40,454 results match your criteria cvd

A retrospective study of antithrombotic therapy use in an outpatient haemodialysis unit.

J Clin Pharm Ther 2021 Jun 15. Epub 2021 Jun 15.

Department of Pharmacy, University Health Network, Toronto, Ontario, Canada.

What Is Known And Objective: Patients on haemodialysis (HD) are at increased risk of both bleeding and thrombotic events, due to comorbidities and nature of dialysis treatment. However, there is a lack of research on evidence-based treatment strategies and prescribing patterns for antithrombotic therapies (ATT) in this population. To characterize ATT use and its main indications in an outpatient HD unit. Read More

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The spectrum, prevalence and in-hospital outcomes of cardiovascular diseases in a South African district hospital: a retrospective study.

Cardiovasc J Afr 2021 Jun 10;32:1-6. Epub 2021 Jun 10.

Cardiac Clinic, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Introduction: The increasing prevalence of cardiovascular risk factors in South African rural communities is well reported. However, the prevalence of cardiovascular disease (CVD) leading to hospital admission and related in-hospital mortality in rural and semi-rural hospitals is unknown.

Methods: We conducted a retrospective review of hospital records for patients admitted to the Department of Internal Medicine at Dora Nginza Hospital in Port Elisabeth, South Africa between 1 April and 31 October 2016. Read More

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Dietary intakes of green leafy vegetables and incidence of cardiovascular diseases.

Cardiovasc J Afr 2021 Jun 10;32:1-9. Epub 2021 Jun 10.

Department of Medicine, College of Medicine, University of Ibadan; University College Hospital, Ibadan, Nigeria; Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria; Department of Medicine, College of Medicine, University of Ibadan; University College Hospital; Blossom Specialist Medical Centre, Ibadan, Nigeria. Email:

Aim: Low- and middle-income countries (LMICs) are currently experiencing increasing cardiovascular disease (CVD) rates. Green leafy vegetables (GLV), which are abundant in these countries, are known to be particularly rich in cardioprotective nutrients. This study sought to determine the specific effect of GLV intake on the incidence of CVD. Read More

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Impact of Cancer and Cardiovascular Disease on In-Hospital Outcomes of COVID-19 Patients: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry.

Res Sq 2021 Jun 11. Epub 2021 Jun 11.

While pre-existing cardiovascular disease (CVD) appears to be associated with poor outcomes in patients with Coronavirus Disease 2019 (COVID-19), data on patients with CVD and concomitant cancer is limited. Evaluate the effect of underlying CVD and CVD risk factors with cancer history on in-hospital mortality in those with COVID-19. Data from symptomatic adults hospitalized with COVID-19 at 86 hospitals in the US enrolled in the American Heart Association’s COVID-19 CVD Registry was analyzed. Read More

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Increased Hemoglobin A Time in Range Reduces Adverse Health Outcomes in Older Adults With Diabetes.

Diabetes Care 2021 Jun 14. Epub 2021 Jun 14.

VA Boston Healthcare System, Boston, MA.

Objective: Short- and long-term glycemic variability are risk factors for diabetes complications. However, there are no validated A1C target ranges or measures of A1C stability in older adults. We evaluated the association of a patient-specific A1C variability measure, A1C time in range (A1C TIR), on major adverse outcomes. Read More

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The Exosomes: Staring biomarkers and novel therapeutic strategies.

Curr Pharm Des 2021 Jun 13. Epub 2021 Jun 13.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Extracellular vesicles (EVs, formerly known as exosomes) are small, extracellular membrane-bound particles that play a role in cellular communication via transporting different cargos including proteins, DNAs, RNAs, etc. Their role has been shown in different endocrine/paracrine signaling in different organs such as the cardiovascular system. These days mortality and morbidity rates caused by cardiovascular disease (CVD) have become an important issue among healthcare systems all over the world. Read More

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Optical modulation frequency mediated tunable response time and responsivity in graphene-PbS QD based hybrid photodetectors.

Nanotechnology 2021 Jun 14. Epub 2021 Jun 14.

CEA de Grenoble, Avenue des Martyrs, Grenoble, 38054, FRANCE.

Graphene/lead sulfide (PbS) quantum dot (QD) hybrid infrared photodetectors have gained a lot of attention in recent times due to their high resolution and cost effective fabrication process. In spite of exhibiting remarkably high responsivity, such hybrid detectors are slow as a result of their internal gain mechanism process. In this work, we present a convenient strategy to modulate the correlation between their responsivity and response time giving access to high resolution fast photodetectors in the broadband wavelength range for imaging purpose. Read More

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Use of statin for the primary prevention of cardiovascular outcomes in elderly patients: A propensity-matched cohort study.

Atherosclerosis 2021 Jun 5;328:92-99. Epub 2021 Jun 5.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea. Electronic address:

Background And Aims: Herein, we investigate whether statin treatment as primary prevention reduces cardiovascular outcomes in elderly Asian patients.

Methods: Data were obtained from the Korean National Health Insurance Service-Senior Cohort database (n = 558,147). A total of 81,729 elderly patients (≥75 years) without clinically recognized atherosclerotic cardiovascular disease (CVD) were included. Read More

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Low physical activity levels 1 year after pregnancy complications.

Pregnancy Hypertens 2021 Jun 2;25:136-142. Epub 2021 Jun 2.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171 Blindern, 0318 Oslo, Norway; Division of Gynaecology and Obstetrics, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, Norway; Department of Obstetrics and Gynaecology, Baerum Hospital, Vestre Viken Hospital Trust, Drammen, Sogneprest Munthe-Kaas vei 100, 1346 Gjettum, Norway. Electronic address:

Objectives: Women with previous preeclampsia (PE), gestational hypertension (GH), or gestational diabetes mellitus (GDM) have increased cardiovascular disease (CVD) risk. Physical activity (PA) is an important CVD risk modifier. We aimed to assess PA levels, using a validated objective method, and other modifiable CVD risk factors in women with these previous pregnancy complications. Read More

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Sarcopenic obesity as a determinant of cardiovascular disease risk in older people-a systematic review.

Postgrad Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Geriatric Medicine, Rotherham General Hospital, Moorgate Road, Rotherham S60 2UD, UK.

Background: Ageing is associated with body composition changes that include a reduction of muscle mass or sarcopenia and an increase in visceral obesity. Thus, ageing involves a muscle-fat imbalance with a shift towards more fat and less muscle. Therefore, sarcopenic obesity, defined as a combination of sarcopenia and obesity, is a global health phenomenon due to the increased ageing of the population combined with the increased epidemic of obesity. Read More

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General practitioners' knowledge about pregnancy complications associated with long-term cardiovascular risk.

Gac Med Mex 2021 ;157(1):47-51

Division of Endocrinology, Diabetes and Hypertension, Brigham & Women's Hospital, Harvard Medical School, Boston, United States.

Introduction: Cardiovascular disease (CVD) is the leading cause of mortality in women; preeclampsia (PE) and gestational diabetes mellitus (GDM) are associated with an increased risk of CVD.

Objective: To evaluate general practitioners (GP) knowledge about complicated pregnancies and their association with CVD.

Methods: An anonymous case-based electronic questionnaire designed to assess the level of understanding on the influence of a history of pregnancy complications on long-term cardiovascular risk and general knowledge about CVD risk was sent to GPs. Read More

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January 2021

Assessment of Studies of Quality Improvement Strategies to Enhance Outcomes in Patients With Cardiovascular Disease.

JAMA Netw Open 2021 Jun 1;4(6):e2113375. Epub 2021 Jun 1.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: Clinical care quality improvement (QI) strategies are critical to prevent and control cardiovascular disease (CVD). However, there is limited evidence regarding which components of the health system-, clinician-, and patient-based QI strategies contribute to their impact on CVD.

Objectives: To identify, map, and organize evidence on the effectiveness and implementation of cardiovascular QI strategies that seek to improve outcomes in patients with CVD. Read More

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The Cardiovascular Cost of Silence: Relationships Between Self-silencing and Carotid Atherosclerosis in Midlife Women.

Ann Behav Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Individuals engage in a range of behaviors to maintain close relationships. One behavior is self-silencing or inhibiting self-expression to avoid relationship conflict or loss. Self-silencing is related to poor mental health and self-reported physical health in women but has not been examined in relation to cardiovascular health, particularly using direct measures of the vasculature. Read More

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Testosterone, HIV, and cardiovascular disease risk.

Cardiovasc Endocrinol Metab 2021 Jun 9;10(2):72-79. Epub 2020 Oct 9.

Cardiovascular Division, University of Miami Hospital, Miami, Florida, USA.

There has been a recent increase in the use of testosterone supplementation among young adults in the United States, despite the controversy of testosterone replacement therapy (TRT) and cardiovascular safety. The lower testosterone levels and earlier age of TRT use in persons living with HIV (PLHIV) is of particular relevance for this population because cardiovascular disease (CVD) comorbidities are known to be increased among PLHIV. There is very limited data on TRT in PLHIV, as such, in this article, we sought to compile current evidence regarding the diagnosis and management of testosterone deficiency and its link to CVD risk including among PLHIV. Read More

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Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery.

Int J Cardiol Heart Vasc 2021 Jun 28;34:100799. Epub 2021 May 28.

Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Denmark.

Background: Early systolic lengthening (ESL), a paradoxical stretch of myocardial fibers, has been linked to loss of myocardial viability and contractile dysfunction. We assessed the long-term prognostic potential of ESL in coronary artery bypass graft (CABG) patients.

Methods: We retrospectively included patients (n = 709; mean age 68 years; 85% men) who underwent speckle tracking echocardiography (median 15 days) prior to CABG. Read More

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Association Between Hemoglobin Glycation Index and Risk of Cardiovascular Disease and All Cause Mortality in Type 2 Diabetic Patients: A Meta-Analysis.

Front Cardiovasc Med 2021 28;8:690689. Epub 2021 May 28.

Department of Cardiology, The Second People's Hospital of Foshan, Foshan, China.

The hemoglobin glycation index (HGI) has been proposed as a marker to quantify inter-individual variation in hemoglobin glycosylation. However, whether HGI is associated with an increased risk of diabetic complications independent of glycated hemoglobin (HbA1c) remains unclear. This meta-analysis aimed to determine the association between HGI and the risk of all cause mortality and composite cardiovascular disease (CVD). Read More

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Longitudinal Effect of Hemoglobin Concentration With Incident Ischemic Heart Disease According to Hepatic Steatosis Status Among Koreans.

Front Cardiovasc Med 2021 28;8:677040. Epub 2021 May 28.

Department of Family Medicine, Yongin Severance Hospital, Yongin, South Korea.

An increased hemoglobin (Hb) level may have detrimental effects on hepatic steatosis (HS) as well as cardiovascular disease (CVD). We investigated Hb's effect on incident ischemic heart disease (IHD) risk in the context of hepatic steatosis (HS). We assessed 17,521 non-diabetic participants and retrospectively screened for IHD using the Korea National Health Insurance data. Read More

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Leisure-Time Physical Activity and Cardiovascular Disease Risk Among Hypertensive Patients: A Longitudinal Cohort Study.

Front Cardiovasc Med 2021 28;8:644573. Epub 2021 May 28.

Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Few studies estimated the effect of leisure-time physical activity (LTPA) on cardiovascular disease (CVD) risk among hypertensive patients in a longitudinal cohort. This study aims to evaluate the association between LTPA and CVD in a longitudinal management cohort of hypertensive patients. A total of 58,167 hypertensive patients without baseline CVD from a longitudinal cohort were included in this study. Read More

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Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review.

Front Cell Dev Biol 2021 26;9:674103. Epub 2021 May 26.

Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

The oxidative modification of the major cholesterol carrying lipoprotein, oxLDL, is a biomarker as well as a pathological factor in cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM), obesity and other metabolic diseases. Perturbed cellular homeostasis due to physiological, pathological and pharmacological factors hinder the proper functioning of the endoplasmic reticulum (ER), which is the major hub for protein folding and processing, lipid biosynthesis and calcium storage, thereby leading to ER stress. The cellular response to ER stress is marked by a defensive mechanism called unfolded protein response (UPR), wherein the cell adapts strategies that favor survival. Read More

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Adiponectin Is Related to Cardiovascular Risk in Severe Mental Illness Independent of Antipsychotic Treatment.

Front Psychiatry 2021 28;12:623192. Epub 2021 May 28.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) associated with elevated cardiovascular disease (CVD) risk, including obesity. Leptin and adiponectin are secreted by adipose tissue, with pro- and anti-inflammatory properties, respectively. The second generation antipsychotics (AP) olanzapine, clozapine, and quetiapine have been associated with high leptin levels in SMI. Read More

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Association of Angiotensin-Converting Enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in Polycystic ovarian syndrome: A case-control study.

Saudi J Biol Sci 2021 Jun 14;28(6):3483-3489. Epub 2021 Mar 14.

Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.

Background: Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma. High ACE levels induce insulin resistance and hyperandrogenism, which are the main attributes of polycystic ovary syndrome (PCOS). Therefore, it was hypothesized that I/D polymorphism plays a role in the pathogenesis of PCOS. Read More

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Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia.

Growth Factors 2020 Jun-Jul;38(3-4):189-196

Department of Medical Sciences, Division of Hematology, University Hospital, Uppsala, Sweden.

Individuals suffering from cancer, including hematological malignancies, are at increased risk of cardiovascular disease (CVD). Elevated levels of several biomarkers in blood are associated with an increased risk of CVD. The aim of this study was to investigate whether a subset of such CVD risk biomarkers was elevated in patients with untreated chronic lymphocytic leukemia (CLL). Read More

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Association of soft drink and 100% fruit juice consumption with all-cause mortality, cardiovascular diseases mortality, and cancer mortality: A systematic review and dose-response meta-analysis of prospective cohort studies.

Crit Rev Food Sci Nutr 2021 Jun 13:1-12. Epub 2021 Jun 13.

Gansu Provincial Hospital, Lanzhou, China.

Sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and 100% fruit juices are frequently consumed and have been documented that they could lead to serious disease burden. However, inconsistent evidence on the association between SSBs, ASBs, and 100% fruit juices consumption and mortality have been presented. PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and PsycINFO were systematically searched. Read More

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Cardiovascular Risk Factor Knowledge among Monolingual Hispanics.

J Health Care Poor Underserved 2021 ;32(2):688-699

Hispanics in the United States have worse cardiovascular disease (CVD) risk factor profiles than non-Hispanic Whites. Cardiovascular health literacy is important for health promotion but is not well characterized among monolingual Spanish-speaking Hispanics outside of health care settings. We recruited Hispanic participants (N=235) from a community-based health fair in Denver, Colorado. Read More

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January 2021

Association between birthweight, cardiovascular risk factors, and depression in young Mexican adults.

Nutr Hosp 2021 Jun 14. Epub 2021 Jun 14.

Centro de Investigacion Aplicada en Ambiente y Salud (CIAAS). Facultad de Medicina/CIACYT. Universidad Autónoma de San Luis Potosí.

Background: the aim of this study was to investigate the association between birthweight, cardiovascular disease (CVD) risk factors, and depression in young Mexican adults.

Methods: birthweight reports, family history of CVD and diabetes-related diseases, anthropometrics, serum lipid profile (total cholesterol [TC], triglycerides [TG], high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], and very-low density lipoprotein-cholesterol [VLDL-C]), and depressive symptoms were measured in 778 subjects of the UP-AMIGOS cohort study. To investigate the association between birthweight categories and CVD risk factors and depression, a one-way analysis of variance with post-hoc test was performed of quantitative variables, and 2 test for qualitative variables. Read More

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Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management.

J Card Surg 2021 Jun 13. Epub 2021 Jun 13.

Section of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, Libin Cardiovascular Institute, Calgary, Alberta, Canada.

Background: Mental health and wellbeing continue to gain more attention as they are inextricably associated with clinical outcomes, particularly quality of life. Many medical ailments and major surgeries affect patients' mental health, including depression and delirium.

Aims: The objective of this manuscript was to comprehensively review and critically examine the literature pertaining to cardiac surgery, depression, and delirium. Read More

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SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions.


Eur Heart J 2021 Jun 13. Epub 2021 Jun 13.

Aims : The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model to estimate 5- and 10-year risk of cardiovascular disease (CVD) in individuals aged over 70 years in four geographical risk regions.

Methods And Results : Sex-specific competing risk-adjusted models for estimating CVD risk (CVD mortality, myocardial infarction, or stroke) were derived in individuals aged over 65 without pre-existing atherosclerotic CVD from the Cohort of Norway (28 503 individuals, 10 089 CVD events). Models included age, smoking status, diabetes, systolic blood pressure, and total- and high-density lipoprotein cholesterol. Read More

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SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe.


Eur Heart J 2021 Jun 13. Epub 2021 Jun 13.

Aims: The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe.

Methods And Results : We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking status, systolic blood pressure, and total- and HDL-cholesterol. Read More

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Phosphate Control: The Next Frontier in Dialysis Cardiovascular Mortality.

Cardiorenal Med 2021 Jun 11:1-10. Epub 2021 Jun 11.

Baylor University Medical Center, Dallas, Texas, USA.

Background: Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney disease (CKD) on dialysis. Mortality rates are still unacceptably high even though they have fallen in the past 2 decades. Hyperphosphatemia (elevated serum phosphate levels) is seen in almost all patients with advanced CKD and is by far the largest remaining modifiable contributor to CKD mortality. Read More

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Predicting morbidity by Local Similarities in Multi-Scale Patient Trajectories.

J Biomed Inform 2021 Jun 10:103837. Epub 2021 Jun 10.

Biomedical Data Science Lab (BDSLAB), Instituto de Tecnologías de la Información y Comunicaciones (ITACA), Universitat Politécnica de Valéncia, Camino de Vera s/n, 46022 Valencia, Spain.

Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. Read More

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