197,441 results match your criteria data processing

A deep-learning approach for direct whole-heart mesh reconstruction.

Med Image Anal 2021 Sep 8;74:102222. Epub 2021 Sep 8.

Mechanical Engineering Department, University of California, Berkeley, Berkeley, CA 94709, United States. Electronic address:

Automated construction of surface geometries of cardiac structures from volumetric medical images is important for a number of clinical applications. While deep-learning-based approaches have demonstrated promising reconstruction precision, these approaches have mostly focused on voxel-wise segmentation followed by surface reconstruction and post-processing techniques. However, such approaches suffer from a number of limitations including disconnected regions or incorrect surface topology due to erroneous segmentation and stair-case artifacts due to limited segmentation resolution. Read More

View Article and Full-Text PDF
September 2021

AlphaTims: Indexing trapped ion mobility spectrometry - time of flight data for fast and easy accession and visualization.

Mol Cell Proteomics 2021 Sep 17:100149. Epub 2021 Sep 17.

Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany; NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

High resolution mass spectrometry-based proteomics generates large amounts of data, even in the standard liquid chromatography (LC) - tandem mass spectrometry configuration. Adding an ion mobility dimension vastly increases the acquired data volume, challenging both analytical processing pipelines and especially data exploration by scientists. This has necessitated data aggregation, effectively discarding much of the information present in these rich data sets. Read More

View Article and Full-Text PDF
September 2021

Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.

PLoS Comput Biol 2021 Sep 20;17(9):e1009169. Epub 2021 Sep 20.

Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America.

The majority of olfaction studies focus on orthonasal stimulation where odors enter via the front nasal cavity, while retronasal olfaction, where odors enter the rear of the nasal cavity during feeding, is understudied. The coding of retronasal odors via coordinated spiking of neurons in the olfactory bulb (OB) is largely unknown despite evidence that higher level processing is different than orthonasal. To this end, we use multi-electrode array in vivo recordings of rat OB mitral cells (MC) in response to a food odor with both modes of stimulation, and find significant differences in evoked firing rates and spike count covariances (i. Read More

View Article and Full-Text PDF
September 2021

CAFS: Cost-Aware Features Selection Method for Multimodal Stress Monitoring on Wearable Devices.

IEEE Trans Biomed Eng 2021 Sep 20;PP. Epub 2021 Sep 20.

Objective: Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven by multimodal data acquisition and processing. Limited research has addressed the classification cost on multimodal wearable sensors, particularly when the features are cost-dependent. Thus, we design a Cost-Aware Feature Selection (CAFS) methodology that trades-off between prediction-power and energy-cost for multimodal stress monitoring. Read More

View Article and Full-Text PDF
September 2021

Super-Resolution Imaging of the Actin Cytoskeleton in Living Cells Using TIRF-SIM.

Methods Mol Biol 2022 ;2364:3-24

Biology Department, Syracuse University, Syracuse, NY, USA.

Super-resolution (SR) imaging techniques have advanced rapidly in recent years, but only a subset of these techniques is gentle enough to be used by cell biologists to study living cells with minimal photodamage. Our research is focused on studies of the dynamic remodeling of the actin cytoskeleton in living pancreatic beta cells during insulin secretion. These studies require super-resolution light microscopic techniques that are gentle enough to record rapid changes of the actin cytoskeleton in real time. Read More

View Article and Full-Text PDF
January 2022

Microplastics in Tissues (Brain, Gill, Muscle and Gastrointestinal) of Mullus barbatus and Alosa immaculata.

Arch Environ Contam Toxicol 2021 Sep 20. Epub 2021 Sep 20.

Department of Seafood Processing Technology, Faculty of Fisheries, Ataturk University, 25030, Erzurum, Turkey.

The researches on MPs in commercial marine fish are very limited although in marine environments microplastic (MPs) pollution is a global problem. In this study, the presence, composition, and characterization of MPs in different tissues (brain, gill, muscle, and gastrointestinal tract) of commercial fish species [red mullet (Mullus barbatus) and pontic shad (Alosa immaculata Bennett 1835)] from the Black Sea were investigated. M. Read More

View Article and Full-Text PDF
September 2021

Digital technologies and implications for Veterinary Services.

Rev Sci Tech 2021 Aug;40(2):455-468

The pace of digital disruption over the past few years has been spectacular, transforming every sector of the economy, including animal production, health and welfare. This paper reviews some advanced digital technologies that may shape the future of Veterinary Services. These technologies are all data driven and are illustrated by three examples that fall under the following categories: a) wireless and mobile technologies for animal health monitoring, disease surveillance, reporting and information sharing; b) advanced data-processing technologies, such as big data and data analytics used to detect patterns, make predictions, find correlations and other information; and c) promising technologies such as blockchain applications, used for effective and efficient management of various input supply chains. Read More

View Article and Full-Text PDF

The Norwegian childhood cancer biobank.

Cancer Rep (Hoboken) 2021 Sep 20:e1555. Epub 2021 Sep 20.

Department of Oncology, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.

Background: The rapidly expanding era of "omics" research is highly dependent on the availability of quality-proven biological material, especially for rare conditions such as pediatric malignancies. Professional biobanks provide such material, focusing on standardized collection and handling procedures, distinctive quality measurements, traceability of storage conditions, and accessibility. For pediatric malignancies, traditional tumor biobanking is challenging due to the rareness and limited amount of tissue and blood samples. Read More

View Article and Full-Text PDF
September 2021

Antimicrobial and Antiviral Activities of Durable Cotton Fabrics Treated with Nanocomposite Based on Zinc Oxide Nanoparticles, Acyclovir, Nanochitosan, and Clove Oil.

Appl Biochem Biotechnol 2021 Sep 20. Epub 2021 Sep 20.

Cellulose and Paper Department, National Research Centre, Dokki, 12622, Cairo, Egypt.

In this study, cotton fabrics based on zinc oxide nanoparticles in situ synthesis, acyclovir, nanochitosan, and clove oil were treated. The treated cotton fabrics were examined by FTIR, HR-TEM, FE-SEM, EDAX, and the surface roughness processing of FE-SEM images. The obtained characterization data emphasized the nano-size of nanocomposite with high homogeneity of particles in spherical shape as well as affirmed the deposition of nanocomposite onto the textile fibers with concluded that the deposition of nanocomposite was increased parallel with sonication time. Read More

View Article and Full-Text PDF
September 2021

Functional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults.

Cereb Cortex 2021 Sep 20. Epub 2021 Sep 20.

Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

Declines in processing speed performance occur in aging and are a critical marker of functional independence in older adults. Studies suggest that Useful Field of View (UFOV) training may ameliorate cognitive decline. Despite its efficacy, little is known about the neural correlates of this task. Read More

View Article and Full-Text PDF
September 2021

Assigning ICD-O-3 Codes to Pathology Reports using Neural Multi-Task Training with Hierarchical Regularization.

ACM BCB 2021 Aug;2021

Division of Biomedical Informatics (Internal Medicine), University of Kentucky, Lexington, Kentucky, USA.

Tracking population-level cancer information is essential for researchers, clinicians, policymakers, and the public. Unfortunately, much of the information is stored as unstructured data in pathology reports. Thus, too process the information, we require either automated extraction techniques or manual curation. Read More

View Article and Full-Text PDF

Skin problems of Korean military personnel changes in the use of cosmetics and differences in preference according to different characteristics: Focused on comparison pre- and post-enlistment.

Health Sci Rep 2021 Sep 14;4(3):e368. Epub 2021 Sep 14.

Division of Beauty Arts Care, Department of Practical Arts, Graduate School of Culture and Arts Dongguk University Seoul South Korea.

Background: Recently, men's interest and participation in cosmetology have increased, and the number of "grooming" men who are exorbitantly investing in fashion and looks has increased, further increasing the growth potential of men's cosmetics.

Objectives: The purpose of this study was to analyze the skin diseases of men in their 20s and 30s in Korea, focusing on the comparison before and after enlistment, and to study the changes in cosmetic use and the difference in cosmetic preference according to the military service problem of Korean men.

Methods: We enrolled 450 people, after excluding 50 dishonest respondents. Read More

View Article and Full-Text PDF
September 2021

Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair.

Wellcome Open Res 2017 12;2:83. Epub 2017 Sep 12.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

Trimethylation at histone H3 at lysine 36 (H3K36me3) is associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein ( ) is a transcriptional coactivator, possesses a  H3K36me3 reader PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adaptor proteins to recruit transcriptional modulators, splicing factors and proteins that promote homology directed repair (HDR), to H3K36me3 chromatin. Read More

View Article and Full-Text PDF
September 2017

Derivative-free optimization adversarial attacks for graph convolutional networks.

PeerJ Comput Sci 2021 24;7:e693. Epub 2021 Aug 24.

School of Information Engineering, China University of Geosciences, Beijing, China.

In recent years, graph convolutional networks (GCNs) have emerged rapidly due to their excellent performance in graph data processing. However, recent researches show that GCNs are vulnerable to adversarial attacks. An attacker can maliciously modify edges or nodes of the graph to mislead the model's classification of the target nodes, or even cause a degradation of the model's overall classification performance. Read More

View Article and Full-Text PDF

Solving musculoskeletal biomechanics with machine learning.

PeerJ Comput Sci 2021 26;7:e663. Epub 2021 Aug 26.

Department of Human Performance-Exercise Physiology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States.

Deep learning is a relatively new computational technique for the description of the musculoskeletal dynamics. The experimental relationships of muscle geometry in different postures are the high-dimensional spatial transformations that can be approximated by relatively simple functions, which opens the opportunity for machine learning (ML) applications. In this study, we challenged general ML algorithms with the problem of approximating the posture-dependent moment arm and muscle length relationships of the human arm and hand muscles. Read More

View Article and Full-Text PDF

Analysis of 3D Cellular Organization of Fixed Plant Tissues Using a User-guided Platform for Image Segmentation.

Bio Protoc 2017 Jun 20;7(12):e2355. Epub 2017 Jun 20.

Department of Plant and Microbial Biology, University of Zürich, Zürich, Switzerland.

The advent of non-invasive, high-resolution microscopy imaging techniques and computational pipelines for high-throughput image processing has contributed to gain insights in plant organ morphogenesis at the cellular level. Confocal scanning laser microscopy (CSLM) allows the generation of three dimensional images constituted of serial optical sections reporting on stained subcellular structures. Fluorescent labels of cell walls or cell membranes, either chemically or through reporter proteins, are particularly useful for the analyses of tissue organization and cellular shapes in 3D. Read More

View Article and Full-Text PDF

Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5' Leader Pre-tRNA Recognition.

Front Mol Biosci 2021 3;8:730274. Epub 2021 Sep 3.

Department of Chemistry, Marquette University, Milwaukee, WI, United States.

Ribonuclease P (RNase P) is a universal RNA-protein endonuclease that catalyzes 5' precursor-tRNA (ptRNA) processing. The RNase P RNA plays the catalytic role in ptRNA processing; however, the RNase P protein is required for catalysis and interacts with the 5' leader sequence. A single P RNA and a P protein form the functional RNase P holoenzyme yet dimeric forms of bacterial RNase P can interact with non-tRNA substrates and influence bacterial cell growth. Read More

View Article and Full-Text PDF
September 2021

Recent Developments Toward Integrated Metabolomics Technologies (UHPLC-MS-SPE-NMR and MicroED) for Higher-Throughput Confident Metabolite Identifications.

Front Mol Biosci 2021 2;8:720955. Epub 2021 Sep 2.

Division of Biochemistry, University of Missouri, Columbia, MO, United States.

Metabolomics has emerged as a powerful discipline to study complex biological systems from a small molecule perspective. The success of metabolomics hinges upon reliable annotations of spectral features obtained from MS and/or NMR. In spite of tremendous progress with regards to analytical instrumentation and computational tools, < 20% of spectral features are confidently identified in most untargeted metabolomics experiments. Read More

View Article and Full-Text PDF
September 2021

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer.

Front Mol Biosci 2021 1;8:649395. Epub 2021 Sep 1.

Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland.

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Read More

View Article and Full-Text PDF
September 2021

Transcriptome analysis reveals gene expression differences in exposed to combined heat and abamectin exposure.

PeerJ 2021 31;9:e12064. Epub 2021 Aug 31.

Yangzhou University, College of Horticulture and Plant Protection & Institute of Applied Entomology, Yangzhou, China.

is an invasive pest of horticultural and vegetable crops that possesses robust competitive advantages that enable it to replace closely-related species. High temperatures often occur concomitantly with insecticide usage during outbreaks. In this study, we compared the transcriptomes of exposed to high temperature (40 °C T40), insecticide (LC of technical grade abamectin, I50) and combined high temperature and abamectin exposure (IT5040, I50 followed by T40; and TI4050, T40 followed by I50). Read More

View Article and Full-Text PDF

Task-Oriented Intelligent Solution to Measure Parkinson's Disease Tremor Severity.

J Healthc Eng 2021 10;2021:9624386. Epub 2021 Sep 10.

School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK.

Tremor is a common symptom of Parkinson's disease (PD). Currently, tremor is evaluated clinically based on MDS-UPDRS Rating Scale, which is inaccurate, subjective, and unreliable. Precise assessment of tremor severity is the key to effective treatment to alleviate the symptom. Read More

View Article and Full-Text PDF
September 2021

An integrated analysis of enhancer RNAs in glioma and a validation of their prognostic values.

Am J Transl Res 2021 15;13(8):8611-8631. Epub 2021 Aug 15.

Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou 510080, Guangdong Province, P. R. China.

Glioma, a highly aggressive neuroepithelial malignant brain tumor, is associated with high disability and recurrence rates. Enhancer RNA (eRNA) plays a significant role in tumor proliferation and metastasis; however, their functions in gliomas need further evaluation. We used the computational pipeline, PreSTIGE, to predict tissue-specific enhancer-derived RNAs and the underlying regulatory genes. Read More

View Article and Full-Text PDF

spp.: A Review on Phytochemical Composition, Biological Activity, and Health-Promoting Effects.

Oxid Med Cell Longev 2021 7;2021:4014867. Epub 2021 Sep 7.

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Cyperaceae are a plant family of grass-like monocots, comprising 5600 species with a cosmopolitan distribution in temperate and tropical regions. Phytochemically, is one of the most promising health supplementing genera of the Cyperaceae family, housing ≈950 species, with L. being the most reported species in pharmacological studies. Read More

View Article and Full-Text PDF
September 2021

Optimization Algorithm of Tourism Security Early Warning Information System Based on Long Short-Term Memory (LSTM).

Lei Feng Yukai Hao

Comput Intell Neurosci 2021 8;2021:9984003. Epub 2021 Sep 8.

School of Management, Wuhan University of Technology, Wuhan 400070, China.

Tourism safety is the focus of the tourism industry. It is not only related to the safety of tourists' lives and property, but also related to social stability and sustainable development of the tourism industry. However, the security early warning of many scenic spots focuses on the response measures and remedial plans after the occurrence of security incidents, and the staff of many scenic spots have limited security awareness and information analysis ability, which is prone to lag in information release, and do not pay attention to the information of potential security problems. Read More

View Article and Full-Text PDF
September 2021

Humor of the Leader: A Source of Creativity of Employees Through Psychological Empowerment or Unethical Behavior Through Perceived Power? The Role of Self-Deprecating Behavior.

Front Psychol 2021 3;12:635300. Epub 2021 Sep 3.

Institute of Business and Management, University of Engineering and Technology, Lahore, Pakistan.

Although we use humor in our daily communication, there still needs to cognize its effects on the attitudes and behavior of the employees. Based on benign violation theory (BVT), the study proposes that leader's humor (LH) conveys social information about counter norms. The BVT has been amalgamated with social information processing theory (SIPT) to develop hypotheses assuming the consequences of LH on the attitude and behavior of the employees. Read More

View Article and Full-Text PDF
September 2021

Multi-Modal Pain Intensity Assessment Based on Physiological Signals: A Deep Learning Perspective.

Front Physiol 2021 1;12:720464. Epub 2021 Sep 1.

Institute of Neural Information Processing, Ulm University, Ulm, Germany.

Traditional pain assessment approaches ranging from self-reporting methods, to observational scales, rely on the ability of an individual to accurately assess and successfully report observed or experienced pain episodes. Automatic pain assessment tools are therefore more than desirable in cases where this specific ability is negatively affected by various psycho-physiological dispositions, as well as distinct physical traits such as in the case of professional athletes, who usually have a higher pain tolerance as regular individuals. Hence, several approaches have been proposed during the past decades for the implementation of an autonomous and effective pain assessment system. Read More

View Article and Full-Text PDF
September 2021

Clinically-Driven Virtual Patient Cohorts Generation: An Application to Aorta.

Front Physiol 2021 1;12:713118. Epub 2021 Sep 1.

Computational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.

The combination of machine learning methods together with computational modeling and simulation of the cardiovascular system brings the possibility of obtaining very valuable information about new therapies or clinical devices through experiments. However, the application of machine learning methods demands access to large cohorts of patients. As an alternative to medical data acquisition and processing, which often requires some degree of manual intervention, the generation of virtual cohorts made of synthetic patients can be automated. Read More

View Article and Full-Text PDF
September 2021

Fiber Clustering Acceleration With a Modified Kmeans++ Algorithm Using Data Parallelism.

Front Neuroinform 2021 1;15:727859. Epub 2021 Sep 1.

Department of Computer Science, Universidad de Concepción, Concepción, Chile.

Fiber clustering methods are typically used in brain research to study the organization of white matter bundles from large diffusion MRI tractography datasets. These methods enable exploratory bundle inspection using visualization and other methods that require identifying brain white matter structures in individuals or a population. Some applications, such as real-time visualization and inter-subject clustering, need fast and high-quality intra-subject clustering algorithms. Read More

View Article and Full-Text PDF
September 2021

Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles.

Front Mol Neurosci 2021 3;14:741895. Epub 2021 Sep 3.

Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.

The central nucleus of the amygdala (CeA) and the lateral division of the bed nucleus of the stria terminalis (BNST) are the two major nuclei of the central extended amygdala that plays essential roles in threat processing, responsible for emotional states such as fear and anxiety. While some studies suggested functional differences between these nuclei, others showed anatomical and neurochemical similarities. Despite their complex subnuclear organization, subnuclei-specific functional impact on behavior and their underlying molecular profiles remain obscure. Read More

View Article and Full-Text PDF
September 2021

Aberrant Intraregional Brain Activity and Functional Connectivity in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

Front Neurosci 2021 3;15:721822. Epub 2021 Sep 3.

Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Background And Purpose: The appearance and aggravation of diarrhea-predominant irritable bowel syndrome (IBS-D) have proven to be closely related to psychosocial factors. We aimed to measure altered spontaneous brain activity and functional connectivity (FC) in patients with IBS-D using resting-state functional magnetic resonance imaging (RS-fMRI) and to analyze the relationship between these parameters and emotional symptoms.

Methods: Thirty-six adult IBS-D patients and thirty-six demographic-matched healthy controls (HCs) underwent RS-fMRI scans. Read More

View Article and Full-Text PDF
September 2021