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Efficacy of needle aspiration in patients with oral-maxillofacial abscesses: A retrospective study of 15 consecutive patients.

Am J Otolaryngol 2021 Sep 11;43(1):103216. Epub 2021 Sep 11.

Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatalogy, Shanghai, China. Electronic address:

The aim of this study was to determine the adequacy and safety of needle aspiration (NA) as an alternative to open surgical drainage for oral-maxillofacial abscesses. Fifteen consecutive patients who were diagnosed with oral-maxillofacial abscesses via contrast-enhanced CT from January 2020 to December 2020 were included. All patients were on antibiotics and treated with NA under local anaesthesia using a 20 mL syringe. Read More

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September 2021

Evaluation of the impact of deep neuromuscular blockade on surgical conditions for laryngeal microsurgery with High Frequency Jet Ventilation. A comparison with no block during intravenous general anesthesia with topical lidocaine.

Am J Otolaryngol 2021 Sep 4;43(1):103187. Epub 2021 Sep 4.

Université catholique de Louvain, CHU UCL Namur, Department of Anesthesiology, Avenue Dr G Thérasse 1, 5530 Yvoir, Belgium.

Objective: Laryngeal transoral surgery classically requires a neuromuscular block (NMB) to facilitate tracheal intubation and to improve surgical conditions. However, the short duration of most procedures and the potential complications of residual NMB lead to consider a no block approach. The hypothesis that intravenous anesthesia (remifentanil and propofol infusions) without NMB but including glottis topical lidocaine anesthesia would allow clinically acceptable laryngeal exposure and good surgical conditions was tested in the specific context of procedures undergone with High Frequency Jet Ventilation (HFJV). Read More

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September 2021

Individual and organizational factors of nurses' job satisfaction in long-term care: A systematic review.

Int J Nurs Stud 2021 Aug 26;123:104073. Epub 2021 Aug 26.

University of Ottawa - School of Nursing, Ottawa Hospital Research Institute, General Campus, 501 Smyth Rd, Box 711, Ottawa, ON K1H 8L6, Canada. Electronic address:

Background: In long-term care facilities, nurses' job satisfaction predicts staff turnover, which adversely affects resident outcomes. Thus, it is important to develop a comprehensive understanding of factors affecting nurses' job satisfaction in long-term care facilities.

Objectives: To analyze factors associated with job satisfaction among nurses in nursing homes from individual and organizational perspectives utilizing a deductive approach. Read More

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Hemicraniectomy for Dominant vs Nondominant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis.

J Stroke Cerebrovasc Dis 2021 Sep 15;30(11):106102. Epub 2021 Sep 15.

Department of Neurology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki 00290, Finland.

Objectives: Decompressive hemicraniectomy decreases mortality and severe disability from space-occupying middle cerebral artery infarction in selected patients. However, attitudes towards hemicraniectomy for dominant-hemispheric stroke have been hesitant. This systematic review and meta-analysis examines the association of stroke laterality with outcome after hemicraniectomy. Read More

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September 2021

A systematic review of addiction substitution in recovery: Clinical lore or empirically-based?

Clin Psychol Rev 2021 Sep 10;89:102083. Epub 2021 Sep 10.

Department of Psychology, University of Calgary, Calgary, AB, Canada.

This systematic review synthesized the literature examining addiction substitution during recovery from substance use or behavioral addictions. A total of 96 studies were included with sample sizes ranging from 6 to 14,885. The most common recovery addictions were opioids (30. Read More

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September 2021

The associations between asymmetries in quadriceps strength and gait in individuals with unilateral transtibial amputation.

Gait Posture 2021 Sep 8;90:267-273. Epub 2021 Sep 8.

Department of Life Sciences, Whitelands College, University of Roehampton, Holybourne Avenue, London, SW15 4JD, UK. Electronic address:

Background: Individuals with unilateral transtibial amputations (ITTAs) are asymmetrical in quadriceps strength. It is unknown if this is associated with gait performance characteristics such as walking speed and limb symmetry.

Research Question: Are quadriceps strength asymmetries related to walking speed and/ or gait asymmetries in ITTAs?

Methods: Knee-extensor isometric maximum voluntary torque (MVT) and rate of torque development (RTD) were measured in eight ITTAs. Read More

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September 2021

The effect of immunosuppression therapy on activities of daily living and comfort level after liver transplantation.

Transpl Immunol 2021 Sep 15:101468. Epub 2021 Sep 15.

Surgical Nursing Department, Health Sciences Faculty, Gaziosmanpasa University, Erbaa Campus, Tokat, Turkey. Electronic address:

Objectives: This study was carried out to investigate the effect of immunosuppression therapy on activities of daily living and comfort level after liver transplantation.

Materials And Methods: This study was conducted in a descriptive and correlational type with the participation of 148 liver transplant patients hospitalized in the liver transplant center of a university hospital. Personal Information Form, Katz Activities of Daily Living Scale and General Comfort Questionnaire were used in data collection. Read More

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September 2021

Endoscopic Management of Low-Grade Upper Tract Urothelial Carcinoma: Characterizing the Long-term Burden of Care in Comparison to Radical Nephroureterectomy.

Urology 2021 Sep 15. Epub 2021 Sep 15.

Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address:

Objectives: To compare procedure burden, oncologic, surgical and renal-function outcomes between patients with low-grade upper urothelial cancer (UTUC) who were referred for either radical management (RM) or kidney-sparing endoscopic management (EM).

Patients And Methods: We retrospectively reviewed data of all patients treated for UTUC at our tertiary medical center between 2000 and 2018 and selected patients diagnosed with unilateral low-grade UTUC.

Results: 24 patients were treated with EM and 37 with RM. Read More

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September 2021

Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy.

Biochem Pharmacol 2021 Sep 15:114765. Epub 2021 Sep 15.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

Prostate cancer (PCa) is one of the leading causes of cancer-related deaths in men. Although androgen deprivation therapies (ADT) and antiandrogens confer increased survival rates, most patients eventually develop castration resistant disease (CRPC). Previous studies have shown that these treatments have limited cytotoxicity, and instead, promote tumor cell growth arrest. Read More

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September 2021

Addendum needed on COVID-19 travel study - Authors' reply.

Lancet Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine and Division of HIV, Infectious Diseases, and Global Medicine, San Francisco, CA 94110, USA. Electronic address:

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September 2021

Dental students' perceptions of the long case.

Eur J Dent Educ 2021 Sep 18. Epub 2021 Sep 18.

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Introduction: The long case examination is used to assess clinical competency in dental education. However, the academic literature, much of which is in medical education, highlights concerns regarding the relevancy and authenticity of the long case. To date, dental students' experiences of the long case have been under-researched. Read More

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September 2021

Collaborative care for depression yields similar improvement among older and younger rural adults.

J Am Geriatr Soc 2021 Sep 18. Epub 2021 Sep 18.

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.

Background: Depressive disorders are among the most prevalent mental health conditions; however, significant barriers to treatment access persist. This study examined differences in depression outcomes between younger and older adults in a large-scale implementation demonstration of the collaborative care model (CoCM).

Methods: Secondary data analysis of a longitudinal, observational implementation demonstration at eight primary care clinics across low-resourced rural or frontier areas of the Western United States. Read More

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September 2021

Implementation of two Policies to Extend Maternity Leave and Further Restrict Marketing of Breast Milk Substitutes in Vietnam: A Qualitative Study.

Health Policy Plan 2021 Sep 18. Epub 2021 Sep 18.

Department of Health Policy and Management, University of California Los Angeles, Fielding School of Public Health, Los Angeles, CA, USA.

Policy research can reveal gaps and opportunities to enhance policy impact and implementation. In this study, we use a theoretically informed qualitative approach to investigate implementation of two policies to promote breastfeeding in Vietnam. We conducted semi-structured interviews with national and local policy stakeholders (n=26) in 2017. Read More

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September 2021

Containment, Health, and Social Policies in the Time of COVID-19 - Patterns and Determinants of Initial Reponses from Spring 2020 Across 120 Countries.

Health Policy Plan 2021 Sep 19. Epub 2021 Sep 19.

University of Southern California.

The COVID-19 pandemic has triggered an unprecedented number of policy responses around the world across multiple policy domains. While governments have combined containment and health policies with social policies (CHSP) during the initial phase of the pandemic in various ways, current literature offers little knowledge of the patterns of these combinations and their determinants and outcomes. This paper fills this gap by investigating CHSP combinations across more than 120 countries. Read More

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September 2021

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, NSW.

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse. In our established diabetes complications assessment service, we recorded nine cases of sight-threatening retinopathy in youth aged 15-17. Read More

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September 2021

Selenomethionine Alleviates Intestinal Ischemia-Reperfusion Injury in Mice Through the Bax-Caspase Pathway.

Biol Trace Elem Res 2021 Sep 18. Epub 2021 Sep 18.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Tech Industrial Development Zone, Daqing, Heilongjiang, 163319, People's Republic of China.

Selenomethionine (SeMet) is known to alleviate ischemia-reperfusion (I/R) injury. However, its details of action have not been thoroughly elucidated in mice with intestinal I/R injury. In this study, intestinal I/R injury mice models were established, and ELISAs were performed to determine the levels of redox factors, including glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA), in mice intestinal tissues. Read More

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September 2021

Involuntary Psychiatric Hospitalization: How Patient Characteristics Affect Decision-Making.

Psychiatr Q 2021 Sep 18. Epub 2021 Sep 18.

Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Emergency department (ED) psychiatrists face the consequential decision to pursue involuntary inpatient psychiatric admission. Research on the relationship between patient characteristics and the decision to pursue involuntary psychiatric admission is limited. Using data from 2017 to 2018 at an urban Los Angeles hospital, we used generalized linear mixed effects models to compare patients who were involuntarily admitted to inpatient psychiatry to patients who were discharged from the ED. Read More

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September 2021

Shared medical appointments for weight loss: a systematic review.

Fam Pract 2021 Sep 18. Epub 2021 Sep 18.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.

Purpose: Shared medical appointments (SMAs) may help mitigate some of the barriers for managing obesity in primary care. The primary aim of this systematic review was to measure the effect of weight loss SMAs.

Methods: Systematic searches using keywords and Medical Subject Headings for overweight, obesity, and SMAs were conducted in the CENTRAL, Medline Complete, PsycINFO, Scopus, CINAHL, EMBASE, and Web of Science databases with no date limits. Read More

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September 2021

Association of dietary fat intake and hepatocellular carcinoma among US adults.

Cancer Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background And Aims: The role of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) remains unclear. We investigated the associations of total fat and fatty acids with risk of HCC among US adults in a hospital-based case-control study.

Methods: We analyzed data from 641 cases and 1034 controls recruited at MD Anderson Cancer Center during 2001-2018. Read More

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September 2021

Physiologically-based pharmacokinetic model predictions of inter-ethnic differences in imatinib pharmacokinetics and dosing regimens.

Br J Clin Pharmacol 2021 Sep 17. Epub 2021 Sep 17.

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Aims: This study implements a physiologically-based pharmacokinetic (PBPK) modelling approach to investigate inter-ethnic differences in imatinib pharmacokinetics and dosing regimens.

Methods: A PBPK model of imatinib was built in the Simcyp Simulator (version 17) integrating in vitro drug metabolism and clinical pharmacokinetic data. The model accounts for ethnic differences in body size and abundance of drug-metabolising enzymes and proteins involved in imatinib disposition. Read More

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September 2021

Whether immunostimulants are effective in susceptible children suffering from recurrent respiratory tract infections: a modeling analysis based on literature aggregate data.

J Clin Pharmacol 2021 Sep 18. Epub 2021 Sep 18.

Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Immunostimulants are gradually being used in the prevention and treatment of recurrent respiratory tract infections in susceptible children, but their drug effects have not been quantified. The purpose of this study was to confirm the efficacy of immunostimulants in the prevention and treatment of recurrent respiratory tract infections in susceptible children. A model-based meta-analysis (MBMA) was used to describe the time course of placebo and immunostimulants in the prevention of respiratory tract infections in children. Read More

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September 2021

The Toxicology Investigators Consortium 2020 Annual Report.

J Med Toxicol 2021 Sep 17. Epub 2021 Sep 17.

University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO, 80045, USA.

The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology in 2010. The registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultation will be entered. This eleventh annual report summarizes the Registry's 2020 data and activity with its additional 6668 cases. Read More

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September 2021

Factors affecting the mother's choice of infant feeding method in Poland: a cross-sectional preliminary study in Poland.

Ir J Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Division of Neonatology, Wroclaw Medical University, Wroclaw, Poland.

Background: The World Health Organization identifies exclusive breastfeeding as the gold standard for child nutrition. Breastfeeding provides many benefits to both the baby and the mother. First days after birth are crucial for breastfeeding and determining its further path. Read More

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September 2021

Preterm births in South-West England before and during the COVID-19 pandemic: an audit of retrospective data.

Eur J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

School of Nursing and Midwifery, Faculty of Health, University of Plymouth, Plymouth, UK.

The COVID-19 lockdown had a series of intended and unintended consequences, including reduced infections and changes in activities and behaviours. Some of these changes may have been beneficial to perinatal outcomes; however, other factors such as reduced access to face-to-face healthcare may have contributed negatively to antenatal care. The aim of this audit was to evaluate neonatal admissions in the South-West of England during the COVID-19 pandemic in 2020 and the previous two years 2018-2019. Read More

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September 2021

Depression, hope and social support among older people with cancer: a comparison of Muslim Palestinian and Jewish Israeli cancer patients.

Support Care Cancer 2021 Sep 17. Epub 2021 Sep 17.

Sharett Oncology Institute, Hadassah University Hospital, Jerusalem, Israel.

Objectives: Studies of depression in older Muslim Palestinians diagnosed with cancer are scarce. To gain insight into the psychological response and coping ability of this very large, globally distributed population, we collected data from older Muslim Palestinian people diagnosed with cancer concerning depression hope and perceived social support. Both hope and social support were selected because they can be manipulated through intervention and education, as shown in the geriatric literature. Read More

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September 2021

Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning.

Schizophr Bull 2021 Sep 18. Epub 2021 Sep 18.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia.

Background: Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a clinical prediction model aimed at predicting 4-6-week remission following a first episode of psychosis.

Method: Baseline clinical data from the Athens First Episode Research Study was used to develop a Support Vector Machine prediction model of 4-week symptom remission in first-episode psychosis patients using repeated nested cross-validation. Read More

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September 2021

Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.

Cereb Cortex 2021 Sep 17. Epub 2021 Sep 17.

Memory Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes in recognition memory. Using two recognition memory paradigms, we tested a rare patient (MH) with a perirhinal lesion that appeared to spare the hippocampus. Consistent with a similar previous case, MH showed impaired familiarity and preserved recollection. Read More

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September 2021

Analysis of outcomes of emergency general and gastrointestinal surgery during the COVID-19 pandemic.

Br J Surg 2021 Sep 18. Epub 2021 Sep 18.

Statistical Unit, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Background: Few surgical studies have provided adjusted comparative postoperative outcome data among contemporary patients with and without COVID-19 infection and patients treated before the pandemic. The aim of this study was to determine the impact of performing emergency surgery in patients with concomitant COVID-19 infection.

Methods: Patients who underwent emergency general and gastrointestinal surgery from March to June 2020, and from March to June 2019 in 25 Spanish hospitals were included in a retrospective study (COVID-CIR). Read More

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September 2021

TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.

Mol Psychiatry 2021 Sep 17. Epub 2021 Sep 17.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the effect of body mass index (BMI), which identified a genome-wide significant single-nucleotide polymorphism (SNP) in the gene encoding the transcription factor 7 like 2 (TCF7L2). However, the molecular function of TCF7L2 in the central nervous system (CNS) and its possible role in the BD and BMI interaction remained unclear. Read More

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September 2021

Critical illness in patients with metastatic cancer: a population-based cohort study of epidemiology and outcomes.

Authors:
Lavi Oud

J Investig Med 2021 Sep 17. Epub 2021 Sep 17.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas, USA

The appropriateness of intensive care unit (ICU) admission of patients with metastatic cancer remains debated. We aimed to examine the short-term outcomes and their temporal pattern in critically ill patients with metastatic disease. We used state-wide data to identify hospitalizations aged ≥18 years with metastatic cancer admitted to ICU in Texas during 2010-2014. Read More

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September 2021