Int J Biol Macromol 2021 Apr 12. Epub 2021 Apr 12.
Graduate Institute of Biomedical Materials and Tissue Engineering, International PhD Program in Biomedical Engineering, Graduate Institute of Biomedical Optomechatronics, School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Research Center of Biomedical Device, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan. Electronic address:
Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Chitosan and fucoidan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Read More