427 results match your criteria dams uteri

Does Bacteria Colonization of Canine Newborns Start in the Uterus?

Animals (Basel) 2021 May 14;11(5). Epub 2021 May 14.

Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.

The assumption that requires the uterus to be a sterile environment to sustain a successful pregnancy has been recently challenged in humans, and is still under debate. The aim of this study was to assess whether bacteria can be isolated from the pregnant uterus and from amniotic fluid and meconium of healthy canine fetuses at term, delivered through cesarean section. Fifteen dams of different breed, age and parity, undergoing either elective ( = 10) or emergency ( = 5) cesarean section after a healthy pregnancy, were included in the study. Read More

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Obesity modifies the implantation window and disrupts intrauterine embryo positioning in rats.

Reproduction 2021 05 31;162(1):61-72. Epub 2021 May 31.

Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina.

Obesity is a chronic disease that impairs female reproduction. When gestation is achieved, maternal obesity can cause offspring's health complications. We intended to evaluate the effects of maternal pre-conceptional obesity on uterine contractile activity, embryo implantation and offspring development. Read More

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Nicotine induces maternal and fetal inflammatory responses which predispose intrauterine infection risk in a rat model.

Nicotine Tob Res 2021 Apr 24. Epub 2021 Apr 24.

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL.

Both smoking and infection adversely impact pregnancy. Previously, our group identified in a rodent model that 6 mg/kg/d nicotine increased the risk of fetal infection at gestation day (GD) 18. Here, we investigate lower nicotine doses. Read More

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Isolation and molecular identification of Brucella spp. in bovine herds kept at householders in the Delta region of Egypt by MALDI-TOF and AMOS-PCR.

Vet Ital 2020 Dec 1;56(4):297-300. Epub 2020 Dec 1.

Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt..

Brucellosis is a widespread disease in Egypt which cause huge economic losses in the dairy industry. The present study aims at isolating and identifying Brucella (B.) spp. Read More

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December 2020

Palmitoylethanolamide: Prenatal Developmental Toxicity Study in Rats.

Int J Toxicol 2021 Mar-Apr;40(2):161-170. Epub 2021 Feb 12.

Gencor Pacific Limited, Lantau Island, Hong Kong, China.

Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals and plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 to 19 of gestation, at dosage of 250, 500, or 1,000 mg/kg body weight, according to Organisation for Economic Co-operation and Development Test Guideline No. 414. Read More

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February 2021

Morphological changes in the experimental model of polycystic ovary syndrome and effects of vitamin D treatment.

J Obstet Gynaecol Res 2021 Mar 25;47(3):1164-1171. Epub 2021 Jan 25.

Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

Aim: This research was designed to develop an animal model by inducing polycystic ovary syndrome (PCOS) with dehydroepiandrosterone (DHEA) and observe reproductive and morphological changes after treatment with vitamin D.

Materials And Methods: Thirty pre-pubertal female Sprague-Dawley (SD) dams were recruited. The animals were distributed 10 each in control, PCOS and vitamin D-treated groups. Read More

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Samples sizes required to accurately quantify viral load and histologic lesion severity at the maternal-fetal interface of PRRSV-inoculated pregnant gilts.

J Vet Diagn Invest 2021 Mar 15;33(2):322-330. Epub 2021 Jan 15.

Departments of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Porcine reproductive and respiratory syndrome virus (PRRSV) is transmitted vertically, causing fetal death in late gestation. Spatiotemporal distribution of virus at the maternal-fetal interface (MFI) is variable, and accurate assessment of viral concentration and lesions is thus subject to sampling error. Our objectives were: 1) to assess whether viral load and lesion severity in a single sample of endometrium (END) and placenta (PLC), collected near the base of the umbilical cord (the current standard), are representative of the entire organ; and 2) to compare sampling strategies and evaluate if spatial variation in viral load can be overcome by pooling of like-tissues. Read More

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Parents ethanol use impairs ethanol-naive offspring development and reproduction.

Reproduction 2021 02;161(2):195-204

Department of Structural and Functional Biology, Institute of Biosciences of Botucatu (IBB), UNESP - Univ Estadual Paulista, São Paulo, Brazil.

Parental ethanol consumption can influence the offspring phenotype. In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, puberty onset and reproductive function of ethanol-naive offspring to birth to adulthood. Female and male UChB rats (voluntary 10%, v/v ethanol consumer) were divided into a control group (C) and an ethanol exposed group (E) from 65 to 80 days of age. Read More

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February 2021

Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice.

Am J Obstet Gynecol 2021 05 26;224(5):530.e1-530.e17. Epub 2020 Nov 26.

Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO; Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO. Electronic address:

Background: Group B Streptococcus is a common vaginal bacterium and the leading cause of invasive fetoplacental infections. Group B Streptococcus in the vagina can invade through the cervix to cause ascending uteroplacental infections or can be transmitted to the neonate during vaginal delivery. Some studies have found that women with a "dysbiotic" polymicrobial or Lactobacillus-depleted vaginal microbiota are more likely to harbor group B Streptococcus. Read More

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Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses.

Sci Rep 2020 11 11;10(1):19544. Epub 2020 Nov 11.

Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt.

Insecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems. The present study evaluated the teratogenic, genotoxic, and oxidative stress effects of residual-level lufenuron exposure on pregnant rats during the organogenesis gestational period of both mother and fetus. Read More

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November 2020

TGF-β1 Neutralization Improves Pregnancy Outcomes by Restoring Endometrial Receptivity in Mice with Adenomyosis.

Reprod Sci 2021 03 9;28(3):877-887. Epub 2020 Sep 9.

Department of Obstetrics and Gynecology, E-Da Hospital, 6 Yida Rd., Jiaosu Village, Yanchao District, Kaohsiung, Taiwan.

The objective of this research is to study the effects of TGF-β1 inhibition on endometrial receptivity and pregnancy outcomes in mice with adenomyosis. Experiments were done using a mouse model of adenomyosis which took place in a hospital-affiliated laboratory. The mouse model used for this research is ICR mouse. Read More

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Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development.

Proc Natl Acad Sci U S A 2020 09 8;117(38):23952-23959. Epub 2020 Sep 8.

Division of Animal Sciences, University of Missouri, Columbia, MO 65211;

Glands of the uterus are essential for pregnancy establishment. Forkhead box A2 (FOXA2) is expressed specifically in the glands of the uterus and a critical regulator of glandular epithelium (GE) differentiation, development, and function. Mice with a conditional deletion of FOXA2 in the adult uterus, created using the lactotransferrin iCre (Ltf-iCre) model, have a morphologically normal uterus with glands, but lack FOXA2-dependent GE-expressed genes, such as leukemia inhibitory factor (LIF). Read More

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September 2020

Fecundity is impaired in a mouse model of osteogenesis imperfecta.

Mol Reprod Dev 2020 09 31;87(9):927-929. Epub 2020 Aug 31.

Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri.

Osteogenesis imperfecta (OI), or brittle bone disease, is most often caused by mutations in genes encoding type I collagen or proteins that process it. Women with OI have a small, but significant increase in risk of serious pregnancy complications including uterine rupture. Here, the OI mouse, Col1a2 , was used to examine the effects of collagen mutation on establishment and maintenance of pregnancy. Read More

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September 2020

Influence of  uterine torsion in water buffaloes (Bubalus bubalis) with insights into the hematological and biochemical prognostic values regarding to manual correction.

Trop Anim Health Prod 2020 Nov 17;52(6):3165-3171. Epub 2020 Jul 17.

Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, 1 Alzeraa Street, Zagazig City, Sharkia Province, 44511, Egypt.

Bovine uterine torsion refers to the rotation of the gravid uterus around its longitudinal axis. It is the dominant cause of dystocia in buffaloes. A total of two hundred and seventeen dystocia's Egyptian buffaloes were examined, and another twenty were apparently normal at the full term (healthy pregnant group). Read More

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November 2020

Maternal obesity modulates both the renin-angiotensin system in mice dams and fetal adiposity.

J Nutr Biochem 2020 10 16;84:108413. Epub 2020 May 16.

Laboratory of Health Science, Montes Claros State University, Montes Claros, Minas Gerais, Brazil; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil, Montes Claros, Minas Gerais, Brazil. Electronic address:

Obesity is a chronic multifactorial disease and is currently a public health problem. Maternal obesity during pregnancy is more dangerous as it impairs the health of the mother and future generations. Obesity leads to several metabolic disorders. Read More

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October 2020

Early maternal separation accelerates the progression of endometriosis in adult mice.

Reprod Biol Endocrinol 2020 Jun 12;18(1):63. Epub 2020 Jun 12.

Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200090, China.

Background: A large body of research highlights the importance of early-life environmental impact on the health outcome in adulthood. However, whether early-life adversity (ELA) has any impact on the development of endometriosis is completely unclear. In this study, we tested the hypothesis that ELA, as manifested by neonatal separation, can accelerate the progression of endometriosis in mouse through activation of the adrenergic receptor β2 (ADRB2) signaling pathway, leading to increased angiogenesis and progression of endometriotic lesions. Read More

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imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy.

Theranostics 2020 16;10(14):6430-6447. Epub 2020 May 16.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

: Zika virus (ZIKV) is a pathogenic virus known to cause a wide range of congenital abnormalities, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and other neurological complications, in humans. This study investigated the noninvasive detection of ZIKV infection , which is necessary for elucidating the virus's mechanisms of viral replication and pathogenesis, as well as to accelerate the development of anti-ZIKV therapeutic strategies. : In this study, a recombinant ZIKV harbouring Nluc gene (ZIKV-Nluc) was designed, recovered, and purified. Read More

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Aberrant corin and PCSK6 in placentas of the maternal hyperinsulinemia IUGR rat model.

Pregnancy Hypertens 2020 Jul 13;21:70-76. Epub 2020 May 13.

Department of Pathology, Hadassah-Hebrew University Medical Center, Mount Scopus, Hebrew University-Hadassah School of Medicine, Ein Kerem, Jerusalem, Israel.

Objectives: Corin is a protease that converts pro-atrial natriuretic peptide (pro-ANP) to ANP. While the involvement of ANP in the cardiovascular regulation is well established, there is increasing evidence that the pregnant uterus produces ANP, which promotes spiral artery remodeling. The present study examines the alterations in corin and PCSK6, a key enzyme in the conversion of pro-corin to corin, in the placenta of hyperinsulinemic dams (HD) featuring pregnancy-induced hypertension (PIH). Read More

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A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice.

Biomater Sci 2020 Jun 7;8(12):3392-3403. Epub 2020 May 7.

Laboratory of Nano-regenerative Medical Engineering, Department of Biomedical Science, College of Life Science, CHA University, 618, CHA Biocomplex, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea.

The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, and effects on human health, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications. It was sought to determine whether nanomaterials pass through the maternal-fetal junction at any stage of pregnancy. Quantum dots (QDs) coated with heparinized Pluronic 127 nanogels and polyethyleneimine (PEI) were administered to pregnant mice. Read More

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Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha.

Iran J Vet Res 2020 ;21(1):46-51

Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

Background: Implantation is a crucial period determining the success of a full pregnancy. Endocrine disruptors such as phytoestrogens (PEs) were thought to adversely influence embryonic implantations. However, the mechanism by which they upset implantation was not fully elucidated. Read More

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January 2020

Maternal Zika Virus (ZIKV) Infection following Vaginal Inoculation with ZIKV-Infected Semen in Timed-Pregnant Olive Baboons.

J Virol 2020 05 18;94(11). Epub 2020 May 18.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

Zika virus (ZIKV) infection is now firmly linked to congenital Zika syndrome (CZS), including fetal microcephaly. While species of mosquito are the primary vector for ZIKV, sexual transmission of ZIKV is a significant route of infection. ZIKV has been documented in human, mouse, and nonhuman primate (NHP) semen. Read More

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Effect of methotrexate on embryonal implantation: an experimental rat model.

Gynecol Endocrinol 2020 Nov 4;36(11):978-981. Epub 2020 Mar 4.

Department of Gynecology and Obstetrics, Karadeniz Technical University School of Medicine, Trabzon, Turkey.

The aim of this study is to investigate the methotrexate (MTX) in rat embryonal implantation and its association with Glycodelin A (GdA) and Mucin-1 (MUC-1) expression. For this purpose, 32 pregnant rats were divided into four equal groups: non-pregnant rats in group I ( = 8, control) and pregnant rats in group III ( = 8) were injected intraperitoneal with single dose of normal saline, non-pregnant rats in group II ( = 8) and pregnant rats in group IV ( = 8) were given 0.2 mg i. Read More

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November 2020

Prenatal exposure to a phthalate mixture leads to multigenerational and transgenerational effects on uterine morphology and function in mice.

Reprod Toxicol 2020 04 29;93:178-190. Epub 2020 Feb 29.

Department of Animal Sciences, University of Illinois, Urbana, IL, United States. Electronic address:

Phthalates are commonly used plasticizers and additives that are found in plastic containers, children's toys and medical equipment. Phthalates are classified as endocrine-disrupting chemicals and exposure to phthalates has been associated with several human health risks including reproductive defects. Most studies focus on a single phthalate; however, humans are exposed to a mixture of phthalates daily. Read More

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In utero exposures to electronic-cigarette aerosols impair the signaling during mouse lung development.

Am J Physiol Lung Cell Mol Physiol 2020 04 21;318(4):L705-L722. Epub 2020 Feb 21.

Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.

Currently, more than 9 million American adults, including women of childbearing age, use electronic-cigarettes (e-cigs). Further, the prevalence of maternal vaping now approaching 10% is similar to that of maternal smoking. Little, however, is known about the effects of fetal exposures to nicotine-rich e-cig aerosols on lung development. Read More

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Mouse Bone Marrow-Derived Mesenchymal Stem Cells Alleviate Perinatal Brain Injury Via a CD8 T Cell Mechanism in a Model of Intrauterine Inflammation.

Reprod Sci 2020 07 29;27(7):1465-1476. Epub 2020 Jan 29.

Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

The objective of this study was to determine if mouse bone marrow-derived mesenchymal stem cells (BMMSCs) ameliorate preterm birth and perinatal brain injury induced by intrauterine inflammation (IUI). A mouse model of IUI-induced perinatal brain injury at embryonic (E) day 17 was utilized. BMMSCs were derived from GFP-transgenic mice and phenotypically confirmed to be CD44, Sca-1, CD45, CD34, CD11b, and CD11c by flow cytometry and sorted by fluorescence-activated cell sorting (FACS). Read More

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Antiviral Inflammation during Early Pregnancy Reduces Placental and Fetal Growth Trajectories.

J Immunol 2020 02 27;204(3):694-706. Epub 2019 Dec 27.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1;

Many viruses are detrimental to pregnancy and negatively affect fetal growth and development. What is not well understood is how virus-induced inflammation impacts fetal-placental growth and developmental trajectories, particularly when inflammation occurs in early pregnancy during nascent placental and embryo development. To address this issue, we simulated a systemic virus exposure in early pregnant rats (gestational day 8. Read More

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February 2020

Characterization of an Adapted Murine Model of Intrauterine Inflammation-Induced Preterm Birth.

Am J Pathol 2020 02 16;190(2):295-305. Epub 2019 Dec 16.

The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland; Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University, Baltimore, Maryland. Electronic address:

Preterm birth (PTB) affects nearly 15 million infants each year. Of these PTBs, >25% are a result of inflammation or infection. Animal models have improved our understanding of the mechanisms leading to PTB. Read More

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February 2020

Inferring lanosterol functions in the female rabbit reproductive tract based on the immunolocalization of lanosterol 14-demethylase and farnesoid beta-receptor.

Acta Histochem 2020 Feb 26;122(2):151472. Epub 2019 Nov 26.

Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico. Electronic address:

Female reproductive organs have de novo synthesis of cholesterol. Some sterol molecules, intermediaries in the cholesterol synthesis, have important paracrine/autocrine actions. Lanosterol binds to the farnesoid beta-receptor (FXRβ), a molecule widely expressed in the ovaries, suggesting that it may play a role in reproduction. Read More

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February 2020

Effect of single-dose depot leuprolide acetate on embryonal implantation: an experimental rat model.

Gynecol Endocrinol 2020 Jul 12;36(7):611-614. Epub 2019 Nov 12.

Department of Obstetrics and Gynecology, Arakli Bayram Halil State Hospital, Trabzon, Turkey.

The objective of this article is to investigate the effect of single-dose depot leuprolide acetate in rat embryonal implantation and its association with glycodelin A, mucin-1 and leukemia inhibitory factor expression. Thirty-two pregnant Wistar Albino rats were divided into four equal groups: untreated control rats in group I ( = 8) and untreated pregnant rats in group II ( = 8) were injected intraperitoneally with single dose of normal saline, treated rats in group III ( = 8) and treated pregnant rats in group IV ( = 8) were given single 1 mg/kg subcutaneous injection of leuprolide acetate at day 8 of pregnancy. The dams were sacrificed on the 15th day of gestation, uterine horn samples were removed. Read More

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E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed .

J Endocr Soc 2019 Oct 5;3(10):1907-1916. Epub 2019 Sep 5.

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina.

Electronic nicotine delivery system (e-cigarette) use is prevalent among pregnant women as a seemingly safe alternative to traditional tobacco use, known to result in fetal developmental abnormalities and impaired fertility of male offspring. However, little is known about the effects of e-cigarette use on fertility or pregnancy outcomes. A successful pregnancy is initiated by a multitude of dynamic molecular alterations in the uterus resulting in embryo implantation at day 4. Read More

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October 2019