2,075,921 results match your criteria data analysis


Ferroptosis-related gene model to predict overall survival of papillary thyroid carcinoma.

Am J Otolaryngol 2021 Jul 26;42(6):103163. Epub 2021 Jul 26.

Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Electronic address:

Background: Ferroptosis is a form of programmed cell death that is closely associated with the development of various tumors. However, the correlation between ferroptosis and papillary thyroid carcinoma (PTC) is unclear. This study was performed to investigate the expression and prognostic value of ferroptosis-related genes (FRG) in PTC. Read More

View Article and Full-Text PDF

Radiomics and functional imaging in lung cancer: the importance of radiological heterogeneity beyond FDG PET/CT and lung biopsy.

Eur J Radiol 2021 Jul 27;142:109874. Epub 2021 Jul 27.

Department of Surgical Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital Via di Grottarossa 1035-1039 00189 Rome, Italy. Electronic address:

Purpose: [F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET/CT) has a central role in the lung nodules' characterization even if, with SUV < 2.5, percutaneous CT-guided Lung Biopsy (CTLB) is needed to assess nodule nature. In that scenario, CT Texture Analysis (CTTA) could be a non-invasive imaging biomarker. Read More

View Article and Full-Text PDF

Investigating the medicinal potential, material basis and mechanism of Polygoni Orientalis Fructus based on multi-technology integrated network pharmacology.

Phytomedicine 2021 Jul 25;91:153685. Epub 2021 Jul 25.

Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, College of Health Sciences, School of Life Science, Jiangsu Normal University, Xuzhou, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. Electronic address:

Background: Polygoni Orientalis Fructus (POF) refers to the dried ripe fruit of Polygonum orientale L. which has a long historical application in clinic for treatment of various conditions in China. However, its chemical constituents, pharmacological effects and their coupled correlation have not been intensively investigated. Read More

View Article and Full-Text PDF

Comparison of Y SIRT predicted and delivered absorbed doses using a PSF conversion method.

Phys Med 2021 Jul 30;89:1-10. Epub 2021 Jul 30.

Joint Department of Physics, Royal Marsden NHSFT, Sutton, United Kingdom; The Institute of Cancer Research, London, United Kingdom.

Purpose: The aims of this study were to develop and apply a method to correct for the differences in partial volume effects of pre-therapy Technetium-99 m (Tc)-MAA SPECT and post-therapy Yttrium-90 (Y) bremsstrahlung SPECT imaging in selective internal radiation therapy, and to use this method to improve quantitative comparison of predicted and delivered Y absorbed doses.

Methods: The spatial resolution of Tc SPECT data was converted to that of Y SPECT data using a function calculated from Tc and Y point spread functions. This resolution conversion method (RCM) was first applied to Tc and Y SPECT phantom data to validate the method, and then to clinical data to assess the power of Tc SPECT imaging to predict the therapeutic absorbed dose. Read More

View Article and Full-Text PDF

Characterization of the aroma compounds of Millet Huangjiu at different fermentation stages.

Food Chem 2021 Jul 24;366:130691. Epub 2021 Jul 24.

Shaanxi Provincial Research Center of Functional Food Engineering Technology, Xi'an, China.

Millet Huangjiu (MHJ), a type of northern Huangjiu with a long history, has attracted considerable attention in China and East Asia for its unique flavor. To elucidate the changing course of aroma components during the fermentation process of MHJ, 15 MHJ samples prepared at different fermentation stages were assessed by gas chromatography-olfactometry (GC-O) and odor activity value (OAV) coupled with multivariate data analysis. A total of 66 volatile compounds were identified, among which 21 odorant active substances were regarded as the main aroma components (OAVs ≥ 1). Read More

View Article and Full-Text PDF

Analyzing drivers' hazard recognition: Precursors to single-vehicle collisions.

Accid Anal Prev 2021 Jul 30;160:106304. Epub 2021 Jul 30.

Department of Civil & Environmental Engineering, The University of Tennessee, Knoxville, United States.

Extensive driver behavior and performance information provided by real-world video surveillance and sensor data in the SHRP2 Naturalistic Driving Study has enabled the examination of new layers and pathways leading to crash outcomes. We note that the prominence of hazards and the importance of recognizing them vary systematically across single vs. multi-vehicle crashes, and address a fundamental question about safety: why do around three-quarters of drivers involved in single-vehicle crashes not recognize, perceive, or react to the precipitating event (PE)? Using a path-analytic framework through marginal effects, this study investigates factors correlated to recognition of the PE in single-vehicle events, and how these correlations may act as crash precursors. Read More

View Article and Full-Text PDF

Factors affecting disc angle restoration in oblique lateral interbody fusion at L5-S1.

Spine J 2021 Jul 30. Epub 2021 Jul 30.

Department of Orthopaedic Surgery, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address:

Background Context: Optimal restoration of the L5-S1 disc angle (DA) is an important surgical goal in spinal reconstructive surgery. Anterior approach is beneficial for L5-S1 DA reconstruction and fusion. However, factors associated with a greater DA restoration in oblique lateral interbody fusion (OLIF) at L5-S1 have not been studied. Read More

View Article and Full-Text PDF

The use of real-world data/evidence in regulatory submissions.

Contemp Clin Trials 2021 Jul 30:106521. Epub 2021 Jul 30.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China. Electronic address:

The 21st Century Cures Act passed by the United States (US) Congress in December 2016 requires the US Food and Drug Administration (FDA) shall establish a program to evaluate the potential use of real-world evidence (RWE) which is generated from real-world data (RWD) to (i) support approval of new indication for a drug approved under section 505 (c) and (ii) satisfy post-approval study requirements. RWE offers the opportunities to develop robust evidence using high-quality data and sophisticated methods for producing causal-effect estimates regardless randomization is feasible. In this article, we have demonstrated that the assessment of treatment effect (RWE) based on RWD could be biased due to the potential selection and information biases of RWD. Read More

View Article and Full-Text PDF

Advances in the computational landscape for repurposed drugs against COVID-19.

Drug Discov Today 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

The COVID-19 pandemic has caused millions of deaths and massive societal distress worldwide. Therapeutic solutions are urgently needed but de novo drug development remains a lengthy process. One promising alternative is computational drug repurposing, which enables the prioritization of existing compounds through fast in silico analyses. Read More

View Article and Full-Text PDF

Cross-national trends of chronic back pain in adolescents: results from the HBSC study, 2001-2014.

J Pain 2021 Jul 30. Epub 2021 Jul 30.

Universitat Rovira i Virgili, Unit for the Study and Treatment of Pain - ALGOS, Research Center for Behavior Assessment (CRAMC), Department of Psychology, Catalonia, Spain; Institut d'Investigació Sanitària Pere Virgili; Universitat Rovira i Virgili, Catalonia, Spain. Electronic address:

Chronic back pain is a common problem that negatively impacts the wellbeing of many adolescents. Prior research suggests that the prevalence of chronic back pain has increased over the last decades, but research on this issue is scarce, single country-based, and has yielded inconsistent results. This study aimed to examine trends in the prevalence of chronic back pain over time in adolescents aged 11, 13 and 15, using data from the Health Behavior in School-aged Children (HBSC) survey. Read More

View Article and Full-Text PDF

Long-term cognitive deficits after traumatic brain injury associated with microglia activation.

Clin Immunol 2021 Jul 30:108815. Epub 2021 Jul 30.

Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Lebanon; Nehme and Therese Tohme Multiple Sclerosis Center, Faculty of Medicine, American University of Beirut Medical Center, Lebanon. Electronic address:

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases of the central nervous system. We hypothesize that microglia may play a beneficial or detrimental role in TBI depending on their state of activation and duration. Read More

View Article and Full-Text PDF

Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: Systematic review and meta-analysis.

Exp Gerontol 2021 Jul 30:111502. Epub 2021 Jul 30.

Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.

The excessive deposition of β-amyloid proteins (Aβ) is directly correlated with the establishment and development of Alzheimer's Disease (AD). Current treatments for AD only reduce symptoms instead of acting on Aβ, which is the primary etiological agent. Hence, the anti-amyloid effect of regular exercise has been widely investigated as an alternative therapy. Read More

View Article and Full-Text PDF

Differential protein expression due to Se deficiency and Se toxicity in rat liver.

J Nutr Biochem 2021 Jul 30:108831. Epub 2021 Jul 30.

The Florey Institute of Neuroscience and Mental Health, CRC for Mental Health, University of Melbourne, Australia; Department of Biochemistry, Emory School of Medicine, Atlanta, GA, USA; Department of Neurology, Emory School of Medicine, Atlanta, GA, USA. Electronic address:

There is a U-shaped dose-response between selenium (Se) status and health outcomes, but underlying metabolic processes are unclear. This study aims to identify candidate proteins in liver regulated by dietary Se, ranging from deficiency to toxic. Male rats (n=4) were fed graded Se concentrations as selenite for 28 days. Read More

View Article and Full-Text PDF

Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma.

Genomics 2021 Jul 30. Epub 2021 Jul 30.

Department of Oncology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, via Mario Negri 2, 20156 Milan, Italy. Electronic address:

Myxoid liposarcoma (MLPS) is a rare soft-tissue sarcoma characterised by the expression of FUS-DDIT3 chimera. Trabectedin has shown significant clinical anti-tumour activity against MLPS. To characterise the molecular mechanism of trabectedin sensitivity and of resistance against it, we integrated genomic and transcriptomic data from treated mice bearing ML017 or ML017/ET, two patient-derived MLPS xenograft models, sensitive to and resistant against trabectedin, respectively. Read More

View Article and Full-Text PDF

A review on traditional uses, phytochemistry, pharmacology, toxicology and the analytical methods of the genus Nardostachys.

J Ethnopharmacol 2021 Jul 30:114446. Epub 2021 Jul 30.

State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, PR China. Electronic address:

Ethnopharmacological Relevance: The plants of the genus Nardostachys (Caprifoliaceae) have been used for a long history in different cultural systems of medicine, including Chinese, Ayurvedic, Korean folk medicine and Islamic, for treatments of disorders in nervous, digestive, cardiovascular and integumentary systems.

Aim Of The Review: This review aims to provide comprehensive information on Nardostachys plants including botany update, traditional uses, data mining of uses in traditional Chinese medicine (TCM) and current Chinese medicinal patents, chemical constituents, pharmacological effects, toxicity and analytical method studies.

Materials And Methods: Studies of the genus Nardostachys were collected via Google Scholar and Baidu Scholar, ScienceDirect, SciFinder, Wiley Online Library, ACS Publications, NLM/NCBI, Web of Science, CNKI, WANFANG DATA, EMBASE, Huabeing database and Traditional Chinese Medicine Resource Network and libraries. Read More

View Article and Full-Text PDF

The temptin gene of the clade Lophotrochozoa is involved in formation of the prismatic layer during biomineralization in molluscs.

Int J Biol Macromol 2021 Jul 30. Epub 2021 Jul 30.

Key Laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Agriculture, Shanghai 201306, China. Electronic address:

The biomineralization mechanism of mollusc shell has been studied for a long time, but there is a lack of understanding about the relationship between the shell formation in vitro and the signaling system in vivo. In this study, we cloned a novel shell matrix protein gene (hc-temptin), which only be characterized as a water-borne protein pheromone of molluscs in previous studies, from the freshwater mussel Hyriopsis cumingii. By bioinformatics analysis we found that temptin was a gene unique to the clade Lophotrochozoa, and it exists in all mollusc taxa except Cephalopoda. Read More

View Article and Full-Text PDF

Machine learning applied to over 900 3D printed drug delivery systems.

J Control Release 2021 Jul 30. Epub 2021 Jul 30.

Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FabRx Ltd., Henwood House, Henwood, Ashford, Kent, England TN24 8DH, UK; Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782, Spain. Electronic address:

Three-dimensional printing (3DP) is a transformative technology that is advancing pharmaceutical research by producing personalized drug products. However, advances made via 3DP have been slow due to the lengthy trial-and-error approach in optimization. Artificial intelligence (AI) is a technology that could revolutionize pharmaceutical 3DP through analyzing large datasets. Read More

View Article and Full-Text PDF

A Mendelian randomization study found causal linkage between telomere attrition and chronic kidney disease.

Kidney Int 2021 Jul 30. Epub 2021 Jul 30.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Kidney Research Institute, Seoul National University, Seoul, Korea. Electronic address:

Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is rarely investigated whether kidney function is causally linked to biological aging itself. In this Mendelian randomization study, genetic instruments for telomere attrition were applied to a CKDGen genome wide association study results for 41,395 cases of CKD among 480,698 individuals as summary-level Mendelian randomization. Read More

View Article and Full-Text PDF

Paths through the Yeast Regulatory Network in Different Physiological States.

J Mol Biol 2021 Jul 30:167181. Epub 2021 Jul 30.

Department of Data Science and Artificial Intelligence, Monash University, Clayton, VIC 3800, Australia. Electronic address:

We analyse paths through the regulatory networks that control gene-expression patterns in Yeast, in five different physiological states: cell cycle, DNA damage, stress response, diauxic shift, and sporulation. The network in each state is specified as a directed graph, containing different sets of edges connecting pairs selected from a combined set of 1475 nodes. Each network contains some nodes that have no parents, and others that have no children. Read More

View Article and Full-Text PDF

The Evolving Landscape of the ABE Certification Process: What it Means for the Future of the Specialty.

J Endod 2021 Jul 30. Epub 2021 Jul 30.

Texas A&M University College of Dentistry, 3302 Gaston Ave, Dallas, TX 75246.

Introduction: ABE Board-certification is an evolving process to ensure the continuing existence of the specialty of endodontics. Recent exam changes have resulted in greater numbers of Diplomates. To fully understand the implications of such changes and evaluate current Diplomates' views of the examination process, a specific set of questions was developed focusing on beliefs and perceptions, age relationships, test components, and hypotheticals for potential changes. Read More

View Article and Full-Text PDF

A process mining approach in big data analysis and modeling decision making risks for measuring environmental health in institutions.

Environ Res 2021 Jul 30:111804. Epub 2021 Jul 30.

Environmental and Food Hygiene Laboratories (LIAA) of Department of Medical Sciences, Surgical and Advanced Technologies "G.F. Ingrassia", Hygiene and Public Health, University of Catania, Italy.

This paper aimed to introduce a process-mining framework for measuring the status of environmental health in institutions. The methodology developed a new software-based index namely Institutional Environmental Health Index (IEHI) that was integrated from ontology-based Multi-Criteria Group Decision-Making models based on the principles of fuzzy modeling and consensus evaluation. Fuzzy Ordered Weighting Average (OWA) with the capability of modeling the uncertainties and decision-making risks along with Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) were employed as the computation engine. Read More

View Article and Full-Text PDF

Perioperative Outcomes of Thymectomy in Myasthenia Gravis: A Thoracic Surgery Database Analysis.

Ann Thorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgery, Division of Cardiothoracic Surgery, Duke University Medical Center.

Background: There is clinical equipoise regarding the perioperative and long-term outcomes of autoimmune myasthenia gravis (MG) patients undergoing open vs minimally invasive thymectomy, particularly for non-thymomatous MG. This analysis utilizes multicenter, real-world clinical evidence to assess perioperative complications of open and minimally invasive thymectomy techniques in MG patients.

Methods: Thymectomy cases 2009-2019 in MG patients were identified in the Society of Thoracic Surgeons General Thoracic Surgery Database. Read More

View Article and Full-Text PDF

Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair.

Am J Ophthalmol 2021 Jul 30. Epub 2021 Jul 30.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: To describe the factors associated with epiretinal membrane (ERM) formation in eyes treated with pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).

Design: Nation-wide, multi-center, clinical cohort study based on registry data.

Methods: Subjects: The 2239 cases treated with PPV for RRD repair registered in the Japan-Retinal Detachment Registry between February 2016 and March 2017. Read More

View Article and Full-Text PDF

Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials.

Authors:

Lancet Oncol 2021 Aug;22(8):1139-1150

Background: Trastuzumab targets the extracellular domain of the HER2 protein. Adding trastuzumab to chemotherapy for patients with early-stage, HER2-positive breast cancer reduces the risk of recurrence and death, but is associated with cardiac toxicity. We investigated the long-term benefits and risks of adjuvant trastuzumab on breast cancer recurrence and cause-specific mortality. Read More

View Article and Full-Text PDF

Effect on genital warts in Australian female and heterosexual male individuals after introduction of the national human papillomavirus gender-neutral vaccination programme: an analysis of national sentinel surveillance data from 2004-18.

Lancet Infect Dis 2021 Jul 30. Epub 2021 Jul 30.

The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia; Sydney Sexual Health Centre, Sydney Hospital, Sydney, NSW, Australia.

Background: In Australia, the government-funded human papillomavirus (HPV) vaccination programme was introduced in April, 2007, for girls and young women, and in February, 2013, for boys. As of Dec 31, 2018, all Australian-born female individuals younger than 38 years and male individuals younger than 21 years have been eligible for the free quadrivalent or nonavalent HPV vaccine. We aimed to examine the trends in genital wart diagnoses among Australian-born female and heterosexual male individuals who attended sexual health clinics throughout Australia before and after the introduction of the gender-neutral HPV vaccination programme in February, 2013. Read More

View Article and Full-Text PDF

Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies.

Lancet HIV 2021 Jul 30. Epub 2021 Jul 30.

Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: Robust age-specific estimates of anal human papillomavirus (HPV) and high-grade squamous intraepithelial lesions (HSIL) in men can inform anal cancer prevention efforts. We aimed to evaluate the age-specific prevalence of anal HPV, HSIL, and their combination, in men, stratified by HIV status and sexuality.

Methods: We did a systematic review for studies on anal HPV infection in men and a pooled analysis of individual-level data from eligible studies across four groups: HIV-positive men who have sex with men (MSM), HIV-negative MSM, HIV-positive men who have sex with women (MSW), and HIV-negative MSW. Read More

View Article and Full-Text PDF

Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.

Lancet Oncol 2021 Jul 30. Epub 2021 Jul 30.

Sarah Cannon Research Institute, Nashville, TN, USA; Tennessee Oncology, Nashville, TN, USA.

Background: Systemic therapies for metastatic biliary tract cancers are few, and patients have a median overall survival of less than 1 year. MyPathway evaluates the activity of US Food and Drug Administration-approved therapies in non-indicated tumours with potentially actionable molecular alterations. In this study, we present an analysis of patients with metastatic biliary tract cancers with HER2 amplification, overexpression, or both treated with a dual anti-HER2 regimen, pertuzumab plus trastuzumab, from MyPathway. Read More

View Article and Full-Text PDF

Breastfeeding within the circle of motherhood, restriction, and patriarchy: A qualitative study.

Health Care Women Int 2021 Aug 2:1-16. Epub 2021 Aug 2.

Department of Nursing, Kırşehir Ahi Evran University Faculty of Health Sciences, Kırşehir, Turkey.

Our purpose in the present study is to analyze the opinions of women regarding the factors that support and hinder their breastfeeding. This is a phenomenological and qualitative study. The present study included 32 breastfeeding women who live in different provinces in the X Region of X. Read More

View Article and Full-Text PDF

Latent Patterns of Posttraumatic Stress Symptoms, Depression, and Posttraumatic Growth Among Adolescents During the COVID-19 Pandemic.

Authors:
Rui Zhen Xiao Zhou

J Trauma Stress 2021 Aug 2. Epub 2021 Aug 2.

Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.

Researchhas shown that posttraumatic reactions can co-occur in trauma-exposed individuals. Many studies have assessed the co-occurring patterns of two types of reactions, but few have assessed the patterns of multiple reactions. To build on existing knowledge, the present study examined co-occurring patterns of posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, and posttraumatic growth (PTG) among adolescents during the COVID-19 pandemic. Read More

View Article and Full-Text PDF

The experiences of the caring dyad: (Un)articulated realities of living with cardiometabolic risk, metabolic syndrome and related diseases in severe mental illness.

Health Expect 2021 Aug 2. Epub 2021 Aug 2.

School of Humanities and Social Sciences, Aston University, Birmingham, UK.

Background: Informal carers play an important role in the care of patients with mental illness. Little is known of the relationship experience of the patient and their informal carer (caring dyad) as the context for the intersection between physical and mental health.

Aim: This study aimed to explore the impact of comorbid cardiometabolic risk (CMR), metabolic syndrome (MetS) and related diseases and severe mental illness (SMI) on the caring dyad. Read More

View Article and Full-Text PDF