111 results match your criteria damaged brush

Behavioral and ultrastructural effects of novaluron on Aedes aegypti larvae.

Infect Genet Evol 2021 09 21;93:104974. Epub 2021 Jun 21.

Department of General Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil. Electronic address:

Chitin synthesis inhibitors (CSI) are supposed to inhibit formation of chitin microfibrils in newly synthesized cuticle during molting process. Conversely, there has been comparatively few data on morphological effects of CSI on non-target insect organs. In this work, the effects of the CSI novaluron on behavior and midgut of A. Read More

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September 2021

Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity.

Elife 2021 Jun 1;10. Epub 2021 Jun 1.

Department of Anatomy, University California, San Francisco, San Francisco, United States.

Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages. Using a tamoxifen-inducible transgenic mouse, here we identified a distinct population of CGRP-expressing excitatory interneurons in lamina III of the spinal cord dorsal horn and trigeminal nucleus caudalis. These interneurons have spine-laden, dorsally directed, dendrites, and ventrally directed axons. Read More

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Nephroprotective effect of Emblica officinalis fruit extract against malachite green toxicity in piscine model: Ultrastructure and oxidative stress study.

Microsc Res Tech 2021 Aug 9;84(8):1911-1919. Epub 2021 Mar 9.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

Malachite green (MG) is a multi-application dye with raised concern as aquatic toxicant. Cyprinus carpio fingerlings were exposed to MG and simultaneously fed with Emblica officinalis (EO) fruit extract to mitigate the MG induced nephrotoxicity. MG exposure developed depressed activity of antioxidant enzymes such as catalase, superoxide dismutase, glutathione-s-transferase, and reduced glutathione, while levels of malondialdehyde got significantly (p < . Read More

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A reduced CP level without medicinal zinc oxide does not alter the intestinal morphology in weaned pigs 24 days post-weaning.

Animal 2021 Apr 18;15(4):100188. Epub 2021 Feb 18.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 2, DK-1870 Frederiksberg C, Copenhagen, Denmark.

The use of medicinal zinc oxide (ZnO) to prevent diarrhoea post-weaning will be banned in the EU from 2022. Therefore, new alternatives are needed to avoid an increase in diarrhoea and higher antibiotic use. A low dietary CP level has shown to lower the frequency of diarrhoea in pigs, due to lower microbial protein fermentation in the colon as well as improved conditions in the small intestine after weaning. Read More

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Stem Rot Disease of Juglans sigillata Dode Caused by Fusarium fujikuroi in China.

Plant Dis 2021 Jan 24. Epub 2021 Jan 24.

Sichuan Agricultural University - Chengdu Campus, 506176, College of Forestry, Chengdu, Sichuan, China;

Juglans sigillata Dode is an endemic species in the southwest China, and is an important nut and woody oil tree. The shell of its fruit is hard and can be used to make various crafts. From 216 to 2019, typical stem rot symptoms of 8-year-old J. Read More

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January 2021

Nanomechanics of the Endothelial Glycocalyx: From Structure to Function.

Am J Pathol 2020 04 7;190(4):732-741. Epub 2020 Feb 7.

Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

The negatively charged, brush-like glycocalyx covers the surface layer of endothelial cells. This layer of membrane-bound, carbohydrate-rich molecules covers the luminal surface of the endothelium along the entire vascular tree, mostly comprising glycoproteins and proteoglycans. Together with the underlying actin-rich endothelial cortex, 50 to 150 nm beneath the plasma membrane, the endothelial glycocalyx (eGC) is recognized as a vasoprotective nanobarrier and responsive hub. Read More

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Early Onset Region and Cell Specific Alterations of Doublecortin Expression in the CNS of Animals with Sound Damage Induced Hearing Loss.

IBRO Rep 2019 Dec 6;7:129-140. Epub 2019 Nov 6.

Department of Otolaryngology- Head and Neck Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, United States.

Sound damage induced hearing loss has been shown to elicit changes in auditory and non-auditory brain regions. A protein critical for neuronal migration and brain development, doublecortin (DCX), has been used as a marker of central nervous system (CNS) neuroplasticity. DCX is expressed in unipolar brush cells (UBCs) of the dorsal cochlear nucleus (DCN), cerebellar parafloccular lobe (PFL) and neuronal precursor cells in the sub-granular zone of the hippocampal dentate gyrus (DG). Read More

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December 2019

A quick tongue: older honey bees dip nectar faster to compensate for mouthpart structure deterioration.

J Exp Biol 2019 11 12;222(Pt 21). Epub 2019 Nov 12.

Division of Intelligent and Biomechanical Systems, State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, 100084 Beijing, PRC.

The western honey bee, L. (Hymenoptera), is arguably the most important pollinator worldwide. While feeding, uses a rapid back-and-forth motion with its brush-like mouthparts to probe pools and films of nectar. Read More

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November 2019

Consensus on Methodology for Experimental Studies of Nasal Mucosal Injury.

J Craniofac Surg 2020 Jan/Feb;31(1):289-291

Ear Nose and Throat Department, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

Objectives: The way wounds heal involves significant complexity, resulting in restoration of functional and anatomical integrity to tissues damaged as a result of trauma (whether mechanical, chemical, or radiation-induced). The authors reviewed the consensus on methodology for experimental studies of nasal mucosal injury.

Methods: The review aims to find where consensus exists amongst different experimental studies in nasal wound healing about the use of animal models. Read More

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Mitochondria transfer from mesenchymal stem cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo.

Sci Rep 2019 03 26;9(1):5184. Epub 2019 Mar 26.

Second Department of Anatomy, Sapporo Medical University, Sapporo, 060-8556, Japan.

The underlying therapeutic mechanism of renal tubular epithelium repair of diabetic nephropathy (DN) by bone marrow-derived mesenchymal stem cells (BM-MSCs) has not been fully elucidated. Recently, mitochondria (Mt) transfer was reported as a novel action of BM-MSCs to rescue injured cells. We investigated Mt transfer from systemically administered BM-MSCs to renal proximal tubular epithelial cells (PTECs) in streptozotocin (STZ)-induced diabetic animals. Read More

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GP37 Facilitated ODVs Cross Insect Peritrophic Membranes and Fuse with Epithelia.

Toxins (Basel) 2019 03 4;11(3). Epub 2019 Mar 4.

Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

The (CpGV) GP37 has synergistic effects on the infectivity of (NPVs), however, the mechanism employed is unclear. In this study, in vitro and in vivo binding assays indicated that GP37 efficiently bound to the midgut peritrophic membrane (PM) of larvae. Treatment with GP37 led to the damage of the PM's compacted structure and the generation of the PM perforations, and the enhancement of the PM's permeability. Read More

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Age-dependent changes in vancomycin-induced nephrotoxicity in mice.

J Toxicol Pathol 2019 Jan 10;32(1):57-66. Epub 2018 Dec 10.

Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.

Vancomycin hydrochloride (VCM) is a glycopeptide antibiotic that is commonly used to eradicate methicillin-resistant gram-positive cocci, despite its nephrotoxic side effects. Elderly people are particularly susceptible to developing VCM-induced nephrotoxicity. However, the precise mechanism by which VCM induces nephrotoxicity in elderly people is not completely understood. Read More

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January 2019

Fault Detection of Electric Impact Drills and Coffee Grinders Using Acoustic Signals.

Adam Glowacz

Sensors (Basel) 2019 Jan 11;19(2). Epub 2019 Jan 11.

Department of Automatic Control and Robotics, Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Kraków, Poland.

Increasing demand for higher safety of motors can be noticed in recent years. Developing of new fault detection techniques is related with higher safety of motors. This paper presents fault detection technique of an electric impact drill (EID), coffee grinder A (CG-A), and coffee grinder B (CG-B) using acoustic signals. Read More

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January 2019

Silicon dioxide nanoparticle exposure affects small intestine function in an in vitro model.

Nanotoxicology 2018 06 18;12(5):485-508. Epub 2018 Apr 18.

a Department of Biomedical Engineering , Binghamton University , Binghamton , NY , USA.

The use of nanomaterials to enhance properties of food and improve delivery of orally administered drugs has become common, but the potential health effects of these ingested nanomaterials remain unknown. The goal of this study is to characterize the properties of silicon dioxide (SiO) nanoparticles (NP) that are commonly used in food and food packaging, and to investigate the effects of physiologically realistic doses of SiO NP on gastrointestinal (GI) health and function. In this work, an in vitro model composed of Caco-2 and HT29-MTX co-cultures, which represent absorptive and goblet cells, was used. Read More

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Wear Resistance Properties Reinforcement Using Nano-Al/Cu Composite Coating in Sliding Bearing Maintenance.

J Nanosci Nanotechnol 2018 Mar;18(3):2152-2157

School of Mechatronics Engineering, China University of Mining and Technology, Xuzhou 22110, China.

Sliding bearing maintenance is crucial for reducing the cost and extending the service life. An efficient and practical solution is to coat a restorative agent onto the worn/damaged bearings. Traditional pure-copper (Cu) coating results in a soft surface and poor abrasion resistance. Read More

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A Clinical Comparative Study of 3-Dimensional Accuracy between Digital and Conventional Implant Impression Techniques.

J Prosthodont 2019 Apr 9;28(4):e902-e908. Epub 2018 Feb 9.

Dental Research Center, Dentistry Research Institute, Department of Prosthodontics, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the accuracy of a digital implant impression technique using a TRIOS 3Shape intraoral scanner (IOS) compared to conventional implant impression techniques (pick-up and transfer) in clinical situations.

Materials And Methods: Thirty-six patients who had two implants (Implantium, internal connection) ranging in diameter between 3.8 and 4. Read More

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Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice.

PLoS One 2017 15;12(12):e0189485. Epub 2017 Dec 15.

Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chronic GSK3 inhibition in diabetic nephropathy is not known. Read More

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January 2018

Blood lactose after dairy product intake in healthy men.

Br J Nutr 2017 Dec 4;118(12):1070-1077. Epub 2017 Dec 4.

1Agroscope,Schwarzenburgstrasse 161,3003 Bern,Switzerland.

The absence of a dedicated transport for disaccharides in the intestine implicates that the metabolic use of dietary lactose relies on its prior hydrolysis at the intestinal brush border. Consequently, lactose in blood or urine has mostly been associated with specific cases in which the gastrointestinal barrier is damaged. On the other hand, lactose appears in the blood of lactating women and has been detected in the blood and urine of healthy men, indicating that the presence of lactose in the circulation of healthy subjects is not incompatible with normal physiology. Read More

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December 2017

NMR spectroscopy and electron microscopy identification of metabolic and ultrastructural changes to the kidney following ischemia-reperfusion injury.

Am J Physiol Renal Physiol 2018 02 4;314(2):F154-F166. Epub 2017 Oct 4.

Department of Chemistry and Biochemistry, Miami University , Oxford, Ohio.

Cellular, molecular, and ultrastructural nephron changes associated with ischemia-reperfusion injury-induced acute kidney injury (IRI-AKI) are not completely understood. Here, a multidisciplinary study was used to identify nephron changes in a mouse model of IRI-AKI. Histological analyses indicated distended Bowman's glomerular spaces and proximal and distal tubules. Read More

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February 2018

Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus.

J Control Release 2017 06 7;255:94-107. Epub 2017 Apr 7.

Fondazione CEN - European Centre for Nanomedicine, Piazza Leonardo da Vinci 32, 20133 Milan, Italy; Dipartimento di Chimica, Materiali ed Ingegneria Chimica "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy; Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Electronic address:

We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to podocytes, in order to overcome the failure of current therapeutic regimens in patients with proteinuric (i.e. abnormal amount of proteins in the urine) diseases. Read More

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Prognosis After Surgical Treatment of Trigeminal Neuropathy with a PGA-c Tube: Report of 10 Cases.

Pain Med 2016 12 31;17(12):2360-2368. Epub 2016 May 31.

Division of Dental Anesthesiology, Niigata University Medical and Dental Hospital, University of Niigata, Niigata, Japan.

Objective: Although surgery using a polyglycolic acid-collagen (PGA-c) tube is effective for peripheral nerve injury-induced chronic hand pain, it has not been applied to trigeminal nerve lesions because of the difficult approach. We used a PGA-c tube during surgery for trigeminal neuropathy and evaluated its prognosis based on the outcomes.

Design: Case report. Read More

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December 2016

Target and non-target toxicity of botanical insecticide derived from Couroupita guianensis L. flower against generalist herbivore, Spodoptera litura Fab. and an earthworm, Eisenia foetida Savigny.

Ecotoxicol Environ Saf 2016 Nov 28;133:260-70. Epub 2016 Jul 28.

Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi Arabia.

Botanical insecticides may provide alternatives to synthetic insecticides for controlling Spodoptera litura (F.) and they are target specific, biodegradable, and harmless to mammals. Eight natural chemical compounds with larvicidal activity were identified from fraction F6 of C. Read More

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November 2016

Climbing fibers mediate vestibular modulation of both "complex" and "simple spikes" in Purkinje cells.

Cerebellum 2015 Oct;14(5):597-612

Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.

Climbing and mossy fibers comprise two distinct afferent paths to the cerebellum. Climbing fibers directly evoke a large multispiked action potential in Purkinje cells termed a "complex spike" (CS). By logical exclusion, the other class of Purkinje cell action potential, termed "simple spike" (SS), has often been attributed to activity conveyed by mossy fibers and relayed to Purkinje cells through granule cells. Read More

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October 2015

Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using an In Vitro Approach.

Biomed Res Int 2015 13;2015:434623. Epub 2015 Jul 13.

Faculty of Pharmacy, IBMM-UMR 5247, University of Montpellier, France.

For most xenobiotics, the rates of percutaneous absorption are limited by diffusion through the horny layer of skin. However, percutaneous absorption of chemicals may seriously increase when the skin is damaged. The aim of this work was to develop an in vitro representative model of mechanically damaged skins. Read More

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Toxicological, Biochemical, and Histopathological Analyses Demonstrating That Cry1C and Cry2A Are Not Toxic to Larvae of the Honeybee, Apis mellifera.

J Agric Food Chem 2015 Jul 1;63(27):6126-32. Epub 2015 Jul 1.

†State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 West Yuanmingyuan Road, Haidian District, Beijing, People's Republic of China.

The honey bee, Apis mellifera, is commonly used as a test species for the regulatory risk assessment of insect-resistant genetically engineered (IRGE) plants. In the current study, a dietary exposure assay was developed, validated, and used to assess the potential toxicity of Cry1C and Cry2A proteins from Bacillus thuringiensis (Bt) to A. mellifera larvae; Cry1C and Cry2A are produced by different IRGE crops. Read More

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Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals.

PLoS One 2015 9;10(6):e0129381. Epub 2015 Jun 9.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Lectins are non-immunoglobulin carbohydrate-binding proteins without enzymatic activity towards the bound carbohydrates. Many lectins of e.g. Read More

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The effects of adriamycin on E-cadherin mediated cell-cell adhesion and apoptosis during early kidney development.

Biotech Histochem 2015 Jul 24;90(5):375-83. Epub 2015 Mar 24.

Department of Histology and Embryology, University of Erciyes, Medicine Faculty , Kayseri , Turkey.

Adriamycin (ADR) is strongly teratogenic. We investigated the effects of ADR on apoptosis and the intensity of E-cadherin expression in developing kidneys. An experimental group of rats was given 2 mg/kg/day ADR on days 6-9 of gestation and a control group was given saline on the same schedule. Read More

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Effect of overhead spray and brush roller treatment on the survival of Pectobacterium and Salmonella on tomato surfaces.

J Food Prot 2015 Jan;78(1):51-6

Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, 359 FSHN Building, Newell Drive, Gainesville, Florida 32611, USA.

Overhead spray and brush roller (OSBR) treatment has been shown to remove significantly more Salmonella from tomato surfaces than flume treatment. However, OSBR is not widely used in tomato packing facilities compared with other commodities, and little is known about whether brushing causes microabrasions or other physical damage. Bacteria such as Pectobacterium, a soft rot-producing plant pathogen, and Salmonella, a human pathogen, show increased survival and growth on damaged tomato surfaces. Read More

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January 2015

Association between pain, central sensitization and anxiety in postherpetic neuralgia.

Eur J Pain 2015 Feb 28;19(2):193-201. Epub 2014 Jul 28.

Department of Neurology, University Medical Center, Mainz, Germany.

Background: In postherpetic neuralgia (PHN), dorsal root ganglia neurons are damaged. According to the proposed models, PHN pain might be associated with nociceptive deafferentation, and peripheral (heat hyperalgesia) or central sensitization (allodynia).

Methods: In 36 PHN patients, afferent nerve fibre function was characterized using quantitative sensory testing and histamine-induced flare analysis. Read More

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February 2015

The effects of diethylstilbestrol administration on rat kidney. Ultrastructural study.

Saudi Med J 2013 Nov;34(11):1114-24

Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Objective: To assess the histological and ultrastructural changes that can be induced by diethylstilbestrol (DES) on renal tissues using histological, immunohistochemical, and ultrastructural methods.

Methods: Thirty adult male Wistar rats were divided into 3 groups (10 rats each): Group 1 - control; Group 2 - received DES at a dose of 60 ug/kg/day, dissolved in 0.1 ml corn oil for 20 days; and Group 3 - received the same dose of DES for 50 days by oral gavage. Read More

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November 2013