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Updated Review on the Role of Curcumin in Gastrointestinal Cancers.

Adv Exp Med Biol 2021 ;1308:55-89

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Malignant conditions of the gastrointestinal tract and accessory organs of digestion, including the oral cavity, esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus, are referred to as gastrointestinal cancers. Curcumin is a natural compound derived from turmeric with a wide range of biological activities. Several in vitro and in vivo studies have investigated the effects of curcumin on gastrointestinal cancers. Read More

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January 2021

An update on the prevalence of eating disorders in the general population: a systematic review and meta-analysis.

Eat Weight Disord 2021 Apr 8. Epub 2021 Apr 8.

Shanghai Yangpu District Central Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: To update the prevalence of eating disorders in the general population before 2021 and to analyze the distribution characteristics at different times and in different regions and sexes, as well as the diagnostic criteria.

Methods: Based on the method from a previous report by the authors, studies were identified from the following databases: PubMed/Medline, PsycINFO, ISI Web of Knowledge, Ovid and the 4 most important Chinese databases. Articles in English and Chinese before 2021 were retrieved. Read More

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Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose-response meta-analysis of epidemiologic studies.

Obes Rev 2021 Apr 7:e13223. Epub 2021 Apr 7.

Department of Community Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Several epidemiological studies examined the association of serum vitamin D with metabolic syndrome (MetS), but the findings were inconsistent. We conducted a systematic review and dose-response meta-analysis to quantify the association between blood vitamin D levels and MetS in adults. A systematic search up to December 2020 was conducted in MEDLINE (PubMed), ISI (Web of Science), Scopus, and Google Scholar databases for epidemiological studies that assessed the relation of serum 25-hydroxyvitamin D (as the exposure) and MetS (as the outcome) in adults. Read More

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Prevalence of sleep disturbances in patients with chronic non-cancer pain: A systematic review and meta-analysis.

Sleep Med Rev 2021 Mar 11;57:101467. Epub 2021 Mar 11.

Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

In individuals with chronic pain, sleep disturbances have been suggested to increase suffering, perception of pain, and to negatively affect long-term prognosis. This systematic review and meta-analysis aims to determine the pooled prevalence of sleep disturbances in chronic non-cancer pain patients with no other sleep disorders, using the patient-rated questionnaires Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI). Multiple databases were searched for studies reporting the prevalence of sleep disturbances in chronic pain patients. Read More

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Adherence to the vegetarian diet may increase the risk of depression: a systematic review and meta-analysis of observational studies.

Nutr Rev 2021 Apr 2. Epub 2021 Apr 2.

S. Fazelian is with the Clinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran. E. Sadeghi is with the Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. S. Firouzi is with the Department of Dietetics, Grafton Base Hospital, New South Wales, Australia. F. Haghighatdoost is with the Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Context: Several epidemiological studies have investigated the association between a vegetarian diet and risk of depression, but because of inconsistency between studies, the exact association remains unclear.

Objective: In this systematic review and meta-analysis, the relationship between vegetarian diets and risk of depression in observational studies was evaluated.

Data Sources: The Medline, Embase, Scopus, ISI Web of Science, and Cochrane Library databases were searched from inception through September 1, 2020. Read More

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Adverse effects of conjugated linoleic acids supplementation on circulating lipoprotein (a) levels in overweight and obese individuals: results of a systematic review and meta-analysis of randomized controlled trials.

Am J Cardiovasc Dis 2021 15;11(1):124-135. Epub 2021 Feb 15.

Nutrition Research Center, Shiraz University of Medical Sciences Shiraz, Iran.

Conjugated Linoleic Acids (CLA) may have beneficial effects on the prevention of atherosclerosis, but their net effects on circulating levels of lipoprotein (a) [Lp (a)] are unclear. The present study aimed to systematically review and analyze the Randomized Clinical Trials (RCTs) assessing the effects of CLA on circulating Lp (a) concentrations. A literature search of SCOPUS, PubMed-Medline, ISI, Web of Science, and Cochrane library databases was conducted for the relevant RCTs investigating the effects of CLA supplementation on circulating Lp (a) levels, which had been published up to 20 August 2020. Read More

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February 2021

Information technology interventions to improve antibiotic prescribing for patients with acute respiratory infection: a systematic review.

Clin Microbiol Infect 2021 Apr 1. Epub 2021 Apr 1.

Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Background: Information technology (IT) interventions provide physicians with easy and quick access to information at the point of care provision and they can play a major role in clinical decision-making for antibiotic prescribing.

Objective: This study aimed to examine the effects and characteristics of IT interventions on improving antibiotic prescribing for patients with acute respiratory infection (ARI).

Data Sources: A comprehensive search was performed in Medline (through PubMed), ISI web of science, Embase, and Cochrane databases from inception to 31 August 2020. Read More

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The Jump Shot Performance in Youth Basketball: A Systematic Review.

Int J Environ Res Public Health 2021 Mar 22;18(6). Epub 2021 Mar 22.

Faculty of Sport Sciences and Physical Education, CIDAF, University of Coimbra, 3040-248 Coimbra, Portugal.

Background: The basketball jump shot (JS) is consensually considered as a high-complexity specific motor skill, with a complex teaching and learning processes involved. The aim of this paper was to conduct a systematic review of the literature on the JS performance among youth basketball players.

Methods: The data search was made according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in the Institute for Scientific Information (ISI) Web of Knowledge, PubMed, Scopus and Sportdiscus databases until March 2021. Read More

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Bond Strength of Universal Adhesives to Dentin: A Systematic Review and Meta-Analysis.

Polymers (Basel) 2021 Mar 7;13(5). Epub 2021 Mar 7.

Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, Circuito Ex Hacienda La Concepción S/N, San Agustín Tlaxiaca, Hidalgo 42160, Mexico.

Currently, the availability of a wide variety of universal adhesives makes it difficult for clinicians to choose the correct system for specific bonding situations to dentin substrate. This study aimed to determine whether there are any alternative techniques or additional strategies available to enhance the bond strength of universal adhesives to dentin through a systematic review and meta-analysis. Two reviewers executed a literature search up to September 2020 in four electronic databases: PubMed, ISI Web of Science, Scopus, and EMBASE. Read More

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Short-term health effects from outdoor exposure to biomass burning emissions: A review.

Sci Total Environ 2021 Mar 26;781:146739. Epub 2021 Mar 26.

Institute of Environmental Assessment and Water Research, IDAEA-CSIC, Barcelona 08034, Spain.

Biomass burning (BB) including forest, bush, prescribed fires, agricultural fires, residential wood combustion, and power generation has long been known to affect climate, air quality and human health. With this work we supply a systematic review on the health effects of BB emissions in the framework of the WHO activities on air pollution. We performed a literature search of online databases (PubMed, ISI, and Scopus) from year 1980 up to 2020. Read More

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Epidemiology and risk factors of needlestick injuries among healthcare workers in Iran: a systematic reviews and meta-analysis.

Environ Health Prev Med 2021 Apr 1;26(1):43. Epub 2021 Apr 1.

Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: Occupational contact with blood and body fluids poses a significant risk to healthcare workers. The aim of this systematic review is to investigate the epidemiology and risk factors affecting needlestick injuries (NSI) in healthcare personnel in Iran.

Methods: In March 2020, researchers studied six international databases such as Medline/PubMed, ProQuest, ISI/WOS, Scopus, Embase, and Google Scholar for English papers and two Iranian databases (MagIran and SID) for Persian papers. Read More

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Appraising the Accuracy of Ischaemia-Modified Albumin in Diagnosing Stroke: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2021 Mar 31:1-6. Epub 2021 Mar 31.

Emergency Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Introduction: Ischaemia-modified albumin (IMA) is a new, sensitive marker of ischaemic diseases that has been approved for diagnosing myocardial ischaemia. However, the accuracy of IMA in the diagnosis of stroke remains to be clarified. The study's purpose is to assess the potential role of IMA as a diagnostic indicator in stroke. Read More

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The 100 most cited papers on retinal detachment: a bibliographic perspective.

Br J Ophthalmol 2021 Mar 30. Epub 2021 Mar 30.

Ophthalmology, Meir Medical Center, Kfar Saba, Israel.

The 100 most cited papers on retinal detachment (RD) were analysed using a bibliographic study. The bibliographic databases of the ISI Web of Knowledge were searched, limited to research articles published between 1965 and 2020 in peer-reviewed journals. The papers were ranked in order of number of citations since publication. Read More

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Interleukin-6 Antagonists: Lessons From Cytokine Release Syndrome to the Therapeutic Application in Severe COVID-19 Infection.

J Pharm Pract 2021 Mar 24:8971900211000691. Epub 2021 Mar 24.

68022Faculty of Pharmacy, Department of Pharmacy, Mahidol University, Bangkok, Thailand.

Current retrospective data have found up to 20% of COVID-19 infection had developed into severe cases with hyperinflammatory pulmonary symptoms. Interleukin 6 (IL-6) is recognized as a key mediator of hyperinflammation previously mentioned in cytokine release syndrome. This leads to implementing IL-6 pathway inhibition in severe COVID-19. Read More

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Systematic Assessment of Safety Threshold for Donor Age in Cadaveric Liver Transplantation.

Front Med (Lausanne) 2021 4;8:596552. Epub 2021 Mar 4.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Donor age affects allograft quality and the prognosis of recipients after liver transplantation (LT). Clinicians have assessed the quality of grafts from older donors based on their appearance and texture, with no reliable quantitative evidence. Our study aimed to assess the quantitative impact of donor age on post-transplant outcomes and its safety threshold for LT, based on the published literature. Read More

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Factors Affecting Women's Adjustment to Postpartum Changes: A Narrative Review.

Iran J Nurs Midwifery Res 2020 Nov-Dec;25(6):463-470. Epub 2020 Nov 7.

Department of Psychiatric Nursing, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Postpartum period is associated with stress and pressure, and the woman must adjust herself to these changes. This study aimed to review the factors affecting women's adjustment to postpartum changes in conducted studies.

Materials And Methods: This review was conducted by searching databases such as ISI Web of Science, Science Direct, Scopus, Cochrane, PubMed and Scientific Information Database (SID), Iranian Medical Articles Database (IranMedex), Iranian Research Institute for Information Science and Technology (IranDoc), and the Iranian Magazine Database (MagIran), as well as searching through Google Scholar (as a Web search engine) in December 2019. Read More

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November 2020

The beneficial effects of cinnamon among patients with metabolic diseases: A systematic review and dose-response meta-analysis of randomized-controlled trials.

Crit Rev Food Sci Nutr 2021 Mar 19:1-19. Epub 2021 Mar 19.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

This systematic review and meta-analysis aims to summarize and conclude the clinical evidence regarding the use of cinnamon among patients with metabolic diseases. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: ISI Web of Science, Embase, Scopus, PubMed, and Google Scholar. Search was conducted up to 23 January 2020. Read More

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The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Complement Med Res 2021 Mar 18:1-10. Epub 2021 Mar 18.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,

Background And Aims: The present systematic review and meta-analysis of randomized controlled trials aimed to determine the effects of saffron supplementation on liver function tests among adults.

Methods: Electronic databases including PubMed, ISI Web of Science, and Scopus were searched up to January 2021. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool. Read More

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Medicinal plants as a fight against murine blood-stage malaria.

Saudi J Biol Sci 2021 Mar 19;28(3):1723-1738. Epub 2020 Dec 19.

Department of Zoology, College of Science, King Saud University, Saudi Arabia.

Objective: Malaria is an infectious parasitic disease affecting most of countries worldwide. Due to antimalarial drug resistance, researchers are seeking to find another safe efficient source for treatment of malaria. Since many years ago, medicinal plants were widely used for the treatment of several diseases. Read More

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Prevalence of G6PD deficiency in Iranian neonates with jaundice: a systematic review and meta-analysis.

J Matern Fetal Neonatal Med 2021 Mar 15:1-8. Epub 2021 Mar 15.

Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Objectives: This systematic review and meta-analysis study aimed to estimate the overall prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in neonates with jaundice who were admitted to hospitals in Iran.

Materials And Methods: In this systematic review and meta-analysis, we searched PubMed/Medline, Scopus, ISI Web of Sciences, and Iranian Local databases up to December 2019.We calculated Prevalence and 95% Confidence Interval (95% CI) of G6PD deficiency as summary measures. Read More

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Opium as a carcinogen: A systematic review and meta-analysis.

EClinicalMedicine 2021 Mar 24;33:100768. Epub 2021 Feb 24.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Opium and its pyrolysates have been investigated as potential carcinogenic material through several studies in different body systems; however, the results were controversial and no consensus was achieved with this regard. Thus, we aimed to systematically review and meta-analyze all existed evidence regarding association between opium consumption and cancer.

Methods: Four major electronic databases including ISI Web of Science, PubMed, Scopus, and Embase along with Magiran and SID were searched thoroughly for all published articles from inception up to September 25, 2020. Read More

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Quantitative assessment of the diagnostic role of mucin family members in pancreatic cancer: a meta-analysis.

Ann Transl Med 2021 Feb;9(3):192

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The use of mucins (MUC) as specific biomarkers for various malignancies has recently emerged. MUC1, MUC4, MUC5AC, and MUC16 can be detected at different stages of pancreatic cancer (PC), and can be valuable for indicating the initiation and progression of this disease. However, the diagnostic significance of the mucin family in patients with PC remains disputed. Read More

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February 2021

Effect of eradication on patients with ITP: a meta-analysis of studies conducted in the Middle East.

Blood Res 2021 Mar;56(1):38-43

Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Immune thrombocytopenia (ITP) is a bleeding disorder. is a Gram-negative bacterium that is presumed to be associated with ITP and therapeutic response of patients. To evaluate the effect of eradication on platelet count of ITP patients, we analyzed the studies conducted on the association between infection and response to therapy in ITP patients in Western Asia focusing on the Middle East region. Read More

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Spouse and Child Abuse Associated With Illicit Drug Use in Iran: A Systematic Review and Meta-Analysis.

Trauma Violence Abuse 2021 Mar 11:1524838021998655. Epub 2021 Mar 11.

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.

Background: There is a high prevalence of substance use disorders, especially among men, in Iran and is associated with a high burden on families. We aimed to systematically review the association between illicit drug use and spouse and child abuse in Iran.

Method: Comprehensive terms were used to search three international databases (ISI, Medline, and Scopus) and a national database of Scientific Information Database up to September 2019. Read More

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Ionizing Radiation Protein Biomarkers in Normal Tissue and Their Correlation to Radiosensitivity: A Systematic Review.

J Pers Med 2021 Feb 19;11(2). Epub 2021 Feb 19.

Bundesamt für Strahlenschutz/Federal Office for Radiation Protection, Ingolstädter Landstraße 1, 85764 Oberschleissheim, Germany.

: Exposure to ionizing radiation (IR) has increased immensely over the past years, owing to diagnostic and therapeutic reasons. However, certain radiosensitive individuals show toxic enhanced reaction to IR, and it is necessary to specifically protect them from unwanted exposure. Although predicting radiosensitivity is the way forward in the field of personalised medicine, there is limited information on the potential biomarkers. Read More

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February 2021

Checklist feasibility and impact in gastrointestinal endoscopy: a systematic review and narrative synthesis.

Endosc Int Open 2021 Mar 19;9(3):E453-E460. Epub 2021 Feb 19.

Department of Internal Medicine, La Tour Hospital and University of Geneva, Geneva, Switzerland.

 Checklists prevent errors and have a positive impact on patient morbidity and mortality in surgical settings. Despite increasing use of checklists in gastrointestinal endoscopy units across many countries, a summary of cumulated experience is lacking. The aim of this study was to identify and evaluate the feasibility of successful checklist implementation in gastrointestinal endoscopy units and summarise the evidence of its impact on the commitment in safety culture. Read More

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Therapeutic role of extracellular vesicles derived from stem cells in cutaneous wound models: A systematic review.

Life Sci 2021 May 27;273:119271. Epub 2021 Feb 27.

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

A growing body of evidence has shown that extracellular vesicles can be efficient as experimental therapeutics in pre-clinical models of skin wounds, but there is a significant unmet need to translate this to clinical utilization. The objectives of the current systematic review were to identify the strength of the therapeutic effects of EVs derived from stem cells in cutaneous wounds and to assess which EV-mediated mechanisms could be involved in the therapeutic response. PubMed, ISI Web of Science, and Scopus databases were systematically searched. Read More

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Comparative performance of PCR using DNA extracted from dried blood spots and whole blood samples for malaria diagnosis: a meta-analysis.

Sci Rep 2021 Mar 1;11(1):4845. Epub 2021 Mar 1.

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Polymerase chain reaction (PCR) using deoxyribonucleic acid (DNA) extracted from dried blood spots (DBS) provides a fast, inexpensive, and convenient method for large-scale epidemiological studies. This study compared the performance of PCR between DNA extracted from DBS and DNA obtained from whole blood for detecting malarial parasites. Primary studies assessing the diagnostic performance of PCR using DNA extracted from DBS and whole blood for detecting malarial parasites were obtained from the ISI Web of Science, Scopus, and PubMed databases. Read More

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Effects of nursing nutrition interventions on outcomes in malnourished hospital inpatients and nursing home residents: A systematic review.

Int J Nurs Stud 2021 Jan 30;117:103888. Epub 2021 Jan 30.

HAN University of Applied Sciences, School of Allied Health, Department of Nutrition and Health, Nijmegen, the Netherlands. Electronic address:

Context: Malnutrition in institutionalized patients is associated with adverse outcomes and increased costs. Nurses have a crucial role in the recognition and treatment of malnutrition and empowering patients in nutritional care.

Objective: This systematic review provides an overview of the effectiveness of nursing nutritional interventions to counteract malnutrition. Read More

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January 2021

Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis.

Cancer Cell Int 2021 Feb 27;21(1):139. Epub 2021 Feb 27.

Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Background: Gastric cancer (GC) is considered one of the most lethal malignancies worldwide, which is accompanied by a poor prognosis. Although reports regarding the importance of cancer stem cell (CSC) markers in gastric cancer progression have rapidly developed over the last few decades, their clinicopathological and prognostic values in gastric cancer still remain inconclusive. Therefore, the current meta-analysis aimed to quantitatively re-evaluate the association of CSC markers expression, overall and individually, with GC patients' clinical and survival outcomes. Read More

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February 2021