16,825 results match your criteria curcumin


Commensal flora triggered target anti-inflammation of alginate-curcumin micelle for ulcerative colitis treatment.

Colloids Surf B Biointerfaces 2021 Apr 8;203:111756. Epub 2021 Apr 8.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, PR China. Electronic address:

Ulcerative colitis (UC) is a chronic, idiopathic inflammatory bowel disease characterized by dysregulation of colon immune response. Curcumin (Cur) has strong anti-inflammatory activities, but the application is severely hindered by the extremely hydrophobicity and pitiful bioavailability. Alginate (Alg), a natural polysaccharide with ideal solubility and biosafety, was introduced to prepare the esterified alginate-curcumin conjugate (Alg-Cur) and constructed stable Alg-Cur micelle in physiological solutions. Read More

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Review on characteristics of biomaterial and nanomaterials based polymeric nanocomposite membranes for seawater treatment application.

Environ Res 2021 Apr 14:111177. Epub 2021 Apr 14.

Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.

Membrane technology, especially nanofiltration (NF) has great attention to provide an imperative solution for water issues. The membrane is considered to be the heart in the separation plant. Understanding the membrane characteristics could allow predicting and optimizing the membrane performance namely flux, rejection and reduced fouling. Read More

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The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach.

Biofactors 2021 Apr 17. Epub 2021 Apr 17.

Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India.

Bleomycin (BLM) injury is associated with the severity of acute lung injury (ALI) leading to fibrosis, a high-morbidity, and high-mortality respiratory disease of unknown etiology. BLM-induced ALI is marked by the activation of a potent fibrogenic cytokine transcription growth factor beta-1 (TGFβ-1), which is considered a critical cytokine in the progression of alveolar injury. Previously, our work demonstrated that a diet-derived compound curcumin (diferuloylmethane), represents its antioxidative and antifibrotic application in TGF-β1-mediated BLM-induced alveolar basal epithelial cells. Read More

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Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response.

Exp Mol Med 2021 Apr 16. Epub 2021 Apr 16.

Division of Orthodontics, The Ohio State University College of Dentistry, Columbus, OH, 43210, USA.

Abnormally increased resorption contributes to bone degenerative diseases such as Paget's disease of bone (PDB) through unclear mechanisms. Recently, the optineurin (OPTN) gene has been implicated in PDB, and global OPTN knockout mice (Optn) were shown to exhibit increased formation of osteoclasts (osteoclastogenesis). Growing evidence, including our own, has demonstrated that intracellular reactive oxygen species (ROS) stimulated by receptor activator of nuclear factor kappa-B ligand (RANKL) can act as signaling molecules to promote osteoclastogenesis. Read More

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Natural antioxidants in the management of Parkinson's disease: Review of evidence from cell line and animal models.

J Integr Med 2021 Mar 27. Epub 2021 Mar 27.

Discipline of Pharmacy, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3084, Australia. Electronic address:

Parkinson's disease (PD) is a chronic progressive neurodegenerative disease. It results from the death of dopaminergic neurons. The pathophysiological mechanisms in idiopathic PD include the production of α-synuclein and mitochondrial respiratory function-affecting complex I, caused by reactive oxygen species. Read More

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Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease.

Adv Exp Med Biol 2021 ;1308:257-272

Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, México.

Non-alcoholic fatty liver disease is becoming in one of the most prevalent liver diseases that leads to liver transplantation. This health problem is a multisystem disease with a complex pathogenesis that involves liver, adipose tissue, gut, and muscle. Although several pharmacological agents have been investigated to prevent or treat non-alcoholic fatty liver disease, currently there is no effective treatment for the management of this chronic liver disease. Read More

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January 2021

The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review.

Adv Exp Med Biol 2021 ;1308:225-248

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. Read More

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January 2021

Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review.

Adv Exp Med Biol 2021 ;1308:161-183

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetes is a major health problem affecting more than four hundred million adults worldwide. The transition from normal glucose tolerance to type 2 diabetes (T2D) is preceded by increased Insulin resistance (IR), an independent predictor of the development of T2D in high risk (e.g. Read More

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January 2021

Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19.

Adv Exp Med Biol 2021 ;1308:127-136

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The novel coronavirus outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was recognized in late 2019 in Wuhan, China. Subsequently, the World Health Organization declared coronavirus disease 2019 (COVID-19) as a pandemic on 11 March 2020. The proportion of potentially fatal coronavirus infections may vary by location, age, and underlying risk factors. Read More

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January 2021

Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial.

Adv Exp Med Biol 2021 ;1308:119-126

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

BackgroundFunctional dyspepsia is the main cause of upper abdominal discomfort affecting 5-10% of the world population. Despite various therapeutic approaches, up to 50% of patients with functional dyspepsia seek alternative treatments. In the present study we evaluated the effect of curcumin supplementation along with famotidine therapy on severity of functional dyspepsia. Read More

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January 2021

Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial.

Adv Exp Med Biol 2021 ;1308:109-117

Department of Gynecology and Obstetrics, Iran University of Medical Sciences, Tehran, Iran.

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, for which the insulin sensitizer metformin has been used therapeutically. It has been shown that curcumin also exhibits insulin-sensitizing properties. Given that metformin acts as an ovulation inducing agent and both curcumin and metformin can reduce insulin resistance, the aim of the current study was to evaluate the effect of metformin with and without curcumin nanomicelles in the treatment of women with polycystic ovary syndrome. Read More

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January 2021

Antifungal Activities of Curcuminoids and Difluorinated Curcumin Against Clinical Dermatophyte Isolates.

Adv Exp Med Biol 2021 ;1308:101-107

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Dermatophytes are a group of fungal agents that can invade humans' keratinized tissues such as skin, nail, and hair, thereby causing dermatophyte infection (dermatophytosis) or ringworm. Some natural products have been reported to possess fungicidal effects. Hence, the present study investigated the effect of curcuminoids (CUR) and difluorinated curcumin (CDF) against clinical isolates of dermatophytes. Read More

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January 2021

Curcumin Can Bind and Interact with CRP: An in silico Study.

Adv Exp Med Biol 2021 ;1308:91-100

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Curcuminis a polyphenol with anti-inflammatory and antioxidative properties, found primarily in turmeric, a flowering plant of the ginger family. Among its numerous medical uses, curcumin has been used in the management of metabolic syndrome, and inflammatory conditions such as artrhritis, anxiety and hyperlipidemia. In this paper, we used molecular docking tools to assess the affinity of four curcumin derivatives (Curcumin, Cyclocurcumin, Demethoxycurcumin, Bisdemethoxycurcumin) as well as the endogenous ligand phosphorylcholine to C-reactive protein (CRP), a sensitive marker of systemic inflammation. Read More

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January 2021

Updated Review on the Role of Curcumin in Gastrointestinal Cancers.

Adv Exp Med Biol 2021 ;1308:55-89

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Malignant conditions of the gastrointestinal tract and accessory organs of digestion, including the oral cavity, esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus, are referred to as gastrointestinal cancers. Curcumin is a natural compound derived from turmeric with a wide range of biological activities. Several in vitro and in vivo studies have investigated the effects of curcumin on gastrointestinal cancers. Read More

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January 2021

Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-Fed Rabbits.

Adv Exp Med Biol 2021 ;1308:45-54

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Orally administered curcumin has been found to have a moderate therapeutic effect on dyslipidemia and atherosclerosis. The present study was conducted to determine lipid-modulating and antiatherosclerosis effects of injectable curcumin in the rabbit model of atherosclerosis induced by a high cholesterol diet (HCD). New Zealand white male rabbits were fed on a normal chow enriched with 0. Read More

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January 2021

Protective Effects of Curcumin Phytosomes Against High-Fat Diet-Induced Atherosclerosis.

Adv Exp Med Biol 2021 ;1308:37-44

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Curcumin has been shown to have beneficial effects on pathogenic factors involved in the development of atherosclerosis. The aim of this study was to assess the effects of curcumin phytosomes on atherosclerosis induced by high-fat diet in rabbits. A total of 16 adult male New Zealand white rabbits (1. Read More

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January 2021

The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial.

Adv Exp Med Biol 2021 ;1308:25-35

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Non-alcoholic fatty liver disease (NAFLD) is a global health problem with increasing prevalence among overweight and obese patients. It is strongly associated with conditions of insulin resistance including type 2 diabetes mellitus (T2DM) and obesity. It has detrimental consequences ranged from simple steatosis to irreversible hepatic fibrosis and cirrhosis. Read More

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January 2021

Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer.

Adv Exp Med Biol 2021 ;1308:13-23

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Phytochemicals are various compounds produced by plants. There is growing evidence on their potential health effects. Some of these compounds are considered as traditional medicines and used as painkillers, anti-inflammatory agents, and for other applications. Read More

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January 2021

The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

Adv Exp Med Biol 2021 ;1308:1-11

Department of Nutrition, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiovascular disease is a leading cause of death in many societies. Arterial stiffness is an initial sign of structural and functional changes in the arterial wall. Pulse wave velocity (PWV) is the gold standard for non-invasive evaluation of aortic stiffness and a modifiable cardiovascular risk factor. Read More

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January 2021

Protective Effects of Curcumin on the Outcome of Cryopreservation in Human Sperm.

Reprod Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy.

Cryopreservation causes decreased sperm fertility potential due to reactive oxygen species (ROS) production and physical-chemical damage, resulting in reduced sperm viability and motility. The addition of antioxidants to freezing media could protect sperm from cryo-damage, counteracting the harmful effects of ROS. The aim of this study was to assess the effects of curcumin supplementation in freezing medium on preventing cryo-damage in human semen. Read More

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In vitro effects of curcumin on proinflammatory cytokines and expression of their genes in minor salivary gland tissue of patients with Sjogren's syndrome.

Rheumatol Int 2021 Apr 16. Epub 2021 Apr 16.

Department of Clinical Immunology and Rheumatology, Christian Medical College and Hospital, Vellore, Tamil Nadu, 632004, India.

Curcumin reduces disease severity and ameliorates lupus-like/Sjögren's Syndrome-like disease in mice model. The immunological basis of these effects is largely unknown. This study examined the effects of curcumin on pro-inflammatory cytokines secreted by minor salivary glands in patients with primary Sjögren's syndrome (pSS). Read More

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Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson's Disease.

Neurotox Res 2021 Apr 16. Epub 2021 Apr 16.

Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. Recent studies have shown that curcumin (CUR) has neuroprotective effects in PD experimental models. However, its efficacy is limited due to low water solubility, bioavailability, and access to the central nervous system. Read More

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From Simple Mouth Cavities to Complex Oral Mucosal Disorders-Curcuminoids as a Promising Therapeutic Approach.

ACS Pharmacol Transl Sci 2021 Apr 17;4(2):647-665. Epub 2021 Mar 17.

Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India.

Oral diseases are among the most common encountered health issues worldwide, which are usually associated with anomalies of the oral cavity, jaws, and salivary glands. Despite the availability of numerous treatment modalities for oral disorders, a limited clinical response has been observed because of the inefficacy of the drugs and countless adverse side effects. Therefore, the development of safe, efficacious, and wide-spectrum therapeutics is imperative in the battle against oral diseases. Read More

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Blue/yellow emissive carbon dots coupled with curcumin: a hybrid sensor toward fluorescence turn-on detection of fluoride ion.

J Hazard Mater 2021 Jun 19;411:125184. Epub 2021 Jan 19.

School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China; Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Ningbo University, Ningbo 315211, China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. Electronic address:

Trace detection of fluoride ion has gained increasing attention due to fluoride's close association with biological and environmental processes. Herein, we construct a novel hybrid nanosystem consisting of carbon dots and curcumin for sensitive and selective sensing of F. Carbon dots are synthesized by hydrothermal treatment of 2,3-diaminopyridine and selenourea in hydrochloric acid. Read More

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Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.

Int J Pharm 2021 Apr 12:120592. Epub 2021 Apr 12.

Department of Animal Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.

Background: Despite recent advances in therapy, colorectal cancer remains a leading cause of death in affected people. Curcumin is the main bioactive compound of turmeric that has been demonstrated as an effective agent against cancer. However, its poor stability and bioavailability limit therapeutic application. Read More

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Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery.

Int J Biol Macromol 2021 Apr 12. Epub 2021 Apr 12.

Graduate Institute of Biomedical Materials and Tissue Engineering, International PhD Program in Biomedical Engineering, Graduate Institute of Biomedical Optomechatronics, School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Research Center of Biomedical Device, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan. Electronic address:

Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Chitosan and fucoidan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Read More

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Follow-up of pressure ulcer treatment with photodynamic therapy, low level laser therapy and cellulose membrane.

J Wound Care 2021 Apr;30(4):304-310

Institute of Physics, USP, São Carlos, SP, Brazil.

Objective: A pressure ulcer (PU) is an area of tissue trauma caused by continuous and prolonged pressure, often associated with hospitalised patients immobilised due to neurological problems, negatively affecting their quality of life, and burdening the public budget. The aim of this study was to report the follow-up, for 45 weeks, of three patients with neurological lesions due to trauma who subsequently developed PUs, and who were treated with a combination of photodynamic therapy (PDT), low level laser therapy (LLLT) and cellulose membrane (CM).

Method: PDT was mediated by the photosensitiser curcumin on a 1. Read More

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Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin.

Int J Nanomedicine 2021 7;16:2667-2687. Epub 2021 Apr 7.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.

Purpose: The goal was to directly deliver curcumin, a natural polyphenolic anticancer and anti-inflammatory compound, to the lung tissues with minimal systemic exposure through the fabrication of proliposomes, overcoming its poor aqueous solubility and oral bioavailability.

Methods: Nano-spray drying was employed to prepare proliposomes using hydroxypropyl beta-cyclodextrin as a carrier. Lecithin and cholesterol were used as lipids, stearylamine and Poloxamer 188 were added as positive charge inducer and a surfactant, respectively. Read More

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Self-Organized Implanting of Micro/Nanofiltration Membranes in Advanced Flow μ-Reactors.

ACS Appl Mater Interfaces 2021 Apr 14. Epub 2021 Apr 14.

Centre for Nanotechnology, Indian Institute of Technology Guwahati, Assam 781039, India.

A low-cost, simple, and one-step synthesis of cellulose acetate nanoparticles (CANPs) has been invented using a continuous-flow advanced microfluidic reactor. For this purpose, the CANPs are self-organized inside a cross-junction microchannel by flowing cellulose acetate (CA) dissolved in ,-dimethylformamide (DMF) through the axial inlet and the antisolvent water through the pair of side inlets. The preferential solubility (insolubility) of DMF (CA) to antisolvent water stimulates the in situ synthesis of CANPs at the DMF/water miscible interface following a phase-inversion process. Read More

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The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial.

Phytother Res 2021 Apr 13. Epub 2021 Apr 13.

Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Metabolic syndrome (MetS) is one of the most important health hazards. Curcumin is extracted from Curcuma longa (turmeric), which can affect the components of MetS. To increase the oral bioavailability of curcumin, nano-micelle curcumin is used instead of curcumin powder. Read More

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