84,643 results match your criteria damage increase

Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung.

J Immunotoxicol 2021 Dec;18(1):61-73

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

There is a large, unmet medical need to treat chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and other respiratory diseases. New modalities are being developed, including gene therapy which treats the disease at the DNA/RNA level. Despite recent innovations in non-viral gene therapy delivery for chronic respiratory diseases, unwanted or adverse interactions with immune cells, particularly macrophages, can limit drug efficacy. Read More

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December 2021

Concentration- and Time-Dependent Induction of Cyp1a and DNA Damage Response by Benzo(a)pyrene in LMH 3D Spheroids.

Environ Mol Mutagen 2021 May 6. Epub 2021 May 6.

Environmental and Climate Change, Canada, National Wildlife Research Centre, Ottawa, ON.

In vitro liver toxicity tests performed using cell lines cultured as two-dimensional (2D) monolayer have limited CYP450 activity and may be inadequate for screening chemicals that require activation to exert toxicity. Metabolic competence is greatly improved using three-dimensional (3D) cell culture. In this study, Cyp1a induction, and subsequent DNA damage response induced by benzo(a)pyrene (BaP) were compared in 2D monolayer cells and 3D spheroids of the chicken hepatic cell line, LMH. Read More

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Probiotic Therapy (BIO-THREE) Mitigates Intestinal Microbial Imbalance and Intestinal Damage Caused by Oxaliplatin.

Probiotics Antimicrob Proteins 2021 May 6. Epub 2021 May 6.

Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou University, Tianshuinanlu #222, Lanzhou, 730000, Gansu, Republic of China.

Gastrointestinal mucositis associated with the use of chemotherapeutic drugs can seriously affect the quality of life of patients. In this study, a probiotic mixture, BIO-THREE, was used to alleviate intestinal damage caused by oxaliplatin in mice and human patients. Kunming mice were injected with 15 mg/kg of oxaliplatin twice, and BIO-THREE tablets were administered to mice for 12 days. Read More

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Enhancement of Zn tolerance and accumulation in plants mediated by the expression of Saccharomyces cerevisiae vacuolar transporter ZRC1.

Planta 2021 May 6;253(6):117. Epub 2021 May 6.

Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134, Verona, Italy.

Main Conclusion: Transgenic Arabidopsis thaliana and Populus alba plants overexpressing the zinc transporter ScZRC1 in shoots exhibit Zn tolerance. Increased Zn concentrations were observed in shoots of P. alba, a species suitable for phytoremediation. Read More

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Anterior Chamber Versus Ciliary Sulcus Ahmed Glaucoma Valve Tube Placement: Longitudinal Evaluation of Corneal Endothelial Cell Profiles.

J Glaucoma 2021 Feb;30(2):170-174

Department of Ophthalmology, Centro Hospitalar e Universitário São João.

Prcis: An Ahmed glaucoma valve (AGV) tube in the ciliary sulcus (CS) is safer for the endothelium. At 4 years of follow-up, there was a significant decrease in endothelial cell count only with anterior chamber (AC) placement.

Purpose: Corneal endothelium (CE) damage is one of the most feared long-term complications that can result from glaucoma drainage devices. Read More

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February 2021

Does knowing about the long-term health effects of alcohol matter? Evidence from a university sample in Lebanon.

East Mediterr Health J 2021 Apr 27;27(4):336-343. Epub 2021 Apr 27.

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, United States of America.

Background: Research linking awareness of health effects of alcohol and harmful alcohol drinking status is limited.

Aims: To investigate the association between awareness of long-term alcohol effects and alcohol use disorders.

Methods: University students aged 18-25 years (n = 1155) completed a self-filled survey. Read More

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LncRNA CCAT1 downregulation increases the radiosensitivity of non-small cell lung cancer cells.

Zhao Wang

Kaohsiung J Med Sci 2021 May 6. Epub 2021 May 6.

Department of Oncology Radiotherapy 2, Yantai Yantaishan Hospital, Yantai, Shandong, China.

This study aims to investigate if the radiosensitivity of non-small cell lung cancer (NSCLC) cells can be regulated by long noncoding RNA (lncRNA) colon cancer associated transcript1 (CCAT1). CCAT1 was detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in NSCLC cells (A549, H1299, SK-MES1, H460, and H647) and human bronchial epithelial cells (16HBE). H460 and A549 cells were then selected for the determination of CCAT1 expression after exposure to radiation (0, 2, 4, 6 Gy) at different time points (0, 6, 12, 24 h). Read More

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Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.

Genetics 2019 Oct;213(2):411-429

Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milano 20126, Italy.

Mecl/ATR and Tell/ATM trigger replicative senescence when telomeres become critically short in the absence of telomerase, but how Tell/ATM promotes senescence is still unclear. Menin et al. studied the functions of Saccharomyces cerevisiae Tel1 in senescence by using. Read More

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October 2019

Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.

Genetics 2019 Oct;213(2):411-429

Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milano 20126, Italy.

Mecl/ATR and Tell/ATM trigger replicative senescence when telomeres become critically short in the absence of telomerase, but how Tell/ATM promotes senescence is still unclear. Menin et al. studied the functions of Saccharomyces cerevisiae Tel1 in senescence by using. Read More

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October 2019

Cyber-attack method and perpetrator prediction using machine learning algorithms.

PeerJ Comput Sci 2021 9;7:e475. Epub 2021 Apr 9.

Department of Computer Engineering, Firat University, Elazığ, Turkey.

Cyber-attacks have become one of the biggest problems of the world. They cause serious financial damages to countries and people every day. The increase in cyber-attacks also brings along cyber-crime. Read More

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TREM1 Blockade Ameliorates Lipopolysaccharide-Induced Acute Intestinal Dysfunction through Inhibiting Intestinal Apoptosis and Inflammation Response.

Biomed Res Int 2021 16;2021:6635452. Epub 2021 Apr 16.

Wuxi Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine Affiliated Wuxi Hospital, Wuxi, 214071 Jiangsu, China.

Objective: The lipopolysaccharide- (LPS-) induced acute intestinal dysfunction model has been widely applied in recent years. Here, our aim was to investigate the effect of triggering receptor expressed on myeloid cells-1 (TREM1) inhibitor in LPS-induced acute intestinal dysfunction.

Methods: Male rats were randomly assigned into normal (saline injection), model (LPS and saline injection), and LP17 (LPS and LP17 (a synthetic TREM1 inhibitor) injection) groups. Read More

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L-Carnitine ameliorates the liver by regulating alpha-SMA, iNOS, HSP90, HIF-1alpha, and RIP1 expressions of CCL4-toxic rats.

Iran J Basic Med Sci 2021 Feb;24(2):184-190

Department of Pathology, Faculty of Veterinary, Erciyes University, Kayseri, Turkey.

Objectives: Carbon tetrachloride (CCL) toxicity triggers fibrosis, activating various mechanisms within the cell. We aimed to create damage with CCL and investigate the effectiveness of L-carnitine on the mechanisms we identified.

Materials And Methods: Forty rats were divided into 5 groups with equal number of rats in each group. Read More

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February 2021

Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation.

Oxid Med Cell Longev 2021 13;2021:6647107. Epub 2021 Apr 13.

Department of Bio and Chemical Engineering, Hongik University, Sejong 30016, Republic of Korea.

Acetylshikonin, a naphthoquinone, is a pigment compound derived from Arnebia sp., which is known for its anti-inflammatory potential. However, its anticarcinogenic effect has not been well investigated. Read More

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Glycolytic Metabolism Is Critical for the Innate Antibacterial Defense in Acute Otitis Media.

Front Immunol 2021 19;12:624775. Epub 2021 Apr 19.

Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.

Objective: () is a common respiratory pathogen and a frequent cause of acute otitis media (AOM) in children. However, little is known about the immunometabolism during AOM. This study was to assess the presence of glucose metabolic reprogramming during AOM and its underlying mechanism affecting inflammatory response and middle ear injury. Read More

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Traumatic jejunal perforation associated with SARS-CoV-2 (COVID-19) infection.

Proc (Bayl Univ Med Cent) 2021 Jan 28;34(3):364-366. Epub 2021 Jan 28.

Department of Medical Education, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Several case reports have suggested that COVID-19 may increase the risk of gastrointestinal perforation. We report a case of a gastrointestinal perforation developing in a COVID-19 patient who presented due to injuries from a motor vehicle accident. On admission, the patient had elevated white blood cells, with neutrophilia and lymphopenia. Read More

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January 2021

Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus.

Cell Death Dis 2021 May 5;12(5):445. Epub 2021 May 5.

Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Gyeongnam, 52727, Republic of Korea.

Dynamin-related protein 1 (Drp1)-mediated mitochondrial dysfunction is associated with synaptic injury in the diabetic brain. However, the dysfunctional mitochondria by Drp1 deletion in the diabetic brain are poorly understood. Here, we investigated the effects of neuron-specific Drp1 deletion on synaptic damage and mitophagy in the hippocampus of a high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice. Read More

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Chemoprotective Effect of Syringic Acid on Cyclophosphamide Induced Ovarian Damage via Inflammatory Pathway.

J Oleo Sci 2021 ;70(5):675-683

Department of Gynecology, Affiliated Hospital of Hebei University.

Cyclophosphamide (CP) is very well-known anticancer drug and commonly used against various cancers. CP therapy is related to female ovarian cancer and causes female infertility. The ovarian cancer associated with the increase oxidative stress and inflammatory reaction. Read More

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January 2021

Integrated metabolomics and transcriptomics reveal the anti-aging effect of melanin from ink (MSMI) on D-galactose-induced aging mice.

Aging (Albany NY) 2021 Apr 21;13(8):11889-11906. Epub 2021 Apr 21.

Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China.

ink, a flavoring and coloring agent in food, has attracted considerable attention due to its various pharmacological activities. Our previous study showed that the melanin of ink (MSMI) can alleviate oxidative damage and delay aging in D-galactose(D-gal)-induced aging mice. This study aimed to reveal the possible mechanisms of the anti-aging effect of MSMI. Read More

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Effects of different ischemic preconditioning occlusion pressures on muscle damage induced by eccentric exercise: a study protocol for a randomized controlled placebo clinical trial.

Trials 2021 May 5;22(1):326. Epub 2021 May 5.

Undergraduate Program in Physiotherapy and the Post-Graduate Program in Physiotherapy at Universidade Estadual Paulista - FCT/UNESP, Presidente Prudente, SP, Brazil.

Introduction: Due to its greater generation of muscle strength and less metabolic demand, eccentric exercise has been widely used in rehabilitation and for improving physical fitness. However, eccentric exercise can induce muscle damage by providing structural changes and reduced muscle function, so even with the protection caused by the repeated bout effect from eccentric exercise, it is necessary to seek alternatives to reduce this damage caused by stress. Thus, ischemic preconditioning could represent an aid to reduce the damage muscle or increase the protective effect caused by eccentric exercise. Read More

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Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold.

J Nanobiotechnology 2021 May 5;19(1):128. Epub 2021 May 5.

Tumor Biology and Vascular Targeting Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.

Background: Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepared bi- or trifunctional nanoparticles bearing tumor necrosis factor-α (TNF) and/or interleukin-12 (IL12) plus a peptide containing isoDGR, and we tested their anti-cancer effects, alone or in combination with doxorubicin, in tumor-bearing mice.

Results: In vitro biochemical studies showed that both nanodrugs were monodispersed and functional in terms of binding to TNF and IL12 receptors and to αvβ3. Read More

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Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Department of Ophthalmology, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasizes its protective behavior in retinal cells that help to provide new information about the development of treatment for retinal complications.

Objectives: This study analyzes the effect of in vitro changes associated with the cell survival and rescue mechanism in IGF2 inhibition and activation using chromeceptin and IGF2 peptides in ARPE-19 cells cultured in high glucose conditions. Read More

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Environmental features contributing to falls in persons with vision impairment: The role of home lighting and home hazards.

Am J Ophthalmol 2021 May 2. Epub 2021 May 2.

Wilmer Eye Institute, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD 21287; Massachusetts Eye and Ear, Glaucoma Division, 243 Charles Street, Boston, MA 02114.

Purpose: To evaluate whether home hazards and lighting levels are associated with higher fall rates in adults with varying degrees of visual field (VF) damage from glaucoma.

Methods: Participants with diagnosed or suspected glaucoma provided three years of prospective falls data via monthly falls diaries. Fall locations were determined via post-fall phone questionnaire. Read More

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Central pontine myelinolysis secondary to rapid correction of hyponatremia historical perspective with Doctor Robert Laureno.

Neurol Sci 2021 May 5. Epub 2021 May 5.

Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA.

Objectives: Central pontine myelinolysis (CPM) is a neurological disorder characterized by damage to the myelin and oligodendrocytes in the pons. This review focuses on the history of CPM and the discovery of its association with the treatment of hyponatremia.

Methods: The author reviewed original publications regarding CPM, hyponatremia, and the treatment of hyponatremia. Read More

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Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer.

Adv Mater 2021 May 5:e2100556. Epub 2021 May 5.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.

Radioresistance is an important challenge for clinical treatments. The main causes of radioresistance include hypoxia in the tumor microenvironment, the antioxidant system within cancer cells, and the upregulation of DNA repair proteins. Here, a multiple radiosensitization strategy of high-Z-element-based radiation enhancement is designed, attenuating hypoxia and microRNA therapy. Read More

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Molecular origin of viscoelasticity in mineralized collagen fibrils.

Biomater Sci 2021 May;9(9):3390-3400

Laboratory for Atomistic and Molecular Mechanics (LAMM), USA.

Bone is mineralized tissue constituting the skeletal system, supporting and protecting the body's organs and tissues. In addition to such fundamental mechanical functions, bone also plays a remarkable role in sound conduction. From a mechanical standpoint, bone is a composite material consisting of minerals and collagen arranged in multiple hierarchical structures, with a complex anisotropic viscoelastic response, capable of transmitting and dissipating energy. Read More

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Biomechanical analysis of lumbar interbody fusion supplemented with various posterior stabilization systems.

Eur Spine J 2021 May 4. Epub 2021 May 4.

Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.

Purpose: Biomechanical comparison between rigid and non-rigid posterior stabilization systems following lumbar interbody fusion has been conducted in several studies. However, most of these previous studies mainly focused on investigating biomechanics of adjacent spinal segments or spine stability. The objective of the present study was to compare biomechanical responses of the fusion devices when using different posterior instrumentations. Read More

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The impact of COVID-19 pandemic on gastrointestinal diseases: a single-center cross-sectional study in central Greece.

Ann Gastroenterol 2021 26;34(3):323-330. Epub 2021 Feb 26.

Department of Gastroenterology, University Hospital of Larissa, Thessaly, Greece (Apostolis Papaefthymiou, Apostolos Koffas, Agoritsa Kaltsa, Fotis Tsiopoulos, Andreas Kapsoritakis, Spyros Potamianos).

Background: The current COVID-19 pandemic induced a suppressive environment for healthcare professionals and patients, especially during the lockdown period. Except for the direct burden of the COVID-19, collateral damage has been identified concerning other diseases. The aim of this study was to evaluate the potential impact of the lockdown on the non-COVID-19 patients' outcome in a tertiary gastroenterology department. Read More

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February 2021

Input-independent homeostasis of developing thalamocortical activity.

eNeuro 2021 May 4. Epub 2021 May 4.

Department of Pharmacology and Physiology, The George Washington University

The isocortex of all mammals studied to date shows a progressive increase in the amount and continuity of background activity during early development. In humans the transition from a discontinuous (mostly silent, intermittently bursting) cortex to one that is continuously active is complete soon after birth and is a critical prognostic indicator. In the visual cortex of rodents this switch from discontinuous to continuous background activity occurs during the two days before eye-opening, driven by activity changes in relay thalamus. Read More

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Maternal exercise during pregnancy modulates mitochondrial function and redox status in a sex-dependent way in adult offspring's skeletal muscle.

J Dev Orig Health Dis 2021 May 5:1-8. Epub 2021 May 5.

Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Maternal exercise has shown beneficial effects on mother and child. Literature confirm progeny's cognition improvement, and upregulation in neurotrophins, antioxidant network, and DNA repair system. Considering that there is a lack of information demonstrating the impact of maternal exercise on offspring's skeletal muscle, we aimed to investigate the mitochondrial and redox effects elicited by maternal swimming. Read More

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Effect of Nitrogen Ion Implantation on the Cavitation Erosion Resistance and Cobalt-Based Solid Solution Phase Transformations of HIPed Stellite 6.

Materials (Basel) 2021 Apr 29;14(9). Epub 2021 Apr 29.

Institute of Physics, Maria Curie-Sklodowska University in Lublin, pl. M. Curie-Sklodowskiej 1, 20-031 Lublin, Poland.

From the wide range of engineering materials traditional Stellite 6 (cobalt alloy) exhibits excellent resistance to cavitation erosion (CE). Nonetheless, the influence of ion implantation of cobalt alloys on the CE behaviour has not been completely clarified by the literature. Thus, this work investigates the effect of nitrogen ion implantation (NII) of HIPed Stellite 6 on the improvement of resistance to CE. Read More

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