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Oxaliplatin/capecitabine or carboplatin/paclitaxel-based preoperative chemoradiation for resectable oesophageal adenocarcinoma (NeoSCOPE): Long-term results of a randomised controlled trial.

Eur J Cancer 2021 Jun 19;153:153-161. Epub 2021 Jun 19.

Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, CF14 2TL, UK.

Aim: This is the first randomised study to evaluate toxicity and survival outcomes of two neoadjuvant chemoradiotherapy (CRT) regimens for patients with localised oesophageal adenocarcinoma (OAC) or gastro-oesophageal junction (GOJ) adenocarcinoma. The initial results showed comparable toxicity between regimens and pathological complete response (pCR) rate favouring CarPacRT. Herein, we report survival, progression patterns, and long-term toxicity after a median follow-up of 40. Read More

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Haloalkaliphilic denitrifiers-dependent sulfate-reducing bacteria thrive in nitrate-enriched environments.

Water Res 2021 Jun 10;201:117354. Epub 2021 Jun 10.

Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

As bridge in global cycles of carbon, nitrogen, and sulfur, sulfate-reducing bacteria (SRB) play more and more important role under various environments, especially the saline-alkali environments with significant increase in area caused by human activities. Sulfate reduction can be inhibited by environmental nitrate. However, how SRB cope with environmental nitrate stress in these extreme environments still remain unclear. Read More

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A novel glucose-based highly selective phosphate adsorbent.

Sci Total Environ 2021 Jun 16;792:148452. Epub 2021 Jun 16.

Agricultural Technology Extension Station, Mian County, Hanzhong 724200, China.

Industrial wastewater discharge leads to serious eutrophication of water bodies, but most of the adsorbents are difficult to selectively remove phosphorus and are difficult to use multiple times, therefore, developing an efficient and reusable material for removal phosphate is extremely necessary. In this work, a kind of highly selective phosphate adsorbent, microporous carbon material (MCM), based on glucose was synthesized by hydrothermal and activation method. The MCM were characterized by SEM, XPS, BET, element analysis, et al. Read More

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J Pediatr Adolesc Gynecol 2021 Jun 19. Epub 2021 Jun 19.

Pediatric Urology Unit, Santobono-PausiliponChildren's Hospital, Naples, Italy.

Background: Yolk sac tumour (YST) is a malignant entity that often occurs in girls less than 3 years of age and is the most frequent type of primary extragonadal germ cell tumours.

Case: We describe the case of an 11-month-old girl who was referred to our centre for vaginal bleeding with evidence of a uterine mass on ultrasonography. Preoperative investigations confirmed YST of the uterine cervix without metastasis. Read More

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Pharmacodynamics and pharmacokinetics of a copper intrauterine contraceptive system releasing ulipristal acetate: a randomized proof-of-concept study.

Contraception 2021 Jun 19. Epub 2021 Jun 19.

Population Council. 1230 York Avenue, New York City, NY, 10065, USA.

Objectives: To assess pharmacodynamic and pharmacokinetic outcomes of a novel copper (Cu) intrauterine system (IUS) releasing ulipristal acetate (UPA) in healthy women.

Study Design: In this single-blinded, randomized proof-of-concept study, ovulatory women received one of three Cu-IUSs releasing low-dose UPA (5, 20 or 40 µg/d) for 12 weeks. The study included a baseline cycle, three 4-week treatment-cycles and two recovery cycles. Read More

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Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

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Hairpin-Spherical Nucleic Acids for Diagnosing COVID-19: a Simple Method to Generalize the Conventional PCR for Molecular Assays.

Anal Chem 2021 Jun 22. Epub 2021 Jun 22.

Department of Molecular Diagnosis, Farzan Molecular and Pathobiology Laboratory, Hamedan 6515638377, Iran.

The COVID-19 pandemic revealed during the first global wave of this infectious disease that mass diagnostic testing was necessary to more rapidly detect infection in patients and control the pandemic. Therefore, extra research efforts to develop reliable and more accessible techniques for disease diagnosis are of supreme importance. Here, a target-responsive assembly of gold nanoparticle-core hairpin-spherical nucleic acids (AuNP-core H-SNAs) was implemented to modify the conventional polymerase chain reaction (PCR) assay for the "naked-eye" colorimetric detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. Read More

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Directionally Tailoring Macroporous Honeycomb-Like Structured Carbon Nanofibers toward High-Capacitive Potassium Storage.

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.

Constructing high-capacitive potassium storage materials can avoid the sluggish and unstable bulk diffusion process via a surface-induced process, which is conducive to swift and frequent potassium storage. Herein, we demonstrated the use of macroporous honeycomb-like carbon nanofibers (MHCNFs) as an excellent anode material for high-capacitive potassium storage. The as-made MHCNFs feature abundant well-controlled macropores, an amorphous structure, and a large specific surface area of around 595. Read More

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Self-Assembled Polyoxometalate Nanodots as Bidirectional Cluster Catalysts for Polysulfide/Sulfide Redox Conversion in Lithium-Sulfur Batteries.

ACS Nano 2021 Jun 22. Epub 2021 Jun 22.

Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.

Polyoxometalates (POMs) are a class of discrete molecular inorganic metal-oxide clusters with reversible multielectron redox capability. Taking advantage of their redox properties, POMs are thus expected to be directly involved in the lithium-sulfur batteries (Li-S, LSBs) system as a bidirectional molecular catalyst. Herein, we design a three-dimensional porous structure of reduced graphene-carbon nanotube skeleton supported POM catalyst as a high-conductive and high-stability host material. Read More

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Adjacent Atomic Pt Site Enables Single-Atom Iron with High Oxygen Reduction Reaction Performance.

Angew Chem Int Ed Engl 2021 Jun 22. Epub 2021 Jun 22.

Tsinghua University, Department of Chemistry, CHINA.

Modulation effect has been widely investigated to tune the electronic state of single-atomic M-N-C catalysts to enhance the activity of oxygen reduction reaction (ORR). However, the in-depth study of modulation effect is rarely reported for the isolated dual-atomic metal sites. Interestingly, guided by the first-principles simulations, we find that the catalytic activities of Fe-N 4 moiety can be enhanced by the adjacent Pt-N 4 moiety through the modulation effect, in which the Pt-N 4 acts as the modulator to tune the 3 d electronic orbitals of Fe-N 4 active site and optimize ORR activity. Read More

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Contrast-enhanced MRI T1 Mapping for Quantitative Evaluation of Putative Dynamic Glymphatic Activity in the Human Brain in Sleep-Wake States.

Radiology 2021 Jun 22:203784. Epub 2021 Jun 22.

From the Departments of Radiology (S.L., R.E.Y., S.H.C., J.Y.L., I.H., K.M.K., T.J.Y., J.H.K., C.H.S.) and Clinical Pharmacology and Therapeutics (K.Y.H.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 03080, Republic of Korea; Center for Nanoparticle Research, Institute for Basic Science, Seoul, Republic of Korea (S.H.C.); School of Chemical and Biological Engineering (S.H.C.) and Department of Electrical and Computer Engineering (S.J., J.L.), Seoul National University, Seoul, Republic of Korea; and Department of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin-si, Republic of Korea (S.H.O.).

Background Evaluation of the glymphatic system with intrathecal contrast material injection has limited clinical use. Purpose To investigate the feasibility of using serial intravenous contrast-enhanced T1 mapping in the quantitative evaluation of putative dynamic glymphatic activity in various brain regions and to demonstrate the effect of sleep on glymphatic activity in humans. Materials and Methods In this prospective study from May 2019 to February 2020, 25 healthy participants (mean age, 25 years ± 2 [standard deviation]; 15 men) underwent two cycles of MRI (day and night cycles). Read More

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High Li-Ion Conductivity Artificial Interface Enabled by Li-Grafted Graphene Oxide for Stable Li Metal Pouch Cell.

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Advanced Li-ion Battery Engineering Laboratory of Zhejiang Province, Key Laboratory of Graphene Technologies and Applications of Zhejiang Province, and CAS Engineering Laboratory for Graphene, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Zhejiang 315201, P. R. China.

The fragile electrolyte/Li interface is responsible for the long-lasting consumption of Li resources and fast failure of Li metal batteries. The polymer artificial interface with high mechanical flexibility is a promising candidate to maintain the stability of the electrolyte/Li interface; however, sluggish Li-ion transportation of the conventional polymer interface hinders the application. In this work, Li-functionalized graphene oxide (GO-ADP-Li), which is synthesized by covalent grafting of adenosine 5'-diphosphate lithium on GO nanosheets, is used as a functional additive to improve the Li-ion conductivity of the polymer artificial interface based on PVDF-HFP/LiTFSI. Read More

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Spinodal Decomposition-Driven Endurable Resistive Switching in Perovskite Oxides.

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

Common pursuits of developing nanometric logic and neuromorphic applications have motivated intensive research studies into low-dimensional resistive random-access memory (RRAM) materials. However, fabricating resistive switching medium with inherent stability and homogeneity still remains a bottleneck. Herein, we report a self-assembled uniform biphasic system, comprising low-resistance 3 nm-wide (Bi,La)FeO nanosheets coherently embedded in a high-resistance (Bi,La)FeO matrix, which were spinodally decomposed from an overall stoichiometry of the (Bi,La)FeO parent phase, as a promising nanocomposite to be a stable and endurable RRAM medium. Read More

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Low-cost insulin for socially at-risk patients: evidence for effectiveness.

Am J Manag Care 2021 Jun;27(6):227-232

ChristianaCare Hospitalist Partners, ChristianaCare, 4755 Ogletown Stanton Rd, Ste 5A43, Newark, DE 19718. Email:

Objectives: The price of analogue insulin has increased dramatically, making it unaffordable for many patients and insurance carriers. By contrast, human synthetic insulins are available at a fraction of the cost. The objective of this study was to examine whether patients with financial constraints were more likely to use low-cost human insulins compared with higher-cost analogue insulins and to determine whether outcomes differ between users of each type of insulin. Read More

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Managing the Uncertainty associated with being a parent of a child with a long-term disability.

Child Care Health Dev 2021 Jun 22. Epub 2021 Jun 22.


Background: Before taking up their role in a collaborative partnership with health professionals parents first need to 'get used' to being a parent of a child with long-term disability or illness. At this time parents experience considerable uncertainty and employ different strategies to try to manage this. This article aims to explore the important theme of uncertainty, how this is experienced by parents and how health professionals might offer support to parents to manage their uncertainty without taking away their hope. Read More

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A Fragment-Based Approach to Discovery of RAGE Inhibitors.

Proteins 2021 Jun 22. Epub 2021 Jun 22.

Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee.

The Receptor for Advanced Glycation End products (RAGE) is a pattern recognition receptor that signals for inflammation via the NF-κB pathway. RAGE has been pursued as a potential target to suppress symptoms of diabetes and is of interest in a number of other diseases associated with chronic inflammation, such as inflammatory bowel disease and bronchopulmonary dysplasia. Screening and optimization have previously produced small molecules that inhibit the activity of RAGE in cell-based assays, but efforts to develop a therapeutically viable direct-binding RAGE inhibitor have yet to be successful. Read More

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Household and Child Food Insecurity and Cardiovascular Disease Risk Factors in Lower-Income Adolescents Aged 12 - 17 Years from the National Health and Nutrition Examination Survey (NHANES) 2007 - 2016.

Public Health Nutr 2021 Jun 21:1-21. Epub 2021 Jun 21.

Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109.

Objective: Household food insecurity is associated with cardiovascular disease (CVD) risk factors in low-income adults, but research on these associations among adolescents is inconsistent. This study investigates whether household and child food insecurity is associated with CVD risk factors in lower-income adolescents.

Design: Cross-sectional. Read More

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Clinical and Molecular Effects of GnRH Agonist and Antagonist on The Cumulus Cells in The Fertilization Cycle.

Int J Fertil Steril 2021 Jul 22;15(3):202-209. Epub 2021 Jun 22.

Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran. Email:

Background: Gonadotropin-releasing hormone (GnRH) analogues have been extensively utilized in the ovarian stimulation cycle for suppression of endogenous rapid enhancement of luteinizing hormone (LH surge). Exclusive properties and functional mechanisms of GnRH analogues in fertilization (IVF) cycles are clearly described. This study was performed to evaluate clinical and molecular impacts of the GnRH agonist and antagonist protocols in IVF cycles. Read More

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Incidence of Pneumocystis jirovecii pneumonia utilizing a polymerase chain reaction-based diagnosis in patients receiving bendamustine.

Cancer Med 2021 Jun 22. Epub 2021 Jun 22.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Pneumocystis jirovecii pneumonia (PJP) is a life-threatening infection occurring in patients receiving bendamustine. The poorly defined incidence, particularly when utilizing polymerase chain reaction (PCR)-based diagnostic techniques, precipitates unclear prophylaxis recommendations. Our objective was to determine the cumulative incidence of PJP diagnosed by single copy target, non-nested PCR in patients receiving bendamustine. Read More

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Nitrogen and Fluorine Dual Doping of Soft Carbon Nanofibers as Advanced Anode for Potassium Ion Batteries.

Small 2021 Jun 21:e2101576. Epub 2021 Jun 21.

Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR, 999078, China.

Potassium-ion batteries (PIBs) are recognized as promising alternatives for lithium-ion batteries as the next-generation energy storage systems. However, the larger radius of K hinders the K insertion into the conventional carbon electrode and results in sluggish potassiation kinetics and poor cycling stability. Here, nitrogen and fluorine dual doping of soft carbon nanotubes (NFSC) anode are synthesized in one pot, achieving extraordinary electrochemical performance for PIBs. Read More

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Monopronucleated (1PN) and tripronuclear (3PN) zygotes formation during assisted reproduction in POSEIDON group 4 patients: Emphasizing on polar bodies.

J Obstet Gynaecol Res 2021 Jun 21. Epub 2021 Jun 21.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Aim: Abnormal fertilization (1PN/3PN) and its accompanying polar body (PB) conditions have been less discussed in poor ovarian responders. By observing the PBs, we analyzed the mechanisms of abnormal fertilization and aimed to explore the role of intracytoplasmic sperm injection/in vitro fertilization (ICSI/IVF) in POSEIDON group 4 patients.

Methods: An observational study. Read More

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The efficacy of adjuvant chemotherapy with capecitabine and cisplatin after surgery in locally advanced esophageal squamous cell carcinoma: a multicenter randomized phase III trial.

Dis Esophagus 2021 Jun 21. Epub 2021 Jun 21.

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

There is limited evidence for the effectiveness of adjuvant chemotherapy in esophageal squamous cell carcinoma (ESCC). This study aimed to assess whether adjuvant capecitabine and cisplatin improve survival compared to surgery alone among patients with locally advanced ESCC. This is a multicenter randomized controlled trial. Read More

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Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis.

J Antibiot (Tokyo) 2021 Jun 21. Epub 2021 Jun 21.

Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.

Resorcylic acid lactones (RALs) with a cis-enone moiety, represented by hypothemycin (1) and (5Z)-7-oxozeaenol (2), are fungal secondary metabolites with irreversible inhibitory activity against protein kinases, with particularly selective activity for inhibition of TAK1 (transforming growth factor beta-activated kinase 1). Gram-scale quantities of these compounds were needed as feedstock for semi-synthesizing RAL-analogues in a step-economical fashion. To do so, this study had three primary goals: identifying fungi that biosynthesized 1 and 2, enhancing their production by optimizing the fermentation conditions on the lab scale, and developing straight forward purification processes. Read More

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Contrast sensitivity and higher-order aberrations in Keratoconus subjects.

Sci Rep 2021 Jun 21;11(1):12971. Epub 2021 Jun 21.

Department of Optometry and Vision Science, Hadassah Academic College, Haniviim St. 37, 9101001, Jerusalem, Israel.

This study analyzes the relationship between contrast-sensitivity and higher-order aberrations (HOA) in mild and subclinical-keratoconus in subjects with good visual-acuity (VA). Keratoconus group (including subclinical-keratoconus) and controls underwent autokeratometry, corneal-tomography, autorefraction and HOA measurement. Contrast-sensitivity was tested using a psychophysical two-alternative forced-choice Gabor patches in three blocks (6, 9, 12 cycles/deg). Read More

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Physical reservoir computing with origami and its application to robotic crawling.

Sci Rep 2021 Jun 21;11(1):13002. Epub 2021 Jun 21.

Department of Mechanical Engineering, Clemson University, Clemson, SC, USA.

A new paradigm called physical reservoir computing has recently emerged, where the nonlinear dynamics of high-dimensional and fixed physical systems are harnessed as a computational resource to achieve complex tasks. Via extensive simulations based on a dynamic truss-frame model, this study shows that an origami structure can perform as a dynamic reservoir with sufficient computing power to emulate high-order nonlinear systems, generate stable limit cycles, and modulate outputs according to dynamic inputs. This study also uncovers the linkages between the origami reservoir's physical designs and its computing power, offering a guideline to optimize the computing performance. Read More

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Biodegradation of crude oil by immobilized Exiguobacterium sp. AO-11 and shelf life evaluation.

Sci Rep 2021 Jun 21;11(1):12990. Epub 2021 Jun 21.

Microbial Technology for Marine Pollution Treatment Research Unit, Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Exiguobacterium sp. AO-11 was immobilized on bio-cord at 10 CFU g carrier for the removal of crude oil from marine environments. To prepare a ready-to-use bioremediation product, the shelf life of the immobilized cells was calculated. Read More

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Evolution and expansion of Li concentration gradient during charge-discharge cycling.

Nat Commun 2021 Jun 21;12(1):3814. Epub 2021 Jun 21.

Analytical Engineering Group, Material Research Center, Samsung Advanced Institute of Technology, Samsung Electronics Co., Ltd., Suwon, Republic of Korea.

To improve the performance of Li-ion batteries (LIBs), it is essential to understand the behaviour of Li ions during charge-discharge cycling. However, the analytical techniques for observing the Li ions are limited. Here, we present the complementary use of scanning transmission electron microscopy and atom probe tomography at identical locations to demonstrate that the evolution of the local Li composition and the corresponding structural changes at the atomic scale cause the capacity degradation of Li(NiCoMn)O (NCM), an LIB cathode. Read More

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Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.

Nat Commun 2021 06 21;12(1):3802. Epub 2021 Jun 21.

Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to medications and vaccinations. Here we describe an engineered human virus receptor, ACE2, by mutagenesis and screening for binding to the receptor binding domain (RBD). Three cycles of random mutagenesis and cell sorting achieved sub-nanomolar affinity to RBD. Read More

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Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

CNRS-Unité Propre de Recherche (UPR) 3212, Institute of Cellular and Integrative Neurosciences, 67084 Strasbourg, France;

Artificial lighting, day-length changes, shift work, and transmeridian travel all lead to sleep-wake disturbances. The nychthemeral sleep-wake cycle (SWc) is known to be controlled by output from the central circadian clock in the suprachiasmatic nuclei (SCN), which is entrained to the light-dark cycle. Additionally, via intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (Opn4), short-term light-dark alternations exert direct and acute influences on sleep and waking. Read More

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[Application of the PCR number of cycle threshold value (Ct) in COVID-19].

Semergen 2021 May 27. Epub 2021 May 27.

Medicina Familiar y Comunitaria, Centro de Salud de la Alamedilla, Servicio de Salud Castilla y León, Salamanca, España.

The SARS-CoV-2 pandemic persists with all its virulence despite 650,382,819 doses of COVID vaccine worldwide. The reference test for infection identification is reverse transcription polymerase chain reaction (RT-qPCR). The usefulness of this test may be diminished by simplifying its result as positive or negative. Read More

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