Mol Immunol 2021 May 11;135:351-364. Epub 2021 May 11.
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan Province, China; International Joint Research Center of National Animal Immunology, Henan Agricultural University, Zhengzhou, Henan Province, China. Electronic address:
Cyclin-dependent kinase 9 (CDK9) is a key regulator of RNA-polymerase II and a candidate therapeutic target for various virus infections such as respiratory syncytial virus, herpes simplex virus, human adenovirus, human cytomegalovirus, hepatitis virus B, and human papillomavirus. We employed CDK9-IN-1, a selective CDK9 inhibitor, to investigate the role of CDK9 in porcine reproductive and respiratory syndrome virus (PRRSV) infection. CDK9-IN-1 dose-dependently reduced PRRSV replication without cytotoxicity in the infected cells. Read More