913,059 results match your criteria cumulative incidence

Lifestyle Intervention for Overweight/Obese Pregnant Women with Polycystic Ovarian Syndrome: Lessons and Challenges.

Obes Facts 2021 Jul 26:1-10. Epub 2021 Jul 26.

Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Introduction And Objective: Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women of reproductive age, and overweight and obesity are highly prevalent in women with PCOS. This study aims to explore whether lifestyle intervention can improve gestational weight gain (GWG), glucolipid metabolism, and perinatal outcomes in overweight/obese pregnant women with PCOS.

Methods: This study is a randomized controlled trial that included overweight and obese pregnant women with PCOS who met the inclusion criteria of 8-12 gestational weeks. Read More

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Depth resolution of transmission ERDA for H in Al under nuclear-elastically enhanced recoiling of H by 8 MeV He.

J Phys Condens Matter 2021 Jul 26. Epub 2021 Jul 26.

University of Tsukuba, Tsukuba, Tsukuba, Ibaraki, 305-8577, JAPAN.

Using stacked samples of Al foil and H-containing resin lm, we have carried out elastic recoil detection analysis with transmission layout (T-ERDA) to investigate the depth resolution in the measurements of H distribution in Al. For narrow and wide acceptance conditions of the detector, the depth resolutions of 1.5{4. Read More

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Survival in Patients With Sentinel Node-Positive Melanoma With Extranodal Extension.

J Natl Compr Canc Netw 2021 Jul 26. Epub 2021 Jul 26.

1Melanoma and Sarcoma Surgical Unit.

Background: Prognostic parameters in sentinel node (SN)-positive melanoma are important indicators to identify patients at high risk of recurrence who should be candidates for adjuvant therapy. We aimed to evaluate the presence of melanoma cells beyond the SN capsule-extranodal extension (ENE)-as a prognostic factor in patients with positive SNs.

Methods: Data from 1,047 patients with melanoma and positive SNs treated from 2001 to 2020 at the Istituto Nazionale dei Tumori in Milano, Italy, were retrospectively investigated. Read More

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Incidence and determinants of catastrophic health expenditures and impoverishment in Pakistan.

Public Health 2021 Jul 23;197:42-47. Epub 2021 Jul 23.

Pakistan Institute of Development Economics, Pakistan. Electronic address:

Objectives: Out-of-pocket (OOP) payment is a major health financing mechanisms across developing nations such as Pakistan. Private health expenditures are estimated to be 64.4%, of which 89% are OOP made by the households (National Health Accounts, 2015-16). Read More

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Atmospheric dispersion and transmission of Legionella from wastewater treatment plants: A 6-year case-control study.

Int J Hyg Environ Health 2021 Jul 23;237:113811. Epub 2021 Jul 23.

National Institute for Public Health and the Environment (RIVM), the Netherlands; Institute for Risk Assessment Sciences, Utrecht University, the Netherlands.

Legionnaires Disease incidence has risen in the Netherlands in recent years. For the majority of the cases, the source of infection is never identified. Two Dutch wastewater treatment plants (WWTPs) have previously been identified as source of outbreaks of Legionnaires Disease (LD) among local residents. Read More

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Predicting PTSS in general population during COVID-19 pandemic: The mediating role of health anxiety.

J Affect Disord 2021 Jul 21;294:329-336. Epub 2021 Jul 21.

Center for Applied Psychology, Department of Health Psychology, Miguel Hernández University, Avenida Universidad s/n, Elche 03202, Spain.

Background: Despite health anxiety (HA) is associated with higher incidence of anxiety disorders, no studies have examined the association between this variable and the increased levels of Post-Traumatic Stress Symptoms (PTSS) reported during COVID pandemic.

Methods: This study was conducted online between April and May 2020. Data were collected from 468 men and women from the Spanish general population. Read More

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Sevoflurane versus desflurane for early postoperative vomiting after general anesthesia in hospitalized adults: A systematic review and meta-analysis of randomized controlled trials.

J Clin Anesth 2021 Jul 23;75:110464. Epub 2021 Jul 23.

Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan. Electronic address:

Study Objective: This systematic review and meta-analysis aimed at assessing the effects of two commonly used anesthetics in general anesthesia (GA), sevoflurane and desflurane, on early postoperative vomiting (POV) in hospitalized adults.

Design: Systematic review and meta-analysis of randomized controlled trials (RCTs).

Setting: Early postoperative vomiting after GA. Read More

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Artifacts in contrast-enhanced mammography: are there differences between vendors?

Clin Imaging 2021 Jul 8;80:123-130. Epub 2021 Jul 8.

University of Western Australia Medical School, Perth, Western Australia 6009, Australia; Department of Radiology, Royal Perth Hospital, Perth, Western Australia 6000, Australia. Electronic address:

Purpose: Contrast-Enhanced Mammography (CEM) produces a dual-energy subtracted (DES) image that demonstrates iodine uptake (neovascularity) in breast tissue. We aim to review a range of artifacts on DES images produced using equipment from two different vendors and compare their incidence and subjective severity.

Methods: We retrospectively reviewed CEM studies performed between September 2013 and March 2017 using GE Senographe Essential (n = 100) and Hologic Selenia Dimensions (n = 100) equipment. Read More

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Persistence rate of DSM-5 somatic symptom disorder: 4-year follow-up in patients from a psychosomatic outpatient clinic.

Compr Psychiatry 2021 Jul 19;110:152265. Epub 2021 Jul 19.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg - Eppendorf, Hamburg, Germany.

Background: Somatic Symptom and Related Disorders (SSD) were introduced by DSM-5 in order to improve the classification of somatoform disorders. There is a lack of longitudinal studies on course and predictors of SSD. The present study investigates the natural course of SSD in a four-year follow-up study in patients from a psychosomatic outpatient clinic. Read More

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Risk factor analysis and outcomes of airway management in antenatally diagnosed cervical masses.

Int J Pediatr Otorhinolaryngol 2021 Jul 21;149:110851. Epub 2021 Jul 21.

Division of Otolaryngology, Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. Electronic address:

Purpose: To investigate antenatally-determined imaging characteristics associated with invasive airway management at birth in patients with cervical masses, as well as to describe postnatal management and outcomes.

Study Design: A retrospective analysis of 52 patients with antenatally diagnosed neck masses was performed using single-center data from January 2008 to January 2019. Antenatal imaging, method of delivery, management, and outcomes data were abstracted from the medical record and analyzed. Read More

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Sexual dysfunction in patients with myasthenia gravis.

J Neuroimmunol 2021 Jul 20;358:577669. Epub 2021 Jul 20.

Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang #37, Chengdu 610041, China. Electronic address:

Background: Myasthenia gravis (MG) is an autoimmune disease that causes fatigueable muscle weakness. Sexual dysfunction (SD) is a common condition, but the association between SD and MG remains poorly understood.

Methods: An observational study was conducted to explore SD incidence and risk factors in MG patients. Read More

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Photochemical reaction to increase melanogenesis using Buddleja officinalis and blue light-emitting diode irradiation in B16F10.

Photodiagnosis Photodyn Ther 2021 Jul 23:102456. Epub 2021 Jul 23.

Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea. Electronic address:

Recently, the incidence of vitiligo has increased because of stresses induced by external environment. Ultraviolet (UV) light therapy is the most commonly used method of treating the disease; however, UV light therapy requires a long treatment period, and prolonged exposure to UV radiation has side effects. The purpose of the present study was to investigate the effects of natural products and LED irradiation (LED-IR) on the synthesis of melanin. Read More

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Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells.

Biochim Biophys Acta Mol Basis Dis 2021 Jul 23:166218. Epub 2021 Jul 23.

Placenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.. Electronic address:

Throughout history, pandemics of infectious diseases caused by emerging viruses have spread worldwide. Evidence from previous outbreaks demonstrated that pregnant women are at high risk of contracting the diseases and suffering from adverse outcomes. However, while some viruses can cause major health complications for the mother and her fetus, others do not appear to affect pregnancy. Read More

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Association of urinary calcium and phosphorus excretion with renal disease progression in type 2 diabetes.

Diabetes Res Clin Pract 2021 Jul 23:108981. Epub 2021 Jul 23.

Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. Electronic address:

Objectives: Diabetes is associated with a high incidence of microvascular disease, including nephropathy. The current study aimed to investigate the association of urinary calcium and phosphorus excretion with chronic kidney disease (CKD) progression in type 2 diabetes mellitus.

Methods: A total of 159 T2DM patients with chronic kidney disease (CKD stage G1-G4) were retrospectively included. Read More

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Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment elevation myocardial infarction.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: To compare effectiveness and safety of clopidogrel, prasugrel, and ticagrelor among all-comers with ST-segment Elevation Myocardial Infarction (STEMI) and extend the knowledge from randomized clinical trials.

Methods: All consecutive patients with STEMI admitted to Copenhagen University Hospital, Rigshospitalet, from 2009 to 2016 were identified via the Eastern Danish Heart Registry. By individual linkage to Danish nationwide registries, claimed drugs and end points were obtained. Read More

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The impact of radiotherapy protocol adherence on the outcome of patients with locally advanced NSCLC treated with concurrent chemoradiation: results from the radiotherapy quality assurance of the multicentre international randomized PET-Plan trial.

Radiother Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Radiation Oncology, Medical Center, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Nuclear Medicine, Medical Center, University of Freiburg, Freiburg, Germany.

Introduction: The success of intensification and personalisation of the curative treatment of non-small cell lung cancer (NSCLC) is strongly associated with the precision in radiotherapy. Here, we evaluate the impact of radiotherapy protocol adherence in a prospective multicentre trial.

Methods: In the open-label, randomised, controlled PET-Plan trial, patients with inoperable NSCLC were randomized at a 1:1 ratio regarding the target volume delineation informed by F-FDG PET and CT plus elective nodal irradiation (arm A) or target volumes informed by PET alone (arm B) and received iso-toxically dose-escalated concurrent chemoradiation. Read More

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Reduction of GTV to high-risk CTV radiation margin in head and neck squamous cell carcinoma significantly reduced acute and late radiation-related toxicity with comparable outcomes.

Radiother Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background And Purpose: We aim to retrospectively investigate whether reducing GTV to high-risk CTV margin will significantly reduce acute and late toxicity without jeopardizing outcome in head-and-neck squamous cell carcinoma (HNSCC) treated with definitive (chemo)radiation.

Materials And Methods: Between April 2015 and April 2019, 155 consecutive patients were treated with GTV to high-risk CTV margin of 10mm and subsequently another 155 patients with 6mm margin. The CTV-PTV margin was 3mm for both groups. Read More

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Mathematically modeling the effect of touch frequency on the environmental transmission of Clostridioides difficile in healthcare settings.

Math Biosci 2021 Jul 23:108666. Epub 2021 Jul 23.

Departments of Mathematics and Electrical Engineering and Computer Science, University of Tennessee, Knoxville 1403 Circle Drive, Knoxville, TN 37916, United States of America.

Clostridioides difficile, formerly Clostridium difficile, is the leading cause of infectious diarrhea and one of the most common healthcare acquired infections in United States hospitals. C. difficile persists well in healthcare environments because it forms spores that can survive for long periods of time and can be transmitted to susceptible patients through contact with contaminated hands and fomites, objects or surfaces that can harbor infectious agents. Read More

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Real World Data of Penile Cancer Treatment at a High-Volume Center in South America: Insights and Survival Trends.

Urology 2021 Jul 23. Epub 2021 Jul 23.

Department of Urologic Oncology, Instituto Nacional de Cancerología. Bogotá, Colombia. Carrera 1 # 9-85.

Objective: To report survival trends and oncological outcomes of penile cancer surgically treated patients, at a high-volume center, treating more than 25 patients each year, in a high incidence country.

Methods: Clinical charts of all patients that underwent surgical management for PC were reviewed. The primary end points were cancer specific survival (CSS), progression-free survival (PFS), and local recurrence free survival (L-RFS). Read More

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Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation.

Eur J Pharmacol 2021 Jul 23:174381. Epub 2021 Jul 23.

The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China. Electronic address:

Epidemiological data suggest that the incidence of rheumatoid arthritis (RA) increases in postmenopausal women, which may be related to estrogen deficiency. Tissue acidosis is a common symptom of RA. Acid-sensitive ion channel 1a (ASIC1a), a member of the extracellular H-activated cation channel family, could be activated by changes in extracellular pH and plays a crucial role in the pathogenesis of RA. Read More

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Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibody detection in lung transplant recipients: A single-center experience.

Immun Inflamm Dis 2021 Jul 26. Epub 2021 Jul 26.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.

Purpose: Induction immunosuppression has improved the long-term outcomes after lung transplant. This is the first report exploring the association of induction immunosuppression with the development of de novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) in lung transplant recipients (LTR).

Methods: Sixty-seven consecutive primary LTR were followed for 3 years posttransplant. Read More

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The effect of simulation-based education before a cadaver dissection course.

Anat Sci Educ 2021 Jul 26. Epub 2021 Jul 26.

Department of Anatomy, Aichi Medical University School of Medicine, Aichi, Japan.

Although the methods for medical education continue to evolve due to the development of medicines, the cadaver dissection course still plays a fundamental role. The cadaver dissection course allows students to learn to handle instruments correctly while actively exploring three-dimensional anatomy. However, dissection comes with the risk of accidental injury. Read More

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HPV infection and vaccination in Sub-Saharan Africa: 10 years of research in Tanzanian female adolescents.

Trop Med Int Health 2021 Jul 26. Epub 2021 Jul 26.

Mwanza Intervention Trials Unit, National Institute of Medical Research, Mwanza, Tanzania.

Cervical cancer is the leading cause of cancer-related morbidity and mortality in many Sub-Saharan African (SSA) countries, including Tanzania. Most cervical cancer cases worldwide are attributable to infection of the cervix with Human Papillomavirus (HPV), a vaccine-preventable sexually transmitted infection (STI). Over the past 10 years, we have conducted a programme of HPV research in pre-adolescents and adolescents in Mwanza, the second-largest city in Tanzania, which is situated in a malaria-endemic region. Read More

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Merkel cell carcinoma is still an unexpected diagnosis.

J Eur Acad Dermatol Venereol 2021 Jul 26. Epub 2021 Jul 26.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

To the editor: Merkel cell carcinoma (MCC) is a rare, but highly aggressive cutaneous neuroendocrine skin cancer that generally occurs in elderly Caucasian people, on sun-exposed areas (1). In Sweden, the incidence of MCC, adjusted to the European standard population, increased from 0.11 to 0. Read More

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Characterization of anaphylaxis reveals different metabolic changes depending on severity and triggers.

Clin Exp Allergy 2021 Jul 26. Epub 2021 Jul 26.

Allergy Department of Hospital, Universitari i Politècnic La Fe, Valencia, Spain.

Background: Despite the increasing incidence of anaphylaxis, its underlying molecular mechanisms and biomarkers for appropriate diagnosis remain undetermined. The rapid onset and potentially fatal outcome in the absence of managed treatment prevent its study. Up today there are still no known biomarkers that allow an unequivocal diagnosis. Read More

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The efficacy of probiotics in Experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta-analysis'.

Lett Appl Microbiol 2021 Jul 26. Epub 2021 Jul 26.

Social Determinants of Health Research Centre, Department of Epidemiology and Biostatistics, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran.

Probiotics immunomodulatory properties and their beneficial effects for diseases such as Multiple Sclerosis (MS) are reported by several studies. The current systematic review and meta-analysis aimed to investigate the favourable effects of probiotics in improving experimental autoimmune/allergic encephalomyelitis (EAE) as an animal model of MS. We systematically searched Scopus, Web of Sciences (ISI), and PubMed databases to identify relevant studies from the inception of these databases to December 2019. Read More

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Multifocality is not associated with worse survival in sporadic pancreatic neuroendocrine tumors.

J Surg Oncol 2021 Jul 26. Epub 2021 Jul 26.

Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background And Objectives: Pancreatic neuroendocrine tumors (pNETs) in patients with hereditary cancer syndromes are typically multifocal. In contrast, sporadic pNETs are usually unifocal and the incidence of multifocal sporadic pNETs is unknown. The primary aim of this study was to investigate the incidence of multifocality in sporadic pNETs and any associated effect on recurrence risk and survival. Read More

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Avelumab expanded access program in metastatic Merkel cell carcinoma: efficacy and safety findings from patients in Europe and the Middle East.

Int J Cancer 2021 Jul 26. Epub 2021 Jul 26.

University of Manchester and the Christie NHS Foundation Trust, Manchester, UK.

Incidence rates of Merkel cell carcinoma (MCC), an uncommon skin cancer with an aggressive disease course, have increased in recent decades. Limited treatment options are available for patients with metastatic MCC (mMCC). Avelumab, an anti-programmed cell death-ligand 1 monoclonal antibody, became the first approved treatment for mMCC following the results of the phase 2 JAVELIN Merkel 200 study. Read More

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The relationship between workplace deviant behaviors and organizational justice among nurses: A cross-sectional survey.

Nurs Forum 2021 Jul 26. Epub 2021 Jul 26.

Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Aim: This study aimed to determine the correlations between workplace deviant behaviors (WDBs) and the levels of the perceived organizational justice among Iranian nurses.

Design: This was a cross-sectional quantitative research.

Methods: The present research was conducted on 424 nurses selected by a convenience sampling method in 2019 (May-August) in Tabriz, Iran. Read More

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Osteonecrosis of the jaw among patients with cancer treated with denosumab or zoledronic acid: Results of a regulator-mandated cohort postauthorization safety study in Denmark, Norway, and Sweden.

Cancer 2021 Jul 26. Epub 2021 Jul 26.

Department of Clinical Epidemiology, Aarhus University Hospital, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Osteonecrosis of the jaw (ONJ) is an adverse effect of antiresorptive treatment. This study estimated incidence proportions and incidence rates of ONJ in cancer patients with bone metastases from solid tumors treated for the prevention of skeletal-related events in routine clinical practice.

Methods: This cohort study in Denmark, Norway, and Sweden in 2011-2018 included 3 treatment cohorts: a denosumab inception cohort (DEIC), a zoledronic acid inception cohort (ZAIC), and a denosumab-switch cohort (DESC). Read More

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