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Description of the Metacercaria of Cardiocephaloides sp. (Digenea, Diplostomoidea), Newly Recorded from the Brain of Gangetic Leaffish (Nandus nandus) and Its Genetic Characterization in India.

Acta Parasitol 2021 Jun 12. Epub 2021 Jun 12.

Molecular Taxonomy Laboratory, Department of Zoology, Chaudhary Charan Singh University, Meerut, 250004, UP, India.

Purpose: Cardiocephaloides comprises strigeid trematodes that represent a small genus. In this study, metacercaria identified as Cardiocephaloides sp. was collected from the Gangetic leaffish Nandus nandus from the Ganga River at Bairaj, Bijnor (29º01'N, 77º45'E) in the state of Uttar Pradesh (U. Read More

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CD3/TCRE Expression and Immunoregulatory Milieu Induced in a Secondary Intermediate Host by Different Phases of Hydatid Cyst.

Acta Parasitol 2021 Jun 10. Epub 2021 Jun 10.

Parasitology, Zoology and Entomology Department, Faculty of Science (for Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

Background: Echinococcosis is a common health problem in the Mediterranean and the Middle East, and manifests without any symptoms, even in the advanced stages.

Objective: The present study aimed to investigate the cell mediated-immunoregulatory milieu in rats' echinococcosis induced by three different viability status of Echinococcus granulosus especially in the semi-calcareous stage, which can be used as novel biomarkers to monitor disease progression and open the door to a deeper understanding of the pathways that could contribute to complementary echinococcosis therapies.

Materials And Methods: Rat infection with echinococcosis was induced by three different viable statuses of Echinococcus granulosus (G6) camel strain. Read More

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Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study.

Transl Vis Sci Technol 2021 Jun;10(7):10

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.

Purpose: To investigate the relationship between Acanthamoeba cysts and inflammatory cells in Acanthamoeba keratitis (AK) by in vivo confocal microscopy (IVCM).

Methods: A case-control study included 30 patients with AK and 20 normal controls. The severity of the AK was divided into mild, moderate, and severe. Read More

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Novel compound heterozygous STN1 variants are associated with Coats Plus syndrome.

Mol Genet Genomic Med 2021 Jun 10:e1708. Epub 2021 Jun 10.

Department of Paediatric Neuroscience, Addenbrooke's Hospital, Cambridge, UK.

Aim: Coats plus syndrome (CP) is a rare autosomal recessive disorder, characterised by retinal telangiectasia exudates (Coats disease), leukodystrophy, distinctive intracranial calcification and cysts, as well as extra-neurological features including abnormal vasculature of the gastrointestinal tract, portal hypertension and osteopenia with a tendency to fractures. CP most frequently occurs due to loss-of-function mutations in CTC1. The encoded protein CTC1 constitutes part of the CST (CTC1-STN1-TEN1) complex, and three patients have been described with CP due to biallelic mutations in STN1. Read More

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Migrated Bulking Material (Solesta) Presenting as a Vaginal "Cyst": Histopathologic and Chemical Analytical Features.

Int J Gynecol Pathol 2021 Jun 9. Epub 2021 Jun 9.

Long School of Medicine, University of Texas Health Science Center at San Antonio (C.S.Z.) Departments of Dermatology & Pathology, San Antonio Military Medical Center (W.E.W.), San Antonio, Texas Department of Dermatology, United States Air Force Academy, Colorado Springs, CO (R.N.M.) The Joint Pathology Center, Silver Spring, Maryland (M.L.S., S.S.).

Performing injections with a bulking agent consisting of nonanimal stabilized hyaluronic acid and dextranomer is a well-tolerated and efficacious treatment for mild to moderate fecal incontinence. Here, we discuss a case of a patient with a history of a bulking procedure for fecal incontinence who presented to the obstetrics/gynecology clinic for evaluation of a new vaginal "cyst," which was excised. Histopathologic examination revealed migrated bulking agent within the excised specimen. Read More

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Development and validation of artificial intelligence to detect and diagnose liver lesions from ultrasound images.

PLoS One 2021 8;16(6):e0252882. Epub 2021 Jun 8.

Division of Gastroenterology, Department of Medicine, Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Artificial intelligence (AI) using a convolutional neural network (CNN) has demonstrated promising performance in radiological analysis. We aimed to develop and validate a CNN for the detection and diagnosis of focal liver lesions (FLLs) from ultrasonography (USG) still images. The CNN was developed with a supervised training method using 40,397 retrospectively collected images from 3,487 patients, including 20,432 FLLs (hepatocellular carcinomas (HCCs), cysts, hemangiomas, focal fatty sparing, and focal fatty infiltration). Read More

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Ultrasound, CT, and MR Imaging for Evaluation of Cystic Renal Masses.

J Ultrasound Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, Hirslanden Clinic, Bern, Switzerland.

Cystic renal masses are often encountered during abdominal imaging. Although most of them are benign simple cysts, some cystic masses have malignant characteristics. The Bosniak classification system provides a useful way to classify cystic masses. Read More

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Early detection of pancreatic cancer using DNA-based molecular approaches.

Nat Rev Gastroenterol Hepatol 2021 Jun 7. Epub 2021 Jun 7.

Departments of Pathology & Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human pancreatic tissue and other biospecimens such as pancreatic cyst fluid, pancreatic juice and blood have opened the possibility of DNA-based molecular approaches for early detection of pancreatic cancer. In this Review, we discuss and focus on the pathological and molecular features of precancerous lesions of the pancreas, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, which are target lesions of early detection approaches. Read More

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EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma.

Mod Pathol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Thyroid-like follicular renal cell carcinoma is an uncommon kidney tumor with no distinct molecular alteration described to date. This cohort of eight women with mean and median ages of 45 and 46 years, respectively (range 19-65 years), had unencapsulated, well-circumscribed tumors composed of tightly packed anastomosing follicle-like cysts filled with eosinophilic colloid-like material and lined by cuboidal cells with high nuclear to cytoplasmic ratios, oval to elongated nuclei with perpendicular arrangement toward the lumens, and prominent nuclear overlapping. The stroma between these was minimal with the exception of two tumors. Read More

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The relationship between vitamin D and insulin in polycystic ovary syndrome - a critical review.

J Physiol Pharmacol 2021 Feb 3;72(1). Epub 2021 Jun 3.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Cracow, Cracow, Poland.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. It is characterized by hormonal, reproductive and metabolic disturbances, including hyperandrogenism, altered gonadotropin level, ovarian cysts and ovulatory dysfunction as well as insulin resistance, hyperinsulinemia and dyslipidemia. It was shown that increased insulin concentration is a plausible factor in the pathogenesis of PCOS. Read More

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February 2021

Totally endoscopic surgical resection for a blood cyst originated from mitral valve: a case report.

J Cardiothorac Surg 2021 Jun 7;16(1):164. Epub 2021 Jun 7.

Department of Cardiovascular Surgery, Chinese PLA General Hospital, No.28. Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Intracardiac blood cysts are very rare primary cardiac tumors. Blood cysts originated from the mitral valve represent a minority of cases, and previous cases have been mainly treated with conventional surgery through median sternotomy. When the tumor involves heart valves and histopathological diagnosis remains unknown preoperatively, minimally invasive surgical resection of an intracardiac tumor can be challenging, especially through an endoscopic approach. Read More

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Neuroendoscopic treatment of symptomatic cyst of the septum pellucidum in children: A case series.

Clin Neurol Neurosurg 2021 May 8;207:106671. Epub 2021 May 8.

Pediatric Neurosurgery Santobono-Pausilipon Children's Hospital, Naples, Italy.

Background: Symptomatic cysts of the septum pellucidum (CSP) are extremely rare in children and surgical indications are not well defined. A very careful clinical and neuroradiologic evaluation is necessary to consider a patient for surgical indication.

Methods: We present a surgical series of 7 pediatric patients. Read More

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Model-based optical and acoustical compensation for photoacoustic tomography of heterogeneous mediums.

Photoacoustics 2021 Sep 19;23:100275. Epub 2021 May 19.

Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA.

Photoacoustic tomography (PAT) is a non-invasive, high-resolution imaging modality, capable of providing functional and molecular information of various pathologies, such as cancer. One limitation of PAT is the depth and wavelength dependent optical fluence, which results in reduced PA signal amplitude from deeper tissue regions. These factors can therefore introduce errors into quantitative measurements such as oxygen saturation (sO) or the localization and concentration of various chromophores. Read More

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September 2021

Successful endobronchial occlusion in empyema with broncho-pleural fistula secondary to COVID-19 pneumonia: a case report and literature review.

Respirol Case Rep 2021 Jul 26;9(7):e00785. Epub 2021 May 26.

Division of Thoracic Surgery Kansai Medical University Medical Center Moriguchishi Japan.

A few cases of empyema secondary to coronavirus disease 2019 (COVID-19) pneumonia have been reported. Here, we report our experience of a successful endobronchial occlusion using endobronchial Watanabe spigots (EWSs) for empyema with broncho-pleural fistula secondary to COVID-19 pneumonia. A 62-year-old man was diagnosed with COVID-19 and progressed to empyema with broncho-pleural fistula. Read More

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Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study.

Front Neurol 2021 20;12:675244. Epub 2021 May 20.

UMR1219 Bordeaux Population Health Center (Team VINTAGE), INSERM-University of Bordeaux, Bordeaux, France.

Young adults represent an increasingly large proportion of healthy volunteers in brain imaging research, but descriptions of incidental findings (IFs) in this age group are scarce. We aimed to assess the prevalence and severity of IFs on brain MRIs of healthy young research participants aged 18-35 years, and to describe the protocol implemented to handle them. The study population comprised 1,867 participants aged 22. Read More

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Third ventricular diverticulum of the suprapineal recess can be a rare and confounding complication of chronic hydrocephalus: A case report with 2-year follow-up.

Childs Nerv Syst 2021 Jun 6. Epub 2021 Jun 6.

Department of Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.

Purpose: Chronic hydrocephalus is rarely seen in developed countries due to the widespread availability of CT scans for diagnosis and early treatment. In developing countries, it is more frequently encountered along with its rare complication of diverticulum formation.

Methods: We report a case of a previously healthy 6 year old girl who presented with a 10 day history of headache, 3 day history of drowsiness and a single episode of generalized tonic clonic seizures. Read More

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Infected simple renal cyst due to Streptococcus pneumoniae rapidly diagnosed by the melting temperature mapping method: a case report.

BMC Pediatr 2021 06 5;21(1):265. Epub 2021 Jun 5.

Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuou-ku, 330-8777, Saitama, Japan.

Background: Spontaneous infection of preexisting solitary renal cysts has been documented in adults but is extremely rare in children. To date, no cases of simple renal cysts infected with Streptococcus pneumoniae have been described. Recently, reports have described the diagnosis of bacterial infection using the 16 S rRNA gene as well as the accompanying antimicrobial stewardship for microorganisms that are difficult to culture and for culture-negative cases after preceding antibacterial administration. Read More

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The correlations of prenatal renal ultrasound abnormalities with pathogenic CNVs in a large Chinese cohort.

Ultrasound Obstet Gynecol 2021 Jun 5. Epub 2021 Jun 5.

Department of Genetic and Metabolic Central Laboratory, Guangxi Maternal and Child Health Hospital, Guangxi Birth Defects Prevention and Control Institute, No59, Xiangzhu Road, Nanning, China.

Objective: Our retrospective study aimed to assess the prenatal clinical utility of chromosome microarray (CMA) and the correlations of pathogenic copy number variants (CNVs) with different types of renal abnormalities detected by prenatal ultrasound screening and help to guide the optimal management for the relative late invasive diagnostic approach for renal abnormalities.

Methods: Fetus at 14-36 weeks of gestation were routinely screened for renal and other structural abnormalities at the Maternal and Child Health Hospital of Guangxi Autonomous Region. 877 fetuses with abnormal renal sonographic findings identified over a period of more than five years were subjected for CMA analysis using materials obtained from chorionic villi sampling, amniocentesis or cordocentesis. Read More

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MRI, CT and FDG-PET/CT findings of Wolffian tumor: four-case series.

Jpn J Radiol 2021 Jun 5. Epub 2021 Jun 5.

Department of Diagnostic Radiology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.

Abstarct: PURPOSE: The purpose of this study is to describe the characteristic MRI, CT, and F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) findings of Wolffian tumor.

Methods: We reviewed preoperative images in four surgical cases of Wolffian tumor. MRI was available for review in all cases with additional diffusion-weighted images (DWI) in three, and contrast-enhanced images in two. Read More

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Spondyloepimetaphyseal dysplasia EXTL3-deficient type: Long-term follow-up and review of the literature.

Am J Med Genet A 2021 Jun 4. Epub 2021 Jun 4.

Department of Pediatric Genetics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Spondyloepimetaphyseal dysplasia (SEMD) is a group of genetic skeletal disorders characterized by disproportionate short stature, and varying degrees of vertebral, epiphyseal, and metaphyseal involvement of the skeleton. According to the Nosology and classification of genetic skeletal disorders 2019 revision, more than 20 types of SEMD have been identified, and SEMD with immune deficiency, EXTL3 type is one of the newcomers. Affected individuals display variable skeletal abnormalities and neurodevelopmental findings. Read More

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Chronic Toxoplasma gondii infection and sleep-wake alterations in mice.

CNS Neurosci Ther 2021 Jun 4. Epub 2021 Jun 4.

Institut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

Aim: Toxoplasma gondii (Tg) is an intracellular parasite infecting more than a third of the human population. Yet, the impact of Tg infection on sleep, a highly sensitive index of brain functions, remains unknown. We designed an experimental mouse model of chronic Tg infection to assess the effects on sleep-wake states. Read More

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Pre and postnatal diagnosis of a third branchial cleft cyst by sonography and magnetic resonance imaging with three-dimensional virtual reconstruction.

J Clin Ultrasound 2021 Jun 4. Epub 2021 Jun 4.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.

Branchial cleft cysts (BCCs) are common causes of cervical tumors in children and adulthood; however, prenatal diagnosis of BCC is rare. In neonates, these cysts can suddenly increase in size, causing airway obstruction and becoming a life-threatening condition. In this case report, we describe the prenatal diagnosis of a third BCC at the 25th week of pregnancy using ultrasound, magnetic resonance imaging, and three-dimensional virtual models, as well as the perinatal outcomes of this rare condition. Read More

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Ocular cysticercosis at a teaching hospital in Northern India.

Oman J Ophthalmol 2021 Jan-Apr;14(1):8-13. Epub 2021 Feb 27.

Department of Ophthalmology, College of Medicine and Health Sciences, Sultan Qaboos University, Sultan Qaboos University Hospital, Muscat, Oman.

Background: Ocular cysticercosis (OC) is common in tropical countries. This study aimed to analyze the clinical presentation patterns, management and treatment outcomes of OC cases seen at a teaching hospital in North India.

Methods: This study took place between March 2014 and February 2019. Read More

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February 2021

Prevalence of (Malmsten, 1857) infection in swine reared in South Italy: A widespread neglected zoonosis.

Vet World 2021 Apr 30;14(4):1044-1049. Epub 2021 Apr 30.

Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.

Background And Aim: Balantidiasis, caused by (syn. or ), represents a neglected parasitic infection of zoonotic significance affecting a variety of hosts, including domestic pigs that are the main reservoir. has a direct life cycle with a fecal-oral route transmission that occurs mainly by the ingestion of food and water contaminated with cysts. Read More

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Multiple Esophageal Duplication Cysts in a Toddler: A Rare Scenario.

J Indian Assoc Pediatr Surg 2021 Mar-Apr;26(2):126-127. Epub 2021 Mar 4.

Department of Pediatric Surgery, Maulana Azad Medical College, New Delhi, India.

The foregut duplication cysts are rare congenital malformation and are usually "solitary" midline noncommunicating mediastinal structures. We present a 2-year-old asymptomatic boy having multiple noncommunicating foregut cysts in the neck as well as the thorax. Read More

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Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst.

Am J Surg Pathol 2021 Jun 3. Epub 2021 Jun 3.

Departments of Pathology Radiology Cell and Chemical Biology, Leiden University Medical Center, Leiden Department of Pathology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands Department of Medical Genetics and Pathology, Bone Tumor Reference Center, University Hospital Basel and University of Basel, Basel, Switzerland.

A simple bone cyst (SBC) is a cystic bone lesion predominantly affecting young males. The cyst is lined by a fibrous membrane and filled with serosanguinous fluid. EWSR1/FUS-NFATC2 rearrangements were recently identified in SBC. Read More

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A Probabilistic Atlas of the Pineal Gland in the Standard Space.

Front Neuroinform 2021 17;15:554229. Epub 2021 May 17.

Neuroimaging and Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.

Pineal gland (PG) is a structure located in the midline of the brain, and is considered as a main part of the epithalamus. There are numerous reports on the facilitatory role of this area for brain function; hormone secretion and its role in sleep cycle are the major reports. However, reports are rarely available on the direct role of this structure in brain cognition and in information processing. Read More

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Technique for Reduced Trocar Decapsulation of a Giant Nonparasitic Splenic Cyst.

Surg Laparosc Endosc Percutan Tech 2021 Jun 10. Epub 2021 Jun 10.

International School Reduced Scar Laparoscopy, Brussels, Belgium.

Background: Minimally invasive surgery is adopted for patients presenting benign splenic cysts. Reduced port laparoscopy is an evolution of conventional laparoscopy, which can be applied for splenic cysts as well. In this video, a 3-trocar laparoscopic decapsulation of a giant nonparasitic splenic cyst is reported. Read More

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Mid Thoracic intra-spinal facet cyst with lumbar canal stenosis: A rare "double crush".

Int J Neurosci 2021 Jun 1:1-6. Epub 2021 Jun 1.

Department of Spine Services, Indian Spinal Injuries Centre, Vasant kunj, Sector C, 110070 New Delhi.

Introduction: Intraspinal synovial cysts occurrence causing spinal canal occlusion are mostly seen in mobile segments of the spine (lumbar and cervical). An appearance of the cyst in thoracic spine is a relatively rare occurrence. We present an interesting case of "double crush" caused by Lumbar canal stenosis with a mid-dorsal Facet cyst. Read More

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  sp. Nov. (Nematoda: Pratylenchidae) on Raspberries in North Italy with a Morphometrical and Molecular Characterization.

Plants (Basel) 2021 May 26;10(6). Epub 2021 May 26.

Consiglio Nazionale delle Ricerche (CNR), Istituto per la Protezione Sostenibile delle Piante (IPSP), v. G. Amendola, 122/D, 70126 Bari, Italy.

Root-lesion nematode species rank third only to root-knot and cyst nematodes as having the greatest economic impact on crops worldwide. A survey of plant-parasitic nematodes associated with decaying raspberries ( sp.) in northern Italy revealed that root-lesion nematodes were the most frequently occurring species among other phytonematodes. Read More

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