733 results match your criteria cuff electrodes

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection.

Sensors (Basel) 2021 Aug 19;21(16). Epub 2021 Aug 19.

Univ Rennes, Inserm, LTSI-UMR 1099, F-35000 Rennes, France.

Effective closed-loop neuromodulation relies on the acquisition of appropriate physiological control variables and the delivery of an appropriate stimulation signal. In particular, electroneurogram (ENG) data acquired from a set of electrodes applied at the surface of the nerve may be used as a potential control variable in this field. Improved electrode technologies and data processing methods are clearly needed in this context. Read More

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Selective neural stimulation methods improve cycling exercise performance after spinal cord injury: a case series.

J Neuroeng Rehabil 2021 07 23;18(1):117. Epub 2021 Jul 23.

Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA.

Background: Exercise after paralysis can help prevent secondary health complications, but achieving adequate exercise volumes and intensities is difficult with loss of motor control. Existing electrical stimulation-driven cycling systems involve the paralyzed musculature but result in rapid force decline and muscle fatigue, limiting their effectiveness. This study explores the effects of selective stimulation patterns delivered through multi-contact nerve cuff electrodes on functional exercise output, with the goal of increasing work performed and power maintained within each bout of exercise. Read More

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A Reversible Low Frequency Alternating Current Nerve Conduction Block Applied to Mammalian Autonomic Nerves.

Sensors (Basel) 2021 Jul 1;21(13). Epub 2021 Jul 1.

Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Electrical stimulation can be used to modulate activity within the nervous system in one of two modes: (1) Activation, where activity is added to the neural signalling pathways, or (2) Block, where activity in the nerve is reduced or eliminated. In principle, electrical nerve conduction block has many attractive properties compared to pharmaceutical or surgical interventions. These include reversibility, localization, and tunability for nerve caliber and type. Read More

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In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block.

Bioelectron Med 2021 Jun 30;7(1). Epub 2021 Jun 30.

Department of Biomedical Engineering, Indiana University - Purdue University Indianapolis, Indianapolis, USA.

Background: This paper describes a method to reversibly block nerve conduction through direct application of a 1 Hz sinusoidal current waveform delivered through a bipolar nerve cuff electrode. This low frequency alternating current (LFAC) waveform was previously shown to reversibly block the effects of vagal pulse stimulation evoked bradycardia in-vivo in the anaesthetised rat model (Mintch et al. 2019). Read More

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Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes.

Sci Rep 2021 Jun 21;11(1):12925. Epub 2021 Jun 21.

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.

Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function and treating disease. However, the vagus nerve also innervates many other organs throughout the body, and off-target effects of VNS could cause major side effects such as changes in blood pressure. Read More

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Restoring Tactile Sensation Using a Triboelectric Nanogenerator.

ACS Nano 2021 Jun 17. Epub 2021 Jun 17.

Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.

Loss of tactile sensation is a common occurrence in patients with traumatic peripheral nerve injury or soft tissue loss, but as yet, solutions for restoring such sensation are limited. Implanted neuro-prosthetics are a promising direction for tactile sensory restoration, but available technologies have substantial shortcomings, including complexity of use and of production and the need for an external power supply. In this work, we propose, fabricate, and demonstrate the use of a triboelectric nanogenerator (TENG) as a relatively simple, self-powered, biocompatible, sensitive, and flexible device for restoring tactile sensation. Read More

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Selective Facial Muscle Activation with Acute and Chronic Multichannel Cuff Electrode Implantation in a Feline Model.

Ann Otol Rhinol Laryngol 2021 Jun 6:34894211023218. Epub 2021 Jun 6.

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.

Objectives: Facial paralysis is a debilitating condition with substantial functional and psychological consequences. This feline-model study evaluates whether facial muscles can be selectively activated in acute and chronic implantation of 16-channel multichannel cuff electrodes (MCE).

Methods: Two cats underwent acute terminal MCE implantation experiments, 2 underwent chronic MCE implantation in uninjured facial nerves (FN) and tested for 6 months, and 2 underwent chronic MCE implantation experiments after FN transection injury and tested for 3 months. Read More

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Short-Term Effects of Vagus Nerve Stimulation on Learning and Evoked Activity in Auditory Cortex.

eNeuro 2021 May-Jun;8(3). Epub 2021 Jun 28.

Oregon Research Hearing Center, Oregon Health and Science University, Portland, Oregon

Chronic vagus nerve stimulation (VNS) has been shown to facilitate learning, but effects of acute VNS on neural coding and behavior remain less well understood. Ferrets implanted with cuff electrodes on the vagus nerve were trained by classical conditioning on an auditory tone frequency-reward association. One tone was associated with reward while another tone was not. Read More

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PEDOT:PSS-Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals.

Adv Healthc Mater 2021 06 10;10(11):e2100061. Epub 2021 May 10.

Institute of Biological Information Processing, Bioelectronics IBI-3, Forschungszentrum Jülich, Jülich, 52425, Germany.

To understand the physiology and pathology of electrogenic cells and the corresponding tissue in their full complexity, the quantitative investigation of the transmission of ions as well as the release of chemical signals is important. Organic (semi-) conducting materials and in particular organic electrochemical transistor are gaining in importance for the investigation of electrophysiological and recently biochemical signals due to their synthetic nature and thus chemical diversity and modifiability, their biocompatible and compliant properties, as well as their mixed electronic and ionic conductivity featuring ion-to-electron conversion. Here, the aim is to summarize recent progress on the development of bioelectronic devices utilizing polymer polyethylenedioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) to interface electronics and biological matter including microelectrode arrays, neural cuff electrodes, organic electrochemical transistors, PEDOT:PSS-based biosensors, and organic electronic ion pumps. Read More

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Stretchable gold nanowire-based cuff electrodes for low-voltage peripheral nerve stimulation.

J Neural Eng 2021 05 25;18(4). Epub 2021 May 25.

Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74 Norrköping, Sweden.

. Electrical stimulation of the peripheral nervous system (PNS) can treat various diseases and disorders, including the healing process after nerve injury. A major challenge when designing electrodes for PNS stimulation is the mechanical mismatch between the nerve and the device, which can lead to non-conformal contact, tissue damage and inefficient stimulation due to current leakage. Read More

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Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.

Front Bioeng Biotechnol 2021 15;9:622524. Epub 2021 Apr 15.

Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, United Kingdom.

The implantation of any foreign material into the body leads to the development of an inflammatory and fibrotic process-the foreign body reaction (FBR). Upon implantation into a tissue, cells of the immune system become attracted to the foreign material and attempt to degrade it. If this degradation fails, fibroblasts envelop the material and form a physical barrier to isolate it from the rest of the body. Read More

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Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation.

Adv Sci (Weinh) 2021 04 5;8(8):2004033. Epub 2021 Feb 5.

Department of Bioengineering Imperial College South Kensington London SW7 2AZ UK.

There is a critical need to transition research level flexible polymer bioelectronics toward the clinic by demonstrating both reliability in fabrication and stable device performance. Conductive elastomers (CEs) are composites of conductive polymers in elastomeric matrices that provide both flexibility and enhanced electrochemical properties compared to conventional metallic electrodes. This work focuses on the development of nerve cuff devices and the assessment of the device functionality at each development stage, from CE material to fully polymeric electrode arrays. Read More

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Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Pain: A Randomized, Sham-controlled Pilot Study.

Anesthesiology 2021 07;135(1):95-110

Background: Percutaneous peripheral nerve stimulation is an analgesic technique involving the percutaneous implantation of a lead followed by the delivery of electric current using an external pulse generator. Percutaneous peripheral nerve stimulation has been used extensively for chronic pain, but only uncontrolled series have been published for acute postoperative pain. The current multicenter study was undertaken to (1) determine the feasibility and optimize the protocol for a subsequent clinical trial and (2) estimate the treatment effect of percutaneous peripheral nerve stimulation on postoperative pain and opioid consumption. Read More

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Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones.

Front Neurosci 2021 15;15:613844. Epub 2021 Mar 15.

Division of Plastic Surgery, Department of Surgery, University of Wisconsin - Madison, Madison, WI, United States.

Sieve electrodes stand poised to deliver the selectivity required for driving advanced prosthetics but are considered inherently invasive and lack the stability required for a chronic solution. This proof of concept experiment investigates the potential for the housing and engagement of a sieve electrode within the medullary canal as part of an osseointegrated neural interface (ONI) for greater selectivity toward improving prosthetic control. are that (A) the addition of a sieve interface to a cuff electrode housed within the medullary canal of the femur as part of an ONI would be capable of measuring efferent and afferent compound nerve action potentials (CNAPs) through a greater number of channels; (B) that signaling improves over time; and (C) that stimulation at this interface generates measurable cortical somatosensory evoked potentials through a greater number of channels. Read More

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Hydrogel-based electrodes for selective cervical vagus nerve stimulation.

J Neural Eng 2021 04 20;18(5). Epub 2021 Apr 20.

Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, United States of America.

Electrical vagus nerve stimulation (VNS) has the potential to treat a wide variety of diseases by modulating afferent and efferent communication to the heart, lungs, esophagus, stomach, and intestines. Although distal vagal nerve branches, close to end organs, could provide a selective therapeutic approach, these locations are often surgically inaccessible. In contrast, the cervical vagus nerve has been targeted for decades using surgically implantable helix electrodes to treat epileptic seizures and depression; however, to date, clinical implementation of VNS has relied on an electrode with contacts that fully wrap around the nerve, producing non-selective activation of the entire nerve. Read More

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Superficial peroneal neuromodulation of persistent bladder underactivity induced by prolonged pudendal afferent nerve stimulation in cats.

Am J Physiol Regul Integr Comp Physiol 2021 05 10;320(5):R675-R682. Epub 2021 Mar 10.

Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.

The purpose of this study is to determine whether superficial peroneal nerve stimulation (SPNS) can reverse persistent bladder underactivity induced by prolonged pudendal nerve stimulation (PNS). In 16 α-chloralose-anesthetized cats, PNS and SPNS were applied by nerve cuff electrodes. Skin surface electrodes were also used for SPNS. Read More

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Lower-Limb Amputees Adjust Quiet Stance in Response to Manipulations of Plantar Sensation.

Front Neurosci 2021 18;15:611926. Epub 2021 Feb 18.

Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States.

Interfering with or temporarily eliminating foot-sole tactile sensations causes postural adjustments. Furthermore, individuals with impaired or missing foot-sole sensation, such as lower-limb amputees, exhibit greater postural instability than those with intact sensation. Our group has developed a method of providing tactile feedback sensations projected to the missing foot of lower-limb amputees via electrical peripheral nerve stimulation (PNS) using implanted nerve cuff electrodes. Read More

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February 2021

Rapid and Low Cost Manufacturing of Cuff Electrodes.

Front Neurosci 2021 16;15:628778. Epub 2021 Feb 16.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.

For many peripheral neuro-modulation applications, the cuff electrode has become a preferred technology for delivering electrical current into targeted volumes of tissue. While basic cuffs with low spatial selectivity, having longitudinally arranged contacts, can be produced from relatively straightforward processes, the fabrication of more complex electrode configurations typically requires iterative design and clean-room fabrication with skilled technicians. Although facile methods for fabricating cuff electrodes exist, their inconsistent products have limited their adoption for rapid manufacturing. Read More

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February 2021

Model-based analysis of implanted hypoglossal nerve stimulation for the treatment of obstructive sleep apnea.

Sleep 2021 04;44(44 Suppl 1):S11-S19

Inspire Medical Systems, Inc., Minneapolis, MN.

Study Objectives: Individuals with obstructive sleep apnea (OSA), characterized by frequent sleep disruptions from tongue muscle relaxation and airway blockage, are known to benefit from on-demand electrical stimulation of the hypoglossal nerve. Hypoglossal nerve stimulation (HNS) therapy, which activates the protrusor muscles of the tongue during inspiration, has been established in multiple clinical studies as safe and effective, but the mechanistic understanding for why some stimulation parameters work better than others has not been thoroughly investigated.

Methods: In this study, we developed a detailed biophysical model that can predict the spatial recruitment of hypoglossal nerve fascicles and axons within these fascicles during stimulation through nerve cuff electrodes. Read More

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All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes.

Front Bioeng Biotechnol 2021 10;9:615218. Epub 2021 Feb 10.

Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, and CIBERNED, Bellaterra, Spain.

Neural regeneration after lesions is still limited by several factors and new technologies are developed to address this issue. Here, we present and test in animal models a new regenerative nerve cuff electrode (RnCE). It is based on a novel low-cost fabrication strategy, called "Print and Shrink", which combines the inkjet printing of a conducting polymer with a heat-shrinkable polymer substrate for the development of a bioelectronic interface. Read More

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February 2021

Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats.

Int Neurourol J 2021 Jun 4;25(2):128-136. Epub 2021 Feb 4.

Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China.

Purpose: The present study determined the effects of saphenous nerve stimulation (SNS) at different stimulation frequencies on bladder reflex and explored a possible action mechanism of tibial nerve stimulation (TNS) on bladder activity in cats.

Methods: Two bipolar nerve cuff electrodes were implanted on the saphenous nerve and the contralateral tibial nerve in 13 cats, respectively. Multiple cystometrograms were obtained to determine the effects of single SNS at different frequencies and that of combined SNS and TNS on the micturition reflex by infusing normal saline. Read More

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Epidural and transcutaneous spinal cord stimulation facilitates descending inputs to upper-limb motoneurons in monkeys.

J Neural Eng 2021 Feb 4. Epub 2021 Feb 4.

Biosciences Institute, Newcastle University Faculty of Medical Sciences, Framlington Place, Newcastle upon Tyne, Tyne and wear, NE2 4HH, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: There is renewed interest in epidural and transcutaneous spinal cord stimulation (SCS) as a therapy following spinal cord injury, both to reanimate paralysed muscles as well as to potentiate weakened volitional control of movements. However, most work to date has focussed on lumbar SCS for restoration of locomotor function. Therefore, we examined upper-limb muscle responses and modulation of supraspinal-evoked movements by different frequencies of cervical SCS delivered to various epidural and transcutaneous sites in anaesthetized, neurologically intact monkeys. Read More

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February 2021

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation.

J Neurosci Methods 2021 03 28;352:109079. Epub 2021 Jan 28.

Medical Physics and Biomedical Engineering, University College London, UK.

Background: Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripheral nerves. Preliminary studies have shown this is possible using a cylindrical multielectrode human-sized nerve cuff in vagus nerve selective neuromodulation. Read More

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Compensation Strategies for Bioelectric Signal Changes in Chronic Selective Nerve Cuff Recordings: A Simulation Study.

Sensors (Basel) 2021 Jan 12;21(2). Epub 2021 Jan 12.

Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G4, Canada.

Peripheral nerve interfaces (PNIs) allow us to extract motor, sensory, and autonomic information from the nervous system and use it as control signals in neuroprosthetic and neuromodulation applications. Recent efforts have aimed to improve the recording selectivity of PNIs, including by using spatiotemporal patterns from multi-contact nerve cuff electrodes as input to a convolutional neural network (CNN). Before such a methodology can be translated to humans, its performance in chronic implantation scenarios must be evaluated. Read More

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January 2021

Electromyographic and kinematic study of reverse total shoulder arthroplasty: an observational prospective cohort study.

J Shoulder Elbow Surg 2021 Jan 9;30(1):165-171. Epub 2020 Jun 9.

Faculty of Medicine, Université Laval, Québec, QC, Canada; Department of Orthopaedic Surgery, CHU de Québec, Hôpital de l'Enfant-Jésus, Québec, QC, Canada; Centre de recherche du CHU de Québec, Québec, QC, Canada. Electronic address:

Background: Reverse total shoulder arthroplasty (RTSA) procedures have significantly increased in the last decade as an alternative to the current treatments for cuff-tear arthropathy. Since Grammont's theory in 1987, few data about the in vivo kinetics of the shoulder-girdle musculature in patients with RTSA have been available. The goals of this study are to (1) describe the contribution of principal muscles around the shoulder by electromyography and (2) access the range of motion of 5 movements of patients with RTSA compared with normal shoulders. Read More

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January 2021

Quantified Morphology of the Cervical and Subdiaphragmatic Vagus Nerves of Human, Pig, and Rat.

Front Neurosci 2020 4;14:601479. Epub 2020 Nov 4.

Department of Biomedical Engineering, Duke University, Durham, NC, United States.

It is necessary to understand the morphology of the vagus nerve (VN) to design and deliver effective and selective vagus nerve stimulation (VNS) because nerve morphology influences fiber responses to electrical stimulation. Specifically, nerve diameter (and thus, electrode-fiber distance), fascicle diameter, fascicular organization, and perineurium thickness all significantly affect the responses of nerve fibers to electrical signals delivered through a cuff electrode. We quantified the morphology of cervical and subdiaphragmatic VNs in humans, pigs, and rats: effective nerve diameter, number of fascicles, effective fascicle diameters, proportions of endoneurial, perineurial, and epineurial tissues, and perineurium thickness. Read More

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November 2020

Sex Differences in Vagus Nerve Stimulation Effects on Rat Cardiovascular and Immune Systems.

Front Neurosci 2020 6;14:560668. Epub 2020 Nov 6.

U.S. Food and Drug Administration, Center for Devices and Radiological Health (CDRH), Office of Science and Engineering Laboratory (OSEL), Division of Biomedical Physics (DBP), Silver Spring, MD, United States.

Background: Investigations into the benefits of vagus nerve stimulation (VNS) through pre-clinical and clinical research have led to promising findings for treating several disorders. Despite proven effectiveness of VNS on conditions such as epilepsy and depression, understanding of off-target effects and contributing factors such as sex differences can be beneficial to optimize therapy design.

New Methods: In this article, we assessed longitudinal effects of VNS on cardiovascular and immune systems, and studied potential sex differences using a rat model of long-term VNS. Read More

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November 2020

Modulation of SI and ACC response to noxious and non-noxious electrical stimuli after the spared nerve injury model of neuropathic pain.

Eur J Pain 2021 03 5;25(3):612-623. Epub 2020 Dec 5.

Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Background: The current knowledge on the role of SI and ACC in acute pain processing and how these contribute to the development of chronic pain is limited. Our objective was to investigate differences in and modulation of intracortical responses from SI and ACC in response to different intensities of peripheral presumed noxious and non-noxious stimuli in the acute time frame of a peripheral nerve injury in rats.

Methods: We applied non-noxious and noxious electrical stimulation pulses through a cuff electrode placed around the sciatic nerve and measured the cortical responses (six electrodes in each cortical area) before and after the spared nerve injury model. Read More

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Partial high frequency nerve block decreases neuropathic signaling following chronic sciatic nerve constriction injury.

J Neural Eng 2020 Oct 7. Epub 2020 Oct 7.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611-7011, UNITED STATES.

Objective: High frequency (HF) block can quickly and reversibly stop nerve conduction. We hypothesized HF block at the sciatic nerve would minimize nociception by preventing neuropathic signals from reaching the central nervous system.

Approach: Lewis rats were implanted with a constriction cuff and a distal cuff electrode around their right sciatic nerve. Read More

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October 2020

Impact of Encapsulation Tissue Growth on Selective Recording in Nerve Cuff Electrodes: A Simulation Study.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:3444-3447

Peripheral nerve interfaces (PNIs) allow us to extract motor, sensory and autonomic information from the nervous system and use it as control signals in neuroprosthetic and neuromodulation systems. Recent efforts have aimed to improve the recording selectivity of PNIs, including by using spatiotemporal patterns from multi-contact nerve cuff electrodes as input to a convolutional neural network (CNN). Before such a methodology can be translated to humans, its performance in chronic implantation scenarios must be evaluated. Read More

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