376,415 results match your criteria data reduced


[Consequences of anterior cruciate ligament rupture: a systematic umbrella review].

Sportverletz Sportschaden 2021 Sep 20. Epub 2021 Sep 20.

Physio Meets Science GmbH, Leimen, Germany.

Introduction:  The treatment of an anterior cruciate ligament rupture is still controversial. In particular, this applies to the question of conservative versus surgical treatment. The answer to this question is often based on consequential damage such as the development of posttraumatic osteoarthritis, secondary damage to the meniscus or cartilage, and participation in sports. Read More

View Article and Full-Text PDF
September 2021

Uniform versus non-uniform dose prescription for proton stereotactic body radiotherapy of liver tumors investigated by extensive motion-including treatment simulations.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Department of Clinical Medicine, Aarhus University, Aarhus, DENMARK.

Compared to x-ray-based stereotactic body radiotherapy (SBRT) of liver cancer, proton SBRT may reduce the normal liver tissue dose. For optimal trade-off between target and liver dose, a non-uniform dose prescription is often applied in x-ray SBRT, but lacks investigation for proton SBRT. Also, proton SBRT is prone to breathing-induced motion-uncertainties causing target mishit or dose alterations by interplay with the proton delivery. Read More

View Article and Full-Text PDF
September 2021

The effects of mindfulness stress reduction program on postmenopausal women's menopausal complaints and their life quality.

Complement Ther Clin Pract 2021 Sep 8;45:101478. Epub 2021 Sep 8.

Inonu University, Faculty of Health Sciences, Department of Nursing, Malatya, Turkey. Electronic address:

Aim: This study was carried out to define the effect of the Mindfulness Stress Reduction Program (MBSR) applied among postmenopausal women on their menopausal complaints and quality of life.

Material And Method: The study was conducted with a quasi-experimental design. The sample consisted of 118 women, including 55 in the experimental group and 63 in the control group. Read More

View Article and Full-Text PDF
September 2021

Effects of blue monochromatic light directed at one eye of pregnant horse mares on gestation, parturition and foal maturity.

Domest Anim Endocrinol 2021 Aug 26;78:106675. Epub 2021 Aug 26.

Centre for Artificial Insemination and Embryo Transfer, Department for Small Animals and Horses, Vetmeduni Vienna, 1210 Vienna, Austria. Electronic address:

Blue light directed at 1 eye advances the equine ovulatory season but may also advance foaling. In this study, effects of blue LED light on pregnancy outcome were assessed. A total of 20 mares with singleton pregnancies were studied over 2 consecutive years in a cross-over design. Read More

View Article and Full-Text PDF

Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats.

Sci Total Environ 2021 Sep 16;805:150368. Epub 2021 Sep 16.

College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City 271018, Shandong Province, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City 271018, Shandong Province, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City 271018, Shandong Province, China. Electronic address:

Glyphosate (GLY), a ubiquitous environmental pollutant, can result in gut microbiota dysbiosis intimately involving various diseases. The latest research has shown an association between gut microbiota alteration and defective spermatogenesis. Here, we aimed to investigate whether GLY-induced gut microbiota dysbiosis contributed to male reproductive toxicity. Read More

View Article and Full-Text PDF
September 2021

Integrated versus non-integrated treatment for perinatal opioid use disorder: Retrospective cohort study.

Am J Obstet Gynecol MFM 2021 Sep 17:100489. Epub 2021 Sep 17.

Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA; Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.

Background: Pregnant women with opioid use disorder (OUD) and their infants often experience worse perinatal outcomes than women without OUD, including longer hospitalizations after delivery and higher risk of preterm delivery. Integrated treatment models, which combine addiction treatment and maternity care, represent an innovative approach which is widely endorsed, but little research has compared outcomes of real-world, integrated versus standard, non-integrated programs.

Objective: To evaluate perinatal and substance use outcomes for pregnant women with opioid use disorder (OUD) receiving coordinated, co-located obstetric care and OUD treatment (integrated treatment), compared to women receiving obstetric care and OUD treatment in distinct programs of care (non-integrated treatment). Read More

View Article and Full-Text PDF
September 2021

CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, University of California, San Francisco, San Francisco, CA; Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital, San Francisco, CA; Center for Vulnerable Populations, University of California, San Francisco, San Francisco, CA.

Rationale & Objective: eGFR equations that incorporate a term for race assign a higher value to Black individuals compared to non-Black individuals not attributable to sex, age, or serum creatinine. This difference may contribute to racial disparities in kidney transplant access. We sought to 1) compare time from meeting a transplant eligibility threshold of eGFR ≤20 ml/min/1. Read More

View Article and Full-Text PDF
September 2021

Optimized expression and purification of adipose triglyceride lipase improved hydrolysis and transacylation catalytic activities in vitro.

J Biol Chem 2021 Sep 17:101206. Epub 2021 Sep 17.

Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed Graz, Austria; BioHealth Field of Excellence, University of Graz, Graz. Electronic address:

Adipose triglyceride lipase (ATGL) plays a key role in intracellular lipolysis, the mobilization of stored triacylglycerol. This work provides an important basis for generating reproducible and detailed data on the hydrolytic and transacylation activities of ATGL. We generated full-length and C-terminally truncated ATGL variants fused with various affinity tags and analyzed their expression in different hosts, namely E. Read More

View Article and Full-Text PDF
September 2021

LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration.

J Cell Physiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.

We report a novel in vitro classification system that tracks microglial activation state and their potential neurotoxicity. Mixed live-cell imaging was used to characterize transition through distinct morphological phenotypes, production of reactive oxygen species (ROS), formation of reactive microglial aggregates, and subsequent cytokine production. Transwell cultures were used to determine microglial migration (control and lipopolysaccharide (LPS) treated) to glutamate pre-stressed or healthy neurons. Read More

View Article and Full-Text PDF
September 2021

TGF- promotes microtube formation in glioblastoma through Thrombospondin 1.

Neuro Oncol 2021 Sep 20. Epub 2021 Sep 20.

University of Bordeaux, INSERM, LAMC, U1029, 33600, Pessac, France.

Background: Microtubes (MTs), cytoplasmic extensions of glioma cells, are important cell communication structures promoting invasion and treatment resistance through network formation. MTs are abundant in chemoresistant gliomas, in particular glioblastomas (GBMs), while they are uncommon in chemosensitive IDH-mutant and 1p/19q co-deleted oligodendrogliomas. The aim of this study was to identify potential signaling pathways involved in MT formation. Read More

View Article and Full-Text PDF
September 2021

Changing lives, dynamic plans: Prospective assessment of 12-month changes in pregnancy timing intentions and personal circumstances using data from HER Salt Lake.

PLoS One 2021 20;16(9):e0257411. Epub 2021 Sep 20.

Department of Obstetrics & Gynecology, University of Utah, Salt Lake City, Utah.

Objectives: To explore the association between changes in personal circumstances and shifts in pregnancy intentions.

Study Design: New start contraceptive clients, who desired to prevent pregnancy for at least one year enrolled in the survey arm of the HER Salt Lake Contraceptive Initiative (September 2015 -March 2017) and responded to the question "What are your future pregnancy plans?" at enrollment and 12-month follow-up. We estimated multivariable binary logistic fixed-effects regressions to examine the association between changes in personal circumstances and a change from never desiring a pregnancy at enrollment to considering one in the future at 12-month follow-up. Read More

View Article and Full-Text PDF
September 2021

Estimated contribution of most commonly consumed industrialized processed foods to salt intake and iodine intakes in Sri Lanka.

PLoS One 2021 20;16(9):e0257488. Epub 2021 Sep 20.

Iodine Global Network, Ontario, Canada.

In Sri Lanka dietary patterns are shifting towards increased consumption of industrially processed foods (IPF). This study aimed to estimate the contribution of IPF to salt and iodine intake and assess the possible impact of salt reduction on iodized salt intake. The assessment was conducted using guidance published by the Iodine Global Network. Read More

View Article and Full-Text PDF
September 2021

Acetylcholine-gated current translates wake neuronal firing rate information into a spike timing-based code in Non-REM sleep, stabilizing neural network dynamics during memory consolidation.

PLoS Comput Biol 2021 Sep 20;17(9):e1009424. Epub 2021 Sep 20.

Biophysics Program, University of Michigan, Ann Arbor, Michigan, United States of America.

Sleep is critical for memory consolidation, although the exact mechanisms mediating this process are unknown. Combining reduced network models and analysis of in vivo recordings, we tested the hypothesis that neuromodulatory changes in acetylcholine (ACh) levels during non-rapid eye movement (NREM) sleep mediate stabilization of network-wide firing patterns, with temporal order of neurons' firing dependent on their mean firing rate during wake. In both reduced models and in vivo recordings from mouse hippocampus, we find that the relative order of firing among neurons during NREM sleep reflects their relative firing rates during prior wake. Read More

View Article and Full-Text PDF
September 2021

Guided Event Filtering: Synergy between Intensity Images and Neuromorphic Events for High Performance Imaging.

IEEE Trans Pattern Anal Mach Intell 2021 Sep 20;PP. Epub 2021 Sep 20.

Many visual and robotics tasks in real-world scenarios rely on robust handling of high speed motion and high dynamic range (HDR) with effectively high spatial resolution and low noise. Such stringent requirements, however, cannot be directly satisfied by a single imager or modality, rather by complementary sensors. In this paper, we explore the synergy between traditional frame-based sensors with high spatial resolution and low sensor noise, and emerging event-based sensors with high speed and high dynamic range. Read More

View Article and Full-Text PDF
September 2021

Flexible Fitting of PROTAC Concentration-Response Curves with Changepoint Gaussian Processes.

SLAS Discov 2021 Oct;26(9):1212-1224

Prioris.ai Inc., Ottawa, ON, Canada.

A proteolysis-targeting chimera (PROTAC) is a new technology that marks proteins for degradation in a highly specific manner. During screening, PROTAC compounds are tested in concentration-response (CR) assays to determine their potency, and parameters such as the half-maximal degradation concentration (DC) are estimated from the fitted CR curves. These parameters are used to rank compounds, with lower DC values indicating greater potency. Read More

View Article and Full-Text PDF
October 2021

The ASCIZ-DYNLL1 axis is essential for TLR4-mediated antibody responses and NF-κB pathway activation.

Mol Cell Biol 2021 Sep 20:MCB0025121. Epub 2021 Sep 20.

St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.

Toll-like receptors (TLRs) and IL-1 receptors regulate immune and inflammatory responses by activating the nuclear factor (NF)-κB pathway. Here we report that B cell-specific loss of Dynein light chain-1 (DYNLL1, LC8) or its designated transcription factor ASCIZ (ATMIN) leads to severely reduced antibody responses to TLR4-dependent but not T cell-dependent antigens in mice. This defect was independent of DYNLL1's established roles in modulating BIM-dependent apoptosis and 53BP1-dependent antibody class-switch recombination. Read More

View Article and Full-Text PDF
September 2021

A mutation of a single core gene, , of Type VI secretion system of influences virulence, epiphytic survival and transmission during pathogenesis on tomato.

Phytopathology 2021 Sep 20. Epub 2021 Sep 20.

Auburn University, 1383, Entomology and Plant Pathology, 209 Rouse Life Science Building, Auburn, Alabama, United States, 36849-5412;

is a seed-borne hemi-biotrophic pathogen that successfully establishes infection in the phyllosphere of tomato. While the majority of the studies investigating mechanistic basis of pathogenesis have focused on successful apoplastic growth, factors important during asymptomatic colonization in the early stages of disease development are not well understood. In this study, we show that gene of the type VI secretion system cluster i3* (T6SS-i3*) plays a significant role during initial asymptomatic epiphytic colonization at different stages during the life cycle of the pathogen. Read More

View Article and Full-Text PDF
September 2021

Correlation Analysis of Pleural Effusion and Lung Infection After Liver Transplantation.

Clin Lab 2021 Sep;67(9)

Background: The aim was to probe the association of pleural effusion with lung infection in patients with liver transplantation and to provide a theoretical foundation for preventing, diagnosing, and remedying pulmonary complications after liver transplantation.

Methods: Our team harvested clinical data of patients undergoing orthotopic allogeneic liver transplantation complicated with pleural effusion after surgery in our institution from May 2018 to July 2019. Based on whether puncture drainage was needed, patients were allocated to either control group or observation group. Read More

View Article and Full-Text PDF
September 2021

The Safety of Agalsidase Alfa Enzyme Replacement Therapy in Canadian Patients with Fabry Disease Following Implementation of a Bioreactor Process.

Drugs R D 2021 Sep 20. Epub 2021 Sep 20.

Division of Nephrology, Department of Medicine, Dalhousie University, Rm 5090 ACC, QE II Health Sciences Centre, 5820 University Ave, Halifax, NS, B3H 1V8, Canada.

Background And Objective: Fabry disease, an X-linked lysosomal storage disorder characterized by absent or reduced alpha-galactosidase activity, is a lifelong disease that impairs patients' quality of life. Patients with Fabry disease have a considerably shortened lifespan, with mortality being mainly due to renal failure, cardiovascular disease, or cerebrovascular disease. Enzyme replacement therapy with agalsidase alfa has been shown to attenuate the renal, cardiovascular, and neuropathic disease progression associated with Fabry disease. Read More

View Article and Full-Text PDF
September 2021

Anticoagulation after intracerebral hemorrhage in patients with atrial fibrillation: between Scylla and Charybdis.

Neurol Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: Oral anticoagulants (OAC) are indicated in patients with atrial fibrillation (AF) and high risk of ischemic stroke. However, the introduction of anticoagulation in patients with AF and previous intracerebral hemorrhage (ICH) is controversial. We aimed to better understand the efficacy and safety of OAC in this context and to assess the factors that may influence this decision. Read More

View Article and Full-Text PDF
September 2021

Tree growth response to soil nutrients and neighborhood crowding varies between mycorrhizal types in an old-growth temperate forest.

Oecologia 2021 Sep 20. Epub 2021 Sep 20.

AMAP (Botanique et Modélisation de l'Architecture des Plantes et des Végétations), Université de Montpellier, CIRAD, CNRS, INRAE, IRD, Montpellier, France.

Forest dynamics are shaped by both abiotic and biotic factors. Trees associating with different types of mycorrhizal fungi differ in nutrient use and dominate in contrasting environments, but it remains unclear whether they exhibit differential growth responses to local abiotic and biotic gradients where they co-occur. We used 9-year tree census data in a 25-ha old-growth temperate forest in Northeast China to examine differences in tree growth response to soil nutrients and neighborhood crowding between tree species associating with arbuscular mycorrhizal (AM), ectomycorrhizal (EM), and dual-mycorrhizal (AEM) fungi. Read More

View Article and Full-Text PDF
September 2021

Recycling Nutrients and Reducing Carbon Emissions in the Baltic Sea Region-Sustainable or Economically Infeasible?

Environ Manage 2021 Sep 20. Epub 2021 Sep 20.

Stockholm Environment Institute, Linnégatan 87D, 104 51, Stockholm, Sweden.

Ecotechnologies have the potential to reduce the use of finite resources while providing a variety of co-benefits to society, though they often lack in market competitiveness. In this study, we investigate the sustainability of ecotechnologies for recovering carbon and nutrients, and demonstrate how a so-called "bottom-up" approach can serve as a decision-making instrument. Based on three case study catchments with a focus on domestic wastewater in Sweden and Poland, and on manure, grass and blackwater substrates in Finland, we apply a cost-benefit analysis (CBA) on system alternatives derived from a participatory process. Read More

View Article and Full-Text PDF
September 2021

Interventions to Reduce Hospital Length of Stay in High-risk Populations: A Systematic Review.

JAMA Netw Open 2021 Sep 1;4(9):e2125846. Epub 2021 Sep 1.

ECRI Evidence-based Practice Center, Center for Clinical Evidence and Guidelines, Plymouth Meeting, Pennsylvania.

Importance: Many strategies to reduce hospital length of stay (LOS) have been implemented, but few studies have evaluated hospital-led interventions focused on high-risk populations. The Agency for Healthcare Research and Quality (AHRQ) Learning Health System panel commissioned this study to further evaluate system-level interventions for LOS reduction.

Objective: To identify and synthesize evidence regarding potential systems-level strategies to reduce LOS for patients at high risk for prolonged LOS. Read More

View Article and Full-Text PDF
September 2021

Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis.

JAMA Pediatr 2021 Sep 20:e213298. Epub 2021 Sep 20.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.

Importance: Intervention for individuals with autism spectrum disorder (ASD) typically commences after diagnosis. No trial of an intervention administered to infants before diagnosis has shown an effect on diagnostic outcomes to date.

Objective: To determine the efficacy of a preemptive intervention for ASD beginning during the prodromal period. Read More

View Article and Full-Text PDF
September 2021

The Effects of Implementation Quality of a School-Based Social and Emotional Well-Being Program on Students' Outcomes.

Eur J Investig Health Psychol Educ 2020 May 22;10(2):595-614. Epub 2020 May 22.

Health Promotion Research Centre, National University of Ireland Galway, University Road, H91TK33 Galway, Ireland.

School-based social and emotional learning (SEL) programs can be effective in producing positive outcomes for students. However, when the implementation quality is poor, these programs often lose their effectiveness and fail to produce the expected positive outcomes. The current study evaluates a school-based SEL program for 15-18-year-olds in Ireland by determining the impact of implementation quality on program outcomes. Read More

View Article and Full-Text PDF

Revisiting the Women Workplace Culture Scale: Validation and Psychometric Properties of a Three-Factor Structure in an Iranian Study Sample.

Eur J Investig Health Psychol Educ 2020 Sep 21;10(3):915-934. Epub 2020 Sep 21.

Department of Psychology, Faculty of Humanities, University of Bojnord, Bojnord 9453155111, Iran.

This paper describes the validation process of the Persian version of the Women Workplace Culture Scale and provides information about the perception of this culture in an Iranian working environment. A 30-item Persian version of the Women Workplace Culture (WWC) Questionnaire was administered to women working in public departments of the city of Bojnord, Iran (N = 200). As a result of a theory- and data-driven bottom-up empirical approach, a reduced 10-item three-dimensional scale was achieved entailing (I) perceived societal barriers for career development, (II) perceived organizational barriers, and (III) sexual harassment. Read More

View Article and Full-Text PDF
September 2020

Acceptance and commitment therapy for older people with treatment-resistant generalised anxiety disorder: the FACTOID feasibility study.

Health Technol Assess 2021 Sep;25(54):1-150

Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.

Background: Generalised anxiety disorder, characterised by excessive anxiety and worry, is the most common anxiety disorder among older people. It is a condition that may persist for decades and is associated with numerous negative outcomes. Front-line treatments include pharmacological and psychological therapy, but many older people do not find these treatments effective. Read More

View Article and Full-Text PDF
September 2021

COMPARISON OF PULSE-DOSE AND HIGH-DOSE CORTICOSTEROIDS WITH NO CORTICOSTEROID TREATMENT FOR COVID-19 PNEUMONIA IN THE INTENSIVE CARE UNIT.

J Med Virol 2021 Sep 20. Epub 2021 Sep 20.

Division of Pulmonary, Critical Care, and Sleep Medicine, Westchester Medical Center, Valhalla, NY, USA.

Introduction: Corticosteroid dosing in the range of 0.5-2mg/kg/day of methylprednisolone equivalents have become a standard part of the management of ICU patients with COVID-19 pneumonia based on positive results of randomized trials and a meta-analysis. Alongside such conventional dosing, administration of 1gm of methylprednisolone daily (pulse dosing) has also been reported in the literature with claims of favorable outcomes. Read More

View Article and Full-Text PDF
September 2021

Treatment of upper limb spasticity with inhibitory repetitive transcranial magnetic stimulation: A randomized placebo-controlled trial.

NeuroRehabilitation 2021 Sep 13. Epub 2021 Sep 13.

BDH-Clinic Hessisch Oldendorf, Institute for Neurorehabilitation Research (InFo), Associated Institute of Hannover Medical School, Hessisch Oldendorf, Germany.

Background: Upper limb dysfunction is a frequent complication after stroke impairing outcome. Inhibitory repetitive transcranial magnetic stimulation (rTMS) applied over the contralesional hemisphere is supposed to enhance the positive effects of conventional rehabilitative treatment.

Objective: This double-blind randomized placebo-controlled trial investigated whether inhibitory rTMS as add-on to standard therapy improves upper limb spasticity. Read More

View Article and Full-Text PDF
September 2021