103,998 results match your criteria csf aβ


Tumefactive demyelination appearing as multiple cystic brain lesions.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurosurgery, St. Vincent's Hospital Melbourne, 41 Victoria Pde, Fitzroy, Victoria 3065, Australia.

Tumefactive demyelinating lesions (TDL) are a rare sequalae of idiopathic inflammatory demyelinating diseases (IIDD) of the central nervous system (CNS). Their propensity to mimic tumor and abscess poses a diagnostic challenge for the clinician. Our case depicts TDL causing right hand focal sensory seizures in an otherwise healthy 35-year-old female. Read More

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Proteomic portraits reveal evolutionarily conserved and divergent responses to spinal cord injury.

Mol Cell Proteomics 2021 Jun 12:100096. Epub 2021 Jun 12.

Division of Neurosurgery, University of British Columbia, Vancouver, BC, Canada.

Despite the emergence of promising therapeutic approaches in preclinical studies, the failure of large-scale clinical trials leaves clinicians without effective treatments for acute spinal cord injury (SCI). These trials are hindered by their reliance on detailed neurological examinations to establish outcomes, which inflate the time and resources required for completion. Moreover, therapeutic development takes place in animal models whose relevance to human injury remains unclear. Read More

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Chemoattractants driven and microglia based biomimetic nanoparticle treating TMZ-resistant glioblastoma multiforme.

J Control Release 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address:

Currently, clinical treatment for temozolomide (TMZ)-resistant glioblastoma multiforme (GBM) is still a difficult problem. The aim of this paper is to set up a new GBM-targeted drug delivery system to treat TMZ-resistant GBM. Zoledronate (ZOL) not only induces apoptosis of TMZ-resistant GBM cells by down-regulation of farnesyl pyrophosphate synthetase (FPPS) but also increases the proportion of M1-type GBM associated macrophages (GAM). Read More

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Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.

Ann Clin Transl Neurol 2021 Jun 15. Epub 2021 Jun 15.

Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.

Objective: Decreased amyloid beta (Aβ) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.

Methods: We utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Read More

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Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake.

J Gen Physiol 2021 Aug 15;153(8). Epub 2021 Jun 15.

Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA.

Extracellular solutes in the central nervous system are exchanged between the interstitial fluid, the perivascular compartment, and the cerebrospinal fluid (CSF). The "glymphatic" mechanism proposes that the astrocyte water channel aquaporin-4 (AQP4) is a major determinant of solute transport between the CSF and the interstitial space; however, this is controversial in part because of wide variance in experimental data on interstitial uptake of cisternally injected solutes. Here, we investigated the determinants of solute uptake in brain parenchyma following cisternal injection and reexamined the role of AQP4 using a novel constant-pressure method. Read More

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Atezolizumab and bevacizumab-induced encephalitis in advanced hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2021 06;100(24):e26377

Department of Hepatology and Gastroenterology.

Introduction: On the basis of the results of the IMBRAVE-150 trial, the combination of atezolizumab, a programmed cell death ligand 1 (PD-L1) antibody, as well as bevacizumab, a vascular endothelial growth factor (VEGF) antibody, represents a promising novel first-line therapy in patients with advanced hepatocellular carcinoma (HCC). Despite favorable safety data, serious adverse events have been described. However, central nervous system complications such as encephalitis have rarely been reported. Read More

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Meningoencephalitis in relapsing polychondritis: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26315

Department of Neurology, Fukushima Medical University School of Medicine, Fukushima.

Rationale: Aseptic meningoencephalitis is a rare central nervous system complication of relapsing polychondritis (RP).

Patient: We report a 61-year-old Japanese male patient with spiking fever and impaired consciousness. Neurological examination revealed meningealirritation, and cerebrospinal fluid (CSF) examination showed lymphocytic pleocytosis with elevated protein (199 mg/dL) and interleukin-6 (3810 pg/mL). Read More

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The AAV9 variant capsid AAV-F mediates widespread transgene expression in non-human primate spinal cord after intrathecal administration.

Hum Gene Ther 2021 Jun 15. Epub 2021 Jun 15.

Massachusetts General Hospital, 2348, Boston, Massachusetts, United States;

Intrathecal delivery of AAV9 into the subarachnoid space has been shown to transduce spinal cord and brain and be less affected by pre-existing antibodies, which are lower in cerebral spinal fluid (CSF). Still, efficiency of transduction needs to be improved. Recently we identified a new capsid from a library selection in mice, called AAV-F, that allowed robust transduction of the spinal cord gray matter after lumbar injection. Read More

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Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro.

Sci Rep 2021 Jun 14;11(1):12454. Epub 2021 Jun 14.

Women and Babies Research, Perinatal Medicine, The University of Sydney, Faculty of Medicine and Health, and Northern, Sydney Local Health District Research (Kolling Institute), St Leonards, NSW, 2065, Australia.

Mesenchymal stromal/stem cells (MSCs) are currently being used in clinical trials as proposed treatments for a large range of genetic, immunological, orthopaedic, cardiovascular, endocrine and neurological disorders. MSCs are potent anti-inflammatory mediators which are considered immune evasive and employ a large range of secreted vesicles to communicate and repair damaged tissue. Despite their prolific use in therapy, sex specific mechanism of action is rarely considered as a potential confounding factor for use. Read More

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Cerebrospinal fluid HIV RNA escape symptomatology.

AIDS 2021 Jun 15. Epub 2021 Jun 15.

Mildmay Hospital, London, UK Unit of Infectious Diseases, San Raffaele Hospital, Milan, Italy Section of Retrovirology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK Department of HIV Medicine, St. Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK Unit of Neuroradiology, ASST Papa Giovanni XXIII, Bergamo, Italy Lazzaro Spallanzani National Institute of Infectious Diseases, Rome, Italy San Paolo Hospital, University of Milan, Milan, Italy University of Bari, Bari, Italy Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy Department of Neurology, St. Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK Neurosciences, Blizard Institute, Queen Mary University of London, London, UK Grahame Hayton Unit, I&I and Neurology Department, Barts Health NHS Trust, London, UK.

Objective: To characterise the clinical, laboratory and radiological characteristics of persons with HIV (PWH) presenting with cerebrospinal fluid (CSF) HIV RNA escape.

Design: Retrospective case review of PWH presenting with symptomatic CSF HIV RNA escape at seven tertiary HIV clinical sites in UK and Italy.

Method: PWH with symptomatic CSF HIV RNA escape episodes were identified and data obtained from medical records. Read More

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[Bacterial Meningitis and Suppurative Thrombophlebitis after Trigger Point Injections: A Case Report].

Brain Nerve 2021 Jun;73(6):737-740

Department of Neurology, Kobe City Medical Center General Hospital.

A 73-year-old woman with untreated diabetes mellitus visited our emergency department with a 4-day history of progressive headache, fever, and chills. She received trigger point injections (TPI) into the right sternocleidomastoid for exercise-induced ipsilateral shoulder pain, 13 days before admission and into the right trapezius, 6 days before admission. Cerebrospinal fluid (CSF) evaluation revealed pleocytosis with a predominance of neutrophils, as well as elevated protein and reduced glucose levels. Read More

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TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood.

EBioMedicine 2021 Jun 10:103429. Epub 2021 Jun 10.

Dipartimento di Medicina Sperimentale e Clinica (DMSC), Laboratory of Neuroimmunology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. Electronic address:

Background: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor (TCR) repertoire in cerebrospinal fluid (CSF) of MS patients by high-throughput sequencing (HTS), a deep analysis on repertoire similarities and differences among compartments is still missing.

Methods: We performed comprehensive bioinformatics on high-dimensional TCR Vβ sequencing data from published and unpublished MS and healthy donors (HD) studies. Read More

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Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition.

Neurobiol Aging 2021 May 21;105:241-251. Epub 2021 May 21.

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Electronic address:

Vascular endothelial growth factor (VEGF) is a complex signaling protein that supports vascular and neuronal function. Alzheimer's disease (AD) -neuropathological hallmarks interfere with VEGF signaling and modify previously detected positive associations between cerebral spinal fluid (CSF) VEGF and cognition and hippocampal volume. However, it remains unknown 1) whether regional relationships between VEGF and glucose metabolism and cortical thinning exist, and 2) whether AD-neuropathological hallmarks (CSF Aβ, t-tau, p-tau) also modify these relationships. Read More

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Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.

Biomed Pharmacother 2021 Jun 11;141:111816. Epub 2021 Jun 11.

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. Electronic address:

Background: Olive oil polyphenols, which possess cytoprotective activities like anti-oxidant and anti-inflammatory effects, could modulate osteoblast functions. The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-α (TNF-α)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts.

Methods: Osteoblast-like MC3T3-E1 cells were pretreated with hydroxytyrosol, oleuropein, deguelin, PD98059 or wedelolactone, and then stimulated by TNF-α. Read More

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Impaired luminal control of intestinal macrophage maturation in patients with ulcerative colitis during remission.

Cell Mol Gastroenterol Hepatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,. Electronic address:

Background & Aims: Intestinal macrophages adopt a hyporesponsive phenotype through education by local signals. Lack of proper macrophage maturation in patients with ulcerative colitis (UC) in remission may initiate gut inflammation. The aim was therefore to determine the effects of fecal luminal factors derived from healthy donors and UC patients in remission on macrophage phenotype and function. Read More

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Enterovirus 71 infection induced Aquaporin-4 depolarization by increasing matrix metalloproteinase-9 activity.

Neurosci Lett 2021 Jun 11:136049. Epub 2021 Jun 11.

Center for Public Health Research, Medical School, Nanjing University, Nanjing, China; State Key Lab of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China; Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China. Electronic address:

Aquaporin-4 (AQP4) is the key water channel protein that regulates brain water homeostasis. Polarized expression of AQP4 on the astroglial endfeet facilitates its role in bi-directional brain water flux control. In the current study, we found that enterovirus 71 (EV71) infection induced depolarization of AQP4 in mouse brain, and demonstrated that β-dystroglycan (β-DG), the key component of dystrophin glycoprotein complex (DGC) that anchors AQP4 to the astroglial endfeet, was degraded upon infection. Read More

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Reduced uterine tissue damage during infection in TREM-1,3 deficient mice.

Infect Immun 2021 Jun 14:IAI0007221. Epub 2021 Jun 14.

Department of Pediatrics, Department of Microbiology and Immunology, Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, U.S.A.

Genital infections with can lead to uterine and oviduct tissue damage in the female reproductive tract. Neutrophils are strongly associated with tissue damage during chlamydial infection, while an adaptive CD4 T cell response is necessary to combat infection. Activation of triggering receptor expressed on myeloid cells-1 (TREM-1) on neutrophils has previously been shown to induce and/or enhance degranulation synergistically with TLR-signaling. Read More

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Pediatric spinal intramedullary anaplastic myxopapillary ependymoma: a case report.

Childs Nerv Syst 2021 Jun 14. Epub 2021 Jun 14.

Department of Neurosurgery, Division of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine/Ann and Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Chicago, IL, 60611, USA.

A 6-year-old girl presented with a 1-week history of progressive upper and lower extremity weakness and bilateral upper extremity dysesthesia. Imaging demonstrated a 4.7 × 1. Read More

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Cerebrospinal fluid lipidomics for biomarkers of Alzheimer's disease.

Mol Omics 2021 Jun;17(3):454-463

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55902, USA. and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA and Department of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Alzheimer's disease (AD) is the most common cause of dementia and is associated with serious neurologic sequelae resulting from neurodegenerative changes. Identification of markers of early-stage AD could be important for designing strategies to arrest the progression of the disease. The brain is rich in lipids because they are crucial for signal transduction and anchoring of membrane proteins. Read More

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Normal cerebrospinal fluid protein and associated clinical characteristics in children with tuberculous meningitis.

Ann Med 2021 Dec;53(1):885-889

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: Although abnormal cerebrospinal fluid (CSF) protein can be used to predict the outcome of tuberculous meningitis (TBM) and diagnose TBM, normal CSF protein remains a concern in patients with TBM. This retrospective study aimed to assess the clinical characteristics associated with normal CSF protein, to resolve the dilemma of CSF protein in the management of childhood TBM.

Methods: Between January 2006 and December 2019, consecutive child patients (≤15 years old, a diagnosis of TBM, and tested for CSF protein) were included for analysis. Read More

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December 2021

SARS-CoV-2 RNA DETECTION IN CEREBROSPINAL FLUID: PRESENTATION OF TWO CASES AND REVIEW OF LITERATURE.

Brain Behav Immun Health 2021 Jun 8:100282. Epub 2021 Jun 8.

Department of Neurology, Sanatorio Güemes - University Hospital, Buenos Aires, Argentina.

Neurological manifestations of SARS-CoV-2 infection are multiple and heterogeneous. However, confirmation of nervous system impairment by viral RNA detection in cerebrospinal fluid (CSF) is uncommon. We report two cases of central nervous system (CNS) involvement with positive real-time reverse-transcriptase polymerase chain reaction (RT-PCR) test in CSF. Read More

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Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis.

Front Cell Dev Biol 2021 28;9:678532. Epub 2021 May 28.

Biomedical Science and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Bone metastasis (BM) is a dismal complication of cancer that frequently occurs in patients with advanced carcinomas and that often manifests as an osteolytic lesion. In bone, tumor cells promote an imbalance in bone remodeling via the release of growth factors that, directly or indirectly, stimulate osteoclast resorption activity. However, carcinoma cells are also characterized by an altered metabolism responsible for a decrease of extracellular pH, which, in turn, directly intensifies osteoclast bone erosion. Read More

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Using Sensitivity Analysis to Develop a Validated Computational Model of Post-operative Calvarial Growth in Sagittal Craniosynostosis.

Front Cell Dev Biol 2021 26;9:621249. Epub 2021 May 26.

Department of Mechanical Engineering, University College London, London, United Kingdom.

Craniosynostosis is the premature fusion of one or more sutures across the calvaria, resulting in morphological and health complications that require invasive corrective surgery. Finite element (FE) method is a powerful tool that can aid with preoperative planning and post-operative predictions of craniosynostosis outcomes. However, input factors can influence the prediction of skull growth and the pressure on the growing brain using this approach. Read More

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Monocular Diplopia in Idiopathic Intracranial Hypertension: A Case Report and Literature Review.

Eur J Case Rep Intern Med 2021 4;8(5):002509. Epub 2021 May 4.

Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.

Background: Diplopia is the double vision of a single object, and can be binocular or monocular. Binocular diplopia is caused by the misalignment of the visual axes, with images falling on the fovea of the fixating eye and on the extra-foveal retina of the non-fixating eye, as a consequence of both neurological (i.e. Read More

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Pooled Analysis on the Effectiveness and Safety of Lipegfilgrastim in Patients With Urological Malignancies in the Real-World Setting.

Front Oncol 2021 28;11:655355. Epub 2021 May 28.

Department of Internal Medicine I, University Hospital St. Poelten, Karl Landsteiner, University of Health Sciences, St. Poelten, Austria.

Lipegfilgrastim is a long-acting glycopegylated granulocyte-colony stimulating factor (G-CSF) approved for the management of chemotherapy-induced neutropenia. In general, there is little information on the use of any G-CSFs specifically in patients with urological malignancies receiving chemotherapy. This report combines information from two prospective non-interventional studies on the prophylactic use of lipegfilgrastim in urological cancer patients receiving chemotherapy in the real-world setting. Read More

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Cryptococcal Meningitis in an HIV-Negative Puerperal Woman.

Case Rep Infect Dis 2021 25;2021:6665624. Epub 2021 May 25.

Head of Department of Infectious Diseases, Infectious Diseases Service, Hospital Garcia de Orta EPE, Almada, Portugal.

Cryptococcal meningitis is a common opportunistic infection in HIV-infected patients and other immunocompromised people. Pregnancy, which is a state of relative immunosuppression, can also be a risk factor for the development of cryptococcal meningitis. We report a clinical case of a 41-year-old woman who developed a severe meningeal syndrome after an otherwise normal pregnancy. Read More

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Impact of the COVID-19 pandemic on health care activities at a Uruguayan mastology unit.

J Cancer Res Ther 2021 Apr-Jun;17(2):547-550

Department of Clinical Oncology, Hospital de Clínicas "Dr. Manuel Quintela", School of Medicine, University of Uruguay, Montevideo, Uruguay.

Purpose: Health emergency due to COVID-19 started in Uruguay on March 13, 2020; our mastology unit tried to ensure adequate oncological care, and protect patients from the virus infection and complications.

Objective: To assess the health care activities in the "peak" of the pandemic during 3 months.

Materials And Methods: we collected data from the electronic health record. Read More

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Matched Cohort Analysis of the Effect of the Facial Recess Approach on Cerebrospinal Fluid Leak After Translabyrinthine Surgery for Schwannoma.

Otol Neurotol 2021 Jun 11. Epub 2021 Jun 11.

Division of Neurotology Division of Neurosurgery, House Institute, Los Angeles, California.

Objective: The facial recess approach during translabyrinthine surgery has been used to expose the eustachian tube (ET) for packing. We sought to determine the effect of this technique on the development of postoperative nasopharyngeal cerebrospinal fluid (CSF) leaks.

Patients: Cohorts of patients with cerebellopontine angle schwannomas who underwent a facial recess approach or no facial recess approach were matched based on tumor size. Read More

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Cerebrospinal Fluid Leaks from the Lateral Ventricle: A Case Series.

Otol Neurotol 2021 Jun 11. Epub 2021 Jun 11.

Department of Otolaryngology-Head and Neck Surgery Indiana University School of Medicine Department of Radiology - Section of Neuroradiology and Imaging Sciences Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, Indiana.

Objectives: Describe the diagnosis and management of lateral skull base (LSB) cerebrospinal fluid (CSF) leaks originating from the lateral ventricle.

Study Design: Retrospective case review.

Setting: Tertiary referral academic center. Read More

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