874,483 results match your criteria cytokine

Immunological Testing in Assisted Reproductive Technology.

Semin Reprod Med 2021 Jun 23. Epub 2021 Jun 23.

Division of Biomedical Sciences, Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, Coventry, United Kingdom.

Fetal implantation requires carefully orchestrated involvement of the maternal immune system. Aberrant function within implantation has been suggested as a cause of implantation failure. The emergence of immunological theories of miscarriage has led to immunological testing as an adjuvant treatment in assisted reproductive technology; however, it remains controversial, with mixed evidence both for immunological cause and the benefits of immunological testing. Read More

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Differential activation of neuroinflammatory pathways in children with seizures: A cross-sectional study.

Seizure 2021 May 31;91:150-158. Epub 2021 May 31.

Division of Neuroimmunology and Neurovirology, NINDS, NIH, Bethesda, MD, United States.

Purpose: Inflammation plays a crucial role in epileptogenesis. We analyzed inflammatory cytokines in plasma and saliva from children with seizures and healthy controls and measured their associations with HHV6 and EBV infection.

Methods: We analyzed plasma from 36 children within 24 h of seizures (cases) and 43 healthy controls and saliva from 44 cases and 44 controls with a multiplex immunoassay. Read More

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Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.

Cytokine 2021 May 24;146:155589. Epub 2021 May 24.

Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Medical Cell Biology, Integrative Physiology, Uppsala University, Uppsala, Sweden.

Background: Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients. Read More

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Phenotypic, functional and serological aspects of genotypic-specific immune response of experimental T. cruzi infection.

Acta Trop 2021 Jun 20:106021. Epub 2021 Jun 20.

Laboratório de Imunologia e Genômica de Parasitos - Departamento de Parasitologia, Instituto de Ciências Biológicas/ICB, Universidade Federal de Minas Gerais, Minas Gerais, Brasil.

The complexity and multifactorial characteristics of Chagas disease pathogenesis hampers the establishment of appropriate experimental/epidemiological sets, and therefore, still represents one of the most challenging fields for novel insights and discovery. In this context, we used a set of attributes including phenotypic, functional and serological markers of immune response as candidates to decode the genotype-specific immune response of experimental T. cruzi infection. Read More

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Study on the compatibility effect and active constituents of Atractylodis Rhizoma in Ermiao Wan against Acute Gouty Arthritis.

J Ethnopharmacol 2021 Jun 20:114353. Epub 2021 Jun 20.

State Key Laboratory of Natural Medicines, Department of Pharmacognosy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Ethnopharmacological Relevance: Ermiao Wan (EMW), composed of Atractylodis Rhizoma (AR) and Phellodendri Chinensis Cortex (PC), is a classical traditional Chinese medicine prescription having been used to treat the disease named "Tong Feng", which is described as "ache in bones and joints" with the same symptom of modern disease named acute gouty arthritis for many years in TCM clinical practice. Besides, both PC and AR were considered to be effective in anti-inflammatory according to modern pharmacological research.

Aim Of The Study: Present study was undertaken to probe the compatibility rationality between the two herbs PC and AR in EMW and the active constituents of AR against acute gouty arthritis (AGA). Read More

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DHX15 is required to control RNA virus-induced intestinal inflammation.

Cell Rep 2021 Jun;35(12):109205

Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

RNA helicases play critical roles in various biological processes, including serving as viral RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 (DHX15) is essential for type I interferon (IFN-I, IFN-β), type III IFN (IFN-λ3), and inflammasome-derived cytokine IL-18 production by intestinal epithelial cells (IECs) in response to poly I:C and RNA viruses with preference of enteric RNA viruses, but not DNA virus. Importantly, we generate IEC-specific Dhx15-knockout mice and demonstrate that DHX15 is required for controlling intestinal inflammation induced by enteric RNA virus rotavirus in suckling mice and reovirus in adult mice in vivo, which owes to impaired IFN-β, IFN-λ3, and IL-18 production in IECs from Dhx15-deficient mice. Read More

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Epigenetic Manipulation to Trigger Production of Guaiane-Type Sesquiterpenes from a Marine-Derived sp. Fungus with Antineuroinflammatory Effects.

J Nat Prod 2021 Jun 23. Epub 2021 Jun 23.

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P.R. China.

Epigenetic manipulation of a deep-sea sediment-derived sp. fungus using suberoylanilide hydroxamic acid (SAHA) induction resulted in the activation of a terpene-related biosynthetic gene cluster, and nine new guaiane-type sesquiterpenes, spiromaterpenes A-I (-), were isolated. Their structures were determined using various spectroscopic techniques, in association with the modified Mosher's method, computed electronic circular dichroism (ECD) spectra, and chemical conversion for configurational assignments. Read More

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Diversity-Oriented A-Macrocyclization for Studying Influences of Ring-Size and Shape of Cyclic Peptides: CD36 Receptor Modulators.

J Med Chem 2021 Jun 23. Epub 2021 Jun 23.

Département de Chimie, Université de Montréal, C.P. 6128, Succursale, Centre-Ville, Montréal, Québec H3C 3J7, Canada.

Cyclic peptide diversity has been broadened by elaborating the A-macrocyclization to include various di-amino carboxylate components with different -amine substituents. Triple-bond reduction provided new cyclic peptide macrocycles with -olefin and completely saturated structures. Moreover, cyclic azasulfurylpeptides were prepared by exchanging the propargylglycine (Pra) component for an amino sulfamide surrogate. Read More

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Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by down-regulating lncRNA ENST00000619282.

Phytother Res 2021 Jun 23. Epub 2021 Jun 23.

College of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, China.

Rheumatoid arthritis (RA), recognized as a common chronic autoimmune disease, is characterized by the excessive proliferation and inflammatory infiltration of fibroblast-like synoviocytes (FLS). In this study, our purpose is to elucidate the mechanisms of triptolide (TPL) in the treatment of RA by regulating the long non-coding RNA (lncRNA) ENST00000619282, which promoted apoptosis and reduced inflammatory infiltration of FLS in RA (RA-FLS). RA-FLS was treated with different concentrations of TPL at different time points. Read More

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Cyclophosphamide-induced inflammation of taste buds and cytoprotection by amifostine.

Chem Senses 2021 Jun 23. Epub 2021 Jun 23.

Department of Biology and Vermont Chemosensory Group, University of Vermont, 109 Carrigan Drive, Burlington, Vermont, United States of America.

Taste buds in the oral cavity have a complex immune system regulating normal functions and inflammatory reactions. Cyclophosphamide (CYP), a chemotherapy drug, has wide ranging disruptive effects on the taste system including loss of taste function, taste sensory cells, and capacity for taste cell renewal. In bladder epithelium, CYP also induces inflammation. Read More

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Atorvastatin Attenuates Vascular Remodeling in Mice with Metabolic Syndrome.

Arq Bras Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Universidade Federal de Jataí - Unidade Acadêmica de Ciências da Saúde, Jataí, GO - Brasil.

Background: Metabolic syndrome is characterized by an array of comorbidities. During this syndrome, structural changes are observed in the cardiovascular system, especially vascular remodeling. One of the predisposing causes for these changes is chronic inflammation resulting from changes in the structure and composition of perivascular adipose tissue. Read More

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Inflammasome genes polymorphisms may influence the development of hepatitis C in the Amazonas, Brazil.

PLoS One 2021 23;16(6):e0253470. Epub 2021 Jun 23.

Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil.

Hepatitis C is considered a major public health problem caused by the hepatitis C virus (HCV). Viral infections are known to induce production of IL1β through the signaling pathway of inflammasomes. Emerging evidences suggest that Inflammasome genes may influence the immune response against HCV as the host genetic background may contribute to the balance between acute and chronic inflammation. Read More

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An Interview with Adolfo Garcia-Sastre, PhD.

J Interferon Cytokine Res 2021 Jun;41(6):203-204

Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA.

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An Interview with Michael Diamond, MD, PhD.

Michael Diamond

J Interferon Cytokine Res 2021 Jun;41(6):200-202

Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.

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Control of Innate Immune Activation by Severe Acute Respiratory Syndrome Coronavirus 2 and Other Coronaviruses.

J Interferon Cytokine Res 2021 Jun;41(6):205-219

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a public health crisis of unprecedented proportions. After the emergence of SARS-CoV-1 in 2002, and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this is the third outbreak of a highly pathogenic zoonotic coronavirus (CoV) that the world has witnessed in the last 2 decades. Infection with highly pathogenic human CoVs often results in a severe respiratory disease characterized by a delayed and blunted interferon (IFN) response, accompanied by an excessive production of proinflammatory cytokines. Read More

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An Interview with Pei-Yong Shi, PhD.

Pei-Yong Shi

J Interferon Cytokine Res 2021 Jun;41(6):197-199

Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, USA.

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Long Noncoding RNA LINC00899/miR-944/ESR1 Axis Regulates Cervical Cancer Cell Proliferation, Migration, and Invasion.

J Interferon Cytokine Res 2021 Jun;41(6):220-233

Department of Gynecology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.

Cervical cancer (CC) is a common malignancy in women. Long noncoding RNA LINC00899 plays a role in cancer, but its effects in CC are unknown. Our experiment aims to investigate the specific effects of LINC00899 in CC. Read More

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Fermented Red Ginseng Alleviates Ovalbumin-Induced Inflammation in Mice by Suppressing Interleukin-4 and Immunoglobulin E Expression.

J Med Food 2021 Jun;24(6):569-576

R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.

Ginseng (the root of Meyer) has been reported to have many biologic therapeutic effects, including anti-inflammatory properties, and ginsenosides are considered as one of the factors responsible for these therapeutic effects. To improve their therapeutic action, probiotic bacteria are used to ferment and chemically transform ginsenosides in red ginseng (RG). In this study, we aimed to investigate the beneficial effects of RG fermented by probiotic bacteria (FRG) against ovalbumin (OVA)-induced allergic rhinitis in a mouse model. Read More

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High irisin and low BDNF levels in aqueous humor of high myopia.

Adv Clin Exp Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Ophthalmology, Peking University People's Hospital, China.

Background: The pathogenesis of myopia remains unclear. Both genetic and environmental factors play a role in the disease progression. Reasons including reduced physical activity (PA) and low-grade intraocular inflammation may be involved in the development of myopia. Read More

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MicroRNAs and related cytokine factors quickly responded in the immune response of Ictalurus punctatus to LPS and β-glucan stimulation.

J Aquat Anim Health 2021 Jun 23. Epub 2021 Jun 23.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Science, South China Agricultural University, Guangzhou, 510642, China.

MicroRNAs (miRNAs) are well-known as powerful regulators of gene expression, with their potential to serve for immunology widely researched in mammals and birds but rarely in fish. To better understand the immunology behavior of fish, we herein investigated 9 immune related miRNAs that were well reported in other animals, as well as 5 related cytokine factors and the Lysozyme (LZM) in the liver, anterior kidney and spleen of the channel catfish (Ictalurus punctatus), after being stimulated by lipopolysaccharides (LPS) and β-glucan. We also predicated the potential targets of these miRNAs via bioinformatics and further investigated 9 of them via qRT-PCR. Read More

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Kinetics of CD4-1+ lymphocytes in brown trout after exposure to viral haemorrhagic septicaemia virus.

J Fish Dis 2021 Jun 23. Epub 2021 Jun 23.

Clinical Division of Fish Medicine, University of Veterinary Medicine Vienna, Vienna, Austria.

T-helper cells express CD4 as a co-receptor that binds to major histocompatibility complex class II to synchronize the immune response against upcoming threats via mediating several cytokines. We have previously reported the presence of CD4 homologues in brown trout. The study of cellular immune responses in brown trout is limited by the availability of specific antibodies. Read More

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Immunotherapy in AML: a brief review on emerging strategies.

Clin Transl Oncol 2021 Jun 23. Epub 2021 Jun 23.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Acute myeloid leukemia (AML), the most common form of leukemia amongst adults, is one of the most important hematological malignancies. Epidemiological data show both high incidence rates and low survival rates, especially in secondary cases among adults. Although classic and novel chemotherapeutic approaches have extensively improved disease prognosis and survival, the need for more personalized and target-specific methods with less side effects have been inevitable. Read More

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miR-483-3p Promotes IL-33 Production from Fibroblast-Like Synoviocytes by Regulating ERK Signaling in Rheumatoid Arthritis.

Inflammation 2021 Jun 23. Epub 2021 Jun 23.

Department of Rheumatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Our previous studies have identified miR-483-3p to be highly expressed in synoviocytes from patients with rheumatoid arhtirits (RA); however, its effects on inflammation of RA fibroblast-like synoviocytes (FLSs) have remained unclear. The expression of miR-483-3p and cytokines in RA FLSs was detected using quantitative real-time polymerase chain reaction. Enzyme-linked immunosorbent was conducted to determine interleukin (IL)-33 production from RA FLSs. Read More

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The immunopathobiology of SARS-CoV-2 infection.

FEMS Microbiol Rev 2021 Jun 23. Epub 2021 Jun 23.

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to coronavirus disease 2019 (COVID-19). Virus-specific immunity controls infection, transmission, and disease severity. With respect to disease severity, a spectrum of clinical outcomes can occur on the basis of the age, genetics, comorbidities, and immune responses in an infected person. Read More

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ACE2 Expression Is Upregulated in Inflammatory Corneal Epithelial Cells and Attenuated by Resveratrol.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):25

Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.

Purpose: The ocular surface is considered an important route for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. The expression level of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is vital for viral infection. However, the regulation of ACE2 expression on the ocular surface is still unknown. Read More

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High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency.

J Exp Med 2021 Aug 23;218(8). Epub 2021 Jun 23.

Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland.

We have described a child suffering from Mendelian susceptibility to mycobacterial disease (MSMD) due to autosomal recessive, complete T-bet deficiency, which impairs IFN-γ production by innate and innate-like adaptive, but not mycobacterial-reactive purely adaptive, lymphocytes. Here, we explore the persistent upper airway inflammation (UAI) and blood eosinophilia of this patient. Unlike wild-type (WT) T-bet, the mutant form of T-bet from this patient did not inhibit the production of Th2 cytokines, including IL-4, IL-5, IL-9, and IL-13, when overexpressed in T helper 2 (Th2) cells. Read More

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The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

J Exp Med 2021 Aug 23;218(8). Epub 2021 Jun 23.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA.

N 6-methyladenosine (m6A) is the most prevalent posttranscriptional modification on RNA. NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor immunity. However, whether and how m6A modifications affect NK cell immunity remain unknown. Read More

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Complicated pulmonary human coronavirus-NL63 infection after a second allogeneic hematopoietic stem cell transplantation for acute B-lymphocytic leukemia: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26446

Department of Bone Marrow Transplantation.

Rationale: Viruses are the most common pathogens that can cause infection-related non-recurrent death after transplantation, occurring mostly from the early stages of hematopoietic stem cell transplantation (HSCT) to within 1 year after transplantation. Human coronavirus (HCoV)-NL63 is a coronavirus that could cause mortality among patients with underlying disease complications. Serological tests are of limited diagnostic value in immunocompromised hosts and cases of latent infection reactivation. Read More

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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.

Elife 2021 Jun 23;10. Epub 2021 Jun 23.

Endocrine Unit, Massachusetts General Hospital, Boston, United States.

Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05-099 potently inhibits salt inducible kinases (SIKs) and may represent a promising new class of bone anabolic agents. Here we report that YKL-05-099 increases bone formation in hypogonadal female mice without increasing bone resorption. Read More

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SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesionin endothelial cells.

J Virol 2021 Jun 23:JVI0079421. Epub 2021 Jun 23.

Department of Internal Medicine, Saint Louis University, Missouri, USA.

Increased mortality in COVID-19 often associates with microvascular complications. We have recently shown that SARS-CoV-2 spike protein promotes an inflammatory cytokine IL-6/IL-6R induced trans-signaling response and alarmin secretion. Virus infected or spike transfected human epithelial cells exhibited an increase in senescence state with the release of senescence associated secretory proteins (SASP) related inflammatory molecules. Read More

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