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Treatment of Surgical Scars with Combination Pulsed Dye and Fractional Nonablative Laser: A Randomized Controlled Trial.

Ann Surg 2022 Jan 25. Epub 2022 Jan 25.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern Feinberg School of Medicine, Chicago, IL, USA Department of Otolaryngology, Feinberg School of Medicine, Northwestern University, Chicago, IL Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objective: To assess the effectiveness and safety of combined pulsed-dye laser (PDL) and nonablative fractional laser (NAFL) for treatment of surgical scars.

Summary Background Data: PDL and NAFL have not been compared to healing by time alone.

Methods: Randomized controlled, single-blinded clinical trial at an urban, university hospital. Read More

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January 2022

Semi-automated quantification of hair cells in the mature mouse utricle.

Hear Res 2022 Jan 14;416:108429. Epub 2022 Jan 14.

Laboratory of Hearing Biology and Therapeutics, National Institute on Deafness and Other Communication Disorders (NIDCD), NIH, Bethesda, Maryland, USA. Electronic address:

The mouse utricle model system is the best-characterized ex vivo preparation for studies of mature mammalian hair cells (HCs). Despite the many advantages of this model system, efficient and reliable quantification of HCs from cultured utricles has been a persistent challenge with this model system. Utricular HCs are commonly quantified by counting immunolabeled HCs in regions of interest (ROIs) placed over an image of the utricle. Read More

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January 2022

[Congenital anomalies from the perspective of social determinants of health].

Cad Saude Publica 2022 7;38(1):e00037021. Epub 2022 Jan 7.

Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Brasil.

The objective of this study was to analyze factors associated with cases of congenital anomalies from the perspective of social determinants of health in the State of Rio Grande do Sul, Brazil. This is a case-control study with all the pairs of mothers and liveborn infants from 2012 to 2015 in the state, based on the total number of liveborn infants with congenital anomalies (5,250) and a random sample of 21,000 without congenital anomalies, according to data on the live birth certificates. The statistical analyses included chi-square tests and logistic regression models with SPSS. Read More

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January 2022

Can women's 3E index impede short birth interval? evidence from Bangladesh Demographic and Health Survey, 2017-18.

PLoS One 2022 26;17(1):e0263003. Epub 2022 Jan 26.

Department of Statistics, University of Dhaka, Dhaka, Bangladesh.

Background: Women's empowerment, education, and economic status are jointly introduced as women's 3E. A number of studies found the significant association of these three variables with maternal health outcomes, but no studies, to the best of knowledge, have been found to justify the joint influence of women's 3E on the birth interval. As several studies have revealed that the short birth interval increases the risk of adverse maternal, perinatal, and infant outcomes and it is also responsible for increasing the country's population size, more research is needed on the birth interval. Read More

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January 2022

Characterization of the cell-mediated immune response to Takeda's live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting.

Vaccine 2022 Jan 22. Epub 2022 Jan 22.

Takeda Vaccines Inc., Cambridge, MA, USA.

Background: As robust dengue-specific CD4+ and CD8+ T cell responses are essential for protective immunity, we assessed cell-mediated immune (CMI) responses to a DENV-2-based dengue tetravalent vaccine candidate (TAK-003) in adolescents living in Panama, a dengue-endemic country.

Methods: Peripheral blood mononuclear cells were collected from a subset of 67 participants ≥ 10 years old included in a phase 2 clinical trial of TAK-003 (Clinicaltrials.gov: NCT02302066). Read More

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January 2022

Disparities in dental health issues and oral health care visits in US children with tobacco smoke exposure.

J Am Dent Assoc 2022 Jan 22. Epub 2022 Jan 22.

Background: The objective of the authors was to assess the relationships between tobacco smoke exposure (TSE) and dental health and dental care visits among US children.

Methods: The authors examined 2018-2019 National Survey of Children's Health data on TSE, dental health, and oral health care visits. Children aged 1 through 11 years (N = 32,214) were categorized into TSE groups: no home TSE (did not live with a smoker), thirdhand smoke (THS) exposure (lived with a smoker who did not smoke inside the home), or secondhand smoke (SHS) and THS exposure (lived with a smoker who smoked inside the home). Read More

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January 2022

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation.

Breast Cancer Res 2022 Jan 25;24(1). Epub 2022 Jan 25.

Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane, QLD, 4102, Australia.

Background: Triple-negative breast cancers (TNBC) have a relatively poor prognosis and responses to targeted therapies. Between 25 and 39% of TNBCs are claudin-low, a poorly differentiated subtype enriched for mesenchymal, stem cell and mitogen-activated signaling pathways. We investigated the role of the cell-surface co-receptor NRP1 in the biology of claudin-low TNBC. Read More

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January 2022

Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor.

Xenobiotica 2022 Jan 26:1-18. Epub 2022 Jan 26.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

The objective of this study was to clarify the species differences of metabolic stability of E28 in liver microsomes, and to study metabolic phenotypes of E28 in human liver microsomes by chemical inhibition method.The metabolites in plasma, urine, and feces samples from mice received caudal vein intravenous were detected and identified by UHPLC-HRMS, and the tissue distribution was studied after oral administration.E28 was metabolized rapidly in liver microsomes of each species with a short half-live T and a moderate clearance, except for rats. Read More

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January 2022

Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes.

J R Soc Interface 2022 Jan 26;19(186):20210734. Epub 2022 Jan 26.

Donald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Intravitreal (ITV) drug delivery is a new cornerstone for retinal therapeutics. Yet, predicting the disposition of formulations in the human eye remains a major translational hurdle. A prominent, but poorly understood, issue in pre-clinical ITV toxicity studies is unintended particle movements to the anterior chamber (AC). Read More

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January 2022

A comparison of the age at first calving of contract-reared versus home-reared replacement dairy heifers.

Theriogenology 2022 Jan 19;181:105-112. Epub 2022 Jan 19.

School of Veterinary Medicine, University College, Belfield, Dublin 4, D04W6F6, Ireland.

Recent rapid expansion and increased specialisation of dairy industries internationally has prompted growing interest in collaborative farming enterprises such as contract-rearing of replacement heifers. While contract-rearing provides obvious benefits to dairy farmers intending to expand their herd, it may adversely impact heifer reproductive performance as the farmer no longer manages the heifers on a day-to-day basis. Hence, the objective of this study was to determine if contract-rearing impacted heifer reproductive performance and ultimately achievement of the industry target age at first calving (AFC) of 24 months. Read More

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January 2022

The effects of early pregnancy loss on health outcomes and health care utilization and costs.

Health Serv Res 2022 Jan 25. Epub 2022 Jan 25.

College of Nursing & Department of Obstetrics, Gynecology and Reproductive Sciences, College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.

Objective: To evaluate the effects of early pregnancy loss on subsequent health care use and costs.

Data Sources: Linked administrative health databases from Manitoba, Canada.

Study Design: This was a population-based cohort study. Read More

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January 2022

Mycobacterium bovis bacille Calmette-Guerin-derived extracellular vesicles as an alternative to live BCG immunotherapy.

Clin Exp Med 2022 Jan 25. Epub 2022 Jan 25.

Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.

For over 40 years, the gold standard treatment for non-muscular invasive bladder cancer (NMIBC) has been repeated administration of Mycobacterium bovis bacille Calmette-Guerin (BCG). Upon administration, BCG initiates a cascade of immunological events that lead to the recruitment of immune cells to the bladder that eliminates NMIBC cells in a multi-mechanistic, yet incompletely defined manner. Despite its effectiveness, live BCG immunotherapy is often impacted by limited supply and availability and can cause rare but serious side effects. Read More

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January 2022

Designing and interpreting 4D tumour spheroid experiments.

Commun Biol 2022 Jan 24;5(1):91. Epub 2022 Jan 24.

Mathematical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.

Tumour spheroid experiments are routinely used to study cancer progression and treatment. Various and inconsistent experimental designs are used, leading to challenges in interpretation and reproducibility. Using multiple experimental designs, live-dead cell staining, and real-time cell cycle imaging, we measure necrotic and proliferation-inhibited regions in over 1000 4D tumour spheroids (3D space plus cell cycle status). Read More

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January 2022

Live imaging of micro and macro wettability variations of carbonate oil reservoirs for enhanced oil recovery and CO trapping/storage.

Sci Rep 2022 Jan 24;12(1):1262. Epub 2022 Jan 24.

Skolkovo Institute of Science and Technology, 121205, Moscow, Russia.

Carbonate hydrocarbon reservoirs are considered as potential candidates for chemically enhanced oil recovery and for CO geological storage. However, investigation of one main controlling parameter-wettability-is usually performed by conventional integral methods at the core-scale. Moreover, literature reports show that wettability distribution may vary at the micro-scale due to the chemical heterogeneity of the reservoir and residing fluids. Read More

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January 2022

Trends in Characteristics and Outcomes of Peripartum Cardiomyopathy Hospitalizations in the United States Between 2004 and 2018.

Am J Cardiol 2022 Jan 21. Epub 2022 Jan 21.

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Data are limited on contemporary temporal trends in maternal characteristics and outcomes in hospitalized patients with peripartum cardiomyopathy (PC). We used the National Inpatient Sample database from January 1, 2004, to December 31, 2018, to identify PC hospitalizations in women aged 15 to 54 years. Weighted survey data were used to derive national estimates for the United States population and examine trends. Read More

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January 2022

Association between hypertensive disorders of pregnancy and later risk of cardiovascular outcomes.

BMC Med 2022 Jan 25;20(1):19. Epub 2022 Jan 25.

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England, UK.

Background: Hypertensive disorders of pregnancy are common pregnancy complications that are associated with greater cardiovascular disease risk for mothers. However, risk of cardiovascular disease subtypes associated with gestational hypertension or pre-eclampsia is unclear. The present study aims to compare the risk of cardiovascular disease outcomes for women with and without a history of gestational hypertension and pre-eclampsia using national hospital admissions data. Read More

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January 2022

A biomimetic remora disc with tunable, reversible adhesion for surface sliding and skimming.

Bioinspir Biomim 2022 Jan 24. Epub 2022 Jan 24.

Mechanical Engineering and Automation, Beihang University, 412, International Research Center, Beihang University, 37 Xueyuan Street, HaiDian District, Beijing, Beijing, 100083, CHINA.

Remora suckerfish (Echeneis naucrates) can perform skimming and sliding motions on the surfaces of moving hosts to optimize adhesion positions. We found that remora achieve skimming and sliding motions through coordinated movement of the suction disc's lamellae and lip locomotion through live animal observations. We implemented an integrated biomimetic remora suction disc based on morphological and kinematic data of biological remoras. Read More

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January 2022

Experience with direct oral anticoagulants in pregnancy - a systematic review.

J Perinat Med 2022 Jan 24. Epub 2022 Jan 24.

Centre of Investigation in Environment, Genetics and Oncobiology (Cimago), Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Objectives: The experience and use of the new direct oral anti coagulants (DOACs) in pregnancy is limited, but as they offer many practical advantages compared to low molecular weight heparin (LMWH), the pursue of their safety is challenging.

Methods: Systematic review of studies in which DOACs were used during pregnancy and the puerperal period (PROSPERO registry-CRD42021237688). Searches were performed on MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases, until July 2021 and secondary sources using the MeSH terms 'pregnancy', 'pregnancy complications', 'venous thrombosis', 'congenital abnormalities', 'Factor Xa Inhibitors,' and names of specific DOACs. Read More

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January 2022

Peripheral mitochondrial DNA, telomere length and DNA methylation as predictors of live birth in in vitro fertilization cycles.

PLoS One 2022 24;17(1):e0261591. Epub 2022 Jan 24.

Dept of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.

Objective: To evaluate whether telomere length (TL), mitochondrial-DNA (mt-DNA) or epigenetic age estimators based on DNA methylation (DNAm) pattern could be considered reliable predictors of in-vitro-fertilization (IVF) success in terms of live birth rate.

Design: Prospective cohort study.

Setting: Infertility Unit of the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. Read More

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January 2022

Endometrioma and assisted reproductive technology: a review.

J Assist Reprod Genet 2022 Jan 24. Epub 2022 Jan 24.

Department of Obstetrics and Gynecology, The George Washington University Hospital, Washington, DC, USA.

Purpose: Endometriomas are a common cause of infertility necessitating assisted reproductive technology (ART). It had been previously thought that surgical removal of the endometriomas prior to ART would improve reproductive outcomes, but recent data suggests that surgical cystectomy might affect the ovarian reserve, decreasing the chances of ART success. The aim of this article is to review the literature on the effects of endometrioma surgery on ART outcomes providing an overview of the current evidence and assessing the need for further studies. Read More

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January 2022

The Smarter Safer Homes Solution to Support Older People Living in Their Own Homes Through Enhanced Care Models: Protocol for a Stratified Randomized Controlled Trial.

JMIR Res Protoc 2022 Jan 24;11(1):e31970. Epub 2022 Jan 24.

Australian eHealth Research Centre, Commonwealth Scientific and Industrial Research Organisation, Herston, Australia.

Background: An aging population, accompanied by the prevalence of age-related diseases, presents a significant burden to health systems. This is exacerbated by an increasing shortage of aged care staff due to the existing workforce entering their retirement and fewer young people being attracted to work in aged care. In line with consumer preferences and potential cost-efficiencies, government and aged care providers are increasingly seeking options to move care and support to the community or home as opposed to residential care facilities. Read More

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January 2022

Prenatal diagnosis of pure 1p36 terminal deletion by chromosome microarry analysis - clinical report of 3 new cases and review of the literature.

Ginekol Pol 2022 Jan 24. Epub 2022 Jan 24.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Air Force Medical University, China.

Objectives: Our objective was to present the experience on prenatal diagnosis of 1p36 terminal deletion, and further delineated the fetal presentation of the syndrome.

Material And Methods: This was a retrospective analysis of three new prenatal cases with pure 1p36 terminal deletion detected by chromosome microarray analysis (CMA) at a single Chinese medical center. We also reviewed 11 published prenatal cases with similar deletion sizes. Read More

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January 2022

The value of LH supplementation in young women with diminished ovarian reserve treated with GnRH Antagonist Protocol for ovarian hyperstimulation in ICSI-cycles.

Ginekol Pol 2022 Jan 24. Epub 2022 Jan 24.

IVF Clinic of the University of Health Sciences School of Medicine, Etlik Zubeyde Hanım Research and Training Hospital, Ankara, Turkey, Turkey.

Objectives: To compare the success of two controlled ovarian hyperstimulation protocols; rFSH + hp-hMG with only rFSH in the GnRH antagonist protocol in diminished ovarian reserve under 35 years of age.

Material And Methods: Data from January 2015 to June 2019 were abstracted from the hospital records of IVF Clinic. The women younger than 35 years of age who were diagnosed as diminished ovarian reserve and underwent standard GnRH antagonist protocol were included. Read More

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January 2022

Hydrochloric acid-treated ghosts induce IL-1 beta, IL-6, and TNF-alpha in murine macrophage.

Mol Cell Toxicol 2022 Jan 18:1-10. Epub 2022 Jan 18.

Department of Biology and Medicinal Science, Pai Chai University, Daejeon, Republic of Korea.

Background: Bacterial ghosts (BGs) are empty cell envelopes commonly generated using Gram-negative bacteria; they represent a potential platform for efficient adjuvant and vaccine delivery systems. However, the efficient production of BGs from bacteria in a short period of time is challenging.

Objective: The purpose of this study was to investigate the possibility of producing BGs in the Gram-positive using various chemicals, and the potential application of BGs as a novel immunomodulatory agent. Read More

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January 2022

An image dataset of cleared, x-rayed, and fossil leaves vetted to plant family for human and machine learning.

PhytoKeys 2021 16;187:93-128. Epub 2021 Dec 16.

Department of Geosciences and Earth and Environmental Systems Institute, Pennsylvania State University, University Park, PA 16802, USA Pennsylvania State University University Park United States of America.

Leaves are the most abundant and visible plant organ, both in the modern world and the fossil record. Identifying foliage to the correct plant family based on leaf architecture is a fundamental botanical skill that is also critical for isolated fossil leaves, which often, especially in the Cenozoic, represent extinct genera and species from extant families. Resources focused on leaf identification are remarkably scarce; however, the situation has improved due to the recent proliferation of digitized herbarium material, live-plant identification applications, and online collections of cleared and fossil leaf images. Read More

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December 2021

Effect of orlistat intervention on fertilization/intracytoplasmic sperm injection outcome in overweight/obese infertile women.

Gynecol Endocrinol 2022 Jan 24:1-5. Epub 2022 Jan 24.

Center for Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: This retrospective study sought to evaluate the effect of orlistat intervention on the outcome of fertilization/intracytoplasmic sperm injection (IVF/ICSI) in overweight/obese infertile women.

Methods: Twenty-nine overweight/obese patients undergoing IVF/ICSI for the first time were treated with orlistat intervention (orlistat group). Another 29 patients with matched age and body mass index (BMI) were included in the control group at a ratio of 1:1. Read More

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January 2022

Retrospective Assessment of Vaccination in Broiler Turkeys Under Field Conditions in 37 Farms from Brittany (France).

Avian Dis 2021 Dec;65(4):659-662

Zoetis, Bâtiment VIVA, 10, Rue Raymond David, 92240 Malakoff, France,

Colibacillosis is a common bacterial disease in broiler production worldwide. It is emerging as a serious health concern in turkey production. Until recently, the disease was managed through antimicrobial therapy. Read More

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December 2021

A Nurse Practitioner service designed to address the health needs of children living in housing instability: A non-randomised, concurrent mixed methods study protocol.

J Adv Nurs 2022 Jan 23. Epub 2022 Jan 23.

College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia.

In 2019-2020 we conducted a pilot study of a Nurse Practitioner clinic working with housing insecure children (0-18 years) that found high levels of developmental delay, missed immunizations and dental caries. This present non-randomized, concurrent mixed-methods study protocol explains the next phase of the research designed proving proof of concept for a Nurse Practitioner model of care for these vulnerable children. Focusing on identifying and understanding clinic admission processes, tracking referral pathways and uptake, and how many vulnerable children miss potential care and why. Read More

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January 2022

Impacts of the Affordable Care Act's Medicaid expansion on live births.

Epidemiology 2022 Jan 21. Epub 2022 Jan 21.

Department of Epidemiology & Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan Harris School of Public Policy, University of Chicago, Chicago, Illinois.

Background: We hypothesize that the Affordable Care Act's (ACA) Medicaid expansion, which extended health insurance coverage to pre-conception, between-conception, and post-conception periods for women meeting income eligibility guidelines, impacted the number of live births in the US, by increasing access to contraception and financial wellbeing. These impacts may differ by maternal socioeconomic and demographic characteristics.

Methods: Using data from birth certificates aggregated to the state-year level and a difference-in-differences design, we estimated the association between Medicaid expansion and count of live births. Read More

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January 2022

Redescription and phylogenetic position of the terrestrial ciliates Gastrostylides dorsicirratus and Heterourosomoida lanceolata (Hypotricha, Dorsomarginalia).

Eur J Protistol 2021 Dec 16;82:125859. Epub 2021 Dec 16.

College of Resources and Environmental Sciences, Gansu Agricultural University, Lanzhou 730070, China; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China. Electronic address:

The morphology and infraciliature of two soil hypotrichous ciliates, Heterourosomoida lanceolata (Shibuya, 1930) Singh and Kamra, 2015 and Gastrostylides dorsicirratus (Foissner, 1982) Foissner, 2016, were investigated using live observation and protargol staining. The Chinese population of H. lanceolata differs slightly from other populations in the body size in vivo, the relative length of the adoral zone, the number of right and left marginal cirri, the total number of dorsal bristles, and the number of micronuclei. Read More

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December 2021