103,951 results match your criteria csf

A biomimetic triple-layered biocomposite with effective multifunction for dura repair.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China. Electronic address:

Dura mater defect and subsequent cerebrospinal fluid (CSF) leakage usually appear in trauma or neurosurgical procedures and are followed by a series of serious complications and even death. The use of a qualified dura mater substitute with multifunction of leakage blockade, adhesion prevention, and dura reconstruction is one of the promising treatment methods. However, even though some products have been used in the clinic, none of the substitutes achieved the required multifunction. Read More

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Effect of backbone circularization on colloidal stability: Compaction of unfolded structures improves aggregation resistance of granulocyte colony-stimulating factor.

Int J Pharm 2021 Jun 8:120774. Epub 2021 Jun 8.

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan. Electronic address:

Aggregation of protein therapeutics can lead to immunogenicity and loss of function in vivo. Its effective prevention requires an understanding of the conformational and colloidal stability of protein and the improvement of both. Granulocyte colony-stimulating factor (G-CSF), which is one of the most widely used protein therapeutics, was previously shown to be conformationally stabilized by connecting its N- and C-termini with amide bonds (backbone circularization). Read More

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Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.

PLoS One 2021 11;16(6):e0251518. Epub 2021 Jun 11.

Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.

Objectives: Meningitis is a medical emergency with permanent disabilities and high mortality worldwide. We aimed to determine causative microorganisms and potential markers for differentiation between bacterial and viral meningitis.

Methodology: Adult patients with acute meningitis were subjected to lumber puncture. Read More

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Increased immune activation and signs of neuronal injury in HIV-negative people on pre-exposure prophylaxis (PrEP).

AIDS 2021 Jun 9. Epub 2021 Jun 9.

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Region Västra Götaland, Sahlgrenska University Hospital, Department of Infectious Diseases, Gothenburg, Sweden Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden UK Dementia Research Institute at UCL, London, United Kingdom Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.

Objective: Persistent immune activation in the central nervous system and systemically are common in people living with HIV (PLHIV) despite antiretroviral therapy. It is not known whether this is generated by HIV replication or other components such as coinfections and lifestyle-related factors.

Design: To determine the importance of different factors, it is crucial to find well-matched HIV-negative controls. Read More

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Gorham Stout disease of the temporal bone with cerebrospinal fluid leak.

Childs Nerv Syst 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Gorham Stout disease (GSD) is a rare disease characterized by the proliferation of endothelial lined vessels and replacement of bone by fibrous tissue. The main imaging features are progressive osteolysis and cortical resorption. Temporal bone involvement is rare but presents as a destructive bone lesion that may be misinterpreted as more common lytic processes in the pediatric population, such as infection or Langerhans cell histiocytosis. Read More

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Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26241

Department of Neurology, Weifang People's Hospital (The First Affiliated Hospital of Weifang Medical University), Weifang, Shandong, China.

Rationale: Todd paralysis (a stroke-like presentation in some patients with epilepsy) caused by limbic encephalitis (LE) is not easily distinguished from acute ischemic stroke by clinicians in the emergency room.

Patient Concerns: We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE.

Diagnoses: CASPR2-Ab-positive LE was the presumed diagnosis. Read More

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Prophylaxis and treatment strategies for optimizing chemotherapy relative dose intensity.

Expert Rev Anticancer Ther 2021 Jun 11. Epub 2021 Jun 11.

University of Rochester Medical Center, Rochester, NY, USA.

Introduction: A decrease in relative dose intensity (RDI) of chemotherapy has been shown to be associated with poor patient outcomes in solid tumors and non-Hodgkin's lymphoma. The actual delivered chemotherapy dose received by patients can be influenced by dose reductions and treatment delays often due to toxicities, most commonly chemotherapy-induced neutropenia (CIN).

Areas Covered: We review seminal evidence and more recent studies that have shown an association between higher RDI and improved patient survival. Read More

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Analysis of the characteristic compounds of Citri Sarcodactylis Fructus from different geographical origins.

Phytochem Anal 2021 Jun 10. Epub 2021 Jun 10.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Introduction: Citri Sarcodactylis Fructus (CSF) is widely used as a food ingredient and a traditional Chinese medicine. In China, CSF is cultivated in many places, including Sichuan, Guangdong, Zhejiang, and Fujian provinces. The types and chemical contents of CSF from different origins may vary greatly due to the difference in climate and environmental conditions. Read More

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Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs.

J Vet Intern Med 2021 Jun 10. Epub 2021 Jun 10.

Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.

Background: Neurofilament light chain (NfL) is a neuron-specific cytoskeletal protein expressed in axons. Damaged axons of the central nervous system release NfLs into the cerebrospinal fluid (CSF) and the blood. In humans with neurologic diseases, NfL is used as a biomarker. Read More

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Integrated understanding of hydrocephalus - a practical approach for a complex disease.

U W Thomale

Childs Nerv Syst 2021 Jun 10. Epub 2021 Jun 10.

Pediatric Neurosurgery, Charité Universitätsmedizin, Berlin, Germany.

Most of childhood hydrocephalus are originating during infancy. It is considered to be a complex disease since it is developed on the basis of heterogeneous pathophysiological mechanisms and different pathological conditions as well as during different age groups. Hence, it is of relevant importance to have a practical concept in mind, how to categorize hydrocephalus to surgically better approach this disease. Read More

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Detection of cytokine storm in patients with achalasia using ELISA.

Biomed Rep 2021 Jul 31;15(1):62. Epub 2021 May 31.

Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan.

Esophageal achalasia is characterized by abnormal peristaltic movements of the esophageal body and impaired relaxation of the lower esophageal sphincter (LES). However, its etiology remains unknown. In our previous study, it was shown that in the LES of patients with achalasia, hsv1-miR-H1 was overexpressed, ATG16L1 expression was downregulated and interleukin (IL)-1β levels were upregulated. Read More

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Case Report: Severe Adolescent Major Depressive Syndrome Turns Out to Be an Unusual Case of Anti-NMDA Receptor Encephalitis.

Front Psychiatry 2021 25;12:679996. Epub 2021 May 25.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroinflammatory condition mediated by autoantibodies against the GluN1 subunit of the receptor. Clinically, it is characterized by a complex neuropsychiatric presentation with rapidly progressive psychiatric symptoms, cognitive deficits, seizures, and abnormal movements. Isolated psychiatric manifestations of anti-NMDAR encephalitis are rare and usually dominated by psychotic symptoms. Read More

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Epidemiological Characteristics and Drug Resistance Analysis of Cerebrospinal Fluid Microbial Infections in Wenzhou Area.

Infect Drug Resist 2021 3;14:2091-2103. Epub 2021 Jun 3.

Department of Laboratory Medicine, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.

Objective: Central nervous system infections (CNSI) are serious diseases that endanger human health. Identifying pathogens and their susceptibility to antibiotics, and promptly using antibiotics under this guidance is essential for treatment. The purpose of this study is to investigate the pathogen characteristics of CNSI patients, which can help clinicians choose appropriate empiric antibiotic . Read More

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iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts.

Life Sci Alliance 2021 Jul 10;4(7). Epub 2021 Jun 10.

Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Invariant natural killer T (iNKT) cells are a conserved population of innate T lymphocytes that interact with key antigen-presenting cells to modulate adaptive T-cell responses in ways that can either promote protective immunity, or limit pathological immune activation. Understanding the immunological networks engaged by iNKT cells to mediate these opposing functions is a key pre-requisite to effectively using iNKT cells for therapeutic applications. Using a human umbilical cord blood xenotransplantation model, we show here that co-transplanted allogeneic CD4 iNKT cells interact with monocytes and T cells in the graft to coordinate pro-hematopoietic and immunoregulatory pathways. Read More

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Levels of bioactive adrenomedullin in plasma and cerebrospinal fluid in relation to delayed cerebral ischemia in patients after aneurysmal subarachnoid hemorrhage: A prospective observational study.

J Neurol Sci 2021 Jun 5;427:117533. Epub 2021 Jun 5.

Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

Objectives: Adrenomedullin (ADM) has been identified as a promising biomarker of mortality and outcome in sepsis, heart failure and after major surgery. A recently developed assay specific for bioactive adrenomedullin (bio-ADM) has not yet been assessed in aneurysmal subarachnoid hemorrhage (aSAH). The objective of this prospective trial was to assess the time course of bio-ADM after aSAH in relation to the development of delayed cerebral ischemia (DCI) and its association with clinical outcome. Read More

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The Effect of Neutropenia and Filgrastim (G-CSF) in Cancer Patients With COVID-19 Infection.

Clin Infect Dis 2021 Jun 10. Epub 2021 Jun 10.

Infectious Disease, Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, NY, USA.

Background: Neutropenia is commonly encountered in cancer patients. Recombinant human granulocyte colony-stimulating factor (G-CSF, filgrastim), a cytokine that initiates proliferation and differentiation of mature granulocytes, is widely given to oncology patients to counteract neutropenia, reducing susceptibility to infection. However, the clinical impact of neutropenia and G-CSF use in cancer patients with COVID-19 remains unknown. Read More

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Optimization of (-)-cubebin biotransformation to (-)-hinokinin by the marine fungus Absidia coerulea 3A9.

Arch Microbiol 2021 Jun 10. Epub 2021 Jun 10.

Center for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.

The genus Absidia is widely used in the biotransformation of different classes of natural products. This study evaluates the ability of the Absidia coerulea 3A9 marine derived strain isolated from the ascidian Distaplia stilyfera to perform biotransformations by conducting assays with (-)-cubebin, as substrate. The experiment was optimized using the experimental design proposed by Plackett-Burman for seven factors and eight experiments, to establish the biotransformation conditions that would allow maximum production of biotransformed dibenzylbutyrolactone (-)-hinokinin. Read More

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Craniosacral Therapy Use in Normal Pressure Hydrocephalus.

Cureus 2021 May 7;13(5):e14886. Epub 2021 May 7.

Primary Care, Touro College of Osteopathic Medicine, New York, USA.

Nearly 700,000 adults in the US have normal pressure hydrocephalus (NPH), but it is often misdiagnosed as Alzheimer's or Parkinson's disease. In fact, a small percentage of people with the disease are properly diagnosed. NPH presents classically with a triad of symptoms: ataxic gait, dementia, and urinary incontinence. Read More

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Macrophage Function in Calcium Oxalate Kidney Stone Formation: A Systematic Review of Literature.

Front Immunol 2021 24;12:673690. Epub 2021 May 24.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background: The global prevalence and recurrence rate of kidney stones is very high. Recent studies of Randall plaques and urinary components , and including gene manipulation, have attempted to reveal the pathogenesis of kidney stones. However, the evidence remains insufficient to facilitate the development of novel curative therapies. Read More

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Functional Polymorphism in the Gene Associated With Tuberculosis Susceptibility.

Front Immunol 2021 24;12:660384. Epub 2021 May 24.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

Background: Nuclear transcription factor erythroid 2 p45-related factor 2 (Nrf2), encoded by , functions as a key transcription factor and regulates expression of antioxidant genes. Our study aimed to investigate the association of single nucleotide polymorphisms of with tuberculosis (TB) and latent tuberculosis infection (LTBI) and the underlying causal mechanisms.

Methods: 1950 unrelated Chinese Han participants were included in our two independent study groups. Read More

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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.

Front Pharmacol 2021 24;12:656561. Epub 2021 May 24.

Cyclerion Therapeutics, Cambridge, MA, United States.

Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP). Impairment of this pathway has been demonstrated in neurodegenerative diseases. Read More

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Adjuvant properties of IFN-γ and GM-CSF in the scFv6.C4 DNA vaccine against CEA-expressing tumors.

Gene Ther 2021 Jun 9. Epub 2021 Jun 9.

Research Center for Gene Therapy, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Tumor-associated carcinoembryonic antigen (CEA) is a natural target for vaccines against colorectal cancers. Our previous experience with a DNA vaccine with scFv6.C4, a CEA surrogate, showed a CEA-specific immune response with 40% of tumor-free mice after challenge with B16F10-CEA and 47% with MC38-CEA cells. Read More

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Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients.

J Chromatogr A 2021 May 28;1651:462299. Epub 2021 May 28.

R&D Neurosciences, Janssen Pharmaceutica, Turnhoutseweg 30, Beerse, Belgium. Electronic address:

In Alzheimer's disease (AD) brain, one of the histopathological hallmarks is the neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. Currently many tau binding antibodies are under development to target the extracellular species responsible for the spreading of the disease in the brain. As such, an in-house developed antibody JNJ-63733657 with picomolar affinity towards tau phosphorylated at both T212 and T217 (further named p217+tau) was recently tested in phase I clinical trial NCT03375697. Read More

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Adult Age Differences in Self-Reported Pain and Anterior CSF Space in Chiari Malformation.

Cerebellum 2021 Jun 9. Epub 2021 Jun 9.

Department of Psychology, The University of Akron, Akron, OH, 44325-4301, USA.

Chiari malformation type I (CMI) is a neural disorder with sensory, cognitive, and motor defects, as well as headaches. Radiologically, the cerebellar tonsils extend below the foramen magnum. To date, the relationships among adult age, brain morphometry, surgical status, and symptom severity in CMI are unknown. Read More

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Giant cell arteritis: what is new in the preclinical and early clinical development pipeline?

Expert Opin Investig Drugs 2021 Jun 9. Epub 2021 Jun 9.

Department of Rheumatology, St. James's Hospital, Dublin, Republic of Ireland.

Introduction: Giant Cell Arteritis (GCA) is the most common systemic vasculitis worldwide. For decades, glucocorticoids have represented the mainstay of treatment, at the expense of toxic systemic effects owing to prolonged courses of high dose treatment regimens. The search for effective drugs permitting lower glucocorticoid treatment regimens in GCA has been a frustrating one. Read More

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HIV-1 Nef induces Hck/Lyn-dependent expansion of MDSC associated with elevated IL-17/G-CSF.

J Virol 2021 Jun 9:JVI0047121. Epub 2021 Jun 9.

Laboratory of Molecular Biology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7.

HIV or SIV infection causes myelodysplasia, anemia and accumulation of inflammatory monocytes (CD14 CD16), through largely unknown cellular and molecular pathways. The mouse cells thought to be equivalent to human CD14 CD16 cells are CD11bGr1 myeloid-derived suppressive cells (MDSC). We used HIV transgenic (Tg) mouse models to study MDSC, namely CD4C/Nef Tg mice expressing in dendritic cells (DC), pDC, CD4 T and other mature and immature myeloid cells and CD11c/Nef Tg mice with a more restricted expression, mainly in DC and pDC. Read More

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Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders.

J Vet Intern Med 2021 Jun 9. Epub 2021 Jun 9.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.

Background: Vascular endothelial growth factor (VEGF) is a key molecular driver of angiogenesis and vascular permeability and is expressed by a wide variety of neoplasms. Although blood VEGF concentrations have been quantified in intracranial tumors of dogs, cerebrospinal fluid (CSF) VEGF concentration might be a more sensitive biomarker of disease.

Objective: Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders. Read More

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Apple consumption reduces markers of postprandial inflammation following a high fat meal in overweight and obese adults: A randomized, crossover trial.

Food Funct 2021 Jun 8. Epub 2021 Jun 8.

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2 W1, Canada.

High fat meal-induced postprandial inflammation is exacerbated in overweight and obesity and may contribute to cardiovascular disease (CVD) risk. This study aimed to determine the effects of apples, rich in anti-inflammatory polyphenols, on biomarkers of postprandial inflammation in individuals with overweight and obesity. A randomized, crossover trial was conducted with n = 26 participants (17 female/9 male; mean age 45. Read More

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[Therapeutic Effect of Spleen Low Molecular Weight Extracts on Leukopenia Caused by Epirubicin in Mice and Its Mechanism].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):969-974

Department of Immunology, School of Basic Medicine, Peking University, Beijing 100191,

Objective: To investigate the therapeutic effect of spleen low molecular weight extracts on epileptics hydrochloride-induced leukopenia in mice and explore its mechanism.

Methods: The model of leukopenia in mice was established by the injection of epirubicin hydrochloride (10 mg/kg). After the injection of chemotherapeutic drugs, leukocytopenia mice were treated with different doses of spleen low molecular weight extract, Ganoderma oral solution and recombinant granulocyte colony stimulating factor (rhG-CSF). Read More

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[Efficacy and Safety of PEG-rhG-CSF in HSC Mobilization in 71 Normal Healthy Donors for Allogeneic Hematopoietic Stem Cell Transplantation].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):951-956

Department of Hematology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China.

Objective: To retrospectively analyze the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in hematopoietic stem cell mobilization in 71 normal healthy donors for allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods: From March 2018 to July 2019, 71 patients received allo-HSCT in The General Hospital of Western Theater Command were enrolled in the study, a single dose of PEG-rhG-CSF was injected subcutaneously at 12 mg to all the stem cell donors. After injection for 4 days, CD34 cell number were detected, stem cells were collected on day 4 or 5 according to the CD34 cell number. Read More

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