Heart Lung Circ 2005 Jun;14(2):107-14
Division of Pathology II, Faculty of Health Sciences, Linköping University, University Hospital, SE-58185 Linköping, Sweden.
Myocardial aging, leading to circulatory dysfunction, complicates numerous pathologies and is an important contributor to overall mortality at old age. In cardiac myocytes, mitochondria and lysosomes suffer remarkable age-related alterations. Mitochondrial changes include structural disorganization and enlargement, while lysosomes, which are responsible for autophagic turnover of mitochondria, accumulate lipofuscin (age pigment), a polymeric, autofluorescent, undegradable material. Read More