8,554 results match your criteria cutaneous side

Masks use and facial dermatitis during COVID-19 outbreak: is there a difference between CE and non-CE approved masks? Multi-center, real-life data from a large Italian cohort.

Ital J Dermatol Venerol 2021 Apr;156(2):220-225

Department of Clinical Dermatology, IRCCS Galeazzi Orthopedic Institute, Milan, Italy.

Background: During the recent COVID-19 outbreak, masks became mandatory and shortages frequent, therefore the prevalence of non-CE (European Conformity Mark) approved masks increased in the general population. We aimed to quantify the prevalence of mask-related cutaneous side effects and the differences between CE and non-CE approved masks.

Methods: In this multicenter prospective observational study conducted from March 20, 2020 to May 12, 2020(during and after quarantine), patients attending emergency departments for a dermatological consult were clinically assessed and their masks were inspected to detect CE marks and UNI (Italian National Unification Entity) norms. Read More

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Toxicity and efficacy of the combination of pembrolizumab with recommended or reduced starting doses of lenvatinib for treatment of recurrent endometrial cancer.

Gynecol Oncol 2021 May 3. Epub 2021 May 3.

Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Objective: We reviewed our institutional data to evaluate toxicity and efficacy outcomes of pembrolizumab/lenvatinib in recurrent endometrial cancer in a "real-world" clinical setting and to compare the impact of reduced lenvatinib starting dose on outcomes.

Methods: Retrospectively, we reviewed toxicity, treatment responses, and survival outcomes of patients with recurrent endometrial cancer who received ≥1 cycle of pembrolizumab/lenvatinib. We compared subgroups based on lenvatinib starting dose (recommended [20 mg] vs reduced [<20 mg]) and histologic type. Read More

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Vaginal mucositis related to immunotherapy in endometrial cancer.

Gynecol Oncol Rep 2021 May 31;36:100742. Epub 2021 Mar 31.

Rutgers Cancer Institute of New Jersey, United States.

Immunotherapy, specifically immune checkpoint inhibitors (ICPi), has revolutionized our approach to treating all solid tumors, including gynecologic malignancies. Compared to standard chemotherapy, the adverse events associated with immunotherapies, are often mild and localized, although more severe systemic responses can also occur. While dermatitisdermatitis is a most commonly reported side effect of ICPi therapy, cutaneous toxicities have a range of clinical manifestations and can provide a challenge in an otherwise favorable treatment protocol. Read More

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A minimally invasive periacetabular osteotomy technique: minimizing intraoperative risks.

J Hip Preserv Surg 2020 Aug 10;7(3):591-595. Epub 2020 Nov 10.

Department of Hip Preservation, University College London Hospitals, 235 Euston Road, London NW12PQ, UK.

The periacetabular osteotomy (PAO) is an extensive surgical procedure associated with potential risk to the adjacent neurovascular structures. A steep learning curve exists, with surgeon experience an important factor in outcome. Little detail exists of the osteotomies themselves, and how to make them safe and reproducible. Read More

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Bloom Time Effect Depends on Muscle Type and May Determine the Results of pH and Color Instrumental Evaluation.

Animals (Basel) 2021 Apr 29;11(5). Epub 2021 Apr 29.

Institute of Animal Breeding, Faculty of Biology and Animal Sciences, Wroclaw University of Environmental and Life Sciences, 51-630 Wroclaw, Poland.

The aim of this study was to determine the effect of 30 min bloom time and the type of muscle on pH and color parameters together with the possibility of estimating these measurements. The research material consisted of 270 samples from 6 muscle types: LD- , LL-, IL-, SEM-, CT-, LTD-. Measurements included pH and color of fresh pork at 0 min, and after 30 min bloom time. Read More

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Cutaneous Bacillary Angiomatosis in a Renal Transplant Patient.

Skinmed 2021 1;19(2):150-154. Epub 2021 Apr 1.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

A 37-year-old man with a history of renal transplantation in 2013 due to focal segmental glomerulosclerosis presented to the emergency room with a 2-week history of fever, chills, anorexia, weight loss, abdominal pain, diarrhea, and a new asymptomatic lesion on the right side of the neck. The patient worked as a truck driver and frequently traveled to Wisconsin; he had not traveled internationally in the past year. He lived with his brother who had a pet cat. Read More

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Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of sp.

J Immunol Res 2021 10;2021:5596876. Epub 2021 Apr 10.

Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, Brazil.

Macrophages play important roles in the innate and acquired immune responses against parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. Read More

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An Updated Guide in the Management of Psoriasis for Every Practitioner.

Int J Clin Pract 2021 Apr 30:e14290. Epub 2021 Apr 30.

Department of Physiology, Iuliu Hatieganu" University of Medicine and Pharmacy, PO code 400006, no. 1 Clinicilor Street, Cluj-Napoca, Romania.

Psoriasis is one of the most common chronic cutaneous skin disorders, having genetic and immunological components. It is currently unknown what exactly triggers it, or how far reaching are the etiological factors, although great strides have been made in uncovering the pathophysiological cascade. Presently, there is a wide diversity of treatment methods for psoriasis, yet not all are applicable for each patient. Read More

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The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands.

J Clin Med 2021 Apr 19;10(8). Epub 2021 Apr 19.

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, College of Medicine, Yonsei University, Seoul 03722, Korea.

Home-use light-emitting diodes (LEDs) are attracting growing attention regarding their anti-aging effects. Although most previous studies on the use of LED devices as a form of low-level laser therapy reported no significant adverse events, questions regarding the safety of using a light source on secretory tissues have been raised. This study aimed to assess the safety and efficacy of a home-use LED device for neck skin rejuvenation, particularly regarding its effect on thyroid gland morphology and function. Read More

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Perceptions and Behavior Regarding Skin Health and Skin Care Products: Analysis of the Questionnaires for the Visitors of Skin Health Expo 2018.

Ann Dermatol 2020 Oct 29;32(5):375-382. Epub 2020 Sep 29.

Department of Dermatology, National Medical Center, Seoul, Korea.

Background: Social standards for skin health have changed and have led to a rise in the general population's interest to achieve flawless skin.

Objective: To survey the Korean public's perception of skin health and dermatologists and skin-health-related behaviors.

Methods: A total of 355 participants of the Skin Health Expo 2018, held by the Dermatological Research Foundation of the Korean Dermatological Association from September 14 to 16, 2018, completed a questionnaire that assessed demographics, status, and behaviors regarding skin health. Read More

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October 2020

Happle-Tinschert Syndrome: A Case Report of Unilateral Segmentally Arranged Basaloid Follicular Hamartoma with Scoliosis and Review of Literature.

Ann Dermatol 2020 Apr 11;32(2):159-163. Epub 2020 Mar 11.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Happle-Tinschert syndrome is a rare disease characterized by unilateral, segmentally arranged basaloid follicular hamartoma (BFH) with osseous, dental, and cerebral anomalies. Although BFH has been demonstrated to be associated with mutations in the patched gene, the genetic basis for Happle-Tinschert syndrome is still unknown. We describe a case of Happle-Tinschert syndrome in a 26-year-old female. Read More

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Comparative Study in Efficacy and Safety of Intralesional Injections of Vitamin D3, Measles Rubella (MR) Vaccine, and Purified Protein Derivative (PPD) in the Management of Cutaneous Warts.

J Cutan Aesthet Surg 2020 Oct-Dec;13(4):326-332

Department of Dermatology, KVG Medical College, Sullia, Karnataka, India.

Introduction: Cutaneous warts caused by human papillomavirus are the most common dermatological diseases being contagious, recurrent, and recalcitrant. Most routinely used treatment modalities are destructive and can cause scarring. Immunotherapy is emerging as new modality of treatment, which enhances cell-mediated immunity against human papillomavirus for clearance of both treated and distant warts. Read More

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Nonsurgical Light and Energy-Based Devices: Utility in Eyelid and Periorbital Surgery.

Facial Plast Surg Clin North Am 2021 May 24;29(2):323-334. Epub 2021 Apr 24.

Ophthalmology, Dermatology, Otolaryngology, Vanderbilt University Medical Center, Nashville, TN, USA.

Periorbital rejuvenation is a common reason for patients to seek cosmetic treatment. There are several nonsurgical light and energy-based devices available to treat various aspects of periorbital rejuvenation without risks of an invasive, surgical procedure. Although ablative laser resurfacing appears to offer the most impressive clinical improvements, nonablative devices result in noticeable cosmetic improvement with more favorable side-effect profiles and shorter recovery times. Read More

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[Adverse drug reactions associated with immune checkpoint inhibitors].

Medicina (B Aires) 2021 ;81(2):208-213

Instituto Alexander Fleming, Buenos Aires. Argentina. E-mail:

The management of patients with immune-related adverse events (irAEs) frequently demands a multidisciplinary approach. We reviewed the causes and clinical course of medical visits and admissions at the Instituto Alexander Fleming due to irAEs between September 2015 and July 2019. Demographic data, diagnosis, toxicity and its severity, requirement of admission, treatment, mortality, and evaluation of the re-administration of immunotherapy were collected. Read More

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Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):255-259. Epub 2021 Apr 17.

Second Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.

Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical bullous lesions in previous and new sites after re-administration of the offending drug. We present a well-documented case of fluconazole-induced GBFDE, with a positive patch test to fluconazole (30% weight/volume preparation) and clinical tolerance to itraconazole proven by negative oral provocation. Even in SCARs, patch testing represents a useful diagnostic tool, while oral provocation remains the gold standard in cases that an alternative but the chemically relevant drug must be administered. Read More

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Ultrasound-guided modified subcostal transversus abdominis plane block and influence of recumbency position on dye spread in equine cadavers.

Vet Anaesth Analg 2021 Mar 25. Epub 2021 Mar 25.

Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address:

Objective: To describe and evaluate an ultrasound-guided modified subcostal approach for the transversus abdominis plane (TAP) block in horse cadavers in lateral or dorsal recumbency.

Study Design: Prospective, experimental cadaveric study.

Animals: Study of one preserved foal and eight fresh adult horse cadavers. Read More

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Hyperpigmentation of an atherosclerotic carotid artery plaque in a patient on chronic suppressive minocycline therapy.

Ann Vasc Surg 2021 Apr 23. Epub 2021 Apr 23.

CVT Surgical Center. Electronic address:

Minocycline is an oral tetracycline antibiotic that has been used to treat a variety of medical conditions. A recognized side effect of minocycline is hyperpigmentation, most commonly a cutaneous phenomenon affecting the lower extremities. In our case report, we present a patient on chronic suppressive minocycline therapy identified intraoperatively with hyperpigmentation involving an atherosclerotic carotid plaque. Read More

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Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma.

ACS Biomater Sci Eng 2021 Apr 23. Epub 2021 Apr 23.

Department of Plastic and Hand Surgery, Inselspital, Bern University Hospital, Freiburgstrasse 4, 3010 Bern, Switzerland.

Seroma formation is a well-recognized postoperative complication for many plastic and general surgical procedures. Although various tissue adhesives and substances have been used in an effort to treat seroma formation, no therapies have been established clinically. Recently, the nano-bridging phenomenon has been introduced as a promising approach to achieve tissue adhesion and strong closure of deep skin wounds in rats. Read More

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Efficacy and safety of Pentamidine isethionate for tegumentary and visceral human leishmaniasis: a systematic review.

J Travel Med 2021 Apr 22. Epub 2021 Apr 22.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Rationale For Review: We performed a systematic review of the literature to investigate the efficacy and safety of pentamidine isethionate for the treatment of human visceral and tegumentary leishmaniasis.

Key Findings: Six hundred and sixteen papers were evaluated, and 88 studies reporting data on 3108 cases of leishmaniasis (2082 patients with tegumentary leishmaniasis and 1026 with visceral leishmaniasis) were finally included. The majority of available studies were on New World cutaneous leishmaniasis and visceral leishmaniasis caused by Leishmania donovani. Read More

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Endocrine prevention of breast cancer.

Mol Cell Endocrinol 2021 Apr 18;530:111284. Epub 2021 Apr 18.

Department of Surgery, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, Tx, 79430, USA.

Breast cancer (BC) is the most common non-cutaneous malignancy among women worldwide and is a significant cause of morbidity, mortality, and national health care expenditure. Unfortunately, with few exceptions like alcohol consumption, obesity, and physical activity, most BC risk factors are unmodifiable. Antiestrogen endocrine therapy, commonly known as BC chemoprevention, is an effective method of BC prevention. Read More

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Infant with a parotid swelling: beware of the rare.

Sudan J Paediatr 2021 ;21(1):95-97

Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.

Salivary gland tumours are rare in children. We present the case of an infant who presented with a progressively increasing swelling of short duration in the parotid region accompanied by a small preauricular cutaneous haemangioma. Failing to comply with the commoner diagnoses like parotitis, help of imaging was taken that pointed towards the rarer diagnosis of parotid haemangioma. Read More

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January 2021

A disseminated Mycobacterium marinum infection in a renal transplant HIV-infected patient successfully treated with a bedaquiline-containing antimycobacterial treatment: a case report.

Int J Infect Dis 2021 Apr 16. Epub 2021 Apr 16.

Department of Infectious Diseases, Tourcoing Hospital, France.

Background: Mycobacterium marinum disseminated infections rarely affected immunocompromised patients. Treatment with prolonged multi-drug regimen, exposed them to frequent drug-drug interactions and side effects.

Case Report: We reported a new case of Mycobacterium marinum disseminated infection in a 54-year-old renal transplant HIV-infected woman. Read More

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Do we need skin toxicity? Association of immune checkpoint inhibitor and tyrosine kinase inhibitor-related cutaneous adverse events with outcomes in metastatic renal cell carcinoma.

Int J Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Introduction: Skin toxicity is a common, expected side effect of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) used for metastatic renal cell carcinoma (mRCC). We evaluated the association between skin toxicity and clinical efficacy outcomes of these agents in mRCC patients.

Methods And Materials: Data were obtained from patients with mRCC treated with TKIs and/or ICIs from 2016-2019 at a referral hospital in Mexico City. Read More

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Small Fiber Neuropathy in the Elderly.

Lan Zhou

Clin Geriatr Med 2021 May 23;37(2):279-288. Epub 2021 Mar 23.

Department of Neurology, Boston Medical Center Cutaneous Nerve Laboratory, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA. Electronic address:

Small fiber neuropathy is common and prevalent in the elderly. The disease can be associated with many medical conditions. It often has a negative impact on quality of life due to painful paresthesia, dizziness, and sedative side effects of pain medications. Read More

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[Rare cutaneous side effect of vemurafenib : Fever and exanthema 14 days after therapy initiation].

Hautarzt 2021 Apr 15. Epub 2021 Apr 15.

Klinik für Dermatologie, Venerologie und Allergologie, Campus Kiel, Hautkrebszentrum, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Str. 3 Haus C, 24105, Kiel, Deutschland.

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Oral Sarecycline for Treatment of Papulopustular Rosacea: Results of a Pilot Study of Effectiveness and Safety.

J Drugs Dermatol 2021 04;20(4):426-431

Background: Cutaneous rosacea is a common inflammatory skin disorder that often presents with facial papulopustular lesions that are frequently bothersome to patients. Studies have shown oral sarecycline to be effective and safe for acne, with a low risk of side effects that are historically associated with other tetracycline-class drugs such as doxycycline and minocycline, in addition to offering a reduced risk of emergence of resistant bacteria due to its narrow-spectrum of antibiotic activity. Oral sarecycline is FDA-approved for the treatment of acne (2018). Read More

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Evaluating safety and compatibility of anti-tumor necrosis factor therapy in patients with connective tissue disorders.

Ann Transl Med 2021 Mar;9(5):430

Department of Dermatology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Inhibition of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) has been utilized as a treatment strategy for a variety of immune-mediated inflammatory disorders (IMID), including rheumatoid arthritis, Crohn's disease and psoriasis. A wide array of biologic therapies targeting the TNFα molecule, including etanercept, infliximab, certolizumab, golimumab and adalimumab, are routinely used in the care of patients with these conditions. In addition to their therapeutic potential, anti-TNFα agents commonly induce the formation of autoantibodies such as anti-nuclear antibodies and anti-double stranded DNA antibodies; however, the vast majority of these are of IgM isotype and of unclear clinical significance, uncommonly leading to drug-induced autoimmune disease. Read More

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Topical ketamine as a local anesthetic agent in reducing venipuncture pain: A randomized controlled trial.

Am J Emerg Med 2021 Apr 3;48:48-53. Epub 2021 Apr 3.

Department of General Surgery, Ealing Hospital, London North West University Healthcare NHS Trust, London, Uxbridge Road, Southall UB1 3HW, UK.

Aim: Pain control is an important aspect of ED patient management, and there are many different protocols used around the world influenced by both availability of local resources as well as staff competency and experience. This study aims to evaluate the use of topical ketamine in acute pain reduction by directly comparing it to lidocaine-prilocaine (EMLA) cream.

Materials And Methods: In this randomized clinical trial, 300 adult patients classified as level 4 or 5 by ESI triage system were enrolled. Read More

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Ribonucleic acid (RNA) COVID-19 vaccine associated cutaneous adverse drug events: a case series of two patients.

Clin Exp Dermatol 2021 Apr 9. Epub 2021 Apr 9.

Jephson Dermatology Centre, South Warwickshire NHS Foundation Trust, Warwick, CV34 5BW, United Kingdom.

Vaccines are biological preparations that enable their recipients to acquire immunity to a specific infectious disease. All vaccines can associate with cutaneous adverse drug events. Ribonucleic acid (RNA) vaccine was first tested in humans in COVID-19 prevention trials in 2020. Read More

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Born in the Purple: An Exceptional Case of Cutis Marmorata Telangiectatica Congenita.

Acta Dermatovenerol Croat 2020 Dec;28(4):247-248

Department of Dermatology, University General Hospital of Patras, Rion, Greece, Greece;

A full-term, 2-day-old female neonate with a congenital non-tender reticular patch that did not disappear with local warming was referred to our department for consultation. The family history as well as the antenatal course and delivery were unremarkable. On examination, we evidenced a fixed, marbled, bluish to deep purple lesion with a fishnet appearance extending over the right side of her body, face, and scalp. Read More

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December 2020