61 results match your criteria ctld receptors

Reviving lost binding sites: Exploring calcium binding-site transitions between human and murine CD23.

FEBS Open Bio 2021 Jun 2. Epub 2021 Jun 2.

King's College London, Randall Centre for Cell & Molecular Biophysics, London, SE1 1UL, United Kingdom.

Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses.IgE's interaction with CD23 modulates both IgE production and functional activities.CD23 is a non-canonical immunoglobulin receptor, unrelated to receptors of other antibody isotypes. Read More

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Identification and expression analysis of group II C-type lectin domain containing receptors in grass carp Ctenopharyngodon idella.

Gene 2021 Jul 18;789:145668. Epub 2021 Apr 18.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address:

Group II C-type lectin domain (CTLD) containing receptors belong to a large family of pattern recognition receptors which mainly act on the innate immunity. They are structurally related and consist of a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and a single extracellular CTLD. Although they have been described in teleost fish, their involvement in immune responses is not well understood. Read More

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An atypical KLRG1 in Nile tilapia involves in adaptive immunity as a potential marker for activated T lymphocytes.

Fish Shellfish Immunol 2021 Jun 31;113:51-60. Epub 2021 Mar 31.

State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, Shanghai, 200241, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address:

Killer cell lectin-like receptor G subfamily 1 (KLRG1) is a receptor generally expressed on effector CD8 T cells or NK cells at terminal differentiation stage, and it will be highly induced for lymphocyte cytotoxicity upon pathogen infection or lymphocyte activation. However, little is known about the character or function of KLRG1 in lower vertebrates. In present study, we reappraised a molecule that previously defined as KLRG1 in the genomic sequence of Nile tilapia Oreochromis niloticus, and identified it as an atypical KLRG1-like molecule (defined as On-KLRG1-L), and illustrated its potential function serving as a marker representing effector T lymphocytes of fish species. Read More

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A C-type lectin with antibacterial activity in weather loach, Misgurnus anguillicaudatus.

J Fish Dis 2020 Dec 13;43(12):1531-1539. Epub 2020 Sep 13.

College of Life Science, Henan Normal University, Xinxiang, China.

C-type lectins are carbohydrate-binding proteins that play important roles in immunity by serving as pattern recognition receptors. In the present study, a novel nattectin-like C-type lectin was obtained from the weather loach, Misgurnus anguillicaudatus, designated as MaCTL. MaCTL encodes a peptide with 165 amino acids, with a signal peptide and a single C-type lectin domain (CTLD), containing a galactose-specific QPD motif and a conserved Ca -binding site. Read More

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December 2020

The complete genome sequence of bearded dragon adenovirus 1 harbors three genes encoding proteins of the C-type lectin-like domain superfamily.

Infect Genet Evol 2020 09 14;83:104321. Epub 2020 Apr 14.

Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary.

Bearded dragon adenovirus 1 (BDAdV-1), also known as agamid adenovirus 1, has been described worldwide as a prevalent infectious agent of the inland bearded dragon (Pogona vitticeps), the most common squamate exotic pet reptile. Previous limited sequence data of the adenoviral DNA polymerase and hexon genes indicated that BDAdV-1 is a member of genus Atadenovirus family Adenoviridae. Atadenoviruses infect ruminants, marsupials, testudine reptiles and birds, yet the genus has been shown to be of squamate reptile origin. Read More

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September 2020

C-Type Lectin Receptors in Phagocytosis.

Curr Top Microbiol Immunol 2020 ;429:1-18

F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRγ), that mediates signaling. Many CLRs directly recognize microbial cell walls and influence innate immunity by activating inflammatory and antimicrobial responses in phagocytes. In this review, we examine the contributions of certain CLRs to activation and regulation of phagocytosis in cells such as macrophages, dendritic cells and neutrophils. Read More

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November 2020

Bark Suppresses Bacterial Infection by Mediating Hemocyte Phagocytosis in an Invertebrate Model, .

Front Immunol 2019 23;10:1992. Epub 2019 Aug 23.

Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of Agriculture, East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai, China.

Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, Bark. was upregulated in hemocytes after challenges with bacteria, suggesting that it might be involved in antibacterial defense. Read More

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September 2020

Identification and tissue-expression profiling of novel chicken c-type lectin-like domain containing proteins as potential targets for carbohydrate-based vaccine strategies.

Mol Immunol 2019 10 3;114:216-225. Epub 2019 Aug 3.

Department of Animal Science, Aarhus University, Blichers Allé 20, 8830, Tjele, Denmark. Electronic address:

C-type lectin-like domain containing proteins (CTLDcps) mainly bind carbohydrate-based ligands, but also other ligands. CTLDcps are involved in several biological processes including cell adhesion, cell-cell interactions, and pathogen recognition. Pathogen recognition by myeloid cells, e. Read More

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October 2019

CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA.

Immunology 2019 10 23;158(2):85-93. Epub 2019 Jul 23.

GRI, Groupe de recherche en immunopathologie, EA4517, Université de la Réunion, Saint-Denis, France.

Bacterial DNA contains CpG oligonucleotide (ODN) motifs to trigger innate immune responses through the endosomal receptor Toll-like receptor 9 (TLR9). One of the cell surface receptors to capture and deliver microbial DNA to intracellular TLR9 is the C-type lectin molecule DEC-205 through its N-terminal C-type lectin-like domain (CTLD). CD93 is a cell surface protein and member of the lectin group XIV with a CTLD. Read More

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October 2019

C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.

FEBS J 2019 09 29;286(17):3299-3332. Epub 2019 Jul 29.

Institutes of Cardiovascular Sciences and Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, UK.

The C-type lectin domain (CTLD) group 14 family of transmembrane glycoproteins consist of thrombomodulin, CD93, CLEC14A and CD248 (endosialin or tumour endothelial marker-1). These cell surface proteins exhibit similar ectodomain architecture and yet mediate a diverse range of cellular functions, including but not restricted to angiogenesis, inflammation and cell adhesion. Thrombomodulin, CD93 and CLEC14A can be expressed by endothelial cells, whereas CD248 is expressed by vasculature associated pericytes, activated fibroblasts and tumour cells among other cell types. Read More

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September 2019

Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor.

J Struct Biol 2019 09 2;207(3):295-300. Epub 2019 Jul 2.

National Center for Protein Science Shanghai, Shanghai Science Research Center; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China. Electronic address:

M-type phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family. Recent evidence shows that PLA2R is a major autoantigen causing idiopathic membranous nephropathy (IMN), which is an autoimmune disease and one of the most common causes for nephrotic syndrome in adults. The epitope mapping data suggest that the major epitopes of PLA2R locate at the CysR, CTLD1 and CTLD7 domains. Read More

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September 2019

Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway.

Front Immunol 2019 26;10:280. Epub 2019 Feb 26.

Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands.

Immune-modulatory effects of β-glucans are generally considered beneficial to fish health. Despite the frequent application of β-glucans in aquaculture practice, the exact receptors and downstream signalling remains to be described for fish. In mammals, Dectin-1 is a member of the C-type lectin receptor (CLR) family and the best-described receptor for β-glucans. Read More

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September 2020

Structurally Robust and Functionally Highly Versatile-C-Type Lectin (-Related) Proteins in Snake Venoms.

Johannes A Eble

Toxins (Basel) 2019 03 1;11(3). Epub 2019 Mar 1.

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstr. 15, 48149 Münster, Germany.

Snake venoms contain an astounding variety of different proteins. Among them are numerous C-type lectin family members, which are grouped into classical Ca- and sugar-binding lectins and the non-sugar-binding snake venom C-type lectin-related proteins (SV-CLRPs), also called snaclecs. Both groups share the robust C-type lectin domain (CTLD) fold but differ in a long loop, which either contributes to a sugar-binding site or is expanded into a loop-swapping heterodimerization domain between two CLRP subunits. Read More

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A mannose receptor is involved in the anti-Vibrio defense of red swamp crayfish.

Fish Shellfish Immunol 2018 Nov 9;82:258-266. Epub 2018 Aug 9.

College of Life Science, Henan Normal University, Xinxiang, Henan, 453007, China. Electronic address:

Mannose receptor (MR), a member of pattern-recognition receptors (PRRs), is the first MR family member to be discovered that plays a critical role in immunity. The function of MRs has been reported in mammals and teleosts while none in invertebrates. In the present study, we identified a MR-like gene (designated as PcMR) from red swamp crayfish, Procambarus clarkii. Read More

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November 2018

Molecular Chaperone Receptors.

Methods Mol Biol 2018 ;1709:331-344

Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA.

Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Read More

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Binding of a C-type lectin's coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection.

PLoS Pathog 2017 Sep 20;13(9):e1006626. Epub 2017 Sep 20.

Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong, China.

C-type lectins (CTLs) are characterized by the presence of a C-type carbohydrate recognition domain (CTLD) that by recognizing microbial glycans, is responsible for their roles as pattern recognition receptors in the immune response to bacterial infection. In addition to the CTLD, however, some CTLs display additional domains that can carry out effector functions, such as the collagenous domain of the mannose-binding lectin. While in vertebrates, the mechanisms involved in these effector functions have been characterized in considerable detail, in invertebrates they remain poorly understood. Read More

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September 2017

Novel Pattern Recognition Receptor Protects Shrimp by Preventing Bacterial Colonization and Promoting Phagocytosis.

J Immunol 2017 04 3;198(8):3045-3057. Epub 2017 Mar 3.

Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong 250100, China; and

The recognition of pathogen-associated molecular patterns is accomplished by the recognition modules of pattern recognition receptors (PRRs). Leucine-rich repeats (LRRs) and C-type lectin-like domain (CTLD) represent the two most universal categories of recognition modules. In the current study, we identified a novel soluble and bacteria-inducible PRR comprising LRRs and a CTLD from the hepatopancreas of kuruma shrimp and named it Leulectin. Read More

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The scavenger receptor repertoire in six cnidarian species and its putative role in cnidarian-dinoflagellate symbiosis.

PeerJ 2016 15;4:e2692. Epub 2016 Nov 15.

School of Biological Sciences, Victoria University of Wellington , Wellington , New Zealand.

Many cnidarians engage in a mutualism with endosymbiotic photosynthetic dinoflagellates that forms the basis of the coral reef ecosystem. Interpartner interaction and regulation includes involvement of the host innate immune system. Basal metazoans, including cnidarians have diverse and complex innate immune repertoires that are just beginning to be described. Read More

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November 2016

A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.

EMBO J 2016 11 17;35(22):2484-2497. Epub 2016 Oct 17.

Immunobiology Laboratory, The Francis Crick Institute, London, UK

DNGR-1 is receptor expressed by certain dendritic cell (DC) subsets and by DC precursors in mouse. It possesses a C-type lectin-like domain (CTLD) followed by a poorly characterized neck region coupled to a transmembrane region and short intracellular tail. The CTLD of DNGR-1 binds F-actin exposed by dead cell corpses and causes the receptor to signal and potentiate cross-presentation of dead cell-associated antigens by DCs. Read More

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November 2016

Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli.

J Immunol Methods 2016 12 12;439:67-73. Epub 2016 Oct 12.

GRI, EA4517, Université de la Réunion, Saint-Denis F-97400, France; CALIXAR, 60 Avenue Rockefeller, 69008 Lyon, France.

CD93 belongs to the group XIV C-type lectin like domain (CTLD) and is closely related to thrombomodulin (CD141). Although CD93 is known to be involved in the regulation of cell adhesion and phagocytosis, its role in innate immunity remains to be fully investigated. Critically, published data about CD141 suggest that CD93 CTLD could be involved in the control of inflammation. Read More

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December 2016

Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.

Biochem J 2016 08 31;473(15):2359-68. Epub 2016 May 31.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China

The proteins of the mannose receptor (MR) family share a common domain organization and have a broad range of biological functions. Urokinase plasminogen activator receptor-associated protein (uPARAP) (or Endo180) is a member of this family and plays an important role in extracellular matrix remodelling through interaction with its ligands, including collagens and urokinase plasminogen activator receptor (uPAR). We report the crystal structures of the first four domains of uPARAP (also named the ligand-binding region, LBR) at pH 7. Read More

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Phospholipase A Receptor Gene Polymorphisms Alter its Functions and Present a Genetic Risk of an Increased Intima-Media Thickness of the Carotid Artery.

J Atheroscler Thromb 2016 Oct 29;23(10):1227-1241. Epub 2016 Mar 29.

Department of Internal Medicine Ⅱ, University of Yamanashi, Faculty of Medicine.

Aims: Phospholipase A receptor 1 (PLAR) has multiple biological functions other than functioning as a receptor for secretory PLAs. Two nonsynonymous polymorphisms in the C-type lectin-like domains (CTLD) 1 of PLAR gene have been associated with idiopathic membranous nephropathy. This study examined whether the same PLAR polymorphisms may alter functions of PLAR in cells expressing the variant PLAR. Read More

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October 2016

Molecular Characterization and Biological Effects of a C-Type Lectin-Like Receptor in Large Yellow Croaker (Larimichthys crocea).

Int J Mol Sci 2015 Dec 10;16(12):29631-42. Epub 2015 Dec 10.

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China.

The C-type lectin-like receptors (CTLRs) play important roles in innate immunity as one type of pattern recognition receptors. Here, we cloned and characterized a C-type lectin-like receptor (LycCTLR) from large yellow croaker Larimichthys crocea. The full-length cDNA of LycCTLR is 880 nucleotides long, encoding a protein of 215 amino acids. Read More

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December 2015

High Innate Immune Specificity through Diversified C-Type Lectin-Like Domain Proteins in Invertebrates.

J Innate Immun 2016 19;8(2):129-42. Epub 2015 Nov 19.

Department of Evolutionary Ecology and Genetics, Zoological Institute, Christian Albrechts University of Kiel, Kiel, Germany.

A key question in current immunity research is how the innate immune system can generate high levels of specificity. Evidence is accumulating that invertebrates, which exclusively rely on innate defense mechanisms, can differentiate between pathogens on the species and even strain level. In this review, we identify and discuss the particular potential of C-type lectin-like domain (CTLD) proteins to generate high immune specificity. Read More

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December 2016

Isolation and characterization of two novel C-type lectins from the oriental river prawn, Macrobrachium nipponense.

Fish Shellfish Immunol 2015 Oct 21;46(2):603-11. Epub 2015 Jul 21.

Jiangsu Key Laboratory for Biodiversity & Biotechnology and Jiangsu Key Laboratory for Aquatic Crustacean Diseases, College of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210046, China. Electronic address:

C-type lectins are a family of calcium-dependent carbohydrate-binding proteins which are believed to play important roles in the innate immunity of invertebrates. This study identified two novel C-type lectins, designated as MnCTLDcp2 and MnCTLDcp3, from the oriental river prawn Macrobrachium nipponense. The full-length cDNA of MnCTLDcp2 was of 1582 bp with an open reading frame (ORF) of 972 bp encoding a polypeptide of 323 amino acids. Read More

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October 2015

Molecular mechanism of statin-mediated LOX-1 inhibition.

Cell Cycle 2015 ;14(10):1583-95

a Department of Systems Medicine and Center of Biostatistics and Bioinformatics ; University of Rome Tor Vergata ; Rome , Italy.

Statins are largely used in clinics in the treatment of patients with cardiovascular diseases for their effect on lowering circulating cholesterol. Lectin-like oxidized low-density lipoprotein (LOX-1), the primary receptor for ox-LDL, plays a central role in the pathogenesis of atherosclerosis and cardiovascular disorders. We have recently shown that chronic exposure of cells to lovastatin disrupts LOX-1 receptor cluster distribution in plasma membranes, leading to a marked loss of LOX-1 function. Read More

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February 2016

C-type lectin-like domain and fibronectin-like type II domain of phospholipase A(2) receptor 1 modulate binding and migratory responses to collagen.

FEBS Lett 2015 Mar 25;589(7):829-35. Epub 2015 Feb 25.

Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan; CREST, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

Phospholipase A2 receptor 1 (PLA2R) mediates collagen-dependent migration. The mechanisms by which PLA2R interacts with collagen remain unclear. We produced HEK293 cells expressing full-length wild-type PLA2R or a truncated PLA2R that lacks fibronectin-like type II (FNII) domains or several regions of C-type lectin-like domain (CTLD). Read More

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C-type lectins in immunity: recent developments.

Curr Opin Immunol 2015 Feb 29;32:21-7. Epub 2014 Dec 29.

Aberdeen Fungal Group, Division of Applied Medicine, Immunity, Infection and Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK. Electronic address:

C-type lectin receptors (CLRs) comprise a large superfamily of proteins, which recognise a diverse range of ligands, and are defined by the presence of at least one C-type lectin-like domain (CTLD). Of particular interest are the single extracellular CTLD-containing receptors of the 'Dectin-1' and 'Dectin-2' clusters, which associate with signalling adaptors or possess integral intracellular signalling domains. These CLRs have traditionally been associated with the recognition of fungi, but recent discoveries have revealed diverse and unexpected functions. Read More

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February 2015

Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147.

Mol Cancer Res 2015 Mar 7;13(3):538-47. Epub 2014 Nov 7.

Department of Surgery and Cancer, Imperial College London, London, United Kingdom. School of Biological, Biomedical and Environmental Sciences, University of Hull, Hull, United Kingdom.

Unlabelled: Epithelial cell-cell contacts maintain normal glandular tissue homeostasis, and their breakage can trigger epithelial-to-mesenchymal transition (EMT), a fundamental step in the development of metastatic cancer. Despite the ability of C-type lectin domains (CTLD) to modulate cell-cell adhesion, it is not known if they modulate epithelial adhesion in EMT and tumor progression. Here, the multi-CTLD mannose receptor, Endo180 (MRC2/uPARAP), was shown using the Kaplan-Meier analysis to be predictive of survival outcome in men with early prostate cancer. Read More

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