618,018 results match your criteria daily


Evaluating the effectiveness of countywide mask mandates at reducing SARS-CoV-2 infection in the United States.

J Osteopath Med 2022 Jan 27. Epub 2022 Jan 27.

Internal Medicine/Pulmonology, Mercy Hospital, Joplin, MO, USA.

Context: With the rise of the Delta variant of SARS-CoV-2 and the low vaccination rates in the United States, mitigation strategies to reduce the spread of SARS-CoV-2 are essential for protecting the health of the general public and reducing strain on healthcare facilities. This study compares US counties with and without mask mandates and determines if the mandates are associated with reduced daily COVID-19 infection. US counties have debated whether masks effectively decrease COVID-19 cases, and political pressures have prevented some counties from passing mask mandates. Read More

View Article and Full-Text PDF
January 2022

Handheld Echocardiography in a Clinical Practice Scenario: Concordances Compared to Standard Echocardiographic Reports.

J Cardiovasc Imaging 2022 Jan;30(1):25-34

Division of Cardiovascular Diseases, University of British Columbia, Vancouver, Canada.

Background: The purpose of this study was to assess the utility of a handheld device (HH) used during common daily practice and its agreement with the results of a standard echocardiography study (STD) performed by experienced sonographers and echocardiographer.

Methods: A prospective follow-up was conducted in an adult outpatient echocardiography clinic. Experienced sonographers performed the STD and an experienced echocardiographer performed the HH. Read More

View Article and Full-Text PDF
January 2022

Association between case management and longitudinal decrease in negative symptoms in patients with first episode psychosis: A 2-year follow-up.

Early Interv Psychiatry 2022 Jan 27. Epub 2022 Jan 27.

Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Parma, Italy.

Aim: Negative symptoms (NS) severely affect daily functioning already at the psychosis onset. However, most studies investigating beneficial effects of specific treatments for NS mainly included individuals with prolonged psychotic disorders. Furthermore, evidence on psychosocial rehabilitation for NS in early psychosis is still relatively poor. Read More

View Article and Full-Text PDF
January 2022

Objective Measures of Near Viewing and Light Exposure in Schoolchildren during COVID-19.

Optom Vis Sci 2022 Jan 25. Epub 2022 Jan 25.

University of Houston College of Optometry, Houston, Texas (all authors).

Significance: Wearable sensors provide the opportunity for continuous objective measurement of the visual environment with high resolution. Our findings show that absolute and temporal properties of near viewing and time outdoors vary between myopic and non-myopic schoolchildren, which are important considerations when studying refractive error pathogenesis.

Purpose: Numerous behavioral factors, including near work, time outdoors, electronic device use, and sleep, have been linked to myopia. Read More

View Article and Full-Text PDF
January 2022

Sestrins' Expression in the Liver Is Not Altered by Short-Term Calorie Restriction in Young and Old Rats.

Gerontology 2022 Jan 27:1-9. Epub 2022 Jan 27.

Department of Histology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Introduction: Short-term calorie restriction (SCR) may have a positive impact on health. We hypothesized that sestrins, a family of stress-inducible proteins (Sesn1, Sesn2, Sesn3) are involved in the response to SCR in the liver.

Methods: Young-adult (4-month) and old (24-month) male Wistar rats were either fed ad libitum (control groups) or received 60% of food intake on a daily basis for 30 days (SCR groups). Read More

View Article and Full-Text PDF
January 2022

Growth differentiation factor-15 (GDF-15) and syndecan-1 are potential biomarkers of cardiac and renal involvement in classical Fabry disease under enzyme replacement therapy.

Kidney Blood Press Res 2022 Jan 27. Epub 2022 Jan 27.

Background And Aims: Inflammation and endothelial damage play a pivotal role in Fabry disease (FD) manifestations. In daily clinical practice, FD are mainly monitored by traditional biomarkers of target organ injury, such as serum creatinine and proteinuria, which provide no information about inflammation and endothelial damage.

Materials And Methods: We investigated the serum levels of 3-nitrotyrosine (3-NT), an oxidative stress biomarker, and of growth differentiation factor-15 (GDF-15) and syndecan-1 in classical FD patients on enzyme replacement therapy (ERT) for at least 6 months and their relationship with Fabry-related cardiac and renal manifestations. Read More

View Article and Full-Text PDF
January 2022

Anxiolytic Effects of Chronic Intranasal Oxytocin on Neural Responses to Threat Are Dose-Frequency Dependent.

Psychother Psychosom 2022 Jan 27:1-12. Epub 2022 Jan 27.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

Introduction: Anxiety disorders are prevalent mental conditions characterized by exaggerated anxious arousal and threat reactivity. Animal and human studies suggest an anxiolytic potential of the neuropeptide oxytocin (OT), yet, while a clinical application will require chronic administration protocols, previous human studies have exclusively focused on single-dose (acute) intranasal OT effects.

Objective: To facilitate the translation of the potential anxiolytic mechanism of OT into clinical application, we determined whether the anxiolytic effects of OT are maintained with repeated (chronic) administration or are influenced by dose frequency and trait anxiety. Read More

View Article and Full-Text PDF
January 2022

Determination of phthalic acid esters and di(2-ethylhexyl) adipate in fish and squid using the ammonium formate version of the QuEChERS method combined with gas chromatography mass spectrometry.

Food Chem 2022 Jan 24;380:132174. Epub 2022 Jan 24.

Departamento de Química, Unidad Departamental de Química Analítica, Facultad de Ciencias, Universidad de La Laguna (ULL). Avda. Astrofísico Fco. Sánchez, s/n. 38206 San Cristóbal de La Laguna, España; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna (ULL), Avda. Astrofísico Fco. Sánchez, s/n. 38206 San Cristóbal de La Laguna, España. Electronic address:

In the present study, the ammonium formate version of the QuEChERS method, considered highly advantageous in relation to instrument maintenance and other issues, was applied for the first time to extract a group of twelve phthalic acid esters (PAEs, i.e. dipropyl phthalate, DPP; diisobutyl phthalate, DIBP; dibutyl phthalate, DBP; diisopentyl phthalate, DIPP; di-n-pentyl phthalate, DNPP; dihexyl phthalate, DHP; butyl benzyl phthalate, BBP; dicyclohexyl phthalate, DCHP; di(2-ethylhexyl) phthalate, DEHP; di-n-octyl phthalate, DNOP; diisononyl phthalate, DINP; and diisodecyl phthalate, DIDP) and one adipate (di(2-ethylhexyl) adipate, DEHA) from two species of fish (Scomber colias and Katsuwonus pelamis) and one of squid (Loligo gahi). Read More

View Article and Full-Text PDF
January 2022

Color criteria of facial skin tone judgment.

Vision Res 2022 Jan 24;193:108011. Epub 2022 Jan 24.

Joshibi University of Art and Design, 1900, Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-8538, Japan. Electronic address:

Facial skin tone recognition provides significant social and ecological information to humans. This study utilized a five-alternative forced-choice test design wherein participants were asked to judge which color (red, yellow, green, blue, or white) they perceived as too strong in stimulus skin tone images. The results showed that the participants' reference point of facial skin tone judgement was closer to the centroid facial skin tone observed on a daily basis than the chromaticity of measured or remembered facial skin tones of the observer. Read More

View Article and Full-Text PDF
January 2022

Short communication: The activity of brigatinib in patients with disease progression after next generation anaplastic lymphoma tyrosine kinase inhibitors and an exploratory analysis of circulating tumor DNA.

Lung Cancer 2022 Jan 3;165:43-48. Epub 2022 Jan 3.

University of Colorado Cancer Center, Aurora, CO, USA.

Background: Brigatinib, a second generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), is central nervous system (CNS) penetrant and active against anaplastic lymphoma kinase (ALK) resistance mutations. We prospectively studied the activity of brigatinib in patients with disease progression after second generation ALK TKIs.

Methods: Patients with stage IIIB/IV ALK + non-small cell lung cancer (NSCLC), and progressive disease after second ALK TKIs were eligible. Read More

View Article and Full-Text PDF
January 2022

Who mixes tobacco with cannabis and does mixing relate to nicotine dependence?

Addict Behav 2022 Jan 20;128:107254. Epub 2022 Jan 20.

Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada. Electronic address:

Background: Cannabis users who mix tobacco with cannabis are exposed to nicotine in the tobacco. We identified characteristics of young adult cannabis users who mix and investigated whether mixing frequency is associated with nicotine dependence (ND).

Methods: Data were collected in self-report questionnaires in 2017-20 from 788 young adults (44% male; mean (SD) age 30. Read More

View Article and Full-Text PDF
January 2022

Predictors of Survival: A Retrospective Review of Gastroschisis and Intestinal Atresia in Rwanda.

J Surg Res 2022 Jan 24;273:138-146. Epub 2022 Jan 24.

Division of Pediatric Surgery, University Teaching Hospital-Kigali, Kigali, Rwanda.

Introduction: Neonatal surgical diseases are prime examples of the global disparity in surgical access and outcomes, with survival for conditions like gastroschisis reaching above 95% in high-income settings but usually fatal in low-income settings. This study aims to examine outcomes and predictors of mortality in patients with two specific neonatal surgical conditions that often require early transfer and prolonged inpatient care (gastroschisis and intestinal atresia) at Rwanda's main pediatric referral hospital.

Methods: A single-institution retrospective chart review of neonates with gastroschisis and intestinal atresia was conducted between January 2016 and June 2019. Read More

View Article and Full-Text PDF
January 2022

Tissue-specific accumulation, transformation, and depuration of fipronil in adult crucian carp (Carassius auratus).

Ecotoxicol Environ Saf 2022 Jan 24;232:113234. Epub 2022 Jan 24.

Key Laboratory of Agro-ecological Processes in Subtropical Regions, Changsha Research Station for Agricultural & Environmental Monitoring, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China. Electronic address:

Accumulation and biotransformation of pesticides in fish tissues are essential to assess their toxicity and associated human exposure risk. The mechanisms on time-dependent and tissue-specific accumulation and transformation of fipronil in adult fish are limited. An experiment consisting of 25-d uptake of fipronil at two levels (10 and 50 μg/L) and 25-d depuration in adult crucian carp (Carassius auratus) was conducted. Read More

View Article and Full-Text PDF
January 2022

Photoacoustic imaging for in vivo quantification of alcohol induced structural and functional changes in cerebral vasculature in High alcohol preferring mice (HAP).

Alcohol 2022 Jan 24. Epub 2022 Jan 24.

Department of Medical Engineering, University of South Florida, Tampa, FL 33620, USA. Electronic address:

Alcohol induced structural and functional changes were studied in vivo by Photoacoustic tomography (PAT) of the cerebrovascular system in selectively bred alcohol preferring mice. High (HAP) and Low (LAP) alcohol preferring mice are replicate lines of mice selectively bred to prefer 10% (v/v) ethanol to water and water to ethanol respectively in a free access two-bottle choice scenario. A cohort of 15 singly housed alcohol preferring mice; (5 HAP for experimental group, 5 LAP for control group and 5 other LAP set aside) were given free access two-bottle choice 10% ethanol (v/v) and water in 50 ml graduated drinking bottles mounted on each of their cages for 4-weeks prior to PAT brain scanning. Read More

View Article and Full-Text PDF
January 2022

Bioactive lipids from the fruits of Solanum xanthocarpum and their anti-inflammatory activities.

Fitoterapia 2022 Jan 24:105134. Epub 2022 Jan 24.

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address:

Bioactive lipids widely found in daily consumed plants and animals are essential or beneficial to health and some of them are important physiological regulators in the human body. In our current investigation, 18 bioactive lipids (1-18), including 8 sphingolipids (1-8), 7 oxylipins (9-15), 3 phenolic lipids (16-18) were isolated from the fruits of Solanum xanthocarpum. And compounds 1, 9, 15, 16, and 18 were new lipids. Read More

View Article and Full-Text PDF
January 2022

The antidepressant potential of lactobacillus casei in the postpartum depression rat model mediated by the microbiota-gut-brain axis.

Neurosci Lett 2022 Jan 24:136474. Epub 2022 Jan 24.

Hebei University of Engineering, Handan city, Hebei Province 056038, China. Electronic address:

Lactobacillus casei, a kind of probiotic, was reported as antidepressant effects. However, little is known about the effect of Lactobacillus casei on postpartum depression (PPD). In this study, we investigated the effects of Lactobacillus casei in improving PPD and potential mechanisms. Read More

View Article and Full-Text PDF
January 2022

COVID-19 lockdown: the relationship between trait impulsivity and addictive behaviors in a large representative sample of Italian adults.

J Affect Disord 2022 Jan 24. Epub 2022 Jan 24.

Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Background: The importance of trait impulsivity in development, continuation and escalation of addictive behaviors has long been recognized.

Methods: A cross-sectional population-based survey was conducted during the COVID-19 lockdown on 6003 Italian adults aged 18-74 years, representative of the Italian general population, to investigate the relationship between impulsivity (Barratt Impulsiveness Scale - BIS) and selected addictive behaviors (gambling habits, smoking status, cannabis use, average alcohol daily use).

Results: A statistically significant relationship was found between motor impulsivity and starting/increasing drinking and increasing gambling (high vs. Read More

View Article and Full-Text PDF
January 2022

Synergistic effect of reductions in multiple gaseous precursors on secondary inorganic aerosols in winter under a meteorology-based redistributed daily NH emission inventory within the Beijing-Tianjin-Hebei region, China.

Sci Total Environ 2022 Jan 24:153383. Epub 2022 Jan 24.

State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry (LAPC), Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China.

Secondary inorganic aerosols (SIA) account for 20-60% of the total fine particulates in the Beijing-Tianjin-Hebei (BTH) region of China, indicating an urgent need to clarify the relationship among such compounds. The purpose of this study was to quantify the relationship between emissions of NH, NOx, SO, VOCs and SIA concentrations during a severe winter haze episode using an air quality model and a meteorology-based redistributed NH emission inventory within the BTH region. The results showed that the model performance regarding the NH simulations in January by the four emission inventories improved after the redistribution of daily NH emissions, with an increase of 0. Read More

View Article and Full-Text PDF
January 2022

Heatstroke-related ambulance dispatch risk before and during COVID-19 pandemic: A stratified analysis by age, severity, and incident place.

Sci Total Environ 2022 Jan 24:153310. Epub 2022 Jan 24.

Nagasaki University School of Tropical Medicine and Global Health, Nagasaki, Japan. Electronic address:

Background: In summer 2020 under the COVID-19 pandemic, the Ministry of Health, Labour and Welfare has made public warnings that specific preventive measures such as maskwearing, stay-at-home orders, may increase heatstroke risk. In our previous work, we found a lower risk of heatstroke-related ambulance dispatches (HSAD) during the COVID-19 period, however, it is uncertain whether similar risk reductions can be observed in different vulnerable subgroups. This study aimed to determine the HSAD risk before and during the COVID-19 pandemic by age, severity, and incident place subgroups. Read More

View Article and Full-Text PDF
January 2022

'Behind the scenes' of accelerometer use to quantify in-hospital mobility of older adults.

Arch Phys Med Rehabil 2022 Jan 24. Epub 2022 Jan 24.

The Cheryl Spencer Department of Nursing, Faculty of Social Welfare & Health Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel. Electronic address:

Measuring in-hospital mobility of older adults with accelerometers is becoming more common practice. However, neither the unique challenges surrounding accelerometer use within acute hospital settings, nor the potential solutions to these challenges have been well-documented. The aim of this paper is to present and discuss what occurs 'behind the scenes' when using accelerometers to quantify in-hospital mobility among older adults in acute hospital wards. Read More

View Article and Full-Text PDF
January 2022

Combining baloxavir marboxil with standard-of-care neuraminidase inhibitor in patients hospitalised with severe influenza (FLAGSTONE): a randomised, parallel-group, double-blind, placebo-controlled, superiority trial.

Lancet Infect Dis 2022 Jan 24. Epub 2022 Jan 24.

Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Neuraminidase inhibitors (NAIs) are considered the standard of care for hospitalised patients with influenza. We aimed to test whether combining the cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) with standard-of-care NAIs would result in improved clinical outcomes compared with NAI monotherapy in hospitalised patients with severe influenza.

Methods: We did a randomised, parallel-group, double-blind, placebo-controlled, superiority trial. Read More

View Article and Full-Text PDF
January 2022

Pyrotinib plus capecitabine for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases (PERMEATE): a multicentre, single-arm, two-cohort, phase 2 trial.

Lancet Oncol 2022 Jan 24. Epub 2022 Jan 24.

Department of Medical Oncology, Xinxiang Central Hospital, Xinxiang, China.

Background: Patients with HER2-positive metastatic breast cancer have a high risk of developing brain metastases. Efficacious treatment options are scarce. We investigated the activity and safety of pyrotinib plus capecitabine in patients with HER2-positive metastatic breast cancer and brain metastases. Read More

View Article and Full-Text PDF
January 2022

Translation and validation of the speech, spatial, and qualities of hearing scale (SSQ) and the hearing environments and reflection on quality of life (HEAR-QL) questionnaire for children and adolescents in Dutch.

Int J Audiol 2022 Jan 27:1-9. Epub 2022 Jan 27.

Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands.

Objective: To date, no hearing-specific self-report tool is available in Dutch to give insight into how deficits in auditory skills are experienced by a child in daily life or to examine the impact of hearing loss on children's quality of life. Therefore, we aimed to translate and validate the Speech, Spatial, and Qualities of Hearing Scale (SSQ) and the Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for children and adolescents into Dutch.

Design: Translation of the questionnaires into Dutch was conducted by means of the forward-backward procedure. Read More

View Article and Full-Text PDF
January 2022

Does a Hospital Palliative Care Team Have the Potential to Reduce the Cost of a Terminal Hospitalization? A Retrospective Case-Control Study in a Czech Tertiary University Hospital.

J Palliat Med 2022 Jan 27. Epub 2022 Jan 27.

Department of Internal Medicine, Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic.

More than 50% of patients worldwide die in hospitals and end-of-life care is costly. We aimed to explore whether support from the palliative team can influence end-of-life costs. This was a descriptive retrospective case-control study conducted at a Czech tertiary hospital. Read More

View Article and Full-Text PDF
January 2022

A retrospective multi-center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia.

J Vet Intern Med 2022 Jan 27. Epub 2022 Jan 27.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Disseminated aspergillosis (DA) in dogs has a guarded prognosis and there is a lack of a gold standard treatment protocol.

Objective: To retrospectively assess survival times and factors influencing survival times.

Animals: Dogs diagnosed with DA from January 2007 to June 2017. Read More

View Article and Full-Text PDF
January 2022

Relevant factors of leg strength at hospital discharge in patients hospitalized due to acute decompensated heart failure: multi-institutional prospective observational study.

Eur J Cardiovasc Nurs 2022 Jan 27. Epub 2022 Jan 27.

Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine Hospital, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.

Background: Lower leg strength at hospital discharge is strongly associated with poor prognosis in older patients with acute decompensated heart failure (ADHF). Improving leg strength is important in acute-phase cardiac rehabilitation (CR).

Aims: This study aimed to clarify whether a change in leg strength occurs during hospitalization of older ADHF patients receiving CR and whether it affects leg strength at discharge. Read More

View Article and Full-Text PDF
January 2022

Factors associated with baseline smoking self-efficacy among male Qatari residents enrolled in a quit smoking study.

PLoS One 2022 27;17(1):e0263306. Epub 2022 Jan 27.

Epidemiology and Biostatistics Department, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America.

Smoking self-efficacy, described as confidence in one's ability to abstain from smoking in high-risk situations is a key predictor in cessation outcomes; however, there is a dearth of research on factors that influence self-efficacy surrounding smoking behavior. This study examines factors associated with baseline self-efficacy among treatment seeking participants enrolled in a pilot feasibility smoking cessation study. Participants (n = 247) were daily male smokers, residents of Doha in Qatar (18-60 years) who were enrolled in a telephone-based smoking cessation study. Read More

View Article and Full-Text PDF
January 2022

Association between the caregivers' oral health literacy and the oral health of children and youth with special health care needs.

PLoS One 2022 27;17(1):e0263153. Epub 2022 Jan 27.

Department of Developmental and Preventive Sciences, Faculty of Dentistry, Kuwait University, Safat, Kuwait.

Aim: Previous studies have shown that children of caregivers with low oral health literacy (OHL) had more untreated caries than children of caregivers with adequate OHL. However, there is a paucity of information on this relationship among children and youth with special health care needs (CYSHCN). Accordingly, this study aims to assess the association between the caregivers' OHL and the oral health status of CYSHCN. Read More

View Article and Full-Text PDF
January 2022

The effect of modelling parameters in the development and validation of knee joint models on ligament mechanics: A systematic review.

PLoS One 2022 27;17(1):e0262684. Epub 2022 Jan 27.

Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.

Background: The ligaments in the knee are prone to injury especially during dynamic activities. The resulting instability can have a profound impact on a patient's daily activities and functional capacity. Musculoskeletal knee modelling provides a non-invasive tool for investigating ligament force-strain behaviour in various dynamic scenarios, as well as potentially complementing existing pre-planning tools to optimise surgical reconstructions. Read More

View Article and Full-Text PDF
January 2022

Hidden chaos factors inducing random walks which reduce hospital operative efficiency.

PLoS One 2022 27;17(1):e0262815. Epub 2022 Jan 27.

Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

Operative parameters of La Fuenfría Hospital such as: hospitalized patients; daily admissions and discharges were studies for the hospital as a whole, and for each hospital's service unit (henceforth called 'services'). Conventional statistical analyzes and fractal dimension analyzes were performed on daily In-Patient series. The sequence of daily admissions and patients staying on each service were found to be a kind of random series known as random walks (Rw), sequences where what happens next, depends on what happens now plus a random variable. Read More

View Article and Full-Text PDF
January 2022