1,284 results match your criteria damage lymphatic

Neuroimmune cleanup crews in brain injury.

Trends Immunol 2021 Apr 30. Epub 2021 Apr 30.

Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Medical Scientist Training Program, University of Virginia, Charlottesville, VA 22908, USA; Immunology Training Program, University of Virginia, Charlottesville, VA 22908, USA; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

Traumatic brain injury (TBI) is a leading cause of death and disability. Mounting evidence indicates that the immune system is critically involved in TBI pathogenesis, where it is deployed to dispose of neurotoxic material generated from head trauma and to instruct the wound healing process. However, the immune response to brain damage must be carefully held in check as aberrant regulation of immune signaling can lead to deleterious neuroinflammation, brain pathology, and neurological dysfunction. Read More

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Triggering the downstream apoptotic signal inside human parasitic organisms demonstrates a promising approach for anti-parasitic drug development: A mechanistic perspective.

Adv Protein Chem Struct Biol 2021 23;125:193-213. Epub 2021 Jan 23.

Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati, Santiniketan, West Bengal, India. Electronic address:

Parasitic organisms of various genera have threatened humankind. Although they are not always fatal but can damage the well-being of an individual in terms of both economic and societal crisis. Marked progress has been made toward eliminating those pathogenic organisms, however, complete removal is still not possible. Read More

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January 2021

Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations.

Genes (Basel) 2021 Apr 27;12(5). Epub 2021 Apr 27.

MAGI'S Lab, 38068 Rovereto, Italy.

Forkhead-box C2 (FOXC2) is a transcription factor involved in lymphatic system development. mutations cause Lymphedema-distichiasis syndrome (LD). Recently, a natural antisense was identified, called lncRNA FOXC2-AS1, which increases mRNA stability. Read More

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A Case of Traumatic Intractable Leg Ulcer with Lymphorrhea Diagnosed Using ICG Lymphography.

Plast Reconstr Surg Glob Open 2021 Mar 23;9(3):e3489. Epub 2021 Mar 23.

Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.

We report a case of traumatic lower extremity ulcers with lymphorrhea in a 37-year-old woman. She presented intractable ulcers without lymphedema for nearly 6 months after a traumatic injury. She was treated conservatively for 6 months at a referral hospital. Read More

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Biphasic Effects of Ethanol Exposure on Waste Metabolites Clearance in the CNS.

Mol Neurobiol 2021 Apr 25. Epub 2021 Apr 25.

Laboratory of Neurovascular Inflammation and Neurodegeneration, Department of Biomedical Engineering, Center for Injury Bio Mechanics, Materials and Medicine, New Jersey Institute of Technology, Newark, NJ, 07102, USA.

We have shown that the effects of low-dose ethanol promote the clearance of waste metabolites, such as amyloid-beta (Aβ) proteins, from the brain through the perivascular space (PVS). We demonstrated that dilative reactivity of arterial smooth muscle and endothelial cells regulate this clearance. These findings indicate the importance of blood-brain barrier (BBB) transvascular clearance of large size metabolites from the central nervous system (CNS), where the lymphatic clearance system is absent. Read More

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Surgical Treatment of Peripheral Vascular Malformations: A Systematic Review and Meta-Analysis.

Plast Reconstr Surg 2021 May;147(5):1149-1161

From the Departments of Plastic, Reconstructive, and Hand Surgery, and Dermatology, Amsterdam University Medical Centers, University of Amsterdam; and Amsterdam Public Health, Infection, and Immunity.

Background: Surgical treatment of peripheral vascular malformations is widely performed as primary and secondary treatments. Excellent results have been reported; however, it is thought that complications are likely to occur because of damage to adjacent structures. This systematic review aimed to elucidate the indications and outcomes of surgical treatment of vascular malformations. Read More

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Post-Operative Chylothorax in Children Undergoing Congenital Heart Surgery.

Cureus 2021 Mar 10;13(3):e13811. Epub 2021 Mar 10.

Pediatric Cardiology, Department of Pediatrics, Liaquat National Hospital, Karachi, PAK.

Chylothorax is a rare postoperative complication of congenital heart surgery. It has high morbidity with increased hospital stay and cost of treatment. Damage to the thoracic duct, disruption of accessory lymphatic vessels, and increased venous pressure exceeding that in the thoracic duct have been proposed as the possible causes of chylothorax after surgery for congenital heart disease. Read More

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Idiopathic chylous peritonitis mimicking acute appendicitis A case report.

Ann Ital Chir 2021 Apr 12;10. Epub 2021 Apr 12.

We report an uncommon case of idiopathic acute chylous peritonitis mimicking an acute appendicitis in a 30-year-old female patient with a 2-day history of abdominal pain, nausea and vomiting. Chylous ascites is a rare form of ascites characterized by the presence of a milky fluid rich in triglycerides. It occurs as a result of a damage to the lymphatic system due to trauma or other benign and malignant pathologies. Read More

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Pathogenesis of Higher Blood Pressure and Worse Renal Function in Salt-Sensitive Hypertension.

Kidney Blood Press Res 2021 1;46(2):236-244. Epub 2021 Apr 1.

Department of Cardiology, Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, China.

Background: The underlying pathogenesis of patients with salt-sensitive hypertension expressing higher blood pressure and severer renal damage remains uncertain.

Methods: We recruited 329 subjects, 131 in salt-sensitive (SS) group, 148 in nonsalt-sensitive (NSS) group, and 50 healthy people in normal group and tested their renal function, 24-h ambulatory blood pressure, and growth factor series.

Results: The SS group showed worse renal function with lower estimated glomerular filtration rate and higher urinary microalbumin, α-microglobulin, urinary protein Cr ratio, and urinary immunoglobulin. Read More

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Tissue dose estimation after extravasation of Lu-DOTATATE.

EJNMMI Phys 2021 Mar 31;8(1):33. Epub 2021 Mar 31.

Service de Physique Médicale et Radioprotection, Hospices Civils de Lyon, Lyon, France.

Background: Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234-1243, 2017). Clinical management of these extravasations requires the preliminary estimation of the dose distribution in the extravasation area. Read More

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Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction.

Drug Deliv Transl Res 2021 Mar 29. Epub 2021 Mar 29.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

The objective of the present paper is to formulate nanostructured lipid carriers (NLCs) of a calcium channel blocker, isradipine, to enhance its oral bioavailability and prolong its antihypertensive effect apart from evaluating efficacy of the formulation in isoproterenol induced myocardial infarction in rats. Formulation was optimized using quality by design (QbD)-based approach. Three factors i. Read More

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Breast edema, from diagnosis to treatment: state of the art.

Arch Physiother 2021 Mar 29;11(1). Epub 2021 Mar 29.

Department of Rehabilitation Sciences and Physiotherapy (REVAKI-MOVANT), Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

Introduction: Breast edema can arise from different etiologies; however, it is mostly seen after breast conserving surgery and/or radiotherapy. Combining breast conserving surgery and radiotherapy can cause damage to the lymphatic system and reactions to surrounding tissues, which can lead to breast edema; hereby, the breast size can increase by more than one cup size. Swelling of the breast is not the only criterion associated with breast edema. Read More

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Cancer-Related Lymphedema: Clinical Pearls for Providers.

Curr Oncol 2020 Dec 1;27(6):336-340. Epub 2020 Dec 1.

Lymphedema is a chronic inflammatory condition that results from damage to the lymphatic system. Lymphedema is classified as either primary or secondary, the former being caused by a malformation of lymph vessels or nodes, and the latter resulting from trauma, chronic lymphatic system overload, or the sequelae of cancer treatments. In the present article, we focus on secondary cancer-related lymphedema (CRL), a potential survivorship treatment-related effect. Read More

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December 2020

Embryological Development and Topographic Anatomy of Pelvic Compartments-Surgical Relevance for Pelvic Lymphonodectomy.

J Clin Med 2021 Feb 11;10(4). Epub 2021 Feb 11.

Kurt Semm Center for Minimally Invasive and Robotic Surgery, Center of Clinical Anatomy, Institute of Anatomy, Kiel University, 24098 Kiel, Germany.

Background: The oncological outcome of surgery for the treatment of pelvic malignancies can be improved by performing pelvic lymphonodectomy. However, the extent and regions of lymph node harvest are debated and require profound knowledge of anatomy in order to avoid collateral damage.

Methods: The embryological development and topographic anatomy of pelvic compartments in relation to pelvic lymphonodectomy for rectal, uterine, and prostate cancer are reviewed. Read More

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February 2021

Chylous retroperitoneum following 720 degree anteroposterior-combined corrective surgery for adult spinal deformity with split vertebral fracture subluxation: a case report.

Spine Deform 2021 Mar 2. Epub 2021 Mar 2.

Department of Orthopaedic Surgery, Kitasato University School of Medicine, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Study Design: Clinical case report.

Purpose: To report the rare case with post-operative chylous retroperitoneum after corrective surgery for adult spinal deformity.

Methods: We present a case of a 73-year-old woman with Parkinson's disease. Read More

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The Olfactory Organ Is Populated by Neutrophils and Macrophages During Early Development.

Front Cell Dev Biol 2020 18;8:604030. Epub 2021 Jan 18.

Programa Doctorado en Neurociencia, Facultad de Ciencia, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Instituto de Neurociencia, Universidad de Valparaíso, Valparaíso, Chile.

The immune system of vertebrates is characterized by innate and adaptive immunity that function together to form the natural defense system of the organism. During development innate immunity is the first to become functional and is mediated primarily by phagocytic cells, including macrophages, neutrophils, and dendritic cells. In the olfactory sensory system, the same sensory neurons in contact with the external environment have their first synapse within the central nervous system. Read More

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January 2021

Cerebral Vessels: An Overview of Anatomy, Physiology, and Role in the Drainage of Fluids and Solutes.

Front Neurol 2020 13;11:611485. Epub 2021 Jan 13.

Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

The cerebral vasculature is made up of highly specialized structures that assure constant brain perfusion necessary to meet the very high demand for oxygen and glucose by neurons and glial cells. A dense, redundant network of arteries is spread over the entire pial surface from which penetrating arteries dive into the cortex to reach the neurovascular units. Besides providing blood to the brain parenchyma, cerebral arteries are key in the drainage of interstitial fluid (ISF) and solutes such as amyloid-beta. Read More

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January 2021

GADD45B Facilitates Metastasis of Ovarian Cancer Through Epithelial-Mesenchymal Transition.

Onco Targets Ther 2021 12;14:255-269. Epub 2021 Jan 12.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.

Background: Growth arrest and DNA-damage-inducible 45 beta () is overexpressed and is associated with poor clinical outcomes in many human cancers, but the clinical implication of in epithelial ovarian cancer (EOC) remains unclear.

Methods: Bioinformatics analysis of The Cancer Genome Atlas (TCGA) and gene expression omnibus (GEO) cohorts was used to illustrate the relationship between expression and metastasis, as well as the survival time of EOC. was downregulated by siRNAs in EOC cells, and migration ability was determined by a transwell assay and wound-healing assay. Read More

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January 2021

To be or not to be: endothelial cell plasticity in development, repair, and disease.

Angiogenesis 2021 Jan 15. Epub 2021 Jan 15.

Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.

Endothelial cells display an extraordinary plasticity both during development and throughout adult life. During early development, endothelial cells assume arterial, venous, or lymphatic identity, while selected endothelial cells undergo additional fate changes to become hematopoietic progenitor, cardiac valve, and other cell types. Adult endothelial cells are some of the longest-lived cells in the body and their participation as stable components of the vascular wall is critical for the proper function of both the circulatory and lymphatic systems, yet these cells also display a remarkable capacity to undergo changes in their differentiated identity during injury, disease, and even normal physiological changes in the vasculature. Read More

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January 2021

Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation.

Heliyon 2021 Jan 31;7(1):e05820. Epub 2020 Dec 31.

Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.

The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anti-cancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed tissue responses for high doses of ivermectin using fish as animal model. Read More

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January 2021

COVID-19 and chronic fatigue syndrome: Is the worst yet to come?

Peter Wostyn

Med Hypotheses 2021 Jan 2;146:110469. Epub 2021 Jan 2.

Department of Psychiatry, PC Sint-Amandus, Reigerlostraat 10, 8730 Beernem, Belgium. Electronic address:

There has been concern about possible long-term sequelae resembling myalgic encephalomyelitis/chronic fatigue syndrome in COVID-19 patients. Clarifying the mechanisms underlying such a "post-COVID-19 fatigue syndrome" is essential for the development of preventive and early treatment methods for this syndrome. In the present paper, by integrating insights pertaining to the glymphatic system and the nasal cerebrospinal fluid outflow pathway with findings in patients with chronic fatigue syndrome, idiopathic intracranial hypertension, and COVID-19, I provide a coherent conceptual framework for understanding the pathophysiology of post-COVID-19 fatigue syndrome. Read More

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January 2021

Cancer-related lymphedema: clinical pearls for providers.

Curr Oncol 2020 12 1;27(6):336-340. Epub 2020 Dec 1.

Department of Family Medicine, Secondary Care and Oncology Departments, McGill University Health Centre, and McGill University, Montreal, QC.

Lymphedema is a chronic inflammatory condition that results from damage to the lymphatic system. Lymphedema is classified as either primary or secondary, the former being caused by a malformation of lymph vessels or nodes, and the latter resulting from trauma, chronic lymphatic system overload, or the sequelae of cancer treatments. In the present article, we focus on secondary cancer-related lymphedema (crl), a potential survivorship treatment-related effect. Read More

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December 2020

Favipiravir Use in COVID-19: Analysis of Suspected Adverse Drug Events Reported in the WHO Database.

Infect Drug Resist 2020 14;13:4427-4438. Epub 2020 Dec 14.

All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India.

Background: COVID-19 caused by SARS-CoV-2 virus emerged as an unprecedented challenge to discover effective drugs for its prevention and cure. Hyperinflammation-induced lung damage is one of the poor prognostic indicators causing a higher rate of morbidity and mortality of COVID-19 patients. Favipiravir, an antiviral drug, is being used for COVID-19 treatment, and we currently have limited information regarding its efficacy and safety. Read More

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December 2020

A Rodent Model of Sulfur Mustard Hematologic Toxicity for the Efficacy Evaluation of Candidate Medical Countermeasures.

Mil Med 2020 Dec 21. Epub 2020 Dec 21.

National Institutes of Health/National Institute of Allergy and Infectious Diseases - Chemical Countermeasures Research Program, Bethesda, MD 20892, USA.

Introduction: While exposure to sulfur mustard (SM) is commonly associated with the production of vesicating dermal, ocular, and respiratory injuries, systemic damage to bone marrow and lymphatic tissue can decrease critical immune cell populations leading to higher susceptibility to life-threatening infection and septicemia. There are currently no approved medical countermeasures for SM-induced myelosuppression. An intravenous SM challenge model was developed in adult rats as a preliminary proof-of-principle platform to evaluate the efficacy of candidate immunostimulants. Read More

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December 2020

Chylothorax Associated with Congenital Complete Atrioventricular Block.

AJP Rep 2020 Oct 3;10(4):e403-e407. Epub 2020 Dec 3.

Division of Neonatology, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

 Congenital complete atrioventricular block (CCAVB) associated with congenital chylothorax is a rare finding that has been reported in only one case in the literature. We report here the case of an infant with CCAVB complicated by congenital chylothorax.  We present the case of a male neonate with a birth weight of 2114 g. Read More

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October 2020

Ginsenoside Rg1 promotes lymphatic drainage and improves chronic inflammatory arthritis.

J Musculoskelet Neuronal Interact 2020 12;20(4):526-534

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Objective: The lymphatic system plays an important role in joint diseases. This study aimed to evaluate the effects of ginsenoside Rg1 on lymphatic drainage and accumulation of inflammatory products in the joints.

Methods: Two-month-old transgenic mice that overexpress tumor necrosis factor alpha (TNF-α; TNF-Tg) were used as the animal models. Read More

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December 2020

Lymphatic Flow: A Potential Target in Sepsis-Associated Acute Lung Injury.

J Inflamm Res 2020 23;13:961-968. Epub 2020 Nov 23.

Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Sepsis is life-threatening organ dysfunction caused by an imbalance in the body's response to infection and acute lung injury (ALI) related to sepsis is a common complication. The rapid morbidity and high mortality associated with sepsis is a significant clinical problem facing critical care medicine. Inflammation plays a vital role in the occurrence of sepsis. Read More

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November 2020

Iron Measured in Nasal Exudate Samples as a New and Useful Biomarker in the Differential Diagnosis of Patients with Acute Stroke.

Cerebrovasc Dis 2020 20;49(6):625-631. Epub 2020 Nov 20.

Neurology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

Introduction: Differential diagnosis between ischemic and hemorrhagic strokes in the acute stage is one of the major challenges of neurovascular research. Several biomarkers have been studied, but attempts to date have focused on determining their blood levels. Recently, cerebral lymphatic drainage toward the nostrils has been discovered, giving us the chance to study nasal exudate looking for biomarkers of neural damage. Read More

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