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Creep behavior of reinforced concrete-filled steel tubular columns under axial compression.

PLoS One 2021 20;16(9):e0255603. Epub 2021 Sep 20.

School of Civil Engineering, Liaoning Technical University, Fuxin, China.

The reinforced concrete-filled steel tube (RCFST) column solves several of the problems of the concrete-filled steel tube (CFST) column in practical engineering applications. Moreover, RCFST has a simple joint structure, high bearing capacity, good ductility, and superior fire resistance. From a structural safety perspective, designers prioritize the creep performance of CFST members in structural design. Read More

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September 2021

Urinary Neutrophil Gelatinase-Associated Lipocalin/Hepcidin-25 Ratio for Early Identification of Patients at Risk for Renal Replacement Therapy After Cardiac Surgery: A Substudy of the BICARBONATE Trial.

Anesth Analg 2021 Sep 20. Epub 2021 Sep 20.

Department of Anesthesiology and Intensive Care, Helios Klinikum Leisnig, Leisnig, Germany.

Background: Acute kidney injury requiring renal replacement therapy (AKI-RRT) is strongly associated with mortality after cardiac surgery; however, options for early identification of patients at high risk for AKI-RRT are extremely limited. Early after cardiac surgery, the predictive ability for AKI-RRT even of one of the most extensively evaluated novel urinary biomarkers, neutrophil gelatinase-associated lipocalin (NGAL), appears to be only moderate. We aimed to determine whether the NGAL/hepcidin-25 ratio (urinary concentrations of NGAL divided by that of hepcidin-25) early after surgery may compare favorably to NGAL for identification of high-risk patients after cardiac surgery. Read More

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September 2021

Elevated Circulating Levels of Glycoprotein Non-Metastatic Melanoma Protein B as a Predictor of Gestational Diabetes Mellitus.

Clin Lab 2021 Sep;67(9)

Background: The current study aims to investigate the differences of glycoprotein non-metastatic melanoma protein B (GPNMB) levels between gestational diabetes mellitus (GDM) women and normal blood glucose women during pregnancy to provide the basis for early intervention and treatment of GDM.

Methods: The level of GPNMB was detected using an enzyme-linked immunosorbent assay (ELISA). Pearson's correlation assay was performed to analyze the correlation between serum GPNMB and fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c). Read More

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September 2021

Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease.

JAMA Neurol 2021 Sep 20. Epub 2021 Sep 20.

Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.

Importance: Blood-based tests for brain amyloid-β (Aβ) pathology are needed for widespread implementation of Alzheimer disease (AD) biomarkers in clinical care and to facilitate patient screening and monitoring of treatment responses in clinical trials.

Objective: To compare the performance of plasma Aβ42/40 measured using 8 different Aβ assays when detecting abnormal brain Aβ status in patients with early AD.

Design, Setting, And Participants: This study included 182 cognitively unimpaired participants and 104 patients with mild cognitive impairment from the BioFINDER cohort who were enrolled at 3 different hospitals in Sweden and underwent Aβ positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) and plasma collection from 2010 to 2014. Read More

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September 2021

Diagnostic value of serum tumor-associated autoantibodies in esophageal cancer.

Biomark Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.

To explore the application value of serum autoantibodies in the early diagnosis of esophageal cancer. A total of 130 patients with esophageal cancer and 110 controls were included and tested by ELISA. According to the receiver operating characteristic curve, total sensitivity is 83. Read More

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September 2021

Machine learning for identification of frailty in Canadian primary care practices.

Int J Popul Data Sci 2021 10;6(1):1650. Epub 2021 Sep 10.

Cumming School of Medicine, University of Calgary.

Introduction: Frailty is a medical syndrome, commonly affecting people aged 65 years and over and is characterized by a greater risk of adverse outcomes following illness or injury. Electronic medical records contain a large amount of longitudinal data that can be used for primary care research. Machine learning can fully utilize this wide breadth of data for the detection of diseases and syndromes. Read More

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September 2021

Novel model combining contrast-enhanced ultrasound with serology predicts hepatocellular carcinoma recurrence after hepatectomy.

World J Clin Cases 2021 Aug;9(24):7009-7021

Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, Fujian Province, China.

Background: Surgery is the primary curative option in patients with hepatocellular carcinoma (HCC). However, recurrence within 2 years is observed in 30%-50% of patients, being a major cause of mortality.

Aim: To construct and verify a non-invasive prediction model combining contrast-enhanced ultrasound (CEUS) with serology biomarkers to predict the early recurrence of HCC. Read More

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A Radiomics Model for Predicting Early Recurrence in Grade II Gliomas Based on Preoperative Multiparametric Magnetic Resonance Imaging.

Front Oncol 2021 2;11:684996. Epub 2021 Sep 2.

Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Objective: This study aimed to develop a radiomics model to predict early recurrence (<1 year) in grade II glioma after the first resection.

Methods: The pathological, clinical, and magnetic resonance imaging (MRI) data of patients diagnosed with grade II glioma who underwent surgery and had a recurrence between 2017 and 2020 in our hospital were retrospectively analyzed. After a rigorous selection, 64 patients were eligible and enrolled in the study. Read More

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September 2021

'We would rather die from Covid-19 than from hunger' - Exploring lockdown stringencies in five African countries.

Glob Food Sec 2021 Dec 27;31:100571. Epub 2021 Aug 27.

Institute of Agricultural Sciences in the Tropics (Hans-Ruthenberg-Institute), University of Hohenheim, Wollgrasweg 43, 70599, Stuttgart, Germany.

Facing COVID-19, African countries were confronted with a dilemma: enacting strict lockdowns to "flatten the curve" could potentially have large effects on food security. Given this catch-22 situation, there was widespread concern that Africa would suffer most from the pandemic. Yet, emerging evidence in early 2021 showed that COVID-19 morbidity remained low, while "biblical famines" have been avoided so far. Read More

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December 2021

Significance of amplitude integrated electroencephalography in early stage of neonatal hypoxic-ischemic encephalopathy and cerebral function monitoring in Neonatal Intensive Care Units.

Am J Transl Res 2021 15;13(8):9437-9443. Epub 2021 Aug 15.

Department of Pediatrics, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture Enshi 445000, Hubei Province, China.

Objective: To investigate the role of amplitude integrated electroencephalography (aEEG) diagnosis in early stage of neonatal hypoxic-ischemic encephalopathy (HIE), and to evaluate the feasibility of aEEG in cerebral function monitoring in Neonatal Intensive Care Units (NICU).

Methods: 60 cases of term infants with neonatal HIE were included in the observation group, and 50 healthy term infants were enrolled as the control group. Both groups received aEEG monitoring within 6 hours after birth, and the results were analyzed. Read More

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Expression of miR-192-5p in colon cancer serum and its relationship with clinicopathologic features.

Am J Transl Res 2021 15;13(8):9371-9376. Epub 2021 Aug 15.

Department of Pharmacy, Suzhou Xiangcheng People's Hospital Suzhou 215006, People's Republic of China.

Colon cancer has a poor prognosis due to a lack of biomarkers for early diagnosis and prognosis. The present study analyzed serum miR-192-5p expression levels in colon cancer patients and their correlations with clinicopathologic features. Relative mRNA expression was assessed by real-time fluorescence-based quantitative PCR in the serum of 164 colon cancer patients and 60 healthy controls. Read More

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A study on the clinical value of F-fluorodeoxyglucose positron emission tomography/computed tomography combined with serum squamous cell carcinoma antigen in diagnosing recurrence/metastases in patients with early metaphase cervical cancer.

Oncol Lett 2021 Nov 24;22(5):746. Epub 2021 Aug 24.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Cervical cancer (CC) is the most common female genital tract malignancy, with repercussions on the psychophysiological health of female patients. Patients with CC are faced with a high risk of postoperative recurrence and metastases. The present study aimed to evaluate the clinical value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) combined with serum squamous cell carcinoma antigen (SCC-Ag) in the diagnosis of postoperative recurrence/metastases in patients with early stage CC. Read More

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November 2021

Diagnostic Accuracy of Female Pelvic Ultrasonography in Differentiating Precocious Puberty From Premature Thelarche: A Systematic Review and Meta-analysis.

Front Endocrinol (Lausanne) 2021 1;12:735875. Epub 2021 Sep 1.

Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

Background: The gonadotropin-releasing hormone (GnRH) stimulation test is the benchmark for diagnosing precocious puberty (PP). However, it is invasive, time-consuming, costly, and may create an unpleasant experience for participants. Moreover, some overlaps may occur between PP and premature thelarche (PT) in the early stage of PP. Read More

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September 2021

Contrast-enhanced ultrasound imaging for intestinal lymphoma.

World J Gastroenterol 2021 Aug;27(32):5438-5447

Department of Ultrasound, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: Intestinal lymphoma is a rare tumor. Contrast-enhanced ultrasound (CEUS) findings of intestinal lymphoma have not been reported previously, and the relationship between CEUS and clinicopathological features and prognostic factors is still unknown.

Aim: To describe the B-mode US and CEUS features of intestinal lymphoma and investigate the correlation of CEUS and histopathological features. Read More

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[Can systemic immune inflammation index at admission predict in-hospital mortality in chronic kidney disease patients with SARS-CoV-2 infection].

Nefrologia 2021 Sep 15. Epub 2021 Sep 15.

Department of Nephrology, University of Health Sciences, Bakirkoy Dr.Sadi Konuk Education and Research Hospital, Istanbul, Turkey.

Background And Aim: Patients with chronic kidney disease (CKD) are susceptible to SARS-CoV-2 infection and more prone to develop severe disease. It is important to know predictors of poor outcomes to optimize the strategies of care.

Methods: 93 patients with CKD and 93 age-sex matched patients without CKD were included in the study. Read More

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September 2021

Not as simple as ABC: Tools to Trigger Massive Transfusion in Pediatric Trauma.

J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, USA Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA The Center for Research in Outcomes for Children's Surgery, Center for Children's Surgery, University of Colorado School of Medicine, Aurora, CO, USA Division of Nursing, Children's Hospital Colorado, Aurora, CO, USA Department of Surgery, Denver Health Medical Center, Denver, CO, USA.

Background/purpose: Early and accurate identification of pediatric trauma patients who will receive massive transfusion (MT) is not well-established. We developed the ABCD and BIS scores and hypothesized that the BIS score would perform best in the ability to predict the need for MT in children.

Methods: Pediatric trauma patients (≤ 18 years old) admitted to our trauma center between 2008-2019 were identified. Read More

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September 2021

The use of face masks during vaccine roll-out in New YorkCity and impact on epidemic control.

Vaccine 2021 Sep 16. Epub 2021 Sep 16.

Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MND, USA.

Face masks were mandated in New York during the first wave in 2020, and in 2021 the first vaccine programs have commenced. We aimed to examine the impact of face mask and other NPIs use with a gradual roll out of vaccines in NYC on the epidemic trajectory. A SEIR mathematical model of SARS-CoV-2 transmission was developed for New York City (NYC), which accounted for decreased mobility for lockdown, testing and tracing. Read More

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September 2021

Early identification of women with endometriosisby means of a simple patient-completed questionnaire screening tool: a diagnostic study.

Fertil Steril 2021 Sep 16. Epub 2021 Sep 16.

Department of Obstetrics and Gynaecology, University Hospital of Poitiers, Poitiers, France.

Objectives: To assess the value of a self-completed questionnaire based on patients' verbal descriptors of pelvic painful symptoms to identify women with endometriosis.

Design: Prospective 1:2 nonmatched case-control study.

Setting: Three French endometriosis referral centers. Read More

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September 2021

Quantitative Lesion Water Uptake as Stroke Imaging Biomarker: A Tool for Treatment Selection in the Extended Time Window?

Stroke 2021 Sep 20:STROKEAHA120033025. Epub 2021 Sep 20.

Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany. (G.B., S.T., R.M., L.M., T.D.F., H.K., M.T.N., S.E., N.v.H., J.F., U.H.).

Background And Purpose: Patients presenting in the extended time window may benefit from mechanical thrombectomy. However, selection for mechanical thrombectomy in this patient group has only been performed using specialized image processing platforms, which are not widely available. We hypothesized that quantitative lesion water uptake calculated in acute stroke computed tomography (CT) may serve as imaging biomarker to estimate ischemic lesion progression and predict clinical outcome in patients undergoing mechanical thrombectomy in the extended time window. Read More

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September 2021

Development of accelerometer-based light to vigorous physical activity in fitness profiles of school-aged children.

Scand J Med Sci Sports 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, Jyväskylä, Finland, 40014.

This study examined the developmental trajectories of light (LPA) and moderate-to-vigorous physical activity (MVPA) in fitness profiles derived from motor competence, perceived motor competence, health-related fitness, and MVPA behaviour. Locomotor, stability, and object-control skills, muscular and cardiovascular fitness, and physical activity were assessed in 510 (girls 285, boys 225) Finnish school-aged children (M = 11.26 ± . Read More

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September 2021

Myocardial injury detected by T1 and T2 mapping on CMR predicts subsequent cancer therapy-related cardiac dysfunction in patients with breast cancer treated by epirubicin-based chemotherapy or left-sided RT.

Eur Radiol 2021 Sep 18. Epub 2021 Sep 18.

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Hospital Hamburg Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Objectives: Cancer therapy-related cardiac dysfunction (CTRCD) is a relevant clinical problem and needs early prediction. This study aimed to analyze myocardial injury using serial laboratory and cardiac magnetic resonance imaging (CMR) parameters after epirubicin-based chemotherapy compared with left-sided radiotherapy and to study their value for early prediction of CTRCD.

Methods: Sixty-six consecutive women (53 ± 13 years) including n = 39 with epirubicin-based chemotherapy and n = 27 with left-sided radiotherapy were prospectively studied by 3 T CMR including left ventricular (LV) mass and volumes for ejection fraction (LVEF), as well as feature-tracking with global longitudinal strain (GLS) and T1/T2 mapping. Read More

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September 2021

Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning.

Schizophr Bull 2021 Sep 18. Epub 2021 Sep 18.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia.

Background: Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a clinical prediction model aimed at predicting 4-6-week remission following a first episode of psychosis.

Method: Baseline clinical data from the Athens First Episode Research Study was used to develop a Support Vector Machine prediction model of 4-week symptom remission in first-episode psychosis patients using repeated nested cross-validation. Read More

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September 2021

An efficient context-aware screening system for Alzheimer's disease based on neuropsychology test.

Sci Rep 2021 Sep 17;11(1):18570. Epub 2021 Sep 17.

Department of Psychology, National Taiwan University, Taipei, Taiwan.

Alzheimer's disease (AD) and other dementias have become the fifth leading cause of death worldwide. Accurate early detection of the disease and its precursor, Mild Cognitive Impairment (MCI), is crucial to alleviate the burden on the healthcare system. While most of the existing work in the literature applied neural networks directly together with several data pre-processing techniques, we proposed in this paper a screening system that is to perform classification based on automatic processing of the transcripts of speeches from the subjects undertaking a neuropsychological test. Read More

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September 2021

Estimation of postpartum depression risk from electronic health records using machine learning.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):630. Epub 2021 Sep 17.

KI Research Institute, Kfar Malal, Israel.

Background: Postpartum depression is a widespread disorder, adversely affecting the well-being of mothers and their newborns. We aim to utilize machine learning for predicting risk of postpartum depression (PPD) using primary care electronic health records (EHR) data, and to evaluate the potential value of EHR-based prediction in improving the accuracy of PPD screening and in early identification of women at risk.

Methods: We analyzed EHR data of 266,544 women from the UK who gave first live birth between 2000 and 2017. Read More

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September 2021

[Accuracy of Alignment of Femoral and Tibial Component of the Oxford Medial Unicompartmental Knee Arthroplasty Using Zimmer Microplasty® Instrumentation].

Acta Chir Orthop Traumatol Cech 2021 ;88(4):291-301

Nemocnice České Budějovice, a.s., Ortopedické oddělení, České Budějovice.

PURPOSE OF THE STUDY The purpose of the study is to verify the correct alignment of components of the Oxford medial unicompartmental knee arthroplasty using the Zimmer Microplasty® instrumentation at the beginning of the learning curve. The implantation of prosthetic components of partial knee arthroplasty in proper alignment has an effect on long-term survival of the prosthesis and should eliminate the occurrence of frequent complications. MATERIAL AND METHODS The study group includes 20 patients, 9 men with the mean age of 68 years (range 62-78 years) and 11 women with the mean age of 69 years (range 52-81 years). Read More

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January 2021

Machine learning to investigate superficial white matter integrity in early multiple sclerosis.

J Neuroimaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.

Background And Purpose: This study aims todetermine the sensitivity of superficial white matter (SWM) integrity as a metric to distinguish early multiple sclerosis (MS) patients from healthy controls (HC).

Methods: Fractional anisotropy and mean diffusivity (MD) values from SWM bundles across the cortex and major deep white matter (DWM) tracts were extracted from 29 early MS patients and 31 age- and sex-matched HC. Thickness of 68 cortical regions and resting-state functional-connectivity (RSFC) among them were calculated. Read More

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September 2021

Diagnosis of acute respiratory distress syndrome (DARTS) by bedside exhaled breath octane measurements in invasively ventilated patients: protocol of a multicentre observational cohort study.

Ann Transl Med 2021 Aug;9(15):1262

Department of Intensive Care, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Acute respiratory distress syndrome (ARDS) is currently diagnosed by the Berlin Definition. Diagnosis is subjective and often late. Untargeted metabolomics analysis of exhaled breath with gas chromatography and mass spectrometry (GC-MS) showed that the breath concentration of octane has a high diagnostic accuracy for ARDS. Read More

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Bioinformatics analysis reveals biomarkers with cancer stem cell characteristics in kidney renal clear cell carcinoma.

Transl Androl Urol 2021 Aug;10(8):3501-3514

College of Life Sciences and Technology, Beijing University of Chemical Technology, Beijing, China.

Background: Kidney renal clear cell carcinoma (KIRC) is a renal cortical tumor. KIRC is the most common subtype of kidney cancer, accounting for 70%-80% of kidney cancer. Early identification of the risk of KIRC patients can facilitate more accurate clinical treatment, but there is a lack of effective prognostic markers. Read More

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Diagnostic and prognostic value of MATN3 expression in gastric carcinoma: TCGA database mining.

J Gastrointest Oncol 2021 Aug;12(4):1374-1383

Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Backgrounds: Globally, the high morbidity and mortality of gastric carcinoma (GC) have been one of the great challenges facing humanity. However, the early diagnosis of GC is still unknown. Matrilin-3 (MATN3) is a member of the extracellular matrix (ECM) protein family. Read More

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Urinary 8-OxoGsn as a Potential Indicator of Mild Cognitive Impairment in Frail Patients With Cardiovascular Disease.

Front Aging Neurosci 2021 25;13:672548. Epub 2021 Aug 25.

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Oxidative RNA damage has been found to be associated with age-related diseases and 8-oxo-7,8-dihydroguanosine (8-oxoGsn) is a typical marker of oxidative modification of RNA. Urine tests are a feasible non-invasive diagnostic modality. The present study aimed to assess whether the measurement of urinary 8-oxoGsn could represent a potential early maker in mild cognitive impairment (MCI) of frail patients with cardiovascular disease (CVD). Read More

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