29,070 results match your criteria damage values

Optimizing the microstructure of a new machinable bioactive glass-ceramic.

J Mech Behav Biomed Mater 2021 Jul 13;122:104695. Epub 2021 Jul 13.

Vitreous Materials Laboratory, Materials Engineering Department, Federal University of São Carlos, São Carlos, SP, Brazil.

Objectives: This study aimed to optimize the crystallization process and the microstructure of a new bioactive glass-ceramic (GC) previously developed by our research group to obtain machinable glass-ceramics.

Methods: Differential scanning calorimetry (DSC) analyses were conducted to explore the characteristic temperatures and construct a semi-quantitative nucleation curve. The GC specimens were characterized by X-ray diffraction (XRD) and Rietveld refinement. Read More

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Оxidative stress and endogenous intoxication in cancer patients.

Klin Lab Diagn 2021 Jul;66(7):401-406

Federal State Budgetary Institution "National Medical Research Center of Oncology N.N. Blokhin", under the Ministry of Health of the Russian Federation.

In the blood serum of 93 patients with various localities of the malignant process, the content of nitric oxide (NO), indicators of lipid peroxidation (POL): superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione in red blood cells were determined. 9 patients with ovarian cancer were examined during chemotherapy (6 courses), 40 patients with colon cancer, previously operated, were with malignant liver damage. In 39 patients with anemia, NO indicators were compared with the level of interleukin 6 (IL-6) and hepcidin-25 (GP-25). Read More

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Vitamin D improves oxidative stress and histopathological damage in rat ovaries caused by hyperthyroidism.

J Obstet Gynaecol Res 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Adıyaman University School of Medicine, Adıyaman, Turkey.

Objective: The aim of this study is to investigate the histopathological and biochemical efficacy of vitamin D on oxidative damage and fibrosis in rat ovaries induced by experimental hyperthyroidism.

Methods: This study is a comparative, prospective experimental rat study. Sprague-Dawley female rats were divided into four groups. Read More

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Development of chitosan-coated nanoemulsions of two sulfides present in onion (Allium cepa) essential oil and their nematicidal activities against the pine wood nematode, Bursaphelenchus xylophilus.

Environ Sci Pollut Res Int 2021 Jul 21. Epub 2021 Jul 21.

Department of Agriculture, Forestry and Bioresources, College of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.

Pine wood nematode, Bursaphelenchus xylophilus, is a plant parasitic nematode which causes severe damage to several Pinus species. Two natural compounds, dipropyl trisulfide (DPTS) and methyl propyl trisulfide (MPTS), showed strong nematicidal activity against the pine wood nematode, presenting 4.24 and 17. Read More

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Cognitive Impairment in Multiple System Atrophy Is Related to White Matter Damage Detected by the T1-Weighted/T2-Weighted Ratio.

Eur Neurol 2021 Jul 20:1-9. Epub 2021 Jul 20.

Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Introduction: This study aimed to use a novel MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, to assess damage of the white matter and gray matter in multiple system atrophy (MSA). Furthermore, this study investigated whether the sT1w/T2w ratio was associated with cognitive impairment in MSA.

Methods: The white matter and gray matter sT1w/T2w ratio of 37 MSA patients and 19 healthy controls were measured. Read More

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Intraoperative quality assessment of tissue perfusion with indocyanine green (ICG) in a porcine model of mesenteric ischemia.

PLoS One 2021 20;16(7):e0254144. Epub 2021 Jul 20.

Department of Vascular Medicine, University Heart Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Mesenteric ischemia is a severe and potentially lethal event. Assessment of intestine perfusion is eminently depending on the skills, and the experience of the surgeon. Thus, the therapy is biased by the right evaluation. Read More

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Assessment of acetabular chondral damage and labral pathologies via direct MR arthrography: specialization matters.

Arch Orthop Trauma Surg 2021 Jul 19. Epub 2021 Jul 19.

ARCUS Sportklinik, Rastatter str, 17-19, 75179, Pforzheim, Germany.

Aims: To compare the diagnostic accuracy of investigators from different specialities (radiologists and orthopaedic surgeons) with varying levels of experience of 1.5 T direct magnetic resonance arthrography (dMRA) against intraoperative findings in patients with femoroacetabular impingement syndrome (FAIS).

Methods: A total of 272 patients were evaluated with dMRA and subsequent hip arthroscopy. Read More

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Correlation of SOD and MDA Expression in the Organ of Corti and Changes in the Function of Outer Hair Cells Measured by DPOAE Examination in Noise-Exposed Rat Cochlea.

Rep Biochem Mol Biol 2021 Apr;10(1):41-49

Department of Otorhinolaryngology, Faculty of medicine, Universitas Sumatera Utara, 20155, Medan, North Sumatera, Indonesia.

Background: Hearing loss due to noise can cause the disturbances toward the quality of life and cause mechanical damage and metabolic decompensation. Distortion Product Otoacoustic Emission (DPOAE) is an examination to assess the sensory function of outer hair cells. Superoxide Dismutase (SOD) and Malondialdehyde (MDA) are markers of oxidative stress. Read More

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SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases.

Ann Transl Med 2021 Jun;9(12):992

Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Background: This study aimed to investigate the clinicopathological significance of sine oculis homeobox homolog 1 (SIX1) and eyes absent 1 (EYA1) in patients with chronic hepatitis B (CHB) and other liver diseases.

Methods: SIX1 and EYA1 levels were detected in human serum and liver tissues by enzyme linked immunosorbent assay (ELISA) and immunofluorescent staining method, respectively.

Results: The serum SIX1 and EYA1 levels in 313 CHB patients were 7. Read More

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Forehead Regional Oxygen Saturation (rSO2)-Related Ear-Level Arterial Pressure and Lower Thigh rSO2 in the Steep Trendelenburg Position with CO2 Pneumoperitoneum and the Beach Chair Position.

Cureus 2021 Jun 16;13(6):e15687. Epub 2021 Jun 16.

Department of Anesthesiology, Tokyo Women's Medical University, School of Medicine, Tokyo, JPN.

Introduction Regional oxygen saturation (rSO2) reflects tissue perfusion. This observational study aimed to examine the change in the forehead and lower thigh rSO2 associated with intraoperative posture, anesthesia regimen, or mean arterial pressure (mAP) at heart and external auditory meatus (ear) levels. Methods Patients undergoing robot-assisted laparoscopic radical prostatectomy in the Trendelenburg position at 30° with pneumoperitoneum (TPP) or arthroscopic shoulder surgery in the beach chair position at 70° (BCP) under desflurane-remifentanil (D/R) or propofol-remifentanil (P/R) anesthesia were examined. Read More

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Protective effects of chitosan and chitosan oligosaccharide against oxidative damage in liver tissue of rats with fluorine poisoning.

Pak J Pharm Sci 2021 Jan;34(1(Special)):373-379

Department of Biochemistry, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, Turkey.

Fluorine toxicity has negative effects on soft tissue besides skeletal and dental tissues. In the present study, we have investigated the protective effect of chitosan (CS) and chitosan oligosaccharide (COS) on liver tissue of fluorine-intoxicated rats taking the antioxidant characteristics of chitosan and its derivatives into consideration. In this study, 42 male Wistar albino rats were randomly selected to determine the control and experimental fluorosis groups. Read More

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January 2021

Vascular Ageing in Youth: A Call to Action.

Heart Lung Circ 2021 Jul 15. Epub 2021 Jul 15.

Université de Paris, INSERM, U970, Paris Cardiovascular Research Center (PARCC), Paris, France. Electronic address: https://twitter.com/rosam_bruno.

Extensive evidence shows that risk factors for cardiovascular disease (CVD) begin to develop early in life. Childhood obesity and elevated blood pressure (BP) have become overwhelmingly challenging, with 57% of today's children predicted to be obese by the age of 35 years, and global rates of hypertension in children and adolescents increasing by 75% from 2000 to 2015. Thus, there is an urgent need for tools that can assess early CVD risk in youth, which may lead to better risk stratification, preventative intervention, and personalised medicine. Read More

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Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes.

Arch Toxicol 2021 Jul 17. Epub 2021 Jul 17.

Unidad de Hepatología Experimental, Health Research Institute La Fe, Valencia, Spain.

Drug-induced liver injury (DILI) is an adverse toxic hepatic clinical reaction associated to the administration of a drug that can occur both at early clinical stages of drug development, as well after normal clinical usage of approved drugs. Because of its unpredictability and clinical relevance, it is of medical concern. Three DILI phenotypes (hepatocellular, cholestatic, and mixed) are currently recognized, based on serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) values. Read More

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Differences in wild boar spatial behaviour among land uses and management scenarios in Mediterranean ecosystems.

Sci Total Environ 2021 Jul 9;796:148966. Epub 2021 Jul 9.

Grupo Sanidad y Biotecnología (SaBio), Instituto de Investigación en Recursos Cinegéticos (IREC), UCLM-CSIC-JCCM, 13071 Ciudad Real, Spain.

The ubiquitous wild boar is causing diverse and growing conflicts of socio-ecological and economic relevance worldwide. For that reason, knowledge of its spatial ecology is crucial to designing effective management programmes. But this knowledge is scarce in Mediterranean areas with mixed land uses. Read More

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Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer's disease.

Mol Divers 2021 Jul 17. Epub 2021 Jul 17.

Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) is now ranked as the third leading cause of death after heart disease and cancer. There is no definite cure for AD due to the multi-factorial nature of the disease, hence, multi-target-directed ligands (MTDLs) have attracted lots of attention. In this work, focusing on the efficient cholinesterase inhibitory activity of tacrine, design and synthesis of novel arylisoxazole-tacrine analogues was developed. Read More

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Assessment for Septic Arthritis in Immunocompetent and Immunocompromised Patients: A Single-Institution Study.

J Am Acad Orthop Surg 2021 Jul 15. Epub 2021 Jul 15.

From the Department of Orthopaedic Surgery (Brown, Samade, and Speeckaert), The Ohio State University Wexner Medical Center, the College of Medicine (Turnquist, Mickley, and Lynch), The Ohio State University Wexner Medical Center, and the Division of Hematology (Larkin), Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.

Introduction: Prompt diagnosis of septic arthritis is imperative to prevent irreversible joint damage. Immunocompromised patients are at an increased risk of septic arthritis as well as secondary systemic infection. Our aims were to identify features predictive of septic arthritis and to determine whether these features differed between immunocompetent and immunocompromised patients. Read More

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Sexual behaviour, semen quality and fertility of young Border Leicester rams administered melatonin during spring.

Anim Reprod Sci 2021 Jul 10;231:106804. Epub 2021 Jul 10.

Turretfield Research Centre, South Australian Research and Development Institute, Rosedale, South Australia 5350, Australia.

This study was conducted to test the hypothesis that between year variability in reproductive response to melatonin treatment of young Border Leicester (BL) rams in spring was related to sexual maturity at the time of treatment. Two variables of sexual maturity (mating behaviour and semen quality) were examined. In Experiment 1, mating activity of melatonin-treated and untreated rams was examined at two sites before a flock mating at one site. Read More

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Metformin inhibits polyphosphate-induced hyper-permeability and inflammation.

Int Immunopharmacol 2021 Jul 13;99:107937. Epub 2021 Jul 13.

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Circulating inflammatory factor inorganic polyphosphate (polyP) released from activated platelets could enhance factor XII and bradykinin resulted in increased capillary leakage and vascular permeability. PolyP induce inflammatory responses through mTOR pathway in endothelial cells, which is being reported in several diseases including atherosclerosis, thrombosis, sepsis, and cancer. Systems and molecular biology approaches were used to explore the regulatory role of the AMPK activator, metformin, on polyP-induced hyper-permeability in different organs in three different models of polyP-induced hyper-permeability including local, systemic short- and systemic long-term approaches in murine models. Read More

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Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity.

Int J Nanomedicine 2021 8;16:4713-4737. Epub 2021 Jul 8.

Pharmaceutics Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Background: Amiodarone (AMD) is a widely used anti-arrhythmic drug, but its administration could be associated with varying degrees of pulmonary toxicity. In attempting to circumvent this issue, AMD-loaded polymeric nanoparticles (AMD-loaded NPs) had been designed.

Materials And Methods: AMD was loaded in NPs by the nanoprecipitation method using two stabilizers: bovine serum albumin and Kolliphor P 188. Read More

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Endoscopic Stapedotomy: A Systematic Review.

Otol Neurotol 2021 Jul 9. Epub 2021 Jul 9.

Department of Otolaryngology Head and Neck Surgery, Royal Prince Alfred Hospital Department of Otolaryngology Head and Neck Surgery, Royal North Shore Hospital, Sydney Sydney Endoscopic Ear Surgery ('SEES') Research Group Discipline of Surgery, Sydney Medical School, University of Sydney, Australia.

Objectives: Stapes surgery has evolved from its origins in 1956. Microscopic assisted stapedotomy remains the most common technique but the introduction of endoscopic ear surgery has led to some units using this new approach. The endoscope delivers a wide angled, contextual view of the stapes, and associated pathology. Read More

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Evaluation of RET-He values as an early indicator of iron deficiency anemia in pregnant women.

Hematol Transfus Cell Ther 2021 Jul 2. Epub 2021 Jul 2.

Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (FacFar UFRGS), Porto Alegre, RS, Brazil.

Introduction: During pregnancy, women are at an increased risk of developing iron-deficiency anemia.

Objective: The objective of this study was to assess the diagnostic performance of the reticulocyte hemoglobin equivalent (RET-He) in the early detection of iron-deficiency anemia in a group of pregnant women and to establish a reference range for this parameter in a group of control individuals.

Method: A total of 60 patients and 130 control subjects were included in the study. Read More

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Biomarkers of geno- and cytotoxicity in the native broad-snouted caiman (Caiman latirostris): Chromosomal aberrations and mitotic index.

Mutat Res 2021 Jul 29;867:503353. Epub 2021 Mar 29.

Proyecto Yacaré- Lab. Zoología Aplicada: Anexo Vertebrados (FHUC-UNL/MAyCC), Av. Aristóbulo del Valle 8700 (3000), Santa Fe, Argentina; Laboratorio de Ecología Molecular Aplicada (LEMA) - Instituto de Ciencias Veterinarias del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (ICiVet Litoral-CONICET/UNL), Av. Aristóbulo del Valle 8700 (3000), Santa Fe, Argentina; Cát. Toxicol., Farmacol. y Bioq. Legal (FBCB-UNL, CONICET), Ciudad Universitaria - Paraje El Pozo S/N (3000), Santa Fe, Argentina. Electronic address:

We evaluated the sensitivity of the chromosomal aberration (CA) and mitotic index (MI) assays on peripheral blood lymphocytes (PBLs) of Caiman latirostris, following ex vivo exposure to the alkylating agent, MMS. Two concentrations of MMS were tested in cultured peripheral blood. Relative to controls, MMS exposure reduced the number of metaphases observed, but both the numbers of cells with MN and the percentages of aberrant metaphases increased. Read More

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Awareness of pharmacists and consumers towards protective effects of sunscreens against skin cancer.

J Oncol Pharm Pract 2021 Jul 16:10781552211029358. Epub 2021 Jul 16.

Clinical Sciences Department, Clinical Sciences Department, College of Pharmacy and Health Sciences, Ajman University. Centre of Medical and Bio-allied Health Sciences Research.

The objective of the present study was to assess the awareness level of individuals on the use of sunscreen products, and pharmacists' perception of sunscreen safety. A cross-sectional, descriptive study was conducted in the United Arab Emirates (UAE). Participants involved included 224 female undergraduates of Ajman University (aged 18-25 years old), 234 patients visiting numerous pharmacies, and 58 pharmacists from the private sector in Dubai. Read More

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Lighting quantity indexes for lighting traditional Chinese paintings based on pigments protection and substrates protection in museums.

Opt Express 2021 Jul;29(14):22667-22678

In museum lighting, traditional Chinese paintings are the artworks with the highest light sensitivity. They are vulnerable to the color damage to pigments and the mechanical damage to substrates after the irradiation from light sources. As the basis of effective preventive protection, the research on the two lighting quantity indexes of illuminance and annual exposure (illuminance × time) is currently missing. Read More

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24-epibrassinolide alleviates postharvest yellowing of broccoli via improving its antioxidant capacity.

Food Chem 2021 Jul 5;365:130529. Epub 2021 Jul 5.

College of Food, Shenyang Agricultural University, No.120 Dongling Road, Shenhe District, Shenyang 110866, People's Republic of China. Electronic address:

Postharvest crop yellowing is a major concern in the broccoli industry. The effect and underlying mechanisms of 24-epibrassinolide (EBR) treatment on yellowing in postharvest broccoli were investigated. Treatment with 2 µM EBR markedly inhibited the increase of the yellowing index and L* values, causing higher retention of the metric hue angle and chlorophyll content compared to the control. Read More

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Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B.

Brain Res Bull 2021 Jul 12. Epub 2021 Jul 12.

Department of Neurology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China. Electronic address:

Objective: Long non-coding RNAs (lncRNAs) have diagnostic and therapeutic values in the setting of ischemic stroke (IS). Here, we evaluated the value of myocardial infarction-associated transcript (MIAT) in IS with the involvement of microRNA (miR)-874-3p/interleukin (IL) 1B.

Methods: MIAT, miR-874-3p and IL1B levels in serum of patients with IS were measured. Read More

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Antimicrobial Effects of Novel H2O2-Ag+ Complex on Membrane Damage to Staphylococcus aureus,Escherichia coli and Salmonella typhimurium.

J Food Prot 2021 Jul 15. Epub 2021 Jul 15.

China Agricultural University Tsinghua East Road 17, Haidian District CHINA Beijing 100083.

Diseases caused by harmful microorganisms pose a serious threat to human health. Safe and environment-friendly disinfectants are, therefore, essential in preventing and controlling such pathogens. This study aimed to investigate the antimicrobial activity and mechanism of a novel hydrogen peroxide and silver (H 2 O 2 -Ag + ) complex (HSC) in combatting Staphylococcus aureus ATCC 29213, Escherichia coli O157:H7 NCTC 12900 and Salmonella typhimurium SL 1344. Read More

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Osteoporosis and Endplate Damage Correlation Using a Combined Approach of Hounsfield Unit Values and Total Endplate Scores: A Retrospective Cross-Sectional Study.

Clin Interv Aging 2021 5;16:1275-1283. Epub 2021 Jul 5.

Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Purpose: Osteoporosis and endplate damage, two primary orthopedic disorders that have adverse effects on the quality of life of older adults, may have some previously unknown relationship. The purpose of this study was to determine the potential association between osteoporosis and endplate damage with two specific imaging scoring systems and analyze the underlying mechanisms.

Patients And Methods: A cross-sectional study including 156 patients with degenerative disc disease (DDD) who visited our department in 2018 was performed. Read More

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Long-term consequences of previous preeclampsia and complicated pregnancy: analysis of echocardiographic aspects.

J Cardiovasc Med (Hagerstown) 2021 Jul 12. Epub 2021 Jul 12.

Internal Medicine Prof. Borghi Unit, Department of Medical and Surgical Sciences, S.Orsola-Malpighi University Hospital, Bologna, Italy.

Introduction: Preeclampsia has an increased risk of cardiovascular events later in life. In this retrospective study, we evaluated echocardiographic aspects in women with history of preeclampsia or preeclampsia-related complications in their previous pregnancies.

Materials And Methods: Consecutive women receiving echocardiography during daily clinical echolab activity were studied using complete echocardiographic examination data and anamnestic data collection of hypertension, diabetes, dyslipidemia, and rheumatic diseases. Read More

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[Beneficial effects and related mechanism of hawthorn leaves flavonoids on cardiac function in rats with acute myocardial infarction].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jul 24;49(7):701-707. Epub 2021 Jul 24.

Department 3 of Cardiovascular Medicine, Zhumadian Central Hospital, Zhumadian 463000, China.

To explore the effect and related regulatory mechanism of hawthorn leaf flavonoids (FHL) on cardiac function in rats with acute myocardial infarction (AMI). Sixty SPF male Sprague-Dawley rats (9-week-old, weighing 300-350 g) were used in this study. Ten rats were assigned to sham operation group, and the remaining 50 rats were used to establish the AMI model with coronary artery ligation method, AMI was successfully established in 36 rats. Read More

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