20 results match your criteria currents prevailed

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The evolution in the surgical management of Peyronie's disease.

Urologia 2021 May 30;88(2):79-89. Epub 2021 Mar 30.

Department of Urology, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.

Peyronie's disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible of penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of the disease, etiology still remains uncertain. Read More

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Large mammal burrows in late Miocene calcic paleosols from central Argentina: paleoenvironment, taphonomy and producers.

PeerJ 2018 22;6:e4787. Epub 2018 May 22.

Instituto de Ciencias de la Tierra y Ambientales de La Pampa, Universidad Nacional de La Pampa and Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Rosa, La Pampa, Argentina.

Large cylindrical sediment-filled structures interpreted as mammal burrows occur within the loess-paleosol sequence of the late Miocene Cerro Azul Formation of central Argentina. A total of 115 burrow fills from three localities were measured. They are typically shallowly dipping, subcylindrical, unbranched structures with rounded ends and lacking enlargements. Read More

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HO augments cytosolic calcium in nucleus tractus solitarii neurons via multiple voltage-gated calcium channels.

Am J Physiol Cell Physiol 2017 May 8;312(5):C651-C662. Epub 2017 Mar 8.

Department of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

Reactive oxygen species (ROS) play a profound role in cardiorespiratory function under normal physiological conditions and disease states. ROS can influence neuronal activity by altering various ion channels and transporters. Within the nucleus tractus solitarii (nTS), a vital brainstem area for cardiorespiratory control, hydrogen peroxide (HO) induces sustained hyperexcitability following an initial depression of neuronal activity. Read More

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Neural influences on human intestinal epithelium in vitro.

J Physiol 2016 Jan 23;594(2):357-72. Epub 2015 Nov 23.

Human Biology, Technische Universität München, Freising, Germany.

Key Points: We present the first systematic and, up to now, most comprehensive evaluation of the basic features of epithelial functions, such as basal and nerve-evoked secretion, as well as tissue resistance, in over 2200 surgical specimens of human small and large intestine. We found no evidence for impaired nerve-evoked epithelial secretion or tissue resistance with age or disease pathologies (stomach, pancreas or colon cancer, polyps, diverticulitis, stoma reversal). This indicates the validity of future studies on epithelial secretion or resistance that are based on data from a variety of surgical specimens. Read More

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January 2016

N-methyl-D-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation.

Am J Physiol Cell Physiol 2013 Dec 18;305(11):C1123-38. Epub 2013 Sep 18.

Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;

The presence of N-methyl-d-aspartate receptor (NMDAR) was previously shown in rat red blood cells (RBCs) and in a UT-7/Epo human myeloid cell line differentiating into erythroid lineage. Here we have characterized the subunit composition of the NMDAR and monitored its function during human erythropoiesis and in circulating RBCs. Expression of the NMDARs subunits was assessed in erythroid progenitors during ex vivo erythropoiesis and in circulating human RBCs using quantitative PCR and flow cytometry. Read More

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December 2013

A novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits.

J Biol Chem 2007 Oct 14;282(40):29211-21. Epub 2007 Aug 14.

Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

Voltage-dependent L-type Ca(2+) (Ca(V)1.2) channels are the principal Ca(2+) entry pathway in arterial myocytes. Ca(V)1. Read More

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October 2007

Trajectory of an oil spill off Goa, eastern Arabian Sea: field observations and simulations.

Environ Pollut 2007 Jul 7;148(2):438-44. Epub 2007 Feb 7.

National Institute of Oceanography, Dona Paula, Goa 403 004, India.

An oil spill occurred off Goa, west coast of India, on 23 March 2005 due to collision of two vessels. In general, fair weather with weak winds prevails along the west coast of India during March. In that case, the spill would have moved slowly and reached the coast. Read More

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[The history of medicine and pharmacy in "Kwartalnik Historii Nauki i Techniki" in the years 1956-2005].

Tadeusz Srogosz

Kwart Hist Nauki Tech 2006 ;51(1):93-121

The publications in "Kwartalnik Historii Nauki i Techniki" in the years 1956-2005 reflected the state of Polish history of medicine and pharmacy. After the thaw of 1956, a positivist (physician-oriented) current prevailed in such publications, and that tendency grew even stronger in the 1980s. Marxist attempts at writing the history of medicine never gained a dominant position, and a gradual disppearance of that convention could observed from the 1970s onwards. Read More

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Natural and anthropogenic hydrocarbon inputs to sediments of Patos Lagoon Estuary, Brazil.

Environ Int 2005 Jan;31(1):77-87

Environmental Sciences Graduate Program, Oregon State University, Cordley 2046, Corvallis, OR 97331-2904, USA.

The Patos Lagoon Estuary, southern Brazil, is an area of environmental interest not only because of tourism, but also because of the presence of the second major port of Brazil, with the related industrial and shipping activities. Thus, potential hydrocarbon pollution was examined in this study. Sediment samples were collected at 10 sites in the estuary, extracted, and analyzed by GC-FID and GC-MS for composition and concentration of the following organic geochemical markers: normal and isoprenoid alkanes, petroleum biomarkers, linear alkylbenzenes (LABs), and polycyclic aromatic hydrocarbons (PAHs). Read More

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January 2005

Spontaneous synaptic activity in chick vestibular nucleus neurons during the perinatal period.

Neuroscience 2004 ;127(1):81-90

Department of Anatomy and Cell Biology and Neuroscience Program, George Washington University Medical Center, 2300 I Street Northwest, Washington, DC 20037, USA.

The principal cells of the chick tangential nucleus are second-order vestibular neurons involved in the vestibuloocular and vestibulocollic reflexes. The spontaneous synaptic activity of morphologically identified principal cells was characterized in brain slices from 1-day-old hatchlings (H1) using whole-cell voltage-clamp recordings and Cs-gluconate pipet solution. The frequency was 1. Read More

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October 2004

Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory α-subunit Kv9.3.

J Biol Chem 2003 May 17;278(20):18154-61. Epub 2003 Mar 17.

Max-Planck Institut für Experimentelle Medizin, Molekulare Biologie Neuronaler Signale, Hermann-Rein Strasse 3, 37075 Göttingen, Germany.

Voltage-gated potassium (Kv) channels containing alpha-subunits of the Kv2 subfamily mediate delayed rectifier currents in excitable cells. Channels formed by Kv2.1 alpha-subunits inactivate from open- and closed states with both forms of inactivation serving different physiological functions. Read More

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Convergent and reciprocal modulation of a leak K+ current and I(h) by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones.

J Physiol 2002 Jun;541(Pt 3):717-29

Department of Pharmacology, University of Virginia, Charlottesville 22908, USA.

Neurotransmitters and volatile anaesthetics have opposing effects on motoneuronal excitability which appear to reflect contrasting modulation of two types of subthreshold currents. Neurotransmitters increase motoneuronal excitability by inhibiting TWIK-related acid-sensitive K+ channels (TASK) and shifting activation of a hyperpolarization-activated cationic current (I(h)) to more depolarized potentials; on the other hand, anaesthetics decrease excitability by activating a TASK-like current and inducing a hyperpolarizing shift in I(h) activation. Here, we used whole-cell recording from motoneurones in brainstem slices to test if neurotransmitters (serotonin (5-HT) and noradrenaline (NA)) and an anaesthetic (halothane) indeed compete for modulation of the same ion channels - and we determined which prevails. Read More

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Selective fascicular stimulation of the rat sciatic nerve with multipolar polyimide cuff electrodes.

Restor Neurol Neurosci 2001 ;18(1):9-21

Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain.

Purpose: To assess a new flexible, multicontact spiral-cuff electrode made of polyimide with integrated platinum contacts for selective stimulation of nerve fascicles.

Methods: Polyimide cuff electrodes with 12 Pt sites in the spiral cuff were acutely implanted around the sciatic nerve of rats. Stimulation was applied through each one of the four tripoles of the cuff as single pulses of 10 microsec duration of increasing intensity. Read More

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December 2001

Post-modern drug evaluation. The deconstruction of evidence-based regulation.

J Avorn

Pharmacoeconomics 2000 ;18 Suppl 1:15-20

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Traditionally in medicine, nearly all prescribing decisions were made by the treating physician. The patient had relatively little input and hardly any access to alternative sources of information bearing on that decision; the cost of the prescription was covered by the patient or by an insurer, and neither was likely to provide any feedback to the physician to shape his or her decision. Now, all that has changed. Read More

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February 2001

Activation of presynaptic group III metabotropic receptors enhances glutamate release in rat entorhinal cortex.

J Neurophysiol 2000 May;83(5):2519-25

Department of Physiology, School of Medical Sciences, University of Bristol, United Kingdom.

The role of group III metabotropic glutamate receptors (mGluRs) in modulating excitatory synaptic transmission was investigated in the rat entorhinal cortex (EC) in vitro. AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) were recorded in the whole cell configuration of the patch-clamp technique from visually identified neurons in layers V and II. In layer V, bath application of the specific group III mGluR agonist L(+)-2-amino-4-phosphonobutyric acid (L-AP4, 500 microM) resulted in a marked facilitation of both spontaneous and activity-independent "miniature" (s/mEPSC) event frequency. Read More

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Modulation of HERG current and herg gene expression during retinoic acid treatment of human neuroblastoma cells: potentiating effects of BDNF.

J Neurobiol 1999 Aug;40(2):214-25

Department of Experimental Pathology and Oncology, University of Firenze, Viale G. B. Morgagni, 50, 50134 Firenze, Italy.

The modulation of herg gene and HERG currents (I(HERG)) was studied in SH-SY5Y neuroblastoma (NB) cells treated with all-trans-retinoic acid (RA) in the absence or presence of the neurotrophin brain-derived neurotrophic factor (BDNF). Both treatments produced a strong increase in the percentage of cells differentiated along the neuronal pathway, with an orientation to a cholinergic phenotype, while a minority of cells displayed a glial phenotype particularly evident after long-term exposure to the inducers. Differentiation of NB cells was accompanied by an increase in herg gene transcription, which attained its maximum after 6 days of treatment with RA and was not further increased by BDNF. Read More

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Two types of TTX-resistant and one TTX-sensitive Na+ channel in rat dorsal root ganglion neurons and their blockade by halothane.

Eur J Neurosci 1998 Aug;10(8):2547-56

Physiologisches Institut, Justus-Liebig-Universität Giessen, Aulweg 129, D-35392 Giessen, Germany.

The clinically employed general anaesthetic halothane was shown to exert action on the peripheral nervous system by suppressing spinal reflexes, but it is still unclear which mechanisms underlie this action. The present study addressed the question whether blockade of tetrodotoxin-sensitive (TTXs) and -resistant (TTXr) Na+-channels in rat dorsal root ganglia (DRG) neurons by halothane could explain its peripheral effects. Two types of TTXr Na+-currents, fast and slow, with distinct activation and inactivation kinetics were found in small (< 25 micrometer) and medium sized (25-40 micrometer) DRG neurons. Read More

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Homosexuality and the American left: the impact of Stonewall.

D Thorstad

J Homosex 1995 ;29(4):319-49

NAMBLA, New York, NY 10018, USA.

Following the Stonewall Riots in New York City in June 1969, the left had to reassess negative appraisals of homosexuality that prevailed among virtually all leftist currents. Pressure for change came from within and from without. By the mid-1970s, three approaches had emerged: (1) radical support for sexual liberation and acceptance of same-sex love as being on a par with heterosexuality; (2) liberal support for the civil rights of homosexuals but without challenging heterosupremacy; and (3) continued adherence to the (Stalinist) view that homosexuality is a form of "bourgeois decadence" alien to the working class. Read More

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[Romantic origins of electrophysiology].

H Isler

Schweiz Rundsch Med Prax 1992 Dec;81(49):1485-8

Neurologie, Universitätsspital, Zürich.

Research on static electricity and its effects on the human body date back to the invention of the electrizing or Wimshurst machine and the Leyden jar of 1743 and 1746. Such experiments often served as social pastimes, but they yielded many publications on medical aspects of static electricity. Attempts to explain the 'life force' of the vitalists and the old concept of the active principle of the nervous system, the 'spiritus animales', as electrical phenomena were unsuccessful because of the skeptic comments of leading experimental scientists such as Albrecht von Haller. Read More

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December 1992

Algebraical summation in synaptic activation of motoneurones firing within the 'primary range' to injected currents.

J Physiol 1966 Nov;187(2):379-99

1. In intracellular studies of cat lumbar motoneurones constant synaptic stimuli such as stretch, contraction or a high-frequency stimulation of a cut afferent nerve have been superimposed on firing in response to injected currents.2. Read More

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November 1966
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