41,857 results match your criteria current calcium

Kaempferol alleviates calcium oxalate crystal-induced renal injury and crystal deposition via regulation of the AR/NOX2 signaling pathway.

Phytomedicine 2021 Mar 27;86:153555. Epub 2021 Mar 27.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Background: Calcium oxalate (CaOx) crystal deposition and crystal-induced renal tubular epithelial cell injury have been found to fundamentally contribute to the formation of CaOx nephrolithiasis.

Purpose: In the current work, we aim to study the role and mechanism of kaempferol in CaOx crystal kidney deposition and crystal-induced renal injury.

Study Design: Mice models and HK-2 cells were used to investigate the effect of kaempferol in CaOx crystal-induced renal injury and crystal deposition in the kidney and its underlying mechanism by a series of experiments. Read More

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The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites.

Med Res Rev 2021 Apr 13. Epub 2021 Apr 13.

Infectious Diseases, Mayo Clinic, Jacksonville, Florida, 32224, USA.

Calcium channels (CCs), a group of ubiquitously expressed membrane proteins, are involved in many pathophysiological processes of protozoan parasites. Our understanding of CCs in cell signaling, organelle function, cellular homeostasis, and cell cycle control has led to improved insights into their structure and functions. In this article, we discuss CCs characteristics of five major protozoan parasites Plasmodium, Leishmania, Toxoplasma, Trypanosoma, and Cryptosporidium. Read More

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Nutrition, genetic variation and male fertility.

Transl Androl Urol 2021 Mar;10(3):1410-1431

Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.

Infertility affects nearly 50 million couples worldwide, with 40-50% of cases having a male factor component. It is well established that nutritional status impacts reproductive development, health and function, although the exact mechanisms have not been fully elucidated. Genetic variation that affects nutrient metabolism may impact fertility through nutrigenetic mechanisms. Read More

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Massive efflux of adenosine triphosphate into the extracellular space immediately after experimental traumatic brain injury.

Exp Ther Med 2021 Jun 31;21(6):575. Epub 2021 Mar 31.

Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine, University of California, LA 90095-6901, USA.

The aim of the current study was to determine effects of mild traumatic brain injury (TBI), with or without blockade of purinergic ATP Y1 (P2Y1) receptors or store-operated calcium channels, on extracellular levels of ATP, glutamate, glucose and lactate. Concentrations of ATP, glutamate, glucose and lactate were measured in cerebral microdialysis samples obtained from the ipsilateral cortex and underlying hippocampus of rats with mild unilateral controlled cortical impact (CCI) or sham injury. Immediately after CCI, a large release of ATP was observed in the cortex (3. Read More

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Investigation of the combined use of capping and oxidizing agents in the immobilization of arsenic in sediments.

Sci Total Environ 2021 Apr 6;782:146930. Epub 2021 Apr 6.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China.

The combined use of capping (lanthanum modified bentonite; LMB) and oxidizing (calcium nitrate; CN) agents was investigated to immobilize arsenic (As) in sediments. The vertical changes in labile As and dissolved As were measured using diffusive gradients in thin films (DGT) and Rhizon devices. The results showed that the combined application of LMB and CN had the optimal effect on the immobilization of both DGT-labile As and dissolved As, compared to single treatments using LMB or CN. Read More

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Antihypertensive prescribing patterns and hypertension control in females of childbearing age.

Am J Health Syst Pharm 2021 Apr 13. Epub 2021 Apr 13.

University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, USA.

Purpose: The use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) to treat hypertension (HTN) during pregnancy presents well-established risks to a developing fetus. A cross-sectional study was conducted to evaluate the current state of antihypertensive prescribing and contraceptive use in females of childbearing age within a large safety-net health system.

Methods: The retrospective cross-sectional study of females aged 18-49 years with a documented diagnosis of HTN. Read More

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Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement.

JAMA 2021 04;325(14):1436-1442

Tufts University School of Medicine, Boston, Massachusetts.

Importance: Vitamin D is a fat-soluble vitamin that performs an important role in calcium homeostasis and bone metabolism and also affects many other cellular regulatory functions outside the skeletal system. Vitamin D requirements may vary by individual; thus, no one serum vitamin D level cutpoint defines deficiency, and no consensus exists regarding the precise serum levels of vitamin D that represent optimal health or sufficiency.

Objective: To update its 2014 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a systematic review on screening for vitamin D deficiency, including the benefits and harms of screening and early treatment. Read More

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Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism.

Ann Transl Med 2021 Mar;9(5):399

Department of Pediatric Cardiothoracic Surgery, Shanghai Children's Medical Center; School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Ventricular-like human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) exhibit the electrophysiological characteristics of spontaneous beating. Previous studies demonstrated that dexmedetomidine (DMED), a highly selective and widely used α-adrenoceptor agonist for sedation, analgesia, and stress management, may induce antiarrhythmic effects, especially ventricular tachycardia. However, the underlying mechanisms of the DMED-mediated antiarrhythmic effects remain to be fully elucidated. Read More

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Temperature but not ocean acidification affects energy metabolism and enzyme activities in the blue mussel, .

Ecol Evol 2021 Apr 5;11(7):3366-3379. Epub 2021 Mar 5.

Department of Biological Sciences University of North Carolina at Charlotte Charlotte NC USA.

In mosaic marine habitats, such as intertidal zones, ocean acidification (OA) is exacerbated by high variability of pH, temperature, and biological CO production. The nonlinear interactions among these drivers can be context-specific and their effect on organisms in these habitats remains largely unknown, warranting further investigation.We were particularly interested in (the blue mussel) from intertidal zones of the Gulf of Maine (GOM), USA, for this study. Read More

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A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.

Kidney Int 2021 Apr 6. Epub 2021 Apr 6.

Departments of Medicine and Physiology, University of California San Francisco, CA, USA.

Hypertension is a major cause of cardiovascular morbidity and mortality, despite the availability of antihypertensive drugs with different targets and mechanisms of action. Here, we provide evidence that pharmacological inhibition of TMEM16A (ANO1), a calcium-activated chloride channel expressed in vascular smooth muscle cells, blocks calcium-activated chloride currents and contraction in vascular smooth muscle in vitro and decreases blood pressure in spontaneously hypertensive rats. The acylaminocycloalkylthiophene TMinh-23 fully inhibited calcium-activated TMEM16A chloride current with nanomolar potency in Fischer rat thyroid cells expressing TMEM16A, and in primary cultures of rat vascular smooth muscle cells. Read More

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MicroRNA-17-5p restrains the dysfunction of Ang-II induced podocytes by suppressing secreted modular calcium-binding protein 2 via NF-κB and TGFβ signaling.

Environ Toxicol 2021 Apr 9. Epub 2021 Apr 9.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Jilin, China.

Glomerulonephritis, also known as nephritis syndrome (nephritis for short), is a common kidney disease. Previous research has proved that microRNAs (miRNAs) frequently regulate various diseases including nephritis. Nonetheless, the biological function and molecular mechanism of miR-17-5p are unclear in nephritis. Read More

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Mitochondrial Contributions to Vascular Endothelial Dysfunction, Arterial Stiffness and Cardiovascular Diseases.

Am J Physiol Heart Circ Physiol 2021 Apr 9. Epub 2021 Apr 9.

Department of Kinesiology and Applied Physiology, University of Delaware, United States.

Cardiovascular diseases (CVD) affect 1 in 3 adults and remain the leading causes of death in America. Advancing age is the major risk factor for CVD. Recent plateaus in CVD-related mortality rates in high income countries after decades of decline highlight a critical need to identify novel therapeutic targets and strategies to mitigate and manage the risk of CVD development and progression. Read More

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Evaluation of Vitamin D3 and Calcium Deficiency after Recovery from Extensive Burn.

World J Plast Surg 2021 Jan;10(1):60-65

Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Previous studies in pediatric populations have demonstrated that vitamin D deficiency is common in patients with large burns. The aim of the current comparative study was to investigate the serum level of vitamin D in patients with large burns [>20% total body surface area (TBSA)] after 6 months of therapy.

Methods: This case control study was conducted during 6-month period from 2017 to 2018 in Amiralmomenin Hospital, Shiraz, Iran. Read More

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January 2021

Azithromycin induced contractile responses of intestinal smooth muscles: A mechanistic approach.

Pak J Pharm Sci 2020 Sep;33(5(Special)):2385-2392

Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, KP, Pakistan/Department of Pharmacy, University of Malakand, Chakdara Dir Lower, KP, Pakistan.

The current work is documented to investigate the actions of azithromycin on intestinal smooth muscles as there are reports of gastrointestinal upsets with use of azithromycin. Azithromycin was tested on rabbit's jejunal and rat's ileal preparations in test concentrations (μM) of 0.01, 0. Read More

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September 2020

The Cardiac Late Sodium Channel Current is a Molecular Target for the Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin.

Circulation 2021 Apr 9. Epub 2021 Apr 9.

Alberta Diabetes Institute and the Departments of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

Sodium/glucose co-transporter 2 (SGLT2) inhibitors exert robust cardioprotective effects against heart failure in diabetes patients and there is intense interest to identify the underlying molecular mechanisms that afford this protection. As the induction of the late component of the cardiac sodium channel current (late-I) is involved in the etiology of heart failure, we investigated whether these drugs inhibit late-I. Electrophysiological, in silico molecular docking, molecular, calcium imaging and whole heart perfusion techniques were employed to address this question. Read More

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Magnesium and calcium over-accumulate in the leaves of a schengen3 mutant of Brassica rapa.

Plant Physiol 2021 Apr 8. Epub 2021 Apr 8.

School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK.

Magnesium (Mg) and calcium (Ca) are essential mineral nutrients poorly supplied in many human food systems. In grazing livestock, Mg and Ca deficiencies are costly welfare issues. Here, we report a Brassica rapa loss-of-function schengen3 (sgn3) mutant, braA. Read More

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Porcine endometrial 3D co-culture: Morphological changes in 3D endometrium tissues according to hormonal changes.

Histol Histopathol 2021 Apr 8:18335. Epub 2021 Apr 8.

Institute of Genetic Engineering, Hankyong National University, Jungang-ro, Ansung, Gyeonggi-do, Korea.

Cells cultured as monolayers proliferate well, but do not sustain their differentiation characteristics. Previous studies have investigated the interactions between cells and growth factors or cytokines by establishing either in vivo or in vitro three-dimensional (3D) cultures. Using porcine uterine epithelial cells and endometrial cells, the current study was designed to develop a 3D uterine culture system and investigate the response to hormone treatment. Read More

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Investigation of long interspersed element-1 retrotransposons as potential risk factors for idiopathic temporal lobe epilepsy.

Epilepsia 2021 Apr 7. Epub 2021 Apr 7.

Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Objective: To determine if long interspersed element-1 (L1) retrotransposons convey risk for idiopathic temporal lobe epilepsy (TLE).

Methods: Surgically resected temporal cortex from individuals with TLE (N = 33) and postmortem temporal cortex from individuals with no known neurological disease (N = 33) were analyzed for L1 content by Restriction Enzyme Based Enriched L1Hs sequencing (REBELseq). Expression of three KCNIP4 splice variants was assessed by droplet digital PCR (ddPCR). Read More

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The effect of calcium and magnesium on activity, immunogenicity, and efficacy of a recombinant N1/N2 neuraminidase vaccine.

NPJ Vaccines 2021 Apr 6;6(1):48. Epub 2021 Apr 6.

LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine (NAV) was developed. Stability assays were used to determine optimal temperature and buffer conditions for vaccine storage. Read More

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Lack of calcium rich foods in the diet, low knowledge on calcium level recommendations and severe food insecurity predicts low calcium intake among Vietnamese women.

Appetite 2021 Apr 3;163:105242. Epub 2021 Apr 3.

Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, 2500 Broadway, Lubbock, TX, 79409, USA. Electronic address:

Objective: To assess nutrition knowledge related to osteoporosis and calcium, osteoporosis health beliefs, dietary calcium intake and household food insecurity among adult women in Vietnam.

Methods: Two hundred fifty-one women aged 30-65 years living in a rural district in Hanoi -Vietnam were recruited. A questionnaire was used to collect information on nutrition knowledge related to osteoporosis and calcium intake, health beliefs, household food security, and dietary calcium intake. Read More

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Atrial fibrillation during pregnancy: a 9-month period with limited options.

Herzschrittmacherther Elektrophysiol 2021 Apr 6. Epub 2021 Apr 6.

Klinik für Kardiologie und Rhythmologie, Evangelisches Krankenhaus Hagen, Brusebrinkstraße 20, 58135, Hagen, Germany.

Pregnancy is a physiological condition with reversible hemodynamic, neurohormonal and coagulation changes to the maternal body during this 9‑month period. The occurrence of atrial fibrillation (AF) is altogether rare among pregnant women, but necessitates immediate treatment und further work-up. Despite numerous pharmacological and invasive therapeutic modalities for AF in non-pregnant patients, very few options are considered safe enough for the fetus and the mother during pregnancy. Read More

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Curcumin attenuates spatial memory impairment by anti-oxidative, anti-apoptosis, and anti-inflammatory mechanism against methamphetamine neurotoxicity in male Wistar rats: histological and biochemical changes.

Neurotoxicology 2021 Apr 2. Epub 2021 Apr 2.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Objective: Methamphetamine is used extensively around the world as a psychostimulant. The complications related to methamphetamine include methamphetamine-induced neurotoxicity, mainly involving intraneuronal processes, such as oxidative stress and excitotoxicity. Curcumin is effective against neuronal injury due to its antioxidant, anti-inflammatory effects. Read More

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Dietary calcium, vitamin D, and breast cancer risk in women: findings from the SUN cohort.

Eur J Nutr 2021 Apr 5. Epub 2021 Apr 5.

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, C/Irunlarrea, 31008, Pamplona, Spain.

Purpose: Epidemiological evidence concerning the relationship between calcium and vitamin D intake and breast cancer (BC) is inconclusive. Moreover, the association according to menopausal status remains unclear. We aimed to assess whether total intakes from dietary and supplemental sources of calcium and vitamin D were associated with the incidence of BC in a Mediterranean cohort. Read More

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Aquaporins in platelet function.

Platelets 2021 Apr 4:1-7. Epub 2021 Apr 4.

School of Physiology, Pharmacology and Neuroscience, University of Bristol, England, UK.

Structurally, aquaporins (AQPs) are small channel proteins with monomers of ~ 30 kDa that are assembled as tetramers to form pores on cell membranes. Aquaporins mediate the conduction of water but at times also small solutes including glycerol across cell membranes and along osmotic gradients. Thirteen isoforms of AQPs have been reported in mammalian cells, and several of these are likely expressed in platelets. Read More

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Study of the Electro-Activation Process of Calcium Lactate, Calcium Ascorbate Solutions, and Their Equimolar Mixture: Assessment of Their Physicochemical Properties.

ACS Omega 2021 Mar 20;6(12):8531-8547. Epub 2021 Mar 20.

Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, QC G1V 0A6, Canada.

The aim of this study was to prepare electro-activated solutions (EAS) from calcium lactate, calcium ascorbate, and an equimolar mixture of these two salts to obtain their corresponding acids and to study their physicochemical characteristics, in particular, pH, titratable acidity, p, and antioxidant activity. Indeed, the solutions were electro-activated in a reactor comprising three compartments (anodic, central, and cathodic) separated by anionic and cationic exchange membranes, respectively. The electric current intensities used were set at 250, 500, and 750 mA for a maximum period of 30 min. Read More

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Effect of different reconstruction algorithms on coronary artery calcium scores using the reduced radiation dose protocol: a clinical and phantom study.

Quant Imaging Med Surg 2021 Apr;11(4):1504-1517

Central China Fuwai Hospital, Zhengzhou, China.

Background: This study aimed to evaluate the effects of different iterative reconstruction (IR) algorithms on coronary artery calcium (CAC) score quantification using the reduced radiation dose (RRD) protocol in an anthropomorphic phantom and in patients.

Methods: A thorax phantom, containing 9 calcification inserts with varying hydroxyapatite (HA) densities, was scanned with the reference protocol [120 kv, 80 mAs, filtered back projection (FBP)] and RRD protocol (120 kV, 20-80 mAs, 5 mAs interval) using a 256-slice computed tomography (CT) scanner. Raw data were reconstructed with different reconstruction algorithms [iDose levels 1-7 and iterative model reconstruction (IMR) levels 1-3]. Read More

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Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer's Disease.

Aging Dis 2021 Apr 1;12(2):441-465. Epub 2021 Apr 1.

1Division of Neurodegenerative Disorders, St. Boniface Hospital Research, Winnipeg, MB, Canada.

Current treatments targeting amyloid beta in Alzheimer's disease (AD) have minimal efficacy, which results in a huge unmet medical need worldwide. Accumulating data suggest that brain mitochondrial dysfunction play a critical role in AD pathogenesis. Targeting cellular mechanisms associated with mitochondrial dysfunction in AD create a novel approach for drug development. Read More

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Primary breast angiosarcoma with disseminated intravascular coagulation is successfully treated with self-subcutaneous unfractionated heparin calcium injection: A case report.

Mol Clin Oncol 2021 May 17;14(5):104. Epub 2021 Mar 17.

Department of Orthopedic Surgery, Osaka International Cancer Institute, Osaka 541-8567, Japan.

Angiosarcoma is a rare sarcoma with a poor prognosis and is prone to disseminated intravascular coagulation (DIC), where DIC often interferes with chemotherapy. Primary angiosarcoma of the breast (PASB) is a type of angiosarcoma that is located in mammary parenchyma and is not associated with radiation exposure. The current study reported a 47-year-old female with DIC associated with PASB. Read More

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Application of Animal Models in Diabetic Cardiomyopathy.

Diabetes Metab J 2021 Mar 25;45(2):129-145. Epub 2021 Mar 25.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

Diabetic heart disease is a growing and important public health risk. Apart from the risk of coronary artery disease or hypertension, diabetes mellitus (DM) is a well-known risk factor for heart failure in the form of diabetic cardiomyopathy (DiaCM). Currently, DiaCM is defined as myocardial dysfunction in patients with DM in the absence of coronary artery disease and hypertension. Read More

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Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities.

Biotechnol J 2021 Apr 3:e2000116. Epub 2021 Apr 3.

Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.

Background: The success of biomedical implants in orthopedic and dental applications are usually limited due to insufficient bone-implant integration, and implant-related infections. Biointerfaces are critical in regulating their interactions and the desirable performance of biomaterials in biological environment. Surface engineering has been widely studied to realize better control of the interface interaction to further enhance the desired behavior of biomaterials. Read More

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