11 results match your criteria csnk1g2

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CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.

PLoS One 2021 16;16(4):e0246264. Epub 2021 Apr 16.

Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Jeollabuk-do, Republic of Korea.

Tamoxifen (TAM) is a selective estrogen receptor modulator used for breast cancer patients. Prolonged use of tamoxifen is not recommended for some patients. In this study, we aimed to identify molecular targets sensitive to TAM using a genome-wide gene deletion library screening of fission yeast heterozygous mutants. Read More

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Genome-wide association study of stage III/IV grade C periodontitis (former aggressive periodontitis) in a Spanish population.

J Clin Periodontol 2021 Jul 19;48(7):896-906. Epub 2021 Apr 19.

Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Aim: To identify loci associated with stages III/IV, grade C periodontitis (PIII/IV-C) through a genome-wide association study (GWAS).

Materials And Methods: 441 Caucasian Spanish PIII/IV-C cases from the SEPA Network of Research Clinics and 1141 controls from the Banco Nacional de ADN were genotyped with "Axiom Spain Biobank Array," which contains 757836 markers, including rare and low-frequency Spanish variants. The analysis of the individual association and subsequently the gene-level analysis with Sequence Kernel Association Test (SKAT) were carried out adjusting for age, sex and PC1 covariates. Read More

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Characterisation of sperm piRNAs and their correlation with semen quality traits in swine.

Anim Genet 2021 Feb 23;52(1):114-120. Epub 2020 Nov 23.

Centre for Research in Agricultural Genomics,, CSIC-IRTA-UAB-UB, Campus UAB, Cerdanyola del Vallès, Catalonia, 08193, Spain.

Piwi-interacting RNAs (piRNAs) are a class of non-coding RNAs that are essential in the transcriptional silencing of transposable elements and warrant genome stability in the mammalian germline. In this study, we have identified piRNAs in porcine sperm using male germline and zygote datasets from human, mice, cow and pig, and evaluated the relation between their abundances and sperm quality traits. In our analysis, we identified 283 382 piRNAs, 1355 of which correlated with P ≤ 0. Read More

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February 2021

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.

Elife 2020 11 18;9. Epub 2020 Nov 18.

National Institute of Biological Sciences, Beijing, China.

Casein kinases are a large family of intracellular serine/threonine kinases that control a variety of cellular signaling functions. Here we report that a member of casein kinase 1 family, casein kinase 1G2, CSNK1G2, binds and inhibits the activation of receptor-interacting kinase 3, RIPK3, thereby attenuating RIPK3-mediated necroptosis. The binding of CSNK1G2 to RIPK3 is triggered by auto-phosphorylation at serine 211/threonine 215 sites in its C-terminal domain. Read More

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November 2020

The Genomic Landscape of Mucinous Breast Cancer.

J Natl Cancer Inst 2019 07;111(7):737-741

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Mucinous carcinoma of the breast (MCB) is a rare histologic form of estrogen receptor (ER)-positive/HER2-negative breast cancer (BC) characterized by tumor cells floating in lakes of mucin. We assessed the genomic landscape of 32 MCBs by whole-exome sequencing and/or RNA-sequencing. GATA3 (23. Read More

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Cryopreservation and egg yolk medium alter the proteome of ram spermatozoa.

J Proteomics 2018 06 5;181:73-82. Epub 2018 Apr 5.

Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, NSW 2006, Australia.

Cryopreservation causes significant lethal and sub-lethal damage to spermatozoa. In order to improve freezing outcomes, a comprehensive understanding of sub-lethal damage is required. Cryopreservation induced changes to sperm proteins have been investigated in several species, but few have employed currently available state of the art, data independent acquisition mass spectrometry (MS) methods. Read More

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Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood.

BMC Med Genomics 2009 Aug 5;2:49. Epub 2009 Aug 5.

Department of Neurology and M,I,N,D, Institute, University of California at Davis Medical Center, Sacramento, CA 95817, USA.

Background: Gene expression studies require appropriate normalization methods. One such method uses stably expressed reference genes. Since suitable reference genes appear to be unique for each tissue, we have identified an optimal set of the most stably expressed genes in human blood that can be used for normalization. Read More

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A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.

Mod Pathol 2007 Oct 27;20(10):1095-102. Epub 2007 Jul 27.

Department of Histopathology, Trinity College, University of Dublin, Dublin, Ireland.

Follicular variant of papillary thyroid carcinoma is a lesion that frequently causes difficulties from a diagnostic perspective in the laboratory. The purpose of this study was to interrogate a cohort of archival thyroid lesions using gene expression analysis of a panel of markers proposed to have utility as adjunctive markers in the diagnosis of thyroid neoplasia and follicular variant of papillary thyroid carcinoma in particular. Laser Capture Microdissection was used to procure pure cell populations for extraction. Read More

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October 2007

Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population.

Neurosci Lett 2004 Sep;368(1):2-6

Department of Pediatrics, Peking University First Hospital, No. 8 Xishiku Street, Beijing 100034, PR China.

Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) family, may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Based on our previous linkage analysis data that mapped our simple febrile seizures (FS) families to 19p13.3 and the function of CSNK1G2 in this region, CSNK1G2 was chosen as a candidate gene for FS. Read More

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September 2004

[Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004 Aug;21(4):347-50

Central Labortary, First Hospital of Peking University, Beijing, 100034 PR China.

Objective: To investigate the association between single nucleotide polymorphisms (SNPs) of casein kinase I gamma 2 (CSNK1G2) gene and children with familial febrile convulsions.

Methods: The study samples were collected from unrelated Chinese Han population of Hebei province, including a cohort of 53 children with familial febrile convulsions(FC) and a control cohort of 101 individuals. Genotypes of SNPs rs2074882, rs740423, rs2277737, rs4806825, rs1059684 were typed by polymerase chain reaction-restriction fragment length polymorphism. Read More

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Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2).

Genomics 1997 Nov;46(1):133-7

Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan.

A clone of immature cDNA for human casein kinase I gamma 2 (CSNK1G2) was isolated by screening the human testis cDNA library with a PCR-amplified probe (about 400 bp) representing the kinase domain of rat casein kinase I gamma 2 (CKI gamma 2). Comparison of the entire sequence with that of rat CKI gamma 2 showed that the cDNA contained the complete coding sequence of CKI gamma 2 as well as an intron-like sequence of 1006 bp, part of which was homologous to the Alu sequence. To obtain an insertion-free CSNK1G2 cDNA, PCR cloning was performed based on the above sequence. Read More

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November 1997
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