10,289 results match your criteria cutaneous nerve

Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats.

J Physiol Sci 2021 Jun 23;71(1):19. Epub 2021 Jun 23.

Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.

Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the peripheral neural mechanisms of nociception remain unclear. Using single-fiber electrophysiological recordings in vitro, we examined the general characteristics of cutaneous C-fiber afferents in the saphenous nerve and their responsiveness to mechanical and heat stimuli in a rat model of immobilization-induced pain by subjecting the rats to hindlimb cast immobilization for 4 weeks. Read More

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Harefuah 2021 Jun;160(6):346-348

Spine Surgery Unit, Meir Medical Center, Kfar Saba.

Introduction: Entrapment of the iliohypogastric nerve is a rare cause of abdominal pain in children. We present a case report of a 12 year old girl with abdominal pain following a fall accompanied by nausea, vomiting and odynuria. Thorough investigation was normal and a non-organic cause was proposed. Read More

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Recovery of Sensation over the Distribution of the Inferior Alveolar Nerve following Mandibular resection without Nerve Reconstruction.

M Anthony Pogrel

J Oral Maxillofac Surg 2021 May 13. Epub 2021 May 13.

Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA. Electronic address:

TO ASSESS: the long-term recovery of sensation in the lower lip after mandibular resection without reconstruction of the inferior alveolar nerve. MATERIAL AND METHODS: Thirty patients who had mandibular resection carried out without reconstruction of the inferior alveolar nerve were examined after an interval ranging from 6 to 33 years. RESULTS: Only 1 patient, seen 10 years after resection, was totally numb over the distribution of the inferior alveolar nerve. Read More

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Variable patterns of the cutaneous innervation of the dorsum of the foot and its clinical implication.

Ann Med Surg (Lond) 2021 Jun 27;66:102404. Epub 2021 May 27.

Department of Anatomy, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

Background: The superficial sensory nerves are at great risk for injury from lacerations and operative incisions. Precise knowledge regarding the course and distribution of sensory nerves over the dorsum of foot is important to avoid iatrogenic damage by surgeons who are planning the surgical intervention around the distal leg, ankle and foot. The objective of the study is to report the variation in the branching pattern and distribution of the cutaneous nerves over the dorsum of foot. Read More

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MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

Pain 2021 07;162(7):2120-2131

Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States.

Abstract: Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. To address this gap, we investigated the function of nonpeptidergic afferents using the MrgprdCre allele. Read More

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Risk factors of meralgia paresthetica after prone position surgery: Possible influence of operating position, laminectomy level, and preoperative thoracic kyphosis.

J Clin Neurosci 2021 Jul 21;89:292-296. Epub 2021 May 21.

Department of Neurosurgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Obesity and a prolonged surgical duration are reported risk factors for meralgia paresthetica (MP) after prone position surgery; however, this fails to explain why MP seldom occurs after prone position craniotomy. We reviewed the incidence of MP after spinal surgery and craniotomy in the prone position and investigated whether unidentified factors are involved in the mechanism of postoperative MP. Between January 2014 and March 2020, we performed 556 prone position surgeries. Read More

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Persistent pain relief following a single injection of a local anesthetic for neuropathic abdominal wall and groin pain.

Scand J Pain 2021 Jun 10. Epub 2021 Jun 10.

Department of Surgery, Máxima Medical Center, Eindhoven/Veldhoven, The Netherlands.

Objectives: It is our experience that a small portion of patients with neuropathic abdominal wall pain syndromes such as the anterior cutaneous nerve entrapment syndrome (ACNES) have a long term beneficial response following just one single tender point injection (TPI) with a local anesthetic agent. This report focuses on the phenomenon of ongoing pain relief following a single local anesthetic injection in neuropathic abdominal wall and groin pain syndromes.

Methods: This report is an overview based on earlier studies from a center of expertise for neuropathic abdominal wall and groin pain syndromes. Read More

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Treatment of painful median nerve neuroma using pedicled vascularized lateral antebrachial cutaneous nerve with adipofascial flap: a cadaveric study and exploration of clinical application.

J Plast Surg Hand Surg 2021 Jun 9:1-5. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan.

The most common procedure for the treatment of painful median nerve neuroma is coverage with vascularized soft tissue following external neurolysis. However, the ideal treatment should include reconnecting the proximal and distal stumps of the damaged nerve to allow the growth of regenerating axons to their proper targets for a functional recovery. We developed a useful technique employing radial artery perforator adipofascial flap including the lateral antebrachial cutaneous nerve (LABCN) to repair the median nerve by vascularized nerve grafting and to achieve coverage of the nerve with vascularized soft tissue. Read More

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Spare Parts Surgery with a Free Posterior Interosseous Artery Perforator Flap for Thumb Tip.

Plast Reconstr Surg Glob Open 2021 Jun 7;9(6):e3624. Epub 2021 Jun 7.

Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Replantation is an ideal method for treating fingertip amputation. However, in some cases, replantation is known to be a challenging issue. This report described a successful thumb tip reconstruction performed with bone and nail bed salvaged as spare parts, and a free posterior interosseous artery perforator (PIAP) flap. Read More

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Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats.

Mol Pain 2021 Jan-Dec;17:17448069211023230

Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Cancer-associated pain is debilitating. However, the mechanism underlying cancer-induced spontaneous pain and evoked pain remains unclear. Here, using behavioral tests with immunofluorescent staining, overexpression, and knockdown of TRESK methods, we found an extensive distribution of TRESK potassium channel on both CGRP and IB4 nerve fibers in the hindpaw skin, on CGRP nerve fibers in the tibial periosteum which lacks IB4 fibers innervation, and on CGRP and IB4 dorsal root ganglion (DRG) neurons in rats. Read More

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Modified Carpal Tunnel Release: A New Approach to Minimizing Pillar Pain.

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S503-S509

From the Prisma Health/University of South Carolina School of Medicine, Columbia SC.

Introduction: Pillar pain is a frequent postoperative complication of carpal tunnel release (CTR). The precise definition of pillar pain is lacking, but most authors describe it as diffuse aching pain and tenderness in the thenar and hypothenar area. The etiology of pillar pain is unclear. Read More

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Transposition of the superficial femoral artery combined with ultrasound-guided returning-venous cannulation as a last resort for vascular access in a multi-complicated hemodialysis patient.

J Vasc Access 2021 Jun 6:11297298211023288. Epub 2021 Jun 6.

Department of Surgery, Saiwaicho Memorial Hospital, Okayama, Japan.

A superficialized artery as a blood-drawing route could be an option for vascular access (VA) in hemodialysis patients with cardiac failure, vessel damage, steal syndrome, and venous hypertension, and it could be a secondary VA option in those with repetitive vascular access troubles, routinely requiring a blood-returning venous route. The brachial artery is preferably used for superficialization due to the benefit of its appropriate diameter for cannulation, procedural ease of surgery under local anesthesia, and usable subcutaneous vein for blood-returning route in the upper limb. The superficial femoral artery (SFA) has also been reported as a candidate for arterial transposition; however, its subcutaneous transposition could have difficulties in requiring general anesthesia and securing blood-inflow-venous routes. Read More

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Am J Phys Med Rehabil 2021 May 28. Epub 2021 May 28.

Neurology Unit, EMG Lab, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy. Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

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Excision of deep endometriosis nodules of the sciatic nerve in 10 steps.

J Minim Invasive Gynecol 2021 Jun 3. Epub 2021 Jun 3.

Endometriosis Center, Clinique Tivoli-Ducos, Bordeaux, 33000, France.

Objective: To present 10 standardized and reproducible surgical steps allowing for complete excision of deep endometriosis nodules involving the sciatic nerve.

Design: Surgical education video. The local IRB confirmed that the video met ethical criteria required for publication. Read More

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Efficacy of Two Unique Combinations of Nerve Blocks on Postoperative Pain and Functional Outcome After Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Study.

J Arthroplasty 2021 May 19. Epub 2021 May 19.

Department of Orthopaedics Surgery, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Background: This study aimed to explore the efficacy of two unique combinations of nerve blocks on postoperative pain and functional outcome after total knee arthroplasty (TKA).

Methods: Patients scheduled for TKA were randomized to receive a combination of adductor canal block (ACB) + infiltration between the popliteal artery and capsule of the posterior knee block (IPACK) + sham obturator nerve block (ONB) + sham lateral femoral cutaneous nerve block (LFCNB) (control group), or a combination of ACB + IPACK + ONB + sham LFCNB (triple nerve block group), or a combination of ACB + IPACK + ONB + LFCNB (quadruple nerve block group). All patients received local infiltration analgesia. Read More

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Novel ALDH3A2 mutations in structural and functional domains of FALDH causing diverse clinical phenotypes in Sjögren-Larsson syndrome patients.

Hum Mutat 2021 Jun 3. Epub 2021 Jun 3.

School of Biotechnology, Madurai Kamaraj University, Madurai, India.

Mutations in ALDH3A2 cause Sjögren-Larsson syndrome (SLS), a neuro-ichthyotic condition due to the deficiency of fatty aldehyde dehydrogenase (FALDH). We screened for novel mutations causing SLS among Indian ethnicity, characterized the identified mutations in silico and in vitro, and retrospectively evaluated their role in phenotypic heterogeneity. Interestingly, asymmetric distribution of nonclassical traits was observed in our cases. Read More

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Indirect Vibration of the Upper Limbs Alters Transmission Along Spinal but Not Corticospinal Pathways.

Front Hum Neurosci 2021 17;15:617669. Epub 2021 May 17.

School of Engineering and Computer Science, University of Hertfordshire, Hatfield, United Kingdom.

The use of upper limb vibration (ULV) during exercise and rehabilitation continues to gain popularity as a modality to improve function and performance. Currently, a lack of knowledge of the pathways being altered during ULV limits its effective implementation. Therefore, the aim of this study was to investigate whether indirect ULV modulates transmission along spinal and corticospinal pathways that control the human forearm. Read More

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Total Denervation of the Elbow: Cadaveric Feasibility Study.

J Hand Surg Am 2021 May 29. Epub 2021 May 29.

Department of Orthopaedic Surgery, Hôpital Pierre-Paul Riquet, Toulouse, France.

Purpose: Total elbow arthroplasty for the treatment of patients with severe elbow osteoarthritis is associated with postoperative activity limitations and risk of midterm complications. Elbow denervation could be an attractive therapeutic option for young, active patients. The aim of our study was to assess the feasibility of selective total elbow denervation via 2 anteriorly based approaches. Read More

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Bikini Incision Increases the Incidence of Lateral Femoral Cutaneous Nerve Injury in Direct Anterior Approach Hip Arthroplasty: A Prospective Ultrasonic, Electrophysiological, and Clinical Study.

J Arthroplasty 2021 May 15. Epub 2021 May 15.

Department of Joint Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.

Background: Lateral femoral cutaneous nerve (LFCN) injury has been widely reported as one of the most common complications of direct anterior approach (DAA) hip arthroplasty. Bikini incision is considered to increase the incidence of this complication.

Methods: A prospective randomized study was conducted after including ninety-nine bikini and ninety-six longitudinal incision DAA cases from May to November 2020. Read More

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Improvement of Superficial and Deep Cutaneous Microcirculation Due to Axillary Plexus Anesthesia Impaired by Smoking.

J Clin Med 2021 May 14;10(10). Epub 2021 May 14.

Department of Plastic Surgery and Hand Surgery, Burn Center, BG Universitätsklinikum Bergmannsheil Bochum, Ruhr-University Bochum, 44789 Bochum, Germany.

Background: Understanding microvascular physiology is key to any reconstructive procedure. Current concepts in anesthesia increasingly involve regional peripheral nerve blockade during microvascular reconstructive procedures. Whereas favorable effects on perfusion due to these techniques have been reported earlier, little evidence focusing on its effects in most peripheral vascular compartments is available. Read More

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Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling.

Cancers (Basel) 2021 May 12;13(10). Epub 2021 May 12.

Department of Surgery, Oncology and Gastroenterology, Veneto Institute of Oncology IOV-IRCCS, University of Padova, 35128 Padova, Italy.

Plexiform neurofibromas (Pnfs) are benign peripheral nerve sheath tumors that are major features of the human genetic syndrome, neurofibromatosis type 1 (NF1). Pnfs are derived from Schwann cells (SCs) undergoing loss of heterozygosity (LOH) at the locus in an milieu and thus are variably lacking in the key Ras-controlling protein, neurofibromin (Nfn). As these SCs are embedded in a dense desmoplastic milieu of stromal cells and abnormal extracellular matrix (ECM), cell-cell cooperativity (CCC) and the molecular microenvironment play essential roles in Pnf progression towards a malignant peripheral nerve sheath tumor (MPNST). Read More

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Minimally invasive internal fixation for unstable pelvic ring fractures: a retrospective study of 27 cases.

J Orthop Surg Res 2021 May 31;16(1):350. Epub 2021 May 31.

Department of Orthopaedics, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, 610041, Sichuan, People's Republic of China.

Background: This study aimed to evaluate the radiographic and clinical outcomes of anterior subcutaneous internal fixation (INFIX) with or without posterior fixation for the treatment of unstable pelvic fractures.

Methods: Intraoperative blood loss, operation time, and duration of hospital stay were recorded, and fracture union and postoperative complications were evaluated. The fracture reduction quality was evaluated using the Matta score, pelvic deformity index (PDI), and pubic symphyseal width (PSW). Read More

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Endoscopic Approach to Proximal Hamstring Avulsion Repair.

JBJS Essent Surg Tech 2020 Oct-Dec;10(4). Epub 2020 Dec 24.

Division of Sports Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.

Background: Endoscopic repair of a proximal hamstring avulsion promotes precise anatomical repair and lowers the risk of neurovascular injury.

Description: Indications for proximal endoscopic repair of the proximal part of the hamstrings include acute tears of 2 tendons with >2 cm of retraction in young active patients, acute complete tears of 3 tendons with >2 cm of retraction, or failed conservative treatment of tears of ≥2 tendons with ≤2 cm of retraction. Repair of a proximal hamstring avulsion is performed using 2 portals. Read More

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December 2020

Acute Glaucoma Filtering Surgery Failure following Herpes Zoster Ophthalmicus Infection.

Case Rep Ophthalmol 2021 May-Aug;12(2):324-329. Epub 2021 May 3.

1st Opthhalmology Department, "G.Gennimatas" Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Herein, we report a case of acute failure of a previously successful trabeculectomy, following an infection with herpes zoster ophthalmicus (HZO). HZO remains a common infection, especially among elderly and immunocompromised patients. There is a strong link between HZO infection, the incidence of secondary glaucoma, and the need for glaucoma filtering surgery. Read More

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Displaced distal radius fracture: reduction, follow-up, and clinical outcomes : learning from a pragmatic approach during the 2020 COVID-19 lockdown transition.

Bone Jt Open 2021 May;2(5):338-343

Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham, UK.

Aims: Displaced distal radius fractures were investigated at a level 1 major trauma centre during the COVID-19 2020 lockdown due to the implementation of temporary changes in practice. The primary aim was to establish if follow-up at one week in place of the 72-hour British Orthopaedic Association Standards for Trauma & Orthopaedics (BOAST) guidance was safe following manipulation under anaesthetic. A parallel adaptation during lockdown was the non-expectation of Bier's block. Read More

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[Clinical effects of anterolateral thigh perforator flap with sensory nerves in repairing the plantar skin and soft tissue defects].

Zhonghua Shao Shang Za Zhi 2021 May;37(5):453-459

Department of Foot and Ankle Surgery, Ruihua Affiliated Hospital of Soochow University, Suzhou 215104, China.

To explore the clinical effects of anterolateral thigh perforator flap with sensory nerves in repairing the plantar skin and soft tissue defects. From January 2016 to March 2019, 13 male patients with plantar skin and soft tissue defects were admitted to the Department of Foot and Ankle Surgery of Ruihua Affiliated Hospital of Soochow University, aged 27 to 73 years. The retrospective cohort study was conducted. Read More

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The Electrophysiological Findings in Spinocerebellar Ataxia Type 6: Evidence From 24 Patients.

J Clin Neurophysiol 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurology, Alfred Hospital, Melbourne, Australia; Department of Neurology and Neurological Research, St. Vincent's Hospital Melbourne, Melbourne, Australia; and Balance Disorders and Ataxia Service, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

Purpose: Peripheral neuropathy has been reported commonly in several spinocerebellar ataxia (SCA) types. To date, there is a lack of robust evidence for neuropathy or neuronopathy in SCA type 6 (SCA6). Here, we aim to evaluate the presence of neuropathy or neuronopathy in a cohort of SCA6 patients. Read More

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Trans-oral endoscopic thyroidectomy vestibular approach (TOETVA) for the pediatric population: a multicenter, large case series.

Surg Endosc 2021 May 24. Epub 2021 May 24.

ARM - Center for Head and Neck Surgery and Oncology, Assuta Medical Centers, Tel Aviv, Affiliated with Ben Gurion University, Beer Seva, Israel.

Introduction: A cervical scar has been shown to have an impact on the quality of life of children undergoing thyroid surgery. Transoral endoscopic vestibular thyroidectomy via the vestibular approach (TOETVA) offers the absence of a cutaneous incision, and has not been described to date in the pediatric population.

Objective: To describe the first series of TOETVA in a pediatric population. Read More

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Duplicated transverse cervical nerve and external jugular vein.

Anat Cell Biol 2021 May 25. Epub 2021 May 25.

Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, USA.

The transverse cervical nerve arises from anterior rami of the second and third cervical spinal nerves via the cervical plexus. We present a case of a left duplicated transverse cervical nerve with a duplicated external jugular vein in a 72-year-old female cadver. The transverse cervical nerve bifurcated into two branches, . Read More

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Sex dependent reduction in mechanical allodynia in the sural-sparing nerve injury model in mice lacking Merkel cells.

J Neurosci 2021 May 24. Epub 2021 May 24.

Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore MD 21205, USA

Innocuous touch sensation is mediated by cutaneous low-threshold mechanoreceptors (LTMRs). Aβ slowly adapting type 1 (SA1) neurons constitute one LTMR subtype that forms synapse-like complexes with associated Merkel cells in the basal skin epidermis. Under healthy conditions, these complexes transduce indentation and pressure stimuli into Aβ SA1 LTMR action potentials that are transmitted to the central nervous system, thereby contributing to tactile sensation. Read More

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