587,941 results match your criteria current study


Acetylsalicylic acid improves cognitive performance in sleep deprived adult Zebrafish () model.

Front Biosci (Landmark Ed) 2021 May;26(6):114-124

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, 570015 Mysuru, India.

Sleep deprivation (SD) is commonly associated with decreased attention, reduced responsiveness to external stimuli, and impaired locomotor and cognitive performances. Strong evidence indicates that SD disrupts neuro-immuno-endocrine system which is also linked to cognitive function. Recently Zebrafish have emerged as a powerful model sharing organizational and functional characteristics with other vertebrates, providing great translational relevance with rapid and reliable screening results. Read More

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Effects of a Video-Based mHealth Program for Homebound Older Adults: Study Protocol for a Pilot Randomized Controlled Trial.

Gerontology 2021 Jun 23:1-8. Epub 2021 Jun 23.

The Hong Kong Lutheran Social Service, Homantin, Hong Kong, China.

Background: Although homebound older adults are among the highest users of hospital services, the existing health and social services that are provided to them in the community are limited and fragmented. This study attempts to bring this group of older adults to providers' attention by designing a health-social-oriented self-care mobile Health (mHealth) program and subjecting it to empirical testing. The aim of this study is to shift the current reactive, cure-oriented approach to a preventive and health-promoting model, empowering homebound older adults to take an active role in their health, be responsive to their care needs, and subsequently improve their holistic health. Read More

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Implementation of a triage monitoring program for internal exposure to short-lived radionuclides in Israel - Challenges and recommendations.

J Radiol Prot 2021 Jun 23. Epub 2021 Jun 23.

Radiation Safety, Soreq NRC, Yavne, ISRAEL.

Monitoring internal exposure to short-lived radionuclides is challenging, due to the frequent measurements required. ISO Standard 16637 and the Swiss Personal Dosimetry Ordinance describe a screening measurement (triage monitoring) conducted in the workplace to identify workers suspected of internal exposure. Based on a previous study that examined the feasibility of using several commonly found radiation monitors in Israel in a triage monitoring program, we conducted a pilot study towards the implementation of triage monitoring in nuclear medicine facilities in Israel. Read More

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Comparison between patient-specific deep brain stimulation simulations and commercial system SureTune3.

Biomed Phys Eng Express 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery , Linköping University Hospital, Linköping University Hospital, Linkoping, 581 85, SWEDEN.

Objective: Software to visualize estimated volume of tissue activated (VTA) in deep brain stimulation assuming a homogeneous tissue surrounding such as SureTune3 has recently become available for clinical use. The objective of this study is to compare SureTune3 with homogeneous and heterogeneous patient-specific finite element method (FEM) simulations of the VTA to elucidate how well they coincide in their estimates.

Approach: FEM simulations of the VTA were performed in COMSOL Multiphysics and compared with VTA from SureTune3 with variation of voltage and current amplitude, pulse width, axon diameter, number of active contacts, and surrounding homogeneous grey or white matter. Read More

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Breastfeeding intention and trait mindfulness during pregnancy.

Midwifery 2021 Jun 10;101:103064. Epub 2021 Jun 10.

Center of Research in Psychological and Somatic disorders (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.

Objective: Breastfeeding has been associated with many health benefits for both infant and mother. Trait mindfulness during pregnancy may have a beneficial impact on breastfeeding intention. The current study aimed to examine whether trait mindfulness during pregnancy was associated with antenatal breastfeeding intention. Read More

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Are other tick-borne infections overlooked in patients investigated for Lyme neuroborreliosis? A large retrospective study from South-eastern Sweden.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101759. Epub 2021 Jun 4.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; Department of Infectious Diseases, Region Östergötland County, Linköping/Norrköping, Sweden.

In Europe, the hard tick Ixodes ricinus is considered the most important vector of human zoonotic diseases. Human pathogenic agents spread by I. ricinus in Sweden include Borrelia burgdorferi sensu lato (s. Read More

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Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.

Cytokine 2021 May 24;146:155589. Epub 2021 May 24.

Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Medical Cell Biology, Integrative Physiology, Uppsala University, Uppsala, Sweden.

Background: Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients. Read More

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Correlation between ambulatory blood pressure monitoring and office blood pressure measurement in patients with hypertension: A Community Study.

Am J Med Sci 2021 Jun 20. Epub 2021 Jun 20.

Medical Affairs Department, Eris Life Sciences, Ahmedabad. Electronic address:

Background: The current gold standard for blood pressure (BP) measurements is based on office BP measurements (OBPMs) by a sphygmomanometer or a digital device. Ambulatory BP measurement (ABPM) is a noninvasive method for continuous monitoring of BP over a 24-hour period during routine activities of the patient. Thus, ABPM offers multiple BP readings during the patients' daily routine as compared to the single reading by OBPM at rest. Read More

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Mortality predictive factors of People Living with Human-immunodeficiency-virus and Bloodstream Infection.

Int J Infect Dis 2021 Jun 20. Epub 2021 Jun 20.

Internal Medicine department, Coimbra Hospital and University Center, Coimbra, Portugal; Faculty of Medicine, University of Coimbra. Electronic address:

Introduction: Portugal had one of the highest people living with human-immunodeficiency-virus (PLWHIV) mortality rates in Europe, although it is declined after antiretroviral therapy introduction such as bloodstream infections (BSI) mortality in these patients. However BSI mortality is still high and with few European data. So, characterizing BSI and defining prognostic factors may improve our approach. Read More

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UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer.

Cancer Lett 2021 Jun 20. Epub 2021 Jun 20.

Department of Obstetrics and Gynecology, The Second Hospital, Jilin University, 218 Zi Qiang Street, Changchun, Jilin, 130000, PR China. Electronic address:

Melittin's non-specific cytotoxicity and hemolytic activity restrict its clinical use, but polypeptide modification is thoμght to be highly selective and well-tolerated. Here, we synthesized a novel antineoplastic peptide UM-6 based on melittin and explored the mechanism related to its anti-proliferation and metastasis on cervical cancer (CC). In the present study, we demonstrated that UM-6 inhibits viability of CC cell lines Caski and Hela in vitro by inducing apoptosis and autophagy with low toxicity to normal epithelial cells. Read More

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The Current State of PAG Residency Training in Canada: Summary of Educational Resources to Enhance the Achievement of PAG Objectives.

Authors:
Tania Dumont

J Pediatr Adolesc Gynecol 2021 Jun 20. Epub 2021 Jun 20.

University of Ottawa, Department of Obstetrics and Gynecology, Ottawa, Canada; CHEO, Department of Surgery, Division of Gynecology, Ottawa, Canada; The Ottawa Hospital, Department of Obstetrics, Gynecology and Newborn Care, Ottawa, Canada. Electronic address:

A previous study determined that Obstetrics and Gynecology (ObGyn) residency Program Directors (PD) endorse mandatory Pediatric and Adolescent Gynecology (PAG) training to achieve national PAG objectives. While barriers exist that limit the achievement of PAG objectives, this paper presents existing PAG tools and curriculums. These include the North American Society for Pediatric and Adolescent Gynecology's (NASPAG) short and long curriculums, a wide variety of PAG electives available across Canada, over 25 online clinical cases and a simulation curriculum. Read More

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The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

Cell 2021 Jun 5. Epub 2021 Jun 5.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we investigated the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-COV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or single monoclonal antibody treatments. Read More

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Evaluating the Use of Oral Trials for Inpatient Dysphagia Management: An Initial Cross-Sectional Database Study.

Am J Speech Lang Pathol 2021 Jun 23:1-12. Epub 2021 Jun 23.

Department of Speech and Language Therapy, Derbyshire Community Health Services, Royal Derby Hospital, United Kingdom.

Purpose Oral trials, otherwise known as or are widely used in dysphagia management. However, to date, no studies have investigated the effectiveness of oral trials or outlined how the approach is utilized in everyday practice. This article aims to start a dialogue regarding this much-used but little-evidenced dysphagia intervention by exploring three main aspects to (a) identify the patient demographics and environments in which oral trials are used in hospital, (b) explore clinical decision making around the approach, and (c) consider clinical implications around current findings and future areas for research. Read More

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Potential of Live Spirogyra sp. in the Bioaccumulation of Copper and Nickel ions: A Study for Suitability and Sustainability.

J Appl Microbiol 2021 Jun 23. Epub 2021 Jun 23.

Madhav University, Rajasthan-307026, India.

Aim: Various industrial and municipal wastes are the major source of heavy metal contamination in water and hence thoughtful environmental worries. Bioremediation is an effective and affordable solution for removal of metals and metal pollutants from industrial wastewater. The current study aims to assess the efficacy of live and dead Spirogyra sp. Read More

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Insights into the effect of human civilization on Malus evolution and domestication.

Plant Biotechnol J 2021 Jun 23. Epub 2021 Jun 23.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Horticulture, Northwest A&F University, Yangling, 712100, China.

The evolutionary history of the Malus genus has not been well studied. In the current study, we presented genetic evidence on the origin of the Malus genus based on genome sequencing of 297 Malus accessions, revealing genetic relationship between wild species and cultivated apples. Our results demonstrated that North American and East Asian wild species are closer to the outgroup (pear) than Central Asian species, and Hybrid species including natural (separated before the Pleistocene, about 2. Read More

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Computer Modeling Indicates Dramatically Less DNA Damage from Far-UVC Krypton Chloride Lamps (222 nm) than from Sunlight Exposure.

Photochem Photobiol 2021 Jun 23. Epub 2021 Jun 23.

SUPA, School of Physics and Astronomy, University of St Andrews, St Andrews, KY16 9SS, United Kingdom.

This study aims to investigate, with computer modeling, the DNA damage (assessed by cyclobutane pyrimidine dimer (CPD) formation) from far-ultraviolet C (far-UVC) in comparison with sunlight exposure in both a temperate (Harwell, England) and Mediterranean (Thessaloniki, Greece) climate. The research utilizes the published results from Barnard et al. [Barnard, I. Read More

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Relationship Between Parent and Teacher Reported Executive Functioning and Maladaptive Behaviors in Children With Down Syndrome.

Am J Intellect Dev Disabil 2021 Jul;126(4):307-323

Lisa M. Jacola, St. Jude Children's Research Hospital.

The current study evaluates the concurrent relationship between parent ratings of executive functioning and maladaptive behavior among children and adolescents with Down syndrome and then repeats this evaluation using teacher reports. Parents and teachers of 63 school-age children with Down syndrome rated the child's executive functioning (Behavior Rating Inventory of Executive Function) and behaviors (Achenbach Child Behavior Checklist). For parent and teacher ratings, elevated behavior dysregulation predicted higher levels of rule-breaking, aggressive, and externalizing behavior. Read More

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Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil.

Rev Inst Med Trop Sao Paulo 2021 18;63:e47. Epub 2021 Jun 18.

Universidade Federal de Pelotas, Instituto de Biologia, Programa de Pós-Graduação em Parasitologia, Pelotas, Rio Grande do Sul, Brazil.

Chagas disease (CD) has been considered endemic in the South of Rio Grande do Sul (RS) State, Brazil. This study aimed at evaluating the occurrence of Trypanosoma cruzi vectors based on the main species captured in Southern Rio Grande do Sul State from 2008 to 2019. The study area comprised counties that belong to the 3rd Regional Health Coordination (RHC) and to the 7th RHC, whose headquarters are in Pelotas and Bage, respectively. Read More

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Working conditions of Nursing professionals in coping with the Covid-19 pandemic.

Rev Gaucha Enferm 2021 18;42(spe):e20200339. Epub 2021 Jun 18.

Universidade Federal de Santa Catarina (UFSC). Florianópolis, Santa Catarina, Brasil.

Objective: To trigger a reflection on the current working conditions of Nursing professionals in coping with the Covid-19 pandemic.

Method: A theoretical-reflective study supported by studies from the Marxist perspective, national and international scientific articles, and official documents from the World Health Organization and the Federal Nursing Council.

Results: The daily work of Nursing professionals in the face of the Covid-19 pandemic presents unfavorable working conditions in Brazil and worldwide, with emphasis on the deficit of professionals, overload of activities, low pay, and personal protective equipment, often insufficient and inadequate, conditions that can lead to exhaustion, illness and death. Read More

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Cardiovascular risk factors and major depressive disorder: a cross-sectional study in São Paulo, Brazil.

Sao Paulo Med J 2021 Jun 11. Epub 2021 Jun 11.

MD, PhD. Deputy Coordinator, Center for Clinical and Epidemiological Research, Hospital Universitário (HU), Universidade de Sao Paulo, Sao Paulo, SP, BR, and Full Professor, Department of Internal Medicine, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Background: Cardiovascular risk factors can mediate the association between depression and cardiovascular diseases.

Objective: To evaluate cardiovascular risk factors in adult individuals with and without histories of major depression in the metropolitan region of São Paulo, Brazil.

Design And Setting: Cross-sectional study in São Paulo (SP), Brazil. Read More

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Amazonian soil fungi are efficient degraders of glyphosate herbicide; novel isolates of Penicillium, Aspergillus, and Trichoderma.

Braz J Biol 2021 21;83:e242830. Epub 2021 Jun 21.

Universidade do Estado do Amazonas - UEA, Escola Superior de Ciências da Saúde, Manaus, AM, Brasil.

Pesticide residues that contaminate the environment circulate within the hydrological cycle can accumulate within the food chain and cause problems to both environmental and human health. Microbes, however, are well known for their metabolic versatility and the ability to degrade chemically stable substances, including recalcitrant xenobiotics. The current study focused on bio-prospecting within Amazonian rainforest soils to find novel strains fungi capable of efficiently degrading the agriculturally and environmentally ubiquitous herbicide, glyphosate. Read More

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Potential Hepatoprotective Effect of Cheatomorpha gracilis extract against High Fat Diet (HFD)-Induced Liver Damage, and its characterization by HPLC.

Braz J Biol 2021 21;82:e247102. Epub 2021 Jun 21.

University of Sfax, Faculty of Sciences of Sfax, Laboratory of Animal Physiology, Sfax, Tunisia.

The current investigation was carried out to estimate the protective effect of aqueous extract of Cheatomorpha gracilis (AEC) against High fat Diet (HFD) induced liver damage in mice. The results of the in vitro study showed that AEC have higher antioxidant capacities in the DPPH and hydroxyl radical-scavenging assays. Indeed, many phenolic compounds (gallic acid, quercetin, naringenin, apigenin, kaempferol and rutin) were identified in the AEC. Read More

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Dental pain prevalence associated with caries experience in pediatric patients in a clinical sample in Mexico.

Braz Oral Res 2021 16;35:e076. Epub 2021 Jun 16.

Indiana University, Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.

The aim of this study was to identify if the prevalence of dental pain (past and / or present) is associated with caries experience in Mexican children, as well as to characterize factors associated with dental pain. A cross-sectional study was conducted in a consecutive sample of 309 children 2 to 12 years old who were patients at a dental school clinic in Toluca, Mexico. Data were collected from clinical records. Read More

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Electrofabrication of flexible and mechanically strong tubular chitosan implants for peripheral nerve regeneration.

J Mater Chem B 2021 Jun 23. Epub 2021 Jun 23.

School of Resource and Environmental Science, Hubei Engineering Center of Natural Polymers-Based Medical Materials, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.

The development of peripheral nerve tissue engineering requires a safe and reliable methodology to construct biodegradable conduits. Herein, a new type of chitosan-based nerve-guide hydrogel conduit (CNHC) with enhanced mechanical flexibility in the wet state was fabricated using a one-step electrofabrication technology. The formation of the chitosan conduit is a physical process which can be conducted in a mild water phase without toxic crosslinks. Read More

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Performance of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies in South Africa.

PLoS One 2021 23;16(6):e0252317. Epub 2021 Jun 23.

Department of Immunology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has been identified as the causative agent for causing the clinical syndrome of COVID -19. Accurate detection of SARS-CoV-2 infection is not only important for management of infected individuals but also to break the chain of transmission. South Africa is the current epicenter of SARS-CoV-2 infection in Africa. Read More

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Artificial accommodating intraocular lens powered by an ion polymer-metal composite actuator.

PLoS One 2021 23;16(6):e0252986. Epub 2021 Jun 23.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba-city, Ibaraki, Japan.

The current method of controlling the focus of an accommodating intraocular lens is based on ciliary muscle contraction and cannot be used in older patients with presbyopia. We aimed to develop a dynamically accommodating intraocular lens powered by a membrane-shaped ion polymer metal composite actuator that is thin enough to be inserted in the eye. This study addresses two key problems identified in our previous accommodating intraocular lens prototype: the lack of repeatability due to the use of swine lenses instead of artificial lenses and the occurrence of a sixth order aberration. Read More

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Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.

PLoS Negl Trop Dis 2021 Jun 23;15(6):e0009554. Epub 2021 Jun 23.

Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.

Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. Read More

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Precise temporal control of interferential neural stimulation via phase modulation.

IEEE Trans Biomed Eng 2021 Jun 23;PP. Epub 2021 Jun 23.

Objective: Noninvasive neural stimulation via temporally interferential (TI) electrical field is currently an area of interest as a noninvasive method of brain stimulation. The major limitation of TI stimulation is the difficulty of precise temporal control of the stimulation, due to the nature of the sinusoidal envelope generated by the interference. The purpose of this study was to investigate the possibility of improving interferential stimulation by introducing precise temporal control using phase modulation. Read More

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Inhibition of TLR9 signaling stimulates apoptosis and cell cycle arrest and alleviates angiogenic property in human cervical cancer cells.

Endocr Metab Immune Disord Drug Targets 2021 Jun 22. Epub 2021 Jun 22.

Department of Obstetrics and Gynecology, The Second Hospital of Shandong University, 250033, China.

Aims: The aim of the study was to assess the effect of blocking TLR9 signaling on the proliferation of cervical cancer cells and its angiogenic property.

Background: Toll-like receptors (TLRs) have been implicated for their crucial role in not only cervical cancer but also in other malignancies. TLR9 is expressed on an array of cells such as macrophages, dendritic cells, melanocytes, and keratinocytes. Read More

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Microfracture Augmentation With Trypsin Pretreatment and Growth Factor-Functionalized Self-assembling Peptide Hydrogel Scaffold in an Equine Model.

Am J Sports Med 2021 Jun 23:3635465211021798. Epub 2021 Jun 23.

Department of Clinical Sciences, Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Background: Microfracture augmentation can be a cost-effective single-step alternative to current cartilage repair techniques. Trypsin pretreatment combined with a growth factor-functionalized self-assembling KLD hydrogel ("functionalized hydrogel") has been shown to improve overall cartilage repair and integration to surrounding tissue in small animal models of osteochondral defects.

Hypothesis: Microfracture combined with trypsin treatment and a functionalized hydrogel will improve reparative tissue quality and integration as compared with microfracture alone in an equine model. Read More

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