7,221 results match your criteria curative efficacy

Study towards improving artemisinin-based combination therapies.

Nat Prod Rep 2021 Jul;38(7):1243-1250

Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. and Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China and Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China and Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China and Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China and The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China.

Covering: Up to 2020 Artemisinin has made a significant contribution towards global malaria control since its initial discovery. Countless lives have been saved by this unique and miraculous molecule. In 2006, artemisinin-based combination therapies (ACTs) were recommended by the World Health Organization (WHO) as the first-line treatment for uncomplicated malaria infection and have since remained as the mainstays of the antimalarial treatment. Read More

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The Role of Electrochemotherapy in Curative Treatment of Head and Neck Cancer and Advanced Skin Cancer: A Need for New Treatment Protocols?

Anticancer Res 2021 Aug;41(8):3977-3982

Department of Oncology, Örebro University Hospital, Örebro, Sweden.

Background/aim: Electrochemotherapy (ECT) is a cancer treatment modality where the efficacy of a chemotherapeutic agent is enhanced by an electrical field. It is an established palliative treatment for cutaneous metastases but its role in curative treatment remains mostly undetermined. Studies have previously reported that ECT can be a safe curative treatment in both skin cancer and oral cavity cancer. Read More

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Quantitative Insight into Immunopathology of SARS-CoV-2 Infection.

J Interferon Cytokine Res 2021 07;41(7):244-257

National Centre for Cell Science, Pune, India.

Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV-2), which initiated as an endemic from China, converted into a pandemic disease worldwide within a couple of months' time. This has led researchers from all over the world to come together to find and develop possible curative or preventive strategies, including vaccine development, drug repurposing, plasma therapy, drug discovery, and cytokine-based therapies. Herein, we are providing, a summarized overview of immunopathology of the SARS-CoV-2 along with various therapeutic strategies undertaken to COVID-19 with a vision for their possible outcome. Read More

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Long-Term Outcomes of Laparoscopic Radical Gastrectomy for Highly Advanced Gastric Cancer: Final Report of a Prospective Phase II Trial (KUGC04).

Ann Surg Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: This is the final report evaluating the long-term outcomes of a single-arm phase II clinical trial that demonstrated the short-term efficacy of laparoscopic gastrectomy (LG) for highly advanced gastric cancer (AGC) [KUGC04].

Patients And Methods: Seventy-three patients with histologically confirmed gastric adenocarcinoma and diagnosed with clinical stage II or higher, who potentially underwent curative resection between August 2009 and November 2014, were prospectively enrolled. Long-term outcomes with 5-year progression-free survival (PFS) and 5-year overall survival (OS) were evaluated according to clinical or pathological stages. Read More

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Intraoral and extraoral approach for surgical treatment of Eagle's syndrome: a retrospective study.

Eur Arch Otorhinolaryngol 2021 Jul 19. Epub 2021 Jul 19.

Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, 5 Longbin Road, Development Zone, Dalian, Liaoning, China.

Background And Purpose: Eagle's syndrome is not uncommon in clinical work. Because of its atypical symptoms, it is easy to be misdiagnosed as other diseases, further leading to misdiagnosis and mistreatment. At present, there is no expert consensus or treatment guidelines for the disease. Read More

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Clinical study of apatinib plus temozolomide for the treatment of recurrent high-grade gliomas.

J Clin Neurosci 2021 Aug 5;90:82-88. Epub 2021 Jun 5.

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215007, Jiangsu, China. Electronic address:

Objectives: Recurrent high-grade glioma, a malignant tumor of the brain or spinal cord associated with poor prognosis with a median survival of <6 months. Recurrent high-grade glioma does not have standard treatment even if some strategies have some effect in recurrent gliomas. Apatinib, as a tyrosine kinase inhibitor shown to be effective in treating the lung and gastric cancer. Read More

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The clinical efficacy of computed tomography-guided I particle implantation combined with arterial infusion chemotherapy in the treatment of pancreatic cancer.

J Cancer Res Ther 2021 Jul;17(3):720-725

Department of Medical Oncology, Affiliated Zhongshan Hospital of Dalian University; The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian University, Dalian, P. R. China.

Aims: This study aimed to investigate the clinical value of I radioactive particle implantation combined with regional arterial chemotherapy perfusion in the treatment of pancreatic cancer.

Subjects And Methods: The clinical data of 23 patients with pancreatic cancer were retrospectively analyzed, and the patients were divided into two groups. In the observation group, 11 patients were injected with radioactive particles in combination with regional arterial chemotherapy. Read More

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Comparison of three-dimensional-printed template-guided and traditional implantation of I seeds for gynecological tumors: A dosimetric and efficacy study.

J Cancer Res Ther 2021 Jul;17(3):688-694

Department of Oncology, Hebei Medical University, No.361 East Zhongshan Road; Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, China.

Objective: The objective of the study was to compare the dose parameter and clinical efficacy of three-dimensional-printed template (3D-PT)-guided and traditional I seed implantation in treatment of gynecological tumors.

Materials And Methods: A total of 28 patients with gynecological tumors treated with radioactive seed implantation in Hebei General Hospital from January 2016 to December 2018 were retrospectively analyzed. Twelve patients (template group) were guided by 3D-PT and the remaining 16 patients (traditional group) were guided by computed tomography (CT) with traditional technique. Read More

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Proton re-irradiation of unresectable recurrent brain gliomas: clinical outcomes and toxicity.

J BUON 2021 May-Jun;26(3):970-976

Department of proton therapy, A. Tsyb Medical radiological research center - branch of the National medical research radiological center, Obninsk, Russia.

Purpose: To assess the efficacy and tolerance of proton re-irradiation in patients with unresectable recurrence of previously irradiated brain gliomas.

Methods: Between February 2016 and December 2019, 44 patients with in-field recurrence after prior irradiation of brain gliomas were irradiated with intensity-modulated proton therapy. Seven patients (15. Read More

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Efficacy of trastuzumab combined with SOX or IP chemotherapy regimen in the treatment of advanced gastric cancer.

J BUON 2021 May-Jun;26(3):932-939

Department of Gastroenterology, Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang 222000, China.

Purpose: The purpose of this study was to compare the clinical efficacy and safety of S-1 + oxaliplatin (SOX) chemotherapy regimen combined with trastuzumab and irinotecan + cisplatin (IP) chemotherapy regimen combined with trastuzumab in treating human epidermal growth factor receptor 2 (HER-2)-positive advanced gastric cancer.

Methods: A total of 138 patients with HER-2-positive advanced gastric cancer were divided into SOX group (SOX chemotherapy regimen combined with trastuzumab; n=69) and IP group (IP chemotherapy regimen combined with trastuzumab; n=69). Then, the clinical efficacy, incidence rate of adverse reactions, quality-of-life score and other indicators were compared between the two groups of patients. Read More

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Differences in the individual curative effect of acupuncture for obese women with polycystic ovary syndrome based on metagenomic analysis: study protocol for a randomized controlled trial.

Trials 2021 Jul 15;22(1):454. Epub 2021 Jul 15.

School of Acupuncture-Moxibustion and Tuina/The Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. Read More

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Renal cell carcinoma therapy: Current and new drug candidates.

Drug Discov Today 2021 Jul 12. Epub 2021 Jul 12.

Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal. Electronic address:

Renal cell carcinoma (RCC) is the most common and lethal tumor of the urological system. Curative treatment of localized RCC includes nephrectomy, radio-ablation, and active surveillance, whereas metastatic RCC (mRCC) requires a combination of surgery and systemic therapy. Response to conventional therapy is limited but, recently, many novel therapies for mRCC have emerged, including targeted therapies and new immunotherapeutic agents. Read More

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Medical management of endometriosis.

Minerva Obstet Gynecol 2021 Jul 15. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, University of Connecticut, Farmington, CT, USA.

Introduction: Endometriosis is a benign gynecologic disorder that is defined as functional endometrial tissue outside of the uterine cavity. It is an estrogen-dependent, inflammatory disease that leads to symptoms of pelvic pain, dysmenorrhea, dyspareunia, and infertility, occurring in 6-10% of reproductive aged women. The severity of the disease ranges from asymptomatic to debilitating symptoms that have a major impact on women's lives. Read More

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Control of stripe rust of wheat using indigenous endophytic bacteria at seedling and adult plant stage.

Sci Rep 2021 Jul 14;11(1):14473. Epub 2021 Jul 14.

Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.

Stripe rust (caused by Puccinia striiformis tritici) is one of the most devastating diseases of wheat. The most effective ways to control stripe rust are the use of resistant cultivars and the timely use of an appropriate dose of fungicide. However, the changing nature of rust pathogen outwits the use of resistant cultivars, and the use of a fungicide is associated with environmental problems. Read More

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[Moxibustion on plaque psoriasis of blood stasis: a randomized controlled trial].

Zhongguo Zhen Jiu 2021 Jul;41(7):762-6

Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing Institute of TCM, Capital Medical University, Beijing 100010, China.

Objective: To observe the short-term and long-term effects of moxibustion on plaque psoriasis of blood stasis, and to compare the curative effect between moxibustion and calcipotriol ointment.

Methods: A total of 80 patients with plaque psoriasis of blood stasis were randomly divided into an observation group (40 cases, 2 cases dropped off) and a control group (40 cases, 4 cases dropped off). Both groups were given routine medical vaseline topical emollient basic treatment. Read More

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Within-Host Phenotypic Evolution and the Population-Level Control of Chronic Viral Infections by Treatment and Prophylaxis.

Mathematics (Basel) 2020 Sep 4;8(9). Epub 2020 Sep 4.

Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Chronic viral infections can persist for decades spanning thousands of viral generations, leading to a highly diverse population of viruses with its own complex evolutionary history. We propose an expandable mathematical framework for understanding how the emergence of genetic and phenotypic diversity affects the population-level control of those infections by both non-curative treatment and chemo-prophylactic measures. Our frameworks allows both neutral and phenotypic evolution, and we consider the specific evolution of contagiousness, resistance to therapy, and efficacy of prophylaxis. Read More

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September 2020

miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer.

Cell Death Dis 2021 Jul 13;12(7):696. Epub 2021 Jul 13.

Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China, 510515.

Trastuzumab resistance negatively influences the clinical efficacy of the therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and the underlying mechanisms remain elusive. Exploring the mechanisms and finding effective approaches to address trastuzumab resistance are of great necessity. Here, we confirmed that endoplasmic reticulum (ER) stress-induced trastuzumab resistance by up-regulating miR-301a-3p in HER2-positive GC cells. Read More

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Inhibition of Hepatitis B Virus by AAV8-Derived CRISPR/SaCas9 Expressed From Liver-Specific Promoters.

Front Microbiol 2021 26;12:665184. Epub 2021 Jun 26.

State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China.

Curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal, and the persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is a key barrier that is hard to break through using the drugs currently approved for HBV treatment. Due to the accuracy, efficiency, and cost-effectiveness of genome editing, CRISPR/Cas technologies are being widely used for gene therapy and in antiviral strategies. Although CRISPR/Cas could possibly clear cccDNA, ensuring its safety is requirement for application. Read More

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[Efficacy and tolerance of salvage curative radiotherapy for patients with cervical relapse of differentiated thyroid carcinoma].

Cancer Radiother 2021 Jul 9. Epub 2021 Jul 9.

AP-HP, hôpital universitaire Pitié-Salpêtrière, service d'oncologie radiothérapie, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. Electronic address:

Purpose: Radiation therapy is often the last resource treatment for cervical relapse in iodine refractory differentiated thyroid cancer. We present locoregional control data in patients with cervical relapse treated with curative intent radiation therapy with or without concomitant carboplatin.

Material And Methods: This monocentric retrospective study gathered data on patients with differentiated thyroid carcinoma - vesicular or papillary - in relapse after thyroidectomy who received a curative intent cervical radiation therapy. Read More

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Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola.

Antimicrob Agents Chemother 2021 Jul 12:AAC0111721. Epub 2021 Jul 12.

Sporos Bioventures, Houston, TX, USA.

Remdesivir is a nucleoside monophosphoramidate prodrug that has been FDA-approved for COVID-19. However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences in either time to clinical improvement or mortality between remdesivir-treated and control groups. Similarly, the inability for remdesivir to provide a clinically significant benefit above other investigational agents in patients with Ebola contrasts with strong, curative preclinical data generated in rhesus macaque models. Read More

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mSEPT9 Can Monitor the Response and Predict the Prognosis of Stage IV colorectal cancer Patients with Liver Metastasis Undergoing Potentially Curative Surgery.

J Surg Res 2021 Jul 8;267:485-494. Epub 2021 Jul 8.

Department of Hepatopancreatobiliary Surgery, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, China. Electronic address:

Background: Stage IV colorectal cancer (CRC) patients with liver metastasis undergoing potentially curative surgery represent a subgroup of patients with a relatively good prognosis. In this study, we aimed to evaluate the performance of mSEPT9 to monitor response to treatment and predict prognosis.

Methods: In total, we recruited 51 stage IV CRC patients with liver metastasis, including 20 patients who underwent simultaneous surgery and 31 patients who underwent staged surgery. Read More

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Differential adherence to peer and nurse components of a supportive care package-The appeal of peer support may be related to women's health and psychological status.

Patient Educ Couns 2021 Jun 29. Epub 2021 Jun 29.

Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Swinburne University of Technology, Hawthorn, VIC 3122, Australia. Electronic address:

Objective: Knowledge of factors associated with intervention non-adherence may provide insights into the clinical utility of non-pharmacologic interventions.

Methods: This study compared complete and incomplete adherers to two separate components of a novel intervention package for women undergoing curative intent radiotherapy for gynaecological cancer on socio-demographic, clinical and pre-radiotherapy patient-reported outcomes data.

Results: Adherence to the tailored specialist nurse consultations was satisfactory (71% participated in all available sessions, 19% participated in all but one). Read More

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Next-Generation Allergen-Specific Immunotherapy for Japanese Cedar Pollinosis Using Molecular Approaches.

Fumio Takaiwa

Immunotargets Ther 2021 2;10:213-224. Epub 2021 Jul 2.

Soul Signal Institute, Kojyohama, Shiraoi, Hokkaido, 059-0641, Japan.

Japanese cedar (JC) pollinosis is the most major IgE-mediated type I allergic disease in Japan. Allergen-specific immunotherapy is the only curative treatment for allergic diseases. Subcutaneous immunotherapy and sublingual immunotherapy have been introduced in Japan for JC pollinosis, but do not avoid some adverse side effects, because the natural allergens used as tolerogens cross-link with specific IgE types on mast cells and basophils. Read More

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Laparoscopic lateral lymph node dissection in two fascial spaces for locally advanced lower rectal cancer.

World J Gastroenterol 2021 Jun;27(24):3654-3667

Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.

Background: The procedure for lateral lymph node (LLN) dissection (LLND) is complicated and can result in complications. We developed a technique for laparoscopic LLND based on two fascial spaces to simplify the procedure.

Aim: To clarify the anatomical basis of laparoscopic LLND in two fascial spaces and to evaluate its efficacy and safety in treating locally advanced low rectal cancer (LALRC). Read More

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Inhibitory Effect of PD-1/PD-L1 and Blockade Immunotherapy in Leukemia.

Comb Chem High Throughput Screen 2021 Jul 6. Epub 2021 Jul 6.

School of Computer Science, The University of Adelaide, Adelaide, South Australia. Australia.

Background: PD-1/PD-L1 checkpoint inhibitors have been approved for the treatment of a variety of solid tumors. And some clinical trials have also confirmed the excellent efficacy of PD-1/PD-L1 inhibitors on lymphoma. However, the efficacy of PD-1/PD-L1 inhibitors on leukemia remains unclear. Read More

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Systematic review and meta-analysis of the efficacy of N-acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Ann Palliat Med 2021 Jun;10(6):6564-6576

Department of Respiratory and Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

Background: Whether N-acetylcysteine (NAC) therapy can promote the improvement of clinical symptoms and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has not been verified by large-scale randomized controlled trials, only a few small sample studies.

Methods: English databases were searched using a combination of the following terms: "chronic obstructive pulmonary disease", "acute exacerbation of chronic obstructive pulmonary disease", and "N-acetylcysteine". Studies examining NAC in the treatment of AECOPD were screened, so as to be a reference for the experimental group. Read More

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Clinical efficacy and safety between high-intensity focused ultrasound and uterine artery embolization for cesarean scar pregnancy: a systematic review and a meta-analysis.

Ann Palliat Med 2021 Jun;10(6):6379-6387

Department of Ultrasonic Imaging Division, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, China.

Background: It was reported that high-intensity focused ultrasound (HIFU) of cesarean scar pregnancy (CSP) can locally inactivate pregnancy tissue. Uterine artery embolization (UAE) can achieve good results for CSP too. To investigate the clinical efficacy and safety of HIFU and UAE in the treatment of cesarean scar pregnancy (CSP), we conducted this research. Read More

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Clinicopathologic Characteristics and Clinical Outcome of Localized Liposarcoma: A Single Center Experience Over 25 Years and Evaluation of PD-L1 Expression.

Cancer Res Treat 2021 Jul 6. Epub 2021 Jul 6.

Department of Oncology, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea.

Purpose: For liposarcoma (LPS), clinical course and proper treatment strategies have not been well-established. Recently, immune-checkpoint inhibitors have shown potential efficacy in LPS. We aimed to describe the clinical course of LPS and evaluate the clinical impact of PD-L1. Read More

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Definitive Simultaneous Integrated Boost Versus Conventional-Fractionated Intensity Modulated Radiotherapy for Patients With Advanced Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis.

Front Oncol 2021 21;11:618776. Epub 2021 Jun 21.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The aim of this study was to compare the effects of simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) and conventional fractionated-IMRT (CF-IMRT) for patients with esophageal squamous cell carcinoma (ESCC).

Methods: The data of 1173 patients treated with either CF-IMRT or SIB-IMRT for a curative intent from 2005 to 2016 were retrospectively reviewed. Propensity score matching (PSM) was used to create a well-balanced cohort of 687 patients at 1:2 ratio (237 patients in SIB-IMRT group and 450 patients in CF-IMRT group). Read More

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Effect of Adjuvant Chemotherapy on Survival of Elderly Patients With Stage III Colorectal Cancer.

Anticancer Res 2021 Jul;41(7):3615-3624

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background/aim: The aim of this study was to investigate the efficacy and safety of adjuvant chemotherapy in elderly patients with stage III colorectal cancer in a real-world setting.

Patients And Methods: A total of 165 patients of ≥70 years of age with stage III colorectal cancer who underwent a curative operation between 2008 and 2020 were enrolled in this study.

Results: Among septuagenarians, the relapse-free and overall survival rates in the single-agent therapy group and the combination therapy group were significantly better than those in the group treated by surgery alone. Read More

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