10,575 results match your criteria curve indicating

Umbilical cord miRNAs to predict neonatal early onset sepsis.

PLoS One 2021 7;16(5):e0249548. Epub 2021 May 7.

Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, IL, United States of America.

Objective: To determine if miRNA (miR) expression in umbilical cord blood and umbilical cord tissue differs between neonates with early onset sepsis (EOS) versus neonates without true infection.

Methods: Retrospective case-control study design of human patients with EOS (n = 8), presumed sepsis (N = 12) and non-infected control patients (N = 21). Differential expression of >300 miRs was examined using the MIHS-3001ZE-miScript miRNA PCR Array Human miFinder 384HC. Read More

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Can perioperative hemodilution be monitored with non-invasive measurement of blood hemoglobin?

BMC Anesthesiol 2021 May 6;21(1):138. Epub 2021 May 6.

Department of Anesthesiology and Intensive Care, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: Trends in non-invasive measurements of blood hemoglobin (Hb) may be useful for identifying the need for transfusion in the perioperative period.

Methods: Crystalloid fluid (5-20 mL/kg) was administered intravenously or by mouth to 30 volunteers and 33 surgical patients in five non-randomized clinical studies where Hb was measured on 915 occasions by non-invasive (Radical-7™) and invasive methodology. The hemodilution curves were compared by volume kinetic analysis and linear regression, with the slope and scattering of the data as key outcome measures. Read More

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Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1.

Bioengineered 2021 Dec;12(1):1599-1610

Department of Pathophysiology, Fenyang College of Shanxi Medical University, Fenyang, China.

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults, ranking the second leading cause of cancer-related death. To date, the underlying mechanisms of HCC pathogenesis are still unclear. Recently, more and more studies have reported that long noncoding RNAs (lncRNAs) are involved in the occurrence and development of HCC. Read More

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December 2021

Open Versus Endoscopic Osteotomy of Posterosuperior Calcaneal Tuberosity for Haglund Syndrome: A Retrospective Cohort Study.

Orthop J Sports Med 2021 Apr 19;9(4):23259671211001055. Epub 2021 Apr 19.

Institute of Sports Medicine, Beijing Key Laboratory of Sports Injury, Peking University Third Hospital, Beijing, People's Republic of China.

Background: Although endoscopic calcaneoplasty and retrocalcaneal debridement have been extensively applied to treat Haglund syndrome, evidence of the value of the endoscopic procedure remains to be fully established.

Purpose/hypothesis: The purpose of this study was to compare the postoperative outcomes and the amount of osteotomy between open and endoscopic surgery for the treatment of Haglund syndrome. It was hypothesized that endoscopic calcaneoplasty would lead to higher patient satisfaction and lower complication rates compared with open surgical techniques. Read More

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Creation of an artificial intelligence model for intubation difficulty classification by deep learning (convolutional neural network) using face images: an observational study.

J Intensive Care 2021 May 6;9(1):38. Epub 2021 May 6.

Department of Anesthesiology, Yamagata University Hospital, Yamagata City, Japan.

Background: Tracheal intubation is the gold standard for securing the airway, and it is not uncommon to encounter intubation difficulties in intensive care units and emergency rooms. Currently, there is a need for an objective measure to assess intubation difficulties in emergency situations by physicians, residents, and paramedics who are unfamiliar with tracheal intubation. Artificial intelligence (AI) is currently used in medical imaging owing to advanced performance. Read More

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DNA Recovery Using Ethanol-Based Liquid Medium from FTA Card-Stored Samples for HPV Detection.

Acta Cytol 2021 May 5:1-8. Epub 2021 May 5.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.

Introduction: Alternative methods of dry storage and transportation may be a viable alternative to the use of liquid storage medium for cervical samples, especially for screening programs in places with few resources.

Objective: The objective of this study is to verify the viability and efficacy of human papillomavirus DNA (HPV-DNA) detection in cervical cell samples collected and stored on a Flinders Technology Associates (FTA) card (Whatman Indicating FTA® Elute Micro Card) and subsequently recovered in ethanol-based liquid medium and to compare the results to those obtained using samples stored directly in ethanol-based liquid medium.

Study Design: Thirty-four women submitted to ETZ (excision of the transformation zone of the cervix) were included in this study. Read More

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Musculoskeletal ultrasound for ankylosing spondylitis: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25822

Department of Rheumatology, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou, China.

Objective: To clarify if musculoskeletal ultrasound (US) would give additional information for the clinical examination to diagnose and evaluate the activity of ankylosing spondylitis (AS).

Methods: A literature search was performed in PubMed, Embase, Web of Science, the Cochrane Library, Sinomed, Chinese National Knowledge Infrastructure (CINK), and Wanfang databases from their inceptions to May 15, 2020. Studies that examined the musculoskeletal US, which detected sacroiliac joints in people with AS were included. Read More

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Differentially expressed miR-20, miR-21, miR-100, miR-125a and miR-146a as a potential biomarker for prostate cancer.

Mol Biol Rep 2021 May 4. Epub 2021 May 4.

Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, India.

Prostate cancer is the leading cause of death among men worldwide. Deregulation of microRNAs has been reported in many cancers. Expression of microRNAs miR-20a-5p, miR-21-5p, miR-100-5p, miR-125a-5p and miR-146a-5p in tissue blocks of histologically confirmed prostate cancer patients compared with BPH patients, to identify potential microRNA biomarker for prostate cancer. Read More

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Impact of mixed meal tolerance test composition on measures of beta-cell function in type 2 diabetes.

Nutr Metab (Lond) 2021 May 4;18(1):47. Epub 2021 May 4.

Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.

Background: Application of mixed meal tolerance tests (MMTT) to measure beta-cell function in long-term studies is limited by modification of the commercial products occurring over time. This study assessed the intra-individual reliability of MMTTs and compared the effects of liquid meals differing in macronutrient composition on the estimation of beta-cell function in type 2 diabetes (T2DM).

Methods: To test the reliability of MMTTs, 10 people with T2DM (age 58 ± 11 years, body mass index 30. Read More

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Temporal encephaloceles in epilepsy patients and asymptomatic cases: Size may indicate epileptogenicity.

Epilepsia 2021 May 3. Epub 2021 May 3.

Epilepsy Center Hessen, Department of Neurology, Philipps University Marburg, Marburg, Germany.

Objective: This study was undertaken to identify temporal encephaloceles (TEs) and examine their characteristics in patients with temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE), as well as in asymptomatic cases.

Methods: Four hundred fifty-eight magnetic resonance imaging scans were examined retrospectively to identify TE in 157 patients with TLE, 150 patients with ETLE, and 151 healthy controls (HCs).

Results: At least one TE was identified in 9. Read More

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Pharmacokinetics of Lorlatinib After Single and Multiple Dosing in Patients with Anaplastic Lymphoma Kinase (ALK)-Positive Non-Small Cell Lung Cancer: Results from a Global Phase I/II Study.

Clin Pharmacokinet 2021 May 3. Epub 2021 May 3.

Global Product Development, Clinical Pharmacology, Oncology, Pfizer Inc., San Diego, CA, USA.

Background: Lorlatinib demonstrated efficacy (including intracranial activity) in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in a phase I/II study (NCT01970865).

Background And Objective: This analysis describes the pharmacokinetics (PK) of lorlatinib following single and multiple dosing.

Methods: This ongoing, multicenter, open-label, single-arm, phase I/II trial enrolled patients with ALK-positive or c-ros oncogene 1 (ROS1)-positive advanced NSCLC. Read More

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3D Scanning of the Forearm for Orthosis and HMI Applications.

Front Robot AI 2021 14;8:576783. Epub 2021 Apr 14.

Department of Mechanical Engineering, University of Idaho, Moscow, ID, United States.

The rise of rehabilitation robotics has ignited a global investigation into the human machine interface (HMI) between device and user. Previous research on wearable robotics has primarily focused on robotic kinematics and controls but rarely on the actual design of the physical HMI (pHMI). This paper presents a data-driven statistical forearm surface model for designing a forearm orthosis in exoskeleton applications. Read More

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Kanamycin-Mediated Conformational Dynamics of Outer Membrane Protein TolC.

Front Mol Biosci 2021 15;8:636286. Epub 2021 Apr 15.

Department of Chemistry, Ravenshaw University, Cuttack, India.

TolC is a member of the outer membrane efflux proteins (OEPs) family and acts as an exit duct to export proteins, antibiotics, and substrate molecules across the cell membrane. Export of these molecules is evidenced to be brought about through the reversible interactions and binding of substrate-specific drug molecules or antibiotics with TolC and by being open for transport, which afterward leads to cross-resistance. Hence, the binding of kanamycin with TolC was monitored through molecular docking (MD), the structural fluctuations and conformational changes to the atomic level. Read More

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In vitro evaluation of material dependent force damping behavior of implant-supported restorations using different CAD-CAM materials and luting conditions.

J Prosthet Dent 2021 Apr 28. Epub 2021 Apr 28.

Associate Professor, Department of Fixed Prosthodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt; Head of Fixed prosthodontics department, Faculty of Dentistry, British University, Cairo, Egypt.

Statement Of Problem: Although force-damping behavior that matches natural teeth may be unobtainable, an optimal combination of crown material and luting agent might have a beneficial effect on the force absorption capacity of implant-supported restorations. However, the force-absorbing behavior of various restorative materials has not yet been satisfactorily investigated.

Purpose: The purpose of this in vitro study was to evaluate the material dependent force-damping behavior of implant-supported crowns fabricated from different computer-aided design and computer-aided manufacturing (CAD-CAM) materials luted to implant abutments under different conditions. Read More

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Predicting Lymph Node Metastasis in Non-Small Cell Lung Cancer: Prospective External and Temporal Validation of the HAL and HOMER Models.

Chest 2021 Apr 28. Epub 2021 Apr 28.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Two models, the Help with the Assessment of Adenopathy in Lung cancer (HAL) and Help with Oncologic Mediastinal Evaluation for Radiation (HOMER), were recently developed to estimate the probability of nodal disease in non-small cell lung cancer (NSCLC) patients as determined by endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA). The objective of this study was to prospectively externally validate both models at multiple centers.

Research Question: Are the HAL and HOMER models valid across multiple centers?

Study Design And Methods: This multicenter prospective observational cohort study enrolled consecutive patients with PET-CT clinical-radiographic stage T1-3, N0-3, M0 NSCLC undergoing EBUS-TBNA staging. Read More

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Molecular design real time loop-mediated isothermal amplification method for rapid detection of .

Folia Med (Plovdiv) 2021 Apr;63(2):221-227

AJA University of Medical Sciences, Tehran, Iran.

Introduction: Detection of Neisseria meningitides by using conventional methods is time consuming and laborious. Development of a realiable and rapid method for prompt control and prevention of meningococcal disease is required. Although PCR and real time PCR methods have been developed; they require electrophoresis or expensive Devices. Read More

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Leveraging the thermoresponsiveness of fluorinated poly(-isopropylacrylamide) copolymers as a sensing tool for perfluorooctane sulfonate.

Analyst 2021 Apr 30. Epub 2021 Apr 30.

University of Kentucky, College of Engineering, 512 Administration Drive, 177 F. Paul Anderson Tower, Lexington, KY 40506, USA.

Due to mounting evidence of the negative health effects of persistent perfluoroalkyl acids (PFAAs) with long (i.e., >C7) tails, there is a need for convenient systems capable of sensing these contaminants at dilute aqueous concentrations. Read More

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Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response.

Neurol Sci 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond str. 22., Debrecen, H-4032, Hungary.

Introduction: In the majority of European countries, driving after drinking small-moderate amount of alcohol is legal. Motivated by our previous studies on cerebral hemodynamics, we aimed to study whether a small-moderate blood alcohol content (BAC), at which driving is legal in some countries (0.8 g/L), influences the neuronal activity, neurovascular coupling, and cerebral vasoreactivity. Read More

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Antibacterial and Antibiofilm Activities of Novel Antimicrobial Peptides against Multidrug-Resistant Enterotoxigenic .

Int J Mol Sci 2021 Apr 10;22(8). Epub 2021 Apr 10.

Department of Biotechnology and Animal Science, National Ilan University, Yilan 26047, Taiwan.

Post-weaning diarrhea due to enterotoxigenic (ETEC) is a common disease of piglets and causes great economic loss for the swine industry. Over the past few decades, decreasing effectiveness of conventional antibiotics has caused serious problems because of the growing emergence of multidrug-resistant (MDR) pathogens. Various studies have indicated that antimicrobial peptides (AMPs) have potential to serve as an alternative to antibiotics owing to rapid killing action and highly selective toxicity. Read More

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A ten-gene methylation signature as a novel biomarker for improving prediction of prognosis and indicating gene targets in endometrial cancer.

Genomics 2021 Apr 26;113(4):2032-2044. Epub 2021 Apr 26.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China; Beijing Key Laboratory of Female Pelvic Floor Disorders Diseases, Beijing 100044, China. Electronic address:

Endometrial cancer (EC) is a common female reproductive tumor worldwide. Nonetheless, the pathogenesis of EC still remains ambiguous and associated epigenetic mechanism still to be explored. The goal of this study is to investigate whether gene methylation signature is associated with overall survival (OS) for EC patients. Read More

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The patient acceptable symptom state for the knee society score, oxford knee score and short form-36 following unicompartmental knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 28. Epub 2021 Apr 28.

Department of Orthopaedic Surgery, Singapore General Hospital, 20 College Road, Academia, Level 4, Singapore, 169865, Singapore.

Purpose: The patient acceptable symptom state (PASS) is a target value on a patient-reported outcome measures (PROM) scale beyond which patients deem themselves to have attained an acceptable outcome. This study aimed to define the PASS thresholds for generic and knee-specific PROMs at 2 years after unicompartmental knee arthroplasty (UKA).

Methods: Prospectively collected data of 955 patients who underwent UKA for medial osteoarthritis at a single institution was reviewed. Read More

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Development and Validation of a RNA Binding Protein-Associated Prognostic Model for Hepatocellular Carcinoma.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211004936

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Dysregulation of RNA binding proteins (RBPs) has been identified in multiple malignant tumors correlated with tumor progression and occurrence. However, the function of RBPs is not well understood in hepatocellular carcinoma (HCC).

Methods: The RNA sequence data of HCC was extracted out of the Cancer Genome Atlas (TCGA) database and different RBPs were calculated between regular and cancerous tissue. Read More

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Comparison of screening tests in the evaluation of cognitive status of patients with epilepsy.

Dement Neuropsychol 2021 Jan-Mar;15(1):145-152

Medicine School, Pontifícia Universidade Católica do Paraná - Curitiba, PR, Brazil.

Epilepsy, a chronic neurological condition which is associated with neurobiological and psychosocial changes, affects 0.5 to 1% of the world's population, presenting in most cases a deficit in reasoning, memory and attention.

Objective: To contribute to the implementation of screening strategies for cognitive decline and memory deficits in patients with epilepsy. Read More

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Longitudinal Zeolite-Iron Oxide Nanocomposite Deposited Capacitance Biosensor for Interleukin-3 in Sepsis Detection.

Nanoscale Res Lett 2021 Apr 26;16(1):68. Epub 2021 Apr 26.

Department of Biological Engineering, College of Engineering, Inha University, Incheon, 402-751, Republic of Korea.

Sepsis is an extreme condition involving a physical response to severe microbial infection and causes fatal and life-threatening issues. Sepsis generates during the chemicals release with the immune system into the bloodstream for fighting against an infection, which causes the inflammation and leads to the medical emergency. A complexed longitudinal zeolite and iron oxide nanocomposite was extracted from coal mine fly ash and utilized to improve the surface characteristics of the capacitance biosensor to identify sepsis attacks. Read More

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Temporal augmentation using autologous fat grafting in Chinese women: Effect on temporal hairline.

J Cosmet Dermatol 2021 Apr 26. Epub 2021 Apr 26.

Department of Body Contouring and Liposuction Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Temporal hollowing causes an old and gaunt appearance. An inward curve of the temporal hairline adds to the severity of temporal hollowing, which is visually exacerbated by the dark-colored hairline in most Chinese women. Whether temporal augmentation using autologous fat grafting (AFG) is effective for correcting an inwardly curved temporal hairline remains unclear. Read More

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Comparison of virus neutralization activity and results of 10 different anti-SARS-CoV-2 serological tests in COVID-19 recovered plasma donors.

Pract Lab Med 2021 May 20;25:e00222. Epub 2021 Apr 20.

Institute of Sports and Health Sciences, University of Physical Education, 1112, Budapest, Hungary.

Serological testing is a tool to predict protection against later infection. This potential heavily relies on antibody levels showing acceptable agreement with gold standard virus neutralization tests. The aim of our study was to investigate diagnostic value of the available serological tests in terms of predicting virus neutralizing activity of serum samples drawn 5-7 weeks after onset of symptoms from 101 donors with a history of COVID-19. Read More

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Effect of solid feed level and types of roughage on passage kinetics of milk replacer, concentrate, and roughage in veal calves.

J Dairy Sci 2021 Apr 22. Epub 2021 Apr 22.

Animal Nutrition Group, Wageningen University & Research, PO Box 338, 6700 AH, Wageningen, the Netherlands.

This study aimed (1) to provide estimates of total mean retention times of milk replacer (MR), concentrates, and roughage in veal calves fed a mixed diet; (2) to determine the effect of level and type of solid feed (SF) on passage kinetics of MR, concentrates, and roughages in veal calves; and (3) to compare passage kinetics in veal calves using the fecal excretion curves of indigestible markers and a noninvasive C tracer breath test approach to determine whether the latter technique can serve as an alternative. At the start of the trial, 48 Holstein-Friesian calves (6 wk of age; 68 ± 7.7 kg of body weight; BW) were assigned to 1 of 4 dietary treatments (for statistical analysis, only 39 calf observations were used). Read More

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MR Virtual Endoscopy of the Fetal Limb Anomalies Using Three-Dimensional Fast Imaging Employing Steady-State Acquisition Sequence.

Fetal Diagn Ther 2021 Apr 23:1-9. Epub 2021 Apr 23.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To retrospectively investigate the feasibility of magnetic resonance virtual endoscopy (MRVE) to visualize the normal limbs and limb deformities Methods: MR sequences included two-dimensional (2D) single fast spin-echo sequence and 2D and 3D steady-state procession fast imaging sequences. MRVE reconstruction was retrospectively performed by 2 radiologists in 32 fetuses in 30 pregnant women. The correlation between the radiologists for the virtual endoscopy threshold of MRVE was determined. Read More

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FIS1 Overexpression Is Correlated with Tumor Metastasis in Gastric Adenocarcinoma.

J Gastrointest Cancer 2021 Apr 22. Epub 2021 Apr 22.

Department of General Surgery, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Due to poor prognosis and treatment failure, gastric cancer (GC) is still regarded as one of the deadliest malignancies worldwide, demanding new molecular targets for therapeutic and diagnostic approaches. Therefore, the current study was aimed to investigate the expression levels of FIS1 gene involving in mitochondrial fission as a promising target in gastric tumor progression.

Material And Methods: A total of eighty clinical tissue samples including 40 gastric primary tumor samples and 40 paired marginal samples were prepared. Read More

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A Combined Experimental and Computational Analysis of Failure Mechanisms in Open-Hole Cross-ply Laminates under Flexural Loading.

Compos B Eng 2021 Jun 19;215. Epub 2021 Mar 19.

Department of Materials Manufacturing, Ford Motor Company, Dearborn, MI 48124, USA.

In this study, integrated experimental tests and computational modeling are proposed to investigate the failure mechanisms of open-hole cross-ply carbon fiber reinforced polymer (CFRP) laminated composites. In particular, we propose two effective methods, which include width-tapered double cantilever beam (WTDCB) and fixed-ratio mixed-mode end load split (FRMMELS) tests, to obtain the experimental data more reliably. We then calibrate the traction-separation laws of cohesive zone model (CZM) used among laminas of the composites by leveraging these two methods. Read More

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