Radiology 2021 Sep 7:204587. Epub 2021 Sep 7.
From the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).
MRI-based cartilage compositional analysis shows biochemical and microstructural changes at early stages of osteoarthritis before changes become visible with structural MRI sequences and arthroscopy. This could help with early diagnosis, risk assessment, and treatment monitoring of osteoarthritis. Spin-lattice relaxation time constant in rotating frame (T1ρ) and T2 mapping are the MRI techniques best established for assessing cartilage composition. Read More