2,211,966 results match your criteria data analyses

Distinct Prognostic Factors in Sporadic and Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors.

Horm Metab Res 2021 Apr 20. Epub 2021 Apr 20.

Division of Endocrinology and Metabolism, Sheba Medical Center at Tel Hashomer, Tel Hashomer, Israel.

Pancreatic neuroendocrine tumors (PNET) may develop sporadically or in the context of hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is the leading cause of death. Our aim was to compare the mortality risk in sporadic and MEN1-related PNETs and identify high-risk populations. Read More

View Article and Full-Text PDF

Clinical and Demographic Risk Factors for COVID-19 during Delivery Hospitalizations in New York City.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Maternal-Fetal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York.

Objective:  This study was aimed to review 4 weeks of universal novel coronavirus disease 2019 (COVID-19) screening among delivery hospitalizations, at two hospitals in March and April 2020 in New York City, to compare outcomes between patients based on COVID-19 status and to determine whether demographic risk factors and symptoms predicted screening positive for COVID-19.

Study Design:  This retrospective cohort study evaluated all patients admitted for delivery from March 22 to April 18, 2020, at two New York City hospitals. Obstetrical and neonatal outcomes were collected. Read More

View Article and Full-Text PDF

Twin Vaginal Deliveries in Labor Rooms: A Cost-Effectiveness Analysis.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Objective:  Twin vaginal deliveries (VDs) are often performed in the operating room (OR) given the theoretical risk of conversion to cesarean delivery (CD) for the aftercoming twin. We aim to evaluate the cost-effectiveness of performing VDs for twin gestations in the labor and delivery room (LDR) versus OR.

Study Design:  We conducted a cost-effectiveness analysis using a decision-analysis model that compared the costs and effectiveness of two strategies of twin deliveries undergoing a trial of labor: (1) intended delivery in the LDR and 2) delivery in the OR. Read More

View Article and Full-Text PDF

Latency Period after Preterm Premature Rupture of Membranes: Singletons versus Twins.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, New York Presbyterian Hospital-Columbia University Irving Medical Center, New York, New York.

Objective:  Several studies have evaluated the differences in duration of latency and clinical outcomes between singleton and twin pregnancies after preterm premature rupture of membranes (PPROM); however, these data are limited to single-institution analyses and based on small sample sizes. The aim of this study was to assess differences in latency and clinical outcomes in singletons versus twin gestations affected by PPROM in a large, diverse cohort of women.

Study Design:  This is a secondary analysis of a multicenter trial of magnesium for neuroprotection in women at high risk of preterm birth. Read More

View Article and Full-Text PDF

Comparison of Maternal and Neonatal Subspecialty Care Provision by Hospital.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.

Objective:  The aim of the study is to determine the relationship between a hospital's provision of subspecialty neonatal and maternal care. Specifically, we sought to understand where women with high-risk maternal conditions received intrapartum care and estimate the potential transfer burden for those with maternal high-risk conditions delivering at hospitals without subspecialty maternal care.

Study Design:  This is a descriptive study using data from 2015 State Inpatient Databases and the American Hospital Association Annual Survey. Read More

View Article and Full-Text PDF

Association of Rural and Frontier Residence with Very Preterm and Very Low Birth Weight Delivery in Nonlevel III NICUs.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado.

Objective:  Delivery of very preterm and very low birth weight neonates (VPT/VLBW) in a nonlevel III neonatal intensive care unit (NICU) increases risk of morbidity and mortality. Study objectives included: (1) Determine incidence of VPT/VLBW delivery (<32 weeks gestational age and/or birth weight <1,500 g), in nonlevel III units in Colorado; (2) Evaluate the independent association between residence and nonlevel III unit delivery; (3) Determine the incidence of and factors associated with postnatal transfer.

Study Design:  This retrospective cohort study used 2007 to 2016 Colorado birth certificate data. Read More

View Article and Full-Text PDF

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma.

Aging (Albany NY) 2021 Apr 20;13. Epub 2021 Apr 20.

Department of Science and Education, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen, China.

The occurrence of portal vein tumor thrombus (PVTT) is strongly correlated to the staging and poor prognosis of hepatocellular carcinoma (HCC) patients. However, the mechanisms of PVTT formation remain unclear. This study aimed to investigate differentially expressed genes (DEGs) between primary tumor (PT) and PVTT tissues and comprehensively explored the underlying mechanisms of PVTT formation. Read More

View Article and Full-Text PDF

Impact of geology and anthropogenic activities over the water quality with emphasis on fluoride in water scarce Lalitpur district of Bundelkhand region, India.

Chemosphere 2021 Apr 5;279:130496. Epub 2021 Apr 5.

Groundwater Department WAPCOS, New Delhi, India.

The Bundelkhand region of India is suffering from acute water scarcity, raising concern over the potability in the region. Therefore, to develop a baseline data set of groundwater quality, sampling was carried out from the 110 existing shallow hand pumps and tube wells covering the Lalitpur district. Groundwater samples were investigated for hydro-geochemical and isotopic signatures (δO and δH) to understand the driving factors leading to water quality and its contamination in the region. Read More

View Article and Full-Text PDF

Associations of urinary bisphenol A and its alternatives bisphenol S and F concentrations with depressive symptoms among adults.

Chemosphere 2021 Apr 14;279:130573. Epub 2021 Apr 14.

Department of Epidemiology and Health Statistics, The College of Public Health of Qingdao University, Qingdao, Shandong, 266071, China; Municipal Centre of Disease Control and Prevention of Qingdao, Qingdao Institute of Prevention Medicine, Qingdao, Shandong, 266034, China. Electronic address:

Background: Bisphenol S (BPS) and bisphenol F (BPF), as substitutes for bisphenol A (BPA), are synthetic compounds detected increasingly frequently in plastics and resins. BPA, BPS, and BPF are endocrine disruptors with unclear effects on depressive symptoms. This study aims to evaluate the effects of these compounds on depressive symptoms in adults. Read More

View Article and Full-Text PDF

"Gummy Bears" and "Teddy Grahams": Ultrasounds as religious biopower in Crisis Pregnancy Centers.

Kendra Hutchens

Soc Sci Med 2021 Apr 17;277:113925. Epub 2021 Apr 17.

Department of Sociology, University of Colorado-Boulder, 327 UCB, Boulder, CO, 80309-0327, USA. Electronic address:

Scholars, activists, and medical professionals critique Crisis Pregnancy Centers (CPCs) for disseminating medical misinformation and deceptive counseling practices. Yet much of the scholarship examining CPC's counseling and medical practices relies upon discourse analyses or surreptitious approaches. I use observational data from client appointments in an evangelical CPC in the U. Read More

View Article and Full-Text PDF

Tuberculosis in Myasthenia Gravis patients on immunosuppressive therapy in a high-risk area: Implications for preventative therapy.

J Neurol Sci 2021 Apr 17;425:117447. Epub 2021 Apr 17.

Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Neurology Research Group, UCT Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Electronic address:

Data regarding the risk of tuberculosis (TB) in myasthenia gravis (MG) patients receiving immunosuppressive therapy is limited, and the benefit of TB preventative therapy in these patients is uncertain. We audited observational data collected at an MG clinic in South Africa over a ~ 10-year period, of cases who received immunosuppressive therapy. The total time that the cohort was at risk (patient-years) was used as the denominator to calculate TB incidence after immunosuppressive therapy initiation. Read More

View Article and Full-Text PDF

Responses to Navon tasks differ across development and between tasks with differing attentional demands.

Vision Res 2021 Apr 17;185:17-28. Epub 2021 Apr 17.

School of Psychology, University of Surrey, Guildford, Surrey GU2 7HX, UK.

Navon hierarchical stimuli are designed to measure responses to the global level (grouped local elements, e.g. a forest) and the local level (individuated local elements, e. Read More

View Article and Full-Text PDF

The cost of living with cancer during the second wave of COVID-19: A mixed methods study of Danish cancer patients' perspectives.

Eur J Oncol Nurs 2021 Apr 17;52:101958. Epub 2021 Apr 17.

Research Unit of Oncology, The Academy of Geriatric Cancer Research (www.agecare.org), Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, DK-5000 Odense C, Denmark.

Purpose: This study investigated experiences and levels of distress and resilience of Danish cancer patients during the second wave of the COVID-19 pandemic.

Methods: The mixed methods design included a subset of cancer patients who responded to a cross-sectional survey in May 2020. Data were collected through telephone interviews. Read More

View Article and Full-Text PDF

Evaluation of Promega PowerSeq™ Auto/Y systems prototype on an admixed sample of Rio de Janeiro, Brazil: Population data, sensitivity, stutter and mixture studies.

Forensic Sci Int Genet 2021 Apr 6;53:102516. Epub 2021 Apr 6.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Forensic DNA typing typically relies on the length-based (LB) separation of PCR products containing short tandem repeat loci (STRs). Massively parallel sequencing (MPS) elucidates an additional level of STR motif and flanking region variation. Also, MPS enables simultaneous analysis of different marker-types - autosomal STRs, SNPs for lineage and identification purposes, reducing both the amount of sample used and the turn-around-time of analysis. Read More

View Article and Full-Text PDF

Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China.

Environ Int 2021 Apr 17;154:106568. Epub 2021 Apr 17.

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Medical University, Tianjin 300070, China. Electronic address:

Background: While the relationship between ambient air pollution and diabetes mellitus has recently been reported, data on the association between fine particulate matter (PM) and diabetic complications are limited, especially in microvascular diseases such as diabetic retinopathy.

Objectives: To investigate the associations between long-term exposure to PM and the prevalence of diabetic retinopathy in adult diabetic patients in rural China.

Methods: The study population was based on the Rural Epidemiology for Glaucoma in China (REG-China), a national cross-sectional survey conducted in rural China. Read More

View Article and Full-Text PDF

A novel nomogram for predicting the risk of epilepsy occurrence after operative in gliomas patients without preoperative epilepsy history.

Epilepsy Res 2021 Apr 14;174:106641. Epub 2021 Apr 14.

Department of Radiotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China. Electronic address:

Objective: Epilepsy is a common complication in glioma patients after undergoing brain tumor surgery combined with chemotherapy and/or radiotherapy. Whether antiepileptic drug prophylaxis could be used in these patients remains an open question. The purpose of this study was to produce a model for predicting the risk of epilepsy occurrence in such patients. Read More

View Article and Full-Text PDF

Spectrofluorimetric analyzes of thiamine and riboflavin in monofloral honey varieties of africanized bees (Apis mellifera).

Food Chem 2021 Apr 9;357:129756. Epub 2021 Apr 9.

Department of Biological Chemistry, Regional University of Cariri, R. Cel. Antonio Luis 1161, 63105000 Crato, CE, Brazil.

This research aimed to study the validation of a viable and low-cost spectrofluorimetric method, capable of detecting and quantifying B vitamins in floral varieties of bee honey. The analyzes were performed using chemical and operational methods of pre-defined solutions and standards, performed in triplicate and the results expressed as mean ± standard deviation. The data were recorded in a Microsoft Office Excel spreadsheet (version 2013) and studied using the statistical program Bioestatic version 3. Read More

View Article and Full-Text PDF

Railroad accident analysis using extreme gradient boosting.

Accid Anal Prev 2021 Apr 17;156:106126. Epub 2021 Apr 17.

Upper Great Plains Transportation Institute, North Dakota State University, Fargo, ND, 58108, United States. Electronic address:

Railroads are critical to the economic health of a nation. Unfortunately, railroads lose hundreds of millions of dollars from accidents each year. Trends reveal that derailments consistently account for more than 70 % of the U. Read More

View Article and Full-Text PDF

Are we measuring the right function outcomes for older adults in reviews by the Cochrane Musculoskeletal Group?

Semin Arthritis Rheum 2021 Apr 3;51(3):523-529. Epub 2021 Apr 3.

Bruyere Research Institute, 43 Bruyère Street, Ottawa K1N 5C8, Ontario, Canada. Electronic address:

Background: Musculoskeletal conditions are the leading cause of years lived with disability for older adults. Limitations in functional ability affect healthy aging for aging populations worldwide. Thus, it is important to assess effects of interventions on the multiple dimensions of function for older adults. Read More

View Article and Full-Text PDF

Benefit of adjuvant chemotherapy in patients with lobular breast cancer: A systematic review of the literature and metanalysis.

Cancer Treat Rev 2021 Apr 9;97:102205. Epub 2021 Apr 9.

Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, Milan, Italy; Departement of Hematology and Oncology (DIPO), University of Milan, Milan, Italy. Electronic address:

The role of adjuvant chemotherapy (aCT) for patients with localized lobular breast cancer (ILC) is still controversial. It is unclear what is the magnitude of benefit of the CT in this setting. In this systematic review of the literature and metanalysis, we aimed to estimate the benefit of aCT in addition to the standard treatments in the early ILC setting. Read More

View Article and Full-Text PDF

Alberta Stroke Program Early CT Score Calculation Using the Deep Learning-Based Brain Hemisphere Comparison Algorithm.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105791. Epub 2021 Apr 17.

Department of Neurology, Saiseikai Kumamoto Hospital, Chikami 5-3-1, Minami-ku, Kumamoto, Japan. Electronic address:

Objectives: The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a promising tool for the evaluation of stroke expansion to determine suitability for reperfusion therapy. The aim of this study was to validate deep learning-based ASPECTS calculation software that utilizes a three-dimensional fully convolutional network-based brain hemisphere comparison algorithm (3D-BHCA).

Materials And Methods: We retrospectively collected head non-contrast computed tomography (CT) data from 71 patients with acute ischemic stroke and 80 non-stroke patients. Read More

View Article and Full-Text PDF

Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway.

Int Immunopharmacol 2021 Apr 17;97:107657. Epub 2021 Apr 17.

Department of Orthopedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Osteoarthritis (OA) is a common joint disease that takes joint degeneration or aging as its pathological basis, and joint swelling, pain or dysfunction as its main clinical manifestations. Decursin (DE), the major active component isolated from Angelica gigas Nakai, has been demonstrated to possess anti-inflammatory effect in many diseases. But, the specific physiological mechanism of DE on OA is not clear yet. Read More

View Article and Full-Text PDF

Silver(I)-mediated base pairing in DNA involving the artificial nucleobase 7,8-dihydro-8-oxo-1,N-ethenoadenine.

J Inorg Biochem 2021 Jan 27;219:111369. Epub 2021 Jan 27.

Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 28/30, 48149 Münster, Germany. Electronic address:

The artificial nucleobase 7,8-dihydro-8-oxo-1,N-ethenoadenine (X) was investigated with respect to its ability to engage in Ag(I)-mediated base pairing in DNA. Spectroscopic data indicate the formation of dinuclear X-Ag(I)-X homo base pairs and mononuclear X-Ag(I)-C base pairs (C, cytosine). Density functional theory calculations and molecular dynamics simulations indicate that the nucleobase changes from its lactam tautomeric form prior to the formation of the Ag(I)-mediated base pair to the lactim form after the incorporation of the Ag(I) ions. Read More

View Article and Full-Text PDF
January 2021

Identification and validation of autophagy-related prognostic signature for head and neck squamous cell carcinoma.

Transl Oncol 2021 Apr 17;14(7):101094. Epub 2021 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China. Electronic address:

Background: Many studies have demonstrated that autophagy plays a significant role in regulating tumor growth and progression. However, the effect of autophagy-related genes (ARGs) on the prognosis have rarely been analyzed in head and neck squamous cell carcinoma (HNSCC).

Methods: We obtained differentially expressed ARGs from HNSCC mRNA data in The Cancer Genome Atlas (TCGA) database. Read More

View Article and Full-Text PDF