6,916 results match your criteria ctp

Quantitative collateral assessment evaluated by cerebral blood volume measured by CT perfusion in patients with acute ischemic stroke.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105797. Epub 2021 Apr 17.

Department of Neurosurgery, Soka Municipal Hospital, 2-21-1, Soka, Soka city, Saitama 340-8560, Japan.

Objectives: Collateral status (CS) is considered a predictor of clinical outcome after reperfusion therapy (RT) in patients with acute ischemic stroke (AIS). We proposed a quantitative assessment of CS using cerebral blood volume (CBV) measured by computed tomography perfusion (CTP) imaging.

Materials And Methods: This retrospective study was approved by the Institutional Review Board. Read More

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Phospho-imaging as a tool for visualization and noninvasive measurement of P transport dynamics in arbuscular mycorrhizas.

New Phytol 2002 Jun;154(3):809-819

Risø National Laboratory, DK-4000 Roskilde, Denmark.

• A new method is described for monitoring hyphal P transport in compartmented, monoxenic mycorrhizal root cultures. Nondestructive time-course measurements of P transport in hyphae were obtained by capturing digital autoradiograms on P-imaging screens, and comparing with growth observed by optical scanning. P distribution measured by densitometry on the day of harvest closely agreed with values obtained by liquid scintillation counting after destructive harvest. Read More

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Spontaneous Activity in Primary Visual Cortex Relates to Visual Creativity.

Front Hum Neurosci 2021 1;15:625888. Epub 2021 Apr 1.

Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.

Cognitive and neural processes underlying visual creativity have attracted substantial attention. The current research uses a critical time point analysis (CTPA) to examine how spontaneous activity in the primary visual area (PVA) is related to visual creativity. We acquired the functional magnetic resonance imaging (fMRI) data of 16 participants at the resting state and during performing a visual creative synthesis task. Read More

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Comparison of different prognostic scores for patients with cirrhosis hospitalized with SARS-CoV-2 infection.

Ann Hepatol 2021 Apr 14:100350. Epub 2021 Apr 14.

Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Pilar, Argentina; Latin American Liver Research Educational and Awareness Network (LALREAN), Argentina; Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.

Introduction And Objectives: Viral infections have been described to increase the risk of decompensation in patients with cirrhosis. We aimed to determine the effect of SARS-CoV-2 infection on outcome of hospitalized patients with cirrhosis and to compare the performance of different prognostic models for predicting mortality.

Patients: We performed a prospective cohort study including 2211 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through October 1, 2020 in 38 Hospitals from 11 Latin American countries. Read More

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Correlating Bedrock Folds to Higher Rates of Arsenic Detection in Groundwater, Southeast Wisconsin, USA.

Ground Water 2021 Apr 16. Epub 2021 Apr 16.

Wisconsin Geological and Natural History Survey, Division of Extension, University of Wisconsin-Madison, 3817 Mineral Point Road, Madison, WI, 53705, USA.

Arsenic in private drinking water wells is a significant problem across much of eastern Wisconsin, USA. The release mechanism and stratigraphic distribution of sulfide and iron (hydr)oxide sources of arsenic in bedrock aquifers are well understood for northeastern Wisconsin. However, recent geologic mapping has identified numerous small bedrock folds to the south, and the impact of these geologic structures on local groundwater flow and well contamination has been little studied. Read More

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The longitudinal outcomes of applying non-selective beta-blockers in portal hypertension: real-world multicenter study.

Hepatol Int 2021 Apr 16. Epub 2021 Apr 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, 20, Ilsan-ro, Wonju, 26426, Korea.

Background/aim: We investigated the effect of non-selective β-blockers (NSBB) in real-world situations and whether low-dose NSBB is beneficial compared to maximally tolerated doses.

Methods: We performed a retrospective study of 740 patients with cirrhosis requiring prophylactic treatment of esophageal varices: 473 primary prophylaxis (PP: NSBB = 349, non-NSBB = 124) and 267 secondary prophylaxis (SP: NSBB = 200, non-NSBB = 67). The NSBB group was divided into low-dose (≤ 80 mg/day) and high-dose (> 80 mg/day). Read More

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New pectic polysaccharides from Codonopsis pilosula and C. tangshen: structural characterization and cellular antioxidant activities.

J Sci Food Agric 2021 Apr 15. Epub 2021 Apr 15.

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.

Background: Codonopsis pilosula and C. tangshen are plants widely used in traditional Chinese medicine. Two pectic polysaccharides from roots of C. Read More

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Comparison of CECT and CT perfusion in differentiating benign from malignant neck nodes in oral cavity cancers.

Eur J Radiol Open 2021 26;8:100339. Epub 2021 Mar 26.

Department of Pathology, Maulana Azad Medical College & Associated Hospitals, New Delhi, Delhi, India.

Aim: The objective of the study was to assess the performance of CT Perfusion in comparison to CECT for preoperative detection of metastases to lymph nodes in squamous cell cancers of oral cavity.

Methods: Twenty-five patients with squamous cell cancers of oral cavity underwent CECT and CTP. Two radiologists evaluated CECT and CTP parameters independently. Read More

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Serological evidence of Rift Valley fever virus infection among domestic ruminant herds in Uganda.

BMC Vet Res 2021 Apr 13;17(1):157. Epub 2021 Apr 13.

Metabiota Inc., San Francisco, USA.

Background: Prior to the first recorded outbreak of Rift Valley fever (RVF) in Uganda, in March 2016, earlier studies done until the 1970's indicated the presence of the RVF virus (RVFV) in the country, without any recorded outbreaks in either man or animals. While severe outbreaks of RVF occurred in the neighboring countries, none were reported in Uganda despite forecasts that placed some parts of Uganda at similar risk. The Ministry of Agriculture, Animal Industry and Fisheries (MAAIF) undertook studies to determine the RVF sero-prevalence in risk prone areas. Read More

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The Pursuit of Generalizability to Enable Clinical Translation of Radiomics.

Radiol Artif Intell 2021 Jan 16;3(1):e200227. Epub 2020 Dec 16.

Case School of Engineering-Biomedical Engineering, Case Western Reserve University, 2095 Martin Luther King Jr Dr, Hall Room 500, Cleveland, OH 44106.

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January 2021

CT perfusion based ASPECTS improves the diagnostic performance of early ischemic changes in large vessel occlusion.

BMC Med Imaging 2021 Apr 12;21(1):67. Epub 2021 Apr 12.

Department of Radiology, Changhai Hospital of Shanghai, Navy Medical University (Second Military Medical University), No. 168 Changhai Road, Shanghai, 200433, China.

Background: ASPECTS scoring method varies, but which one is most suitable for predicting the prognosis still unclear. We aimed to evaluate the diagnostic performance of Automated (Auto)-, noncontrast CT (NCCT)- and CT perfusion (CTP) -ASPECTS for early ischemic changes (EICs) in acute ischemic stroke patients with large vessel occlusion (LVO) and to explore which scoring method is most suitable for predicting the clinical outcome.

Methods: Eighty-one patients with anterior circulation LVO were retrospectively enrolled and grouped as having a good (0-2) or poor (3-6) clinical outcome using a 90-day modified Rankin Scale score. Read More

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Patient Age and Cell Concentration Influence Prevalence and Concentration of Progenitors in Bone Marrow Aspirates: An Analysis of 436 Patients.

J Bone Joint Surg Am 2021 Apr 12. Epub 2021 Apr 12.

Department of Biomedical Engineering, Lerner Research Institute (V.P.M., C.B., W.B., and G.F.M), Department of Health Science (I.B.), and Department of Orthopedic Surgery (N.S.P. and G.F.M.), Cleveland Clinic, Cleveland, Ohio.

Background: Connective tissue progenitors (CTPs) resident in native tissues serve as biological building blocks in tissue repair and remodeling processes. Methods for analysis and reporting on CTP quantity and quality are essential for defining optimal cell sources and donor characteristics and the impact of cell processing methods for cell therapy applications. The present study examines the influence of donor characteristics and cell concentration (nucleated cells/mL) on CTP prevalence (CTPs/million nucleated cells) and CTP concentration (CTPs/mL) in bone marrow aspirates (BMAs). Read More

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Draft Genome of Serogroup O18 Elaborating Phosphocholine-Decorated O Antigen.

Front Cell Infect Microbiol 2021 25;11:620010. Epub 2021 Mar 25.

Institute of Biology, Jan Kochanowski University in Kielce, Kielce, Poland.

is a pathogenic, Gram-negative, rod-shaped bacterium that causes ascending urinary tract infections. Swarming motility, urease production, biofilm formation, and the properties of its lipopolysaccharide (LPS) are all factors that contribute to the virulence of this bacterium. Uniquely, members of the O18 serogroup elaborate LPS molecules capped with O antigen polymers built of pentasaccharide repeats; these repeats are modified with a phosphocholine (ChoP) moiety attached to the proximal sugar of each O unit. Read More

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Two-step immobilization of metronidazole prodrug on TEMPO cellulose nanofibrils through thiol-yne click chemistry for in situ controlled release.

Carbohydr Polym 2021 Jun 20;262:117952. Epub 2021 Mar 20.

Univ. Grenoble Alpes, CNRS, Grenoble INP, LGP2, Grenoble, France. Electronic address:

Nowadays, drug encapsulation and drug release from cellulose nanofibrils systems are intense research topics, and commercial grades of cellulose nanomaterials are currently available. In this work we present an ester-containing prodrug of metronidazole that is covalently bound to cellulose nanofibrils in aqueous suspension through a two-step immobilization procedure involving green chemistry principles. The presence of the drug is confirmed by several characterization tools and methods such as Raman spectroscopy, elemental analysis, Dynamic Nuclear Polarization enhanced NMR. Read More

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Maternal and fetal outcomes of patients with liver cirrhosis: a case-control study.

BMC Pregnancy Childbirth 2021 Apr 8;21(1):280. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Beijing Youan Hospital, Capital Medical University, Qihelou street No.17, Dongcheng District, Beijing, 100006, China.

Background: We aimed to describe the characteristics and outcomes in pregnant women with liver cirrhosis, and identify the predictors of adverse events of mother and fetus.

Methods: Retrospectively collected mothers with liver cirrhosis in our center from 6/2010 to 6/2019. Women without liver cirrhosis were selected as a control in a 1:2 ratio. Read More

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We all care just as much about the child: stakeholders' experiences of parenting support in a Norwegian school context.

Int J Qual Stud Health Well-being 2021 Dec;16(1):1908014

Faculty of Nursing and Health Sciences, Nord University, Namsos, Norway.

: Despite increased focus on parenting support internationally, there is a lack of agreement in what constitutes parenting support. This paper explores the experiences of parenting support activities from the perspective of stakeholders in Norwegian basic schools.: Five focus group interviews were conducted with representatives from the schools' parent work committee, class teachers, health nurses, and social workers from nine schools. Read More

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December 2021

A novel prognostic model to predict outcome of artificial liver support system treatment.

Sci Rep 2021 Apr 5;11(1):7510. Epub 2021 Apr 5.

Center of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan, China.

The prognosis of Artificial liver support system (ALSS) for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is hard to be expected, which results in multiple operations of ALSS and excessive consumption of plasma, increase in clinical cost. A total of 375 HBV-ACLF patients receiving ALSS treatment were randomly divided a train set and an independent test set. Logistic regression analysis was conducted and a decision tree was built based on 3-month survival as outcome. Read More

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Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis.

J Struct Biol 2021 Apr 2;213(2):107733. Epub 2021 Apr 2.

Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated precursor for ribitol-phosphate polymerization, is synthesized by a cytidylyltransferase and reductase pair known as TarI and TarJ, respectively. In this study, we present crystal structures of Staphylococcus aureus TarI and TarJ in their apo forms and in complex with substrates and products. Read More

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Utility of CT Perfusion Imaging in Patients With Vertebral Artery Stenosis Treated With Balloon Expandable Stent.

Front Neurol 2021 17;12:650887. Epub 2021 Mar 17.

Department of Neurosurgery, Affiliated Dalian Municipal Central Hospital, Dalian Medical University, Dalian, China.

To investigate the clinical value of CT perfusion (CTP) imaging in vertebral artery stenosis stenting, so as to provide the basis for preoperative and postoperative evaluation. Ninety-seven patients with vertebral artery stenosis were accepted for endovascular stenting between Jan 2016 and Jan 2020. CT angiography, Digital Subtraction Angiography, and CTP were performed pre-operation and post-operation. Read More

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Histone transcription regulator Slm9 is required for cytoophidium biogenesis.

Exp Cell Res 2021 Apr 1;403(1):112582. Epub 2021 Apr 1.

School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. Electronic address:

The cytoophidium, a subcellular structure composed of CTP synthase, can be observed during the division of Schizosaccharomyces pombe. Cytoophidium formation changes periodically with the cell cycle of yeast cells. Here, we find that histone chaperone Slm9 is required for the integrity of cytoophidia in fission yeast. Read More

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Hypoperfusion Index Ratio as a Surrogate of Collateral Scoring on CT Angiogram in Large Vessel Stroke.

J Clin Med 2021 Mar 21;10(6). Epub 2021 Mar 21.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

Background: This study was to evaluate the correlation of the hypoperfusion intensity ratio (HIR) with the collateral score from multiphase computed tomography angiography (mCTA) among patients with large vessel stroke.

Method: From February 2019 to May 2020, we retrospectively reviewed the patients with large vessel strokes (intracranial carotid artery or proximal middle cerebral artery occlusion). HIR was defined as a Tmax > 10 s lesion volume divided by a Tmax > 6 s lesion volume, which was calculated by automatic software (Syngo. Read More

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Development of a Computed Tomography Perfusion Protocol to Support Large Animal Resuscitation Research.

J Trauma Acute Care Surg 2021 Mar 23. Epub 2021 Mar 23.

R Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, Maryland, USA Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Background: Adequate cerebral perfusion is crucial for a positive neurological outcome in trauma; however, it is difficult to characterize in the acute setting with non-invasive methods. Intra-arterial computed tomography perfusion (IA-CTP) may offer a solution. The aim of this study is to develop an IA-CTP protocol for resuscitation research. Read More

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Proximal Hip Geometry, Trabecular Bone Score, Bone Mineral Density and Bone Mineral Parameters in Patients With Cryptogenic and Hepatitis B Related Cirrhosis- A Study From the Indian Subcontinent.

J Clin Densitom 2021 Mar 4. Epub 2021 Mar 4.

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.

The impact of cryptogenic cirrhosis on skeleton has not been studied in Indian context. So this study investigated bone health in male patients with early cryptogenic cirrhosis as defined by Child-Turcot-Pugh A (CTP-A) categorization and compared it with patients diagnosed to have hepatitis B related chronic liver disease (CLD) on treatment and age, sex-matched healthy controls. It was a cross-sectional study, in which thirty male subjects were recruited in each group. Read More

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Warburg's Ghost-Cancer's Self-Sustaining Phenotype: The Aberrant Carbon Flux in Cholesterol-Enriched Tumor Mitochondria via Deregulated Cholesterogenesis.

Front Cell Dev Biol 2021 12;9:626316. Epub 2021 Mar 12.

Kingsborough Community College, Brooklyn, NY, United States.

Interpreting connections between the multiple networks of cell metabolism is indispensable for understanding how cells maintain homeostasis or transform into the decontrolled proliferation phenotype of cancer. Situated at a critical metabolic intersection, citrate, derived via glycolysis, serves as either a combustible fuel for aerobic mitochondrial bioenergetics or as a continuously replenished cytosolic carbon source for lipid biosynthesis, an essentially anaerobic process. Therein lies the paradox: under what conditions do cells control the metabolic route by which they process citrate? The Warburg effect exposes essentially the same dilemma-why do cancer cells, despite an abundance of oxygen needed for energy-generating mitochondrial respiration with citrate as fuel, avoid catabolizing mitochondrial citrate and instead rely upon accelerated glycolysis to support their energy requirements? This review details the genesis and consequences of the metabolic paradigm of a "truncated" Krebs/TCA cycle. Read More

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Decomposing Acute Symptom Severity in Large Vessel Occlusion Stroke: Association With Multiparametric CT Imaging and Clinical Parameters.

Front Neurol 2021 11;12:651387. Epub 2021 Mar 11.

Department of Radiology, University Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.

Acute ischemic stroke of the anterior circulation due to large vessel occlusion (LVO) is a multifactorial process, which causes neurologic symptoms of different degree. Our aim was to examine the impact of neuromorphologic and vascular correlates as well as clinical factors on acute symptom severity in LVO stroke. We selected LVO stroke patients with known onset time from a consecutive cohort which underwent multiparametric CT including non-contrast CT, CT angiography and CT perfusion (CTP) before thrombectomy. Read More

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Adherence to care transitions recommendations among high-risk hospitalized older patients.

J Am Geriatr Soc 2021 Mar 26. Epub 2021 Mar 26.

Florida Atlantic University, Charles E. Schmidt College of Medicine, Boca Raton, Florida, USA.

Background/objectives: Evidence on the effectiveness of inpatient hospital geriatric consultation is scant, and it is unknown whether adherence to specific recommendations will improve care and patient outcomes. This study was conducted to provide insights from a quality improvement project that may help guide further improvements in the effectiveness of these consultations made as a component of a care transitions program (CTP).

Design: Secondary analysis of the implementation of a multicomponent CTP for high-risk hospitalized patients aged 75 and older. Read More

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Non-contrast dual-energy CT virtual ischemia maps accurately estimate ischemic core size in large-vessel occlusive stroke.

Sci Rep 2021 Mar 24;11(1):6745. Epub 2021 Mar 24.

Department of Neuroimaging and Neurointervention, Stanford University Hospital, 300 Pasteur Drive, Room S-047, Stanford, CA, 94305, USA.

Dual-energy CT (DECT) material decomposition techniques may better detect edema within cerebral infarcts than conventional non-contrast CT (NCCT). This study compared if Virtual Ischemia Maps (VIM) derived from non-contrast DECT of patients with acute ischemic stroke due to large-vessel occlusion (AIS-LVO) are superior to NCCT for ischemic core estimation, compared against reference-standard DWI-MRI. Only patients whose baseline ischemic core was most likely to remain stable on follow-up MRI were included, defined as those with excellent post-thrombectomy revascularization or no perfusion mismatch. Read More

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Dynamics of cerebral perfusion and oxygenation parameters following endovascular treatment of acute ischemic stroke.

J Neurointerv Surg 2021 Mar 24. Epub 2021 Mar 24.

Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Baden-Württemberg, Germany

Background: We studied the effects of endovascular treatment (EVT) and the impact of the extent of recanalization on cerebral perfusion and oxygenation parameters in patients with acute ischemic stroke (AIS) and large vessel occlusion (LVO).

Methods: Forty-seven patients with anterior LVO underwent computed tomography perfusion (CTP) before and immediately after EVT. The entire ischemic region (T >6 s) was segmented before intervention, and tissue perfusion (time-to-maximum (T), time-to-peak (TTP), mean transit time (MTT), cerebral blood volume (CBV), cerebral blood flow (CBF)) and oxygenation (coefficientof variation (COV), capillary transit time heterogeneity (CTH), metabolic rate of oxygen (CMRO), oxygen extraction fraction (OEF)) parameters were quantified from the segmented area at baseline and the corresponding area immediately after intervention, as well as within the ischemic core and penumbra. Read More

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Utilization and Availability of Advanced Imaging in Patients With Acute Ischemic Stroke.

Circ Cardiovasc Qual Outcomes 2021 Apr 24;14(4):e006989. Epub 2021 Mar 24.

Department of Neurology, McGovern Medical School (Y.K., S.L., R.A., V.L.-R., S.I.S., A.C., L.D.M., S.A.S.), University of Texas Health Science Center at Houston.

Background: Recent clinical trials have established the efficacy of endovascular stroke therapy and intravenous thrombolysis using advanced imaging, particularly computed tomography perfusion (CTP). The availability and utilization of CTP for patients and hospitals that treat acute ischemic stroke (AIS), however, is uncertain.

Methods: We performed a retrospective cross-sectional analysis using 2 complementary Medicare datasets, full sample Texas and 5% national fee-for-service data from 2014 to 2017. Read More

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Determinants of Outcomes in Autoimmune Hepatitis Presenting as Acute on Chronic Liver Failure Without Extrahepatic Organ Dysfunction upon Treatment With Steroids.

J Clin Exp Hepatol 2021 Mar-Apr;11(2):171-180. Epub 2020 Aug 22.

Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.

Background And Aims: Autoimmune hepatitis presenting as acute on chronic liver failure (AIH-ACLF) is a novel entity with limited data on clinical course and management. We assessed outcomes in patients of AIH-ACLF with no extrahepatic organ dysfunction/failure when administered steroids.

Methods: In this retrospective analysis, clinical data, laboratory parameters, liver biopsy indices and prognostic scores such as model for end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores at baseline were computed for patients with AIH-ACLF and compared across strata of incident infections and transplant-free survival. Read More

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