Medicine, Saarland University, Saarbrücken, Germany.

Introduction: The coronavirus lockdown in 2020 resulted in a worldwide suspension of professional sports. The first major professional football league to restart after the lockdown was the German Bundesliga. This study investigates whether the injury incidence increased after the restart of the season with only 9 days of regular preparation time and without any friendly matches in comparison to three control periods. Read More

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Metrics for evaluating antibiotic use and prescribing in outpatient settings.

JAC Antimicrob Resist 2021 Sep 19;3(3):dlab098. Epub 2021 Jul 19.

Public Health Ontario, ON, Canada.

Antimicrobial stewardship interventions in outpatient settings are diverse and a variety of outcomes have been used to evaluate these efforts. This narrative review describes, compares and provides specific examples of antibiotic use and other prescribing measures to help antimicrobial stewards better understand, interpret and implement metrics for this setting. A variety of data have been used including those generated from drug sales, prescribing and dispensing activities, however data generated closest to when an individual patient consumes an antibiotic is usually more accurate for estimating antibiotic use. Read More

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September 2021

Formation and hydration of eco-friendly cement using industrial wastes as raw materials.

Sci Rep 2021 Jul 20;11(1):14742. Epub 2021 Jul 20.

Department of Silicate Technology, Kaunas University of Technology, Radvilenu 19, 50254, Kaunas, Lithuania.

In this work, the optimal conditions of the synthesis of eco-friendly cement by using industrial wastes as well as the peculiarities of its early stage hydration were investigated. The eco-friendly cement was synthesized within the 1000-1250 °C temperature range when the targeted composition was 60% of belite, 20% of ye'elimite, and 20% of brownmillerite. It was determined that the optimal sintering temperature for eco-friendly cement is 1100 °C because the primary compounds were fully reacted, and hydraulic active compounds were dominant in the products. Read More

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A Case of Immune Thrombocytopenia After BNT162b2 mRNA COVID-19 Vaccination.

Am J Case Rep 2021 Jul 21;22:e931478. Epub 2021 Jul 21.

Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, USA.

BACKGROUND Immune thrombocytopenic purpura (ITP) is an immune response that destroys platelets and increases the risk of bleeding, which can range from bruising to intracranial hemorrhage. ITP is a known complication of coronavirus disease 2019 (COVID-19). In the first studies of the BNT162b2 messenger RNA (mRNA) COVID-19 vaccine, there were no reports of ITP and the incidence of serious adverse events (AEs) was low overall. Read More

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Responding to the COVID-19 second wave in Thailand by diversifying and adapting lessons from the first wave.

BMJ Glob Health 2021 07;6(7)

International Health Policy Program, Ministry of Public Health, Nonthaburi, Thailand.

Thailand's first wave of COVID-19 in March 2020 was triggered from boxing events and nightclubs in Bangkok, which spread to 68 provinces. The nation responded rapidly with strong public health and social measures on 26 March 2020. Contact tracing was performed by over 1000 surveillance and rapid response teams with support from 1. Read More

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Developing a Unit-Based Quality Improvement Program in a Large Neonatal ICU.

Jt Comm J Qual Patient Saf 2021 Jun 18. Epub 2021 Jun 18.

Background: Quality improvement (QI) methods have been widely adopted in health care. Although theoretical frameworks and models for organizing successful QI programs have been described, few reports have provided practical examples to link existing QI theory to building a unit-based QI program. The purpose of this report is to describe the authors' experience in building QI infrastructure in a large neonatal ICU (NICU). Read More

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First Report of Oncological Outcome and Prognostic Analysis in a First-Line Setting of Short Hydration Gemcitabine and Cisplatin Chemotherapy for Patients with Metastatic Urothelial Carcinoma.

Oncology 2021 Jul 20:1-10. Epub 2021 Jul 20.

Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Objectives: The aim of the study was to examine the effectiveness of a modified-short hydration gemcitabine and cisplatin (m-shGC) regimen for patients with metastatic urothelial carcinoma (mUC) and to assess the efficacy of a geriatric nutritional risk index (GNRI) with regard to prognosis.

Patients And Methods: From January 2016 to July 2020, 68 patients with mUC underwent first-line m-shGC therapy with 70 mg/m2 cisplatin and 1,000 mg/m2 gemcitabine (days 1, 8, and 15), with 2,050 mL fluid replaced on the first day of each 28-day cycle. Prior to the start of treatment, the serum neutrophil-to-lymphocyte ratio (NLR), and levels of albumin and C-reactive protein (CRP) in serum, as well as body heights and weights were measured. Read More

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Occurrence of postharvest snow rot caused by on Asian ginseng in China.

Plant Dis 2021 Jul 20. Epub 2021 Jul 20.

Chinese Academy of Agricultural Sciences, 12661, Institute of Special Wild Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China;

Asian ginseng () is a valuable medicinal plant that is commercially cultivated in China. A long postharvest storage period is required before ginseng is processed. From October 2019 to May 2020, snow rot was observed on the roots of 4- and 5-year-old fresh ginseng stored in three cold storage facilities located in Tonghua and Changbai cities in northeastern China, which are the most important regions for Asian ginseng production. Read More

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Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review.

BMJ Evid Based Med 2021 Jul 19. Epub 2021 Jul 19.

Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, University of Oxford, Oxford, UK

Background: In people with mild asthma poor adherence to regular therapy is common and increases the risk of exacerbations, morbidity and mortality. The use of fixed-dose combination inhalers containing an inhaled corticosteroid (ICS) and a fast-acting β-agonist (FABA) is established in moderate asthma, but they may also have potential utility in mild asthma.

Objectives: To evaluate the efficacy and safety of single combined FABA/ICS inhaler only used as needed in people with mild asthma. Read More

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Serum metabolome and gut microbiome alterations in broiler chickens supplemented with lauric acid.

Poult Sci 2021 Jun 9;100(9):101315. Epub 2021 Jun 9.

College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, 311300, Hangzhou, China. Electronic address:

Antibiotic overuse in poultry husbandry poses a potential threat to meat safety and human health. Lauric acid (LA) is a primary medium-chain fatty acid (MCFA) with a strong antibacterial capacity. The goal of this study was to evaluate the beneficial effects of LA on the growth performance, immune responses, serum metabolism, and cecal microbiota of broiler chickens. Read More

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Meteorin Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration.

J Clin Med 2021 Jul 2;10(13). Epub 2021 Jul 2.

Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, From Physiopathology of Retinal Diseases to Clinical Advances, 75006 Paris, France.

The aim of this study was to evaluate the potential anti-angiogenic effect of MTRN (meteorin) in the laser-induced CNV rat model and explore its mechanisms of action. MTRN, thrompospondin-1, glial cell markers (GFAP, vimentin), and phalloidin were immuno-stained in non-human primate flat-mounted retinas and human retina cross sections. The effect of MTRN at different doses and time points was evaluated on laser-induced CNV at 14 days using in vivo fluorescein angiography and ex vivo quantification of CNV. Read More

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Determining the phosphorus release of GraINzyme phytase in diets for nursery pigs.

Transl Anim Sci 2021 Jul 10;5(3):txab105. Epub 2021 Jun 10.

Agrivida Inc., Woburn, MA, USA.

The objective of this study was to determine the available P () release curve for a new phytase source, GraINzyme Phytase (Agrivida Inc., Woburn, MA), which is expressed in corn containing an engineered phytase called Phy02. Plant-expressed phytases are created by inserting phytase-encoding genes into plants resulting in their ability to produce seeds with increased concentrations of phytase. Read More

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Effects of testosterone undecanoate on performance during multi-stressor military operations: A trial protocol for the Optimizing Performance for Soldiers II study.

Contemp Clin Trials Commun 2021 Sep 3;23:100819. Epub 2021 Jul 3.

Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA.

Background: Previously, young males administered 200 mg/week of testosterone enanthate during 28 days of energy deficit (EDef) gained lean mass and lost less total mass than controls (Optimizing Performance for Soldiers I study, OPS I). Despite that benefit, physical performance deteriorated similarly in both groups. However, some experimental limitations may have precluded detection of performance benefits, as performance measures employed lacked military relevance, and the EDef employed did not elicit the magnitude of stress typically experienced by Soldiers conducting operations. Read More

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September 2021

Summer surface temperature and socioeconomic data of Dutch residential zones, 2014.

Authors:
Bardia Mashhoodi

Data Brief 2021 Aug 3;37:107255. Epub 2021 Jul 3.

Landscape Architecture and Spatial Planning Group, Department of Environmental Sciences, Wageningen University & Research, P.O. Box 47, 6700 AA Wageningen, the Netherlands.

The dataset combines and aggregates two data types at the scale of 2400 residential zones ("wijken", in the terminology used by the Dutch Central Bureau for Statistics) of the Netherlands, 2014. The first type of data is summer surface temperature, the average of 40 dates in the summer of 2014, comprising the observations of four satellite images of four local overpassing times: MODIS Terra day (10:30 a.m. Read More

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Pharmacokinetic comparison with different assays for simultaneous determination of cefprozil diastereomers in human plasma.

J Pharm Anal 2021 Jun 5;11(3):351-363. Epub 2020 Jul 5.

College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.

The purpose of this study was to compare pharmacokinetic (PK) parameters obtained using two newly developed assays, HPLC-UV and UPLC-ESI-MS/MS. Selection of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage settings. For this study, we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from them. Read More

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Alternative chemoradiotherapy in anal carcinoma patients with mutations in thymidylate synthase and dihydropyrimidine dehydrogenase genes.

Therap Adv Gastroenterol 2021 3;14:17562848211024464. Epub 2021 Jul 3.

Tufts Medical Center, Boston, MA, USA.

Background: 5-fluorouracil (5-FU) and mitomycin-C (MMC) with radiotherapy (RT) remain an established treatment for patients with anal cancer (AC). Genetic mutations in two major metabolizing enzymes for 5-FU; dihydropyrimidine dehydrogenase ( and thymidylate synthetase (), have been associated with clinical response and toxicity. However, their place in the treatment of AC remains undetermined. Read More

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Cardiovascular Catheterization Using a New Antiseptic Agent Olanexidine Gluconate.

Int Heart J 2021 Jul 17. Epub 2021 Jul 17.

Department of Cardiology, Juntendo University School of Medicine.

Olanexidine gluconate 1.5% (Olanedine) is a colorless and transparent antiseptic agent introduced in 2015. In this study, we examined its usefulness and safety for cardiovascular catheterization and compared them to 10% povidone-iodine (PI). Read More

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U-shaped association between dietary calcium density intake during adolescence and hypertension in adulthood- a 20-y longitudinal nationwide study in China.

Br J Nutr 2021 Jul 19:1-22. Epub 2021 Jul 19.

Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Shaanxi, P. R. China.

Background And Aims: We assessed longitudinal association between calcium intake during adolescence and hypertension in adulthood.

Methods And Results: Longitudinal study data of 1611 participants from the China Health and Nutrition Survey during 1991-2011 were used. On average they were followed for 11. Read More

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Systematic review with meta-analysis: effects of implementing a nutrition support team for in-hospital parenteral nutrition.

Aliment Pharmacol Ther 2021 Jul 18. Epub 2021 Jul 18.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Background: Nutrition support teams (NST) may improve parenteral nutrition (PN) outcomes. No previous systematic review has provided conclusive data on catheter-related infection (CRI) occurrence after NST introduction, nor have previous studies performed meta-analysis or graded the evidence.

Aims: To systematically evaluate the effects of implementing an NST for hospitalised adults on PN and compare these with standard care. Read More

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Trends in emergency department use by older people during the COVID-19 pandemic.

Eur Geriatr Med 2021 Jul 17. Epub 2021 Jul 17.

Mercer's Institute for Successful Ageing, St James's Hospital, James's St, Dublin 8, Ireland.

Purpose: Reports suggest that many older people deferred seeking healthcare during the COVID-19 pandemic due to fear of contracting COVID-19. The aim of this study was to examine trends of emergency department (ED) use by older people during the first wave of the COVID-19 pandemic compared to previous years.

Methods: The study site is a 1000-bed university teaching hospital with annual ED new-patient attendance of > 50,000. Read More

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In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde.

Genes Environ 2021 Jul 16;43(1):30. Epub 2021 Jul 16.

Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-2-26 Tonomachi, Kawasaki City, Kanagawa, 210-9501, Japan.

Background: Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed, several reports have indicated that perillaldehyde and cinnamaldehyde show positive in in vitro and in vivo genotoxicity tests. Read More

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Immediate intravenous iron administration improves anaemia recovery following total knee arthroplasty: A propensity-matched analysis.

Vox Sang 2021 Jul 16. Epub 2021 Jul 16.

Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background And Objectives: Patients who undergo total knee arthroplasty (TKA) have a risk of postoperative anaemia. This observational study evaluated whether single-dose intravenous ferric carboxymaltose (FCM) administered immediately after TKA facilitates the correction of anaemia.

Materials And Methods: We retrospectively analysed 722 patients who underwent primary TKA. Read More

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A Randomized, Multicenter, Open-Label, Blinded End Point, Phase 2, Feasibility, Efficacy, and Safety Trial of Preoperative Microvascular Protection in Patients Undergoing Major Abdominal Surgery.

Anesth Analg 2021 Jul 15. Epub 2021 Jul 15.

Department of Critical Care, University of Melbourne, Melbourne, Australia.

Background: The endothelial glycocalyx, a carbohydrate-rich layer coating all endothelial surfaces, plays a fundamental role in the function of microcirculation. The primary aim of this study was to evaluate the feasibility of using dexamethasone and albumin to protect the endothelial glycocalyx in patients undergoing abdominal surgery. Secondary and exploratory outcomes included efficacy and safety. Read More

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Complete Peripheral Blast Clearance is Superior to the Conventional Cut-Off of 1000/µL in Predicting Relapse in Pediatric Pre-B Acute Lymphoblastic Leukemia.

Indian J Hematol Blood Transfus 2021 Jul 13;37(3):366-371. Epub 2020 Sep 13.

Paediatric Haematology-Oncology Unit, Department of Paediatrics, Christian Medical College and Hospital, Vellore, India.

Risk-stratification has contributed to a dramatic improvement in survival in pediatric acute lymphoblastic leukemia (ALL). This study evaluated the utility of prephase response and day 15 bone marrow when a minimal residual disease (MRD) assessment was available. A file review of children aged ≤ 15 years diagnosed with precursor-B ALL from 2014 to 2019 was performed. Read More

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Teledentistry-based Program to Improve Oral Hygiene Indicators in Rural Pakistan-A Protocol.

J Contemp Dent Pract 2021 Apr 1;22(4):406-411. Epub 2021 Apr 1.

Centre of Clinical Research, Telemedicine and Telepharmacy, School of Medicinal and Health Products Sciences, University of Camerino, Macerta, Italy.

Aim: The primary aim of this research protocol is to secure funding to initiate a teledentistry pilot project in order to improve the oral hygiene conditions of the most vulnerable population of rural Sindh in Pakistan, through hands-on training of 1,000 lady health workers by dentists and community dentistry specialists of other colleges led by Jinnah Medical and Dental College.

Materials And Methods: Training courses on digital health consultation would be given to participating healthcare workers. The trainees would be trained on all aspects of dental hygiene including precautions, tooth brushing techniques, and oral care. Read More

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Incidence and determinants of perinatal mortality among women with obstructed labour in eastern Uganda: a prospective cohort study.

Matern Health Neonatol Perinatol 2021 Jul 15;7(1):13. Epub 2021 Jul 15.

Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.

Background: In Uganda, the incidence and determinants of perinatal death in obstructed labour are not well documented. We determined the incidence and determinants of perinatal mortality among women with obstructed labour in Eastern Uganda.

Methods: Between July 2018 and September 2019, 584 with obstructed labour were recruited and followed up to the 7th day postnatal. Read More

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Ethanol extract of Bergenia ciliata (Haw.) Sternb. (rhizome) impedes the propagation of the malaria parasite.

J Ethnopharmacol 2021 Jul 12;280:114417. Epub 2021 Jul 12.

Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh, 160014, India. Electronic address:

Ethnopharmacological Relevance: The increasing resistant cases even against artemisinin-based combination therapy have necessitated the need to develop new antimalarials. Phytomedicinal therapy is a benchmark for malaria in the Himalayan region. As the dialect and traditional variations have been seen along with this, usage of medicinal plant, its portion (shoot and root system) and mode of preparation also varies. Read More

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