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Meta-Analyzing Multiple Omics Data With Robust Variable Selection.

Front Genet 2021 5;12:656826. Epub 2021 Jul 5.

Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

High-throughput omics data are becoming more and more popular in various areas of science. Given that many publicly available datasets address the same questions, researchers have applied meta-analysis to synthesize multiple datasets to achieve more reliable results for model estimation and prediction. Due to the high dimensionality of omics data, it is also desirable to incorporate variable selection into meta-analysis. Read More

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Multistimuli Responsive Solid-State Emission of a Zinc(II) Complex with Multicolour Switching.

Inorg Chem 2021 Jul 20. Epub 2021 Jul 20.

Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875, China.

The development of smart luminescent materials, especially those stimulus-responsive fluorescent materials that can switch between different colors repeatedly under external stimulation based on a single molecule, is of great significance but a challenge. In this work, a novel zinc(II)-Schiff base complex (ZnL) was obtained and characterized. Upon exposure to the HCl and NH vapors, it displayed remarkable tricolor acidochromic behavior with high contrast and rapid response under the ambient light as well as UV light (365 nm). Read More

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Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model.

J Bone Miner Res 2021 Jul 19. Epub 2021 Jul 19.

Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia, 4102.

Osteal macrophages (osteomacs) support osteoblast function and promote bone anabolism, but their contribution to osteoporosis has not been explored. While mouse ovariectomy (OVX) models have been repeatedly used, variation in strain, experimental design and assessment modalities, have contributed to no single model being confirmed as comprehensively replicating the full gamut of osteoporosis pathological manifestations. We validated an OVX model in adult C3H/HeJ mice and demonstrated that it presents with human post-menopausal osteoporosis features with reduced bone volume in axial and appendicular bone and bone loss in both trabecular and cortical bone including increased cortical porosity. Read More

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Prediction of Hepatocellular Carcinoma Response to Transcatheter Arterial Chemoembolization: A Real-World Study Based on Non-Contrast Computed Tomography Radiomics and General Image Features.

J Hepatocell Carcinoma 2021 9;8:773-782. Epub 2021 Jul 9.

Department of Oncology, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China.

Objective: To construct a predictive model of short-term response and overall survival for transcatheter arterial chemoembolization (TACE) treatment in hepatocellular carcinoma (HCC) patients based on non-contrast computed tomography (NC-CT) radiomics and clinical features.

Methods: Ninety-four HCC patients who underwent CT scanning 1 week before the first TACE treatment were retrospectively recruited and divided randomly into a training group (n = 47) and a validation group (n = 47). NC-CT radiomics data were extracted using MaZda software, and the compound model was calculated from radiomics and clinical features by logistic regression. Read More

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Change in EEG Activity is Associated with a Decrease in Tinnitus Awareness after rTMS.

Front Neurol Neurosci Res 2021 17;2. Epub 2021 May 17.

Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences USA.

Objective: To examine how 1Hz and 10Hz rTMS temporarily influence ratings of tinnitus loudness, annoyance, and awareness. The thalamocortical dysrhythmia (TCD) model of tinnitus was tested by examining changes in spectral power and coherence of resting state EEGs from baseline to each phase of treatment and correlating these data with change in tinnitus.

Methods: Nineteen participants completed a double-blind, placebo (sham rTMS) controlled, within-subjects study with crossover between the two active rTMS treatment conditions. Read More

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Stroke-Like Lesion in an m.3243A>G Carrier Presenting as Hyperperfusion and Hypometabolism.

Cureus 2021 Jun 7;13(6):e15487. Epub 2021 Jun 7.

Nuclear Medicine, Wilhelminenspital, Vienna, AUT.

Carriers of the m.3243A>G variant typically manifest with stroke-like episodes (SLEs), of which the morphological correlate on imaging is the stroke-like lesion (SLL). The pathophysiology of SLLs is poorly understood but acute and chronic stages are delineated. Read More

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Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions.

Front Genet 2021 28;12:686666. Epub 2021 Jun 28.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result from complex interplay between genetic and environmental factors. It is well-established that they are highly heritable disorders, and considerable progress has been made identifying their shared and distinct genetic risk factors. However, the 15-40% of risk that is derived from environmental sources is less definitively known. Read More

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Predictors of Service Satisfaction Among Clients Receiving Antiretroviral Therapy Services at Public Hospitals in Eastern Ethiopia.

HIV AIDS (Auckl) 2021 5;13:737-747. Epub 2021 Jul 5.

Department of Public Health, College of Health Sciences, Institute of Medicine and Health Science, Debre Berhan University, Debre Berhan, Ethiopia.

Background: The issue of service satisfaction with antiretroviral therapy services needs more attention as it indicates the outcome of quality health services. Although different studies have been conducted on client satisfaction in different countries, there is limited evidence on the major predictors of client satisfaction with ART services in Ethiopia.

Objective: To assess the predictors of service satisfaction among clients receiving antiretroviral therapy services at a public hospital in Harar Town, Eastern Ethiopia. Read More

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Predicting the SARS-CoV-2 effective reproduction number using bulk contact data from mobile phones.

Proc Natl Acad Sci U S A 2021 08;118(31)

Digital Health-Machine Learning, Hasso-Plattner-Institut, Universität Potsdam, 14482 Potsdam, Germany.

Over the last months, cases of SARS-CoV-2 surged repeatedly in many countries but could often be controlled with nonpharmaceutical interventions including social distancing. We analyzed deidentified Global Positioning System (GPS) tracking data from 1.15 to 1. Read More

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Approaches for setting occupational exposure limits in the pharmaceutical industry.

J Appl Toxicol 2021 Jul 12. Epub 2021 Jul 12.

Safety Assessment Department, Syngene International Limited, Bangalore, India.

The use of pharmaceutical drugs has provided a cure for many diseases. However, unintended exposure to drugs in the manufacturing workplace can cause significant health hazards to workers. It is important to protect the workforce from these deleterious effects by limiting exposure to an acceptable level, the occupational exposure limit (OEL). Read More

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The Feasibility of Using Virtual Reality and Eye Tracking in Research With Older Adults With and Without Alzheimer's Disease.

Rebecca Davis

Front Aging Neurosci 2021 28;13:607219. Epub 2021 Jun 28.

Kirkhof College of Nursing, Grand Valley State University, Grand Rapids, MI, United States.

To examine the feasibility of using large scale spatial, self-mobile, virtual reality, and eye tracking in older adults with and without Alzheimer's disease (AD). Older adults with early stage AD ( = 38) and a control group without AD ( = 50) were asked to find their way in a large, projected VR simulation of a retirement community repeatedly over 10 trials for each of 2 days, while wearing eye tracking glasses. Feasibility measures, including tolerance, side effects, and ability to complete the VR and eye tracking were collected. Read More

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A brief review of vertebrate sex evolution with a pledge for integrative research: towards ''.

Philos Trans R Soc Lond B Biol Sci 2021 Aug 12;376(1832):20200426. Epub 2021 Jul 12.

INRAE, LPGP, 35000, Rennes, France.

Triggers and biological processes controlling male or female gonadal differentiation vary in vertebrates, with sex determination (SD) governed by environmental factors or simple to complex genetic mechanisms that evolved repeatedly and independently in various groups. Here, we review sex evolution across major clades of vertebrates with information on SD, sexual development and reproductive modes. We offer an up-to-date review of divergence times, species diversity, genomic resources, genome size, occurrence and nature of polyploids, SD systems, sex chromosomes, SD genes, dosage compensation and sex-biased gene expression. Read More

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Twenty-three-year demographic history of the Affenberg Japanese macaques (Macaca fuscata), a translocated semi-free-ranging group in southern Austria.

Primates 2021 Jul 10. Epub 2021 Jul 10.

Austrian Research Center for Primatology, Ossiach 16, 9570, Ossiach, Austria.

Demographic studies on translocated primate groups provide a unique opportunity to study population dynamics, social strategies, and reproductive parameters of a species adapting to new environments. In 1996, 38 Japanese macaques (Macaca fuscata) of the Minoo-H group (Osaka Prefecture, Japan) were translocated to Affenberg Landskron, a four-hectare naturally forested park in southern Austria. By January 2020, the population had increased to 160 individuals, and a total of 223 births were recorded. Read More

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Persistent attention-deficit/hyperactivity disorder predicts socially oriented, but not physical/physiologically oriented, alcohol problems in early adulthood.

Alcohol Clin Exp Res 2021 Jul 10. Epub 2021 Jul 10.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Although individuals with histories of childhood attention-deficit/hyperactivity disorder (ADHD) report more alcohol-related problems in adulthood than those without ADHD, it is unknown whether there are group differences in certain types of alcohol problems. We tested whether the nature of alcohol problems differed for individuals with and without childhood ADHD, as well as adulthood-persistent ADHD, to facilitate a personalized medicine approach for alcohol problems in this high-risk group.

Methods: Data were drawn from a prospective, observational study. Read More

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Using a visual analog scale (VAS) to measure tinnitus-related distress and loudness: Investigating correlations using the Mini-TQ results of participants from the TrackYourTinnitus platform.

Prog Brain Res 2021 20;263:171-190. Epub 2021 May 20.

Institute of Databases and Information Systems, Ulm University, Ulm, Germany.

Introduction: Tinnitus, a perception of ringing and buzzing sound in the ear, has not been completely understood yet. It is well known that tinnitus-related distress and loudness can change over time. However, proper comparability for the data collection approaches requires further focused studies. Read More

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Methylene blue uptake by gum arabic/acrylic amide/3-allyloxy-2-hydroxy-1-propanesulfonic acid sodium salt semi-IPN hydrogel.

Int J Biol Macromol 2021 Jul 7;186:268-277. Epub 2021 Jul 7.

Department of Chemistry, Turabah University College, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia. Electronic address:

In this study, the capacity of methylene blue (MB) uptake from aqueous solution was investigated using acrylic amide-co-3-Allyloxy-2-hydroxy-1-propanesulfonic acid sodium salt/Gum Arabic semi-IPN hydrogel. The semi-IPN hydrogels were prepared by the classical free radical solution technique. The swelling experiments were carried out gravimetrically and the swelling kinetics parameters were calculated. Read More

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A method of sample-wise region-set enrichment analysis for DNA methylomics.

Epigenomics 2021 Jul 9. Epub 2021 Jul 9.

Project for Development of Innovative Research on Cancer Therapeutics, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.

Gene set analysis has commonly been used to interpret DNA methylome data. However, summarizing the DNA methylation level of a gene is challenging due to variability in the number, density and methylation levels of CpG sites, and the numerous intergenic CpGs. Instead, we propose to use region sets to annotate the DNA methylome. Read More

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Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.

PLoS One 2021 8;16(7):e0253953. Epub 2021 Jul 8.

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.

Yellow fever (YF), Chikungunya (CHIK), and Zika(ZIK) are among re-emerging arboviral diseases of major public health concern. Despite the proximity of the Gambella Region to South Sudan where arboviral cases have been recorded repeatedly the current epidemiological situation is unclear in this part of southwest Ethiopia. Therefore, we conducted a community-based seroprevalence survey of YF virus (YFV), CHIK virus (CHIKV), and ZIK virus (ZIKV) infections in two selected districts. Read More

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Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?

Naunyn Schmiedebergs Arch Pharmacol 2021 Aug 8;394(8):1621-1632. Epub 2021 Jul 8.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Acquired multidrug resistance (MDR) in tumor diseases has repeatedly been associated with overexpression of ATP-binding cassette transporters (ABC-transporters) such as P-glycoprotein. Both in vitro and in vivo data suggest that these efflux transporters can cause MDR, albeit its actual relevance for clinical chemotherapy unresponsiveness remains uncertain. The overexpression can experimentally be achieved by exposure of tumor cells to cytotoxic drugs. Read More

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Reversible 3D optical data storage and information encryption in photo-modulated transparent glass medium.

Light Sci Appl 2021 Jul 7;10(1):140. Epub 2021 Jul 7.

State Key Laboratory of Luminescent Materials and Devices, School of Materials Science and Engineering, South China University of Technology, 510640, Guangzhou, China.

Transparent glass has been identified as a vital medium for three-dimensional (3D) optical information storage and multi-level encryption. However, it has remained a challenge for directly writing 3D patterning inside a transparent glass using semiconductor blue laser instead of high-cost femtosecond laser. Here, we demonstrate that rare earth ions doped transparent glass can be used as 3D optical information storage and data encryption medium based on their reversible transmittance and photoluminescence manipulation. Read More

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Evaluation of Nano-Particulate-Matter-Induced Lung Injury in Mice Using Quantitative Micro-Computed Tomography.

J Nanosci Nanotechnol 2021 Dec;21(12):6041-6047

College of Food Science, Shihezi University, Shihezi, 832000, China.

Nano-particulate matters (NPM) induced the lung injury in mice were evaluated using quantitative micro-computed tomography in the present article. It is an important negative effect of health problems that NPM exposure provokes changes in the lung injury. The micro-computed tomography (CT) to assess lung injury in mouse models has been investigated. Read More

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December 2021

Seroprevalence of and Risk Factors Associated With SARS-CoV-2 Infection in Health Care Workers During the Early COVID-19 Pandemic in Italy.

JAMA Netw Open 2021 07 1;4(7):e2115699. Epub 2021 Jul 1.

Center for Health Emergencies, Bruno Kessler Foundation, Trento, Italy.

Importance: Identifying health care settings and professionals at increased risk of SARS-CoV-2 infection is crucial to defining appropriate strategies, resource allocation, and protocols to protect health care workers (HCWs) and patients. Moreover, such information is crucial to decrease the risk that HCWs and health care facilities become amplifiers for SARS-CoV-2 transmission in the community.

Objective: To assess the association of different health care professional categories and operational units, including in-hospital wards, outpatient facilities, and territorial care departments, with seroprevalence and odds of SARS-CoV-2 infection. Read More

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[Research progress of microextraction by packed sorbent and its application in microvolume sample extraction].

Se Pu 2021 Mar;39(3):219-228

State key Laboratory of Nuclear, Biological and Chemical Protection for Civilian, Beijing 102205, China.

Microextraction is a rapidly developing sample preparation technology in the field of analytical chemistry, which is seeing widespread application. Accurate sample preparation can not only save time but also improve the efficiency of analysis, determination, and data quality. At present, sample pretreatment methods must be rapid, allow for miniaturization, automation, and convenient online connection with analytical instruments. Read More

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Long-term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects.

Addict Biol 2021 Jul 5:e13074. Epub 2021 Jul 5.

Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, VA Portland Health Care System (R&D 12), Portland, Oregon, USA.

We have modelled genetic risk for binge-like drinking by selectively breeding High Drinking in the Dark-1 and -2 (HDID-1 and HDID-2) mice for their propensity to reach intoxicating blood alcohol levels (BALs) after binge-like drinking in a single bottle, limited access paradigm. Interestingly, in standard two-bottle choice (2BC) tests for continuously available alcohol versus water, HDID mice show modest levels of preference. This indicates some degree of independence of the genetic contributions to risk for binge-like and sustained, continuous access drinking. Read More

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Understanding Moral Injury and Belief Change in the Experiences of Police Online Child Sex Crime Investigators: an Interpretative Phenomenological Analysis.

J Police Crim Psychol 2021 Jun 30:1-13. Epub 2021 Jun 30.

Creative and Cultural Industries, University of Portsmouth, Portsmouth, UK.

Little is known about the psychological and physiological impacts of moral injury within organizational contexts such as Internet Child Abuse Teams (hereafter abbreviated to ICAT), who are repeatedly exposed to trauma through viewing and grading graphic images of children being sexually abused. The aims of the current research were to explore the key features of, and contributing factors to, moral injury and trauma as experienced by Internet Child Abuse Teams, how these manifested and how these factors can be mitigated. Six participants were recruited from ICATs located at two police constabularies. Read More

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A pilot study on the prevalence of lice in Irish beef cattle and the first Irish report of deltamethrin tolerance in Bovicola bovis.

Ir Vet J 2021 Jul 5;74(1):20. Epub 2021 Jul 5.

School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Pediculosis in cattle causes significant itching, irritation and stress to the animal, often resulting in skin damage and poor coat condition. The control of bovine pediculosis in Ireland is based predominantly on commercial insecticides belonging to one of two chemical classes, the synthetic pyrethroids and the macrocyclic lactones. In recent years, pyrethroid tolerance has been reported in a number of species of livestock lice in the United Kingdom and Australia. Read More

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Associations between fatty acid composition in serum cholesteryl esters and liver fat, basal fat oxidation, and resting energy expenditure: a population-based study.

Am J Clin Nutr 2021 Jul 5. Epub 2021 Jul 5.

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.

Background: We have repeatedly shown in short-term feeding trials that a high intake of dietary n-6 PUFAs, i.e. linoleic acid, prevents liver fat accumulation compared with saturated fat. Read More

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Machine-learning models for activity class prediction: A comparative study of feature selection and classification algorithms.

Gait Posture 2021 Jun 24;89:45-53. Epub 2021 Jun 24.

Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland. Electronic address:

Purpose: Machine-learning (ML) approaches have been repeatedly coupled with raw accelerometry to classify physical activity classes, but the features required to optimize their predictive performance are still unknown. Our aim was to identify appropriate combination of feature subsets and prediction algorithms for activity class prediction from hip-based raw acceleration data.

Methods: The hip-based raw acceleration data collected from 27 participants was split into training (70 %) and validation (30 %) subsets. Read More

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Long-term cortisol levels in hair of children and adolescents with Prader-Willi Syndrome.

Psychoneuroendocrinology 2021 Jun 20;132:105335. Epub 2021 Jun 20.

Dutch Growth Research Foundation, Rotterdam, The Netherlands; Department of Pediatrics, Subdivision of Endocrinology Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands; Dutch Reference Center for Prader-Willi Syndrome, The Netherlands.

Context: Prader-Willi syndrome (PWS) is characterized by hypothalamic dysfunction. In children with PWS, stress-induced central adrenal insufficiency (CAI) has been described, however, daily life cortisol production may be normal. Hair cortisol concentration (HCC) is a marker of long-term systemic cortisol production. Read More

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Storm Waves May Be the Source of Some "Tsunami" Coastal Boulder Deposits.

Geophys Res Lett 2021 Jun 7;48(11):e2020GL090775. Epub 2021 Jun 7.

University College Dublin Dublin Ireland.

Coastal boulder deposits (CBD) provide what are sometimes the only remaining signatures of wave inundation on rocky coastlines; in recent decades, CBD combined with initiation of motion (IoM) analyses have repeatedly been used as primary evidence to infer the existence of ancient tsunamis. However, IoM storm wave heights inferred by these studies have been shown to be highly inaccurate, bringing some inferences into question. This work develops a dimensionless framework to relate CBD properties with storm-wave hindcasts and measurements, producing data-driven relations between wave climate and boulder properties. Read More

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