661 results match your criteria crucial ingredients

Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Leaves Essential Oil from Palestine.

Nidal Jaradat

Molecules 2021 May 10;26(9). Epub 2021 May 10.

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine.

(AJ) is one of the folkloric medicinal plants and grows in the arid condition used by Palestinian Bedouins in the Al-Naqab desert for the treatment of diabetes and gastrointestinal infections. The current investigation aimed, for the first time, to characterize the (AJ) essential oil (EO) components and evaluate EO's antioxidant, anti-obesity, antidiabetic, antimicrobial, anti-inflammatory, and cytotoxic activities. The gas chromatography-mass spectrometer (GC-MS) technique was utilized to characterize the chemical ingredients of (AJ) EO, while validated biochemical approaches were utilized to evaluate the antioxidant, anti-obesity and antidiabetic. Read More

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The active ingredients and mechanisms of Longchai Jiangxue Formula in treating PV, based on UPLC/Q-TOF-MS/MS, systematic pharmacology, and molecular biology validation.

Biomed Pharmacother 2021 May 28;140:111767. Epub 2021 May 28.

Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address:

Background: Polycythemia vera (PV) is a refractory hematological disease that lack of effective therapy. Chinese traditional medicine Longchai Jiangxue formula (LCJX) has showed the powerful effects on PV. However, the active ingredients and mechanisms of this formula have not been elucidated. Read More

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The Composition of Root-Associated Bacteria and Fungi of and Their Relationship With the Bioactive Ingredients.

Front Microbiol 2021 11;12:642730. Epub 2021 May 11.

State Key Laboratory of Crop Stress Biology in Arid Areas, College of Life Science, Northwest A&F University, Xianyang, China.

(Fisch.) Bge. var. Read More

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Comparison of Membrane Depth Determination Techniques for Active Ingredient Skin Penetration Studies Using Microdialysis.

Skin Pharmacol Physiol 2021 May 21:1-11. Epub 2021 May 21.

Cosmetic Functionals, Merck KGaA, Darmstadt, Germany.

Introduction: The skin is a major physical barrier to the environment, and thus, percutaneous delivery of active ingredients to the dermal target site faces a unique set of hurdles. The efficacy of these active ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically.

Objective: The aim of this study was to understand if different physicochemical properties influence the skin penetration of active ingredients and the depth to which they penetrate into the dermis. Read More

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Comparative Efficacy of Commercial Liquid and Mat-Type Electric Vaporizer Insecticides Against Asian Tiger Mosquito (Diptera: Culicidae).

J Med Entomol 2021 May 22. Epub 2021 May 22.

Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, South Korea.

Mat and liquid-type electric insecticide vaporizers continuously emit insecticides into the surrounding air. Because both the target insects, mostly mosquitoes, and humans are exposed to those insecticides, it is crucial to understand and monitor their deposition and spatial distribution in treated areas. In the current study, we examined the evaporation of insecticides from seven commercial liquid and mat vaporizers and measured their knock-down and insecticidal activity against the adult females of the Asian tiger mosquito, Aedes albopictus (Skuse). Read More

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A Timely Review of Cross-Kingdom Regulation of Plant-Derived MicroRNAs.

Front Genet 2021 3;12:613197. Epub 2021 May 3.

School of Pharmaceutical Science, Hunan University of Medicine, Huaihua, China.

MicroRNAs (miRNAs) belong to a class of non-coding RNAs that suppress gene expression by complementary oligonucleotide binding to the sites in target messenger RNAs. Numerous studies have demonstrated that miRNAs play crucial role in virtually all cellular processes of both plants and animals, such as cell growth, cell division, differentiation, proliferation and apoptosis. The study of rice MIR168a has demonstrated for the first time that exogenous plant MIR168a influences cholesterol transport in mice by inhibiting low-density lipoprotein receptor adapter protein 1 expression. Read More

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How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression?

Eur J Pharm Biopharm 2021 May 16. Epub 2021 May 16.

Technische Universität Braunschweig, Institute for Particle Technology, Volkmaroder Straße 5, 38104 Braunschweig, Germany; Technische Universität Braunschweig, Center of Pharmaceutical Engineering (PVZ), Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany.

The deformation behaviour of a powder and, thus, of the individual particles is a crucial parameter in powder compaction and affects powder compressibility and compactibility. The classical approach for the characterization of the deformation behaviour is the performance of powder compression experiments combined with the application of mathematical models, such as the Heckel-Model, for the derivation of characteristic compression parameters. However, the correlation of these parameters with the deformation behaviour is physically often not well understood. Read More

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Investigation of the Mechanism of Traditional Chinese Medicines in Angiogenesis through Network Pharmacology and Data Mining.

Evid Based Complement Alternat Med 2021 28;2021:5539970. Epub 2021 Apr 28.

Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Although traditional Chinese medicine is effective and safe for the treatment of angiogenesis, the intervention mechanism is diverse, complex, and largely unknown. Therefore, we aimed to explore the active ingredients of traditional Chinese medicine and their mechanisms of action against angiogenesis. Data on angiogenesis-related targets were collected from GeneCards, Therapeutic Target Database, Online Mendelian Inheritance in Man, DrugBank, and DisGeNET. Read More

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Ni and Cr impurities profile in Valeriana officinalis L., radix-based herbal medicinal product available in polish pharmacies due to ICH Q3D guideline.

Regul Toxicol Pharmacol 2021 May 13;123:104945. Epub 2021 May 13.

Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.

Elemental impurities (EIs) profiling in final pharmaceutical products is often not adequately treated, however it is crucial problem in pharmaceutical analysis by reason of the various regulatory authorities (like ICH Q3D guideline). EIs in pharmaceuticals may arise from numerous sources of which the herbal ingredients are not a frequent subject of pharmaceutical analyses. However, based on number of traditional use registrations per year for herbal medicinal products (HMPs) in the EU, it can be stated that monocomponent HMPs are still very popular for use. Read More

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Fatty acids promote the expansion of NK-92 cells in vitro by improving energy metabolism.

Appl Microbiol Biotechnol 2021 May 15;105(10):4285-4295. Epub 2021 May 15.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Postbox 309#, 130 Meilong Road, Shanghai, 200237, People's Republic of China.

Natural killer-92 cells (NK-92 cells) need to be efficiently expanded by serum-free culture in vitro to meet clinical requirements. Fatty acids mainly provide substrates for energy production, which is of crucial importance to meet the energy demands of highly proliferating cells. This study optimized the medium (EM) for NK-92 cells by designing an experiment to expand cells efficiently. Read More

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Inhibition of the intestinal postprandial glucose transport by gallic acid and gallic acid derivatives.

Food Funct 2021 May 14. Epub 2021 May 14.

The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P. R. China.

Inhibition of glucose uptake in the intestine through sodium-dependent glucose transporter 1 (SGLT1) or glucose transporter 2 (GLUT2) may be beneficial in controlling postprandial blood glucose levels. Gallic acid and ten of its derivatives were identified in the active fractions of Terminalia chebula Retz. fructus immaturus, a popular edible plant fruit which has previously been associated with the inhibition of glucose uptake. Read More

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[Current situation of nitrogen application and its effects on yield and quality of Chinese materia medica].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(8):1883-1892

State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.

Nitrogen fertilizer has been the long-lasting crucial component in cultivation of Chinese materia medica(CMM) and crops for its profound effects on enhancing the productivity. In consideration of its role in better production, intensive and excessive application of N fertilizer is often found in CMM cultivation. Therefore, firstly, this review summarized various concentrations of N application with regards to different CMM and districts from the literatures published in the last two decades. Read More

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Potential Mechanism of on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics.

Drug Des Devel Ther 2021 4;15:1915-1930. Epub 2021 May 4.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

Background: , a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammation, hyperlipidemia, atherosclerosis and Alzheimer's disease.

Aim Of The Study: To elucidate the mechanism by which modulates lipid metabolism and explore the medicinal effects of at a holistic level.

Materials And Methods: The potential active ingredients of and targets involved in regulating lipid metabolism were identified using a network pharmacology approach. Read More

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Assembled milk protein nano-architectures as potential nanovehicles for nutraceuticals.

Chuan-He Tang

Adv Colloid Interface Sci 2021 Jun 27;292:102432. Epub 2021 Apr 27.

The Research Group of Food Colloids and Nanotechnology, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

Nanoencapsulation of hydrophobic nutraceuticals with food ingredients has become one of topical research subjects in food science and pharmaceutical fields. To fabricate food protein-based nano-architectures as nanovehicles is one of effective strategies or approaches to improve water solubility, stability, bioavailability and bioactivities of poorly soluble or hydrophobic nutraceuticals. Milk proteins or their components exhibit a great potential to assemble or co-assemble with other components into a variety of nano-architectures (e. Read More

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Improving the bioactive ingredients and functions of asparagus from efficient to emerging processing technologies: A review.

Qun Yu Liuping Fan

Food Chem 2021 Oct 20;358:129903. Epub 2021 Apr 20.

State Key Laboratory of Food Science & Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China; Collaborat Innovat Ctr Food Safety & Qual Control, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China. Electronic address:

Historically, asparagus is a vegetable with abundant phytochemicals (polyphenols, saponins, asparagusic acid, and alkaloids) and crucial bioactivities (neuroprotective, antianxiety, antityrosinase, antioxidant, antibacterial, and antiasthma effects). Numerous investigations indicated that processing technologies have a significant influence on the physicochemical, functional, and microstructural characteristics of asparagus. This review presents an updated overview of novel applications of processing technologies, including ultrasound treatments (in terms of extraction, purification, and preservation), heating treatments (hydrothermal treatments, thermal treatments, and combination heating treatments), high-pressure processing, representative shelf-life extension technologies, and green extraction technologies. Read More

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October 2021

Recent Developments in Effective Antioxidants: The Structure and Antioxidant Properties.

Materials (Basel) 2021 Apr 15;14(8). Epub 2021 Apr 15.

Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, 15-351 Bialystok, Poland.

Since the last few years, the growing interest in the use of natural and synthetic antioxidants as functional food ingredients and dietary supplements, is observed. The imbalance between the number of antioxidants and free radicals is the cause of oxidative damages of proteins, lipids, and DNA. The aim of the study was the review of recent developments in antioxidants. Read More

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Wild Foods: A Topic for Food Pre-History and History or a Crucial Component of Future Sustainable and Just Food Systems?

Andrea Pieroni

Foods 2021 Apr 10;10(4). Epub 2021 Apr 10.

University of Gastronomic Sciences, Piazza Vittorio Emanuele II 9, I-12042 Pollenzo/Bra (Cuneo), Italy.

The ethnobiology of wild foods has garnered increasing attention in food studies in recent years, since traditional foodways in less urbanized and globalized areas of the world are sometimes still based on often neglected or even largely unknown wild plant, animal, fungal, microorganism, and mineral ingredients, as well as their food products and culinary preparations [... Read More

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Ninjin'yoeito, a herbal medicine, enhances glucose tolerance in mice.

Neuropeptides 2021 Apr 16;88:102150. Epub 2021 Apr 16.

Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, Australia; School of Medical Sciences, University of NSW, Sydney, NSW, Australia; Faculty of Medicine, University of NSW, Sydney, NSW, Australia.

The prevalence of Type 2 diabetes increases under conditions of obesity but also due to aging. While a variety of treatment options are being explored there are still many unanswered questions about the underlying mechanisms for the aetiology and progression of this illness. Here we show that pre-treatment with Ninjin'yoeito (NYT), a herbal medicine composed of 12 different ingrediencies, before a glucose challenge results in significantly improved glucose tolerance. Read More

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Immunomodulatory Effect of a New Ingredients Group Extracted from Through Membrane Separation Technique.

Drug Des Devel Ther 2021 15;15:1595-1607. Epub 2021 Apr 15.

Department of Traditional Chinese Medicine and Food Engineering, Shanxi University of Traditional Chinese Medicine, Jinzhong, People's Republic of China.

Introduction: is a commonly used traditional Chinese medicine in China, which has been widely applied to enhance the immunomodulatory function of the body. The main bioactive components are complicated. To explore the role of the components, various techniques have been applied in extraction. Read More

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Effectiveness, Core Elements, and Moderators of Response of Cognitive Remediation for Schizophrenia: A Systematic Review and Meta-analysis of Randomized Clinical Trials.

JAMA Psychiatry 2021 Apr 20. Epub 2021 Apr 20.

Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Importance: Cognitive impairment is a core feature of schizophrenia, with negative consequences on functional outcomes. Although cognitive remediation (CR) is effective and mentioned in treatment guidance for schizophrenia, its active ingredients and ideal candidates are still debated.

Objective: To provide a comprehensive update on CR effectiveness for cognition and functioning in schizophrenia and analyze the core ingredients of efficacy and role of patient characteristics. Read More

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The Role of Translation in Citizen Science to Foster Social Innovation.

Barbara Heinisch

Front Sociol 2021 24;6:629720. Epub 2021 Mar 24.

Centre for Translation Studies, University of Vienna, Vienna, WI, Austria.

Citizen science has become a world-wide phenomenon. Especially for citizen science projects that have a global reach, translation is crucial to overcome language and cultural barriers to reach members of the public. Translation, understood as the transfer of meaning (of a text) from one language into another language, is crucial for the transmission of information, knowledge and (social) innovations. Read More

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Approach bias retraining through virtual reality in smokers willing to quit smoking: A randomized-controlled study.

Behav Res Ther 2021 Jun 2;141:103858. Epub 2021 Apr 2.

Department of Clinical Psychology, University of Siegen, Siegen, Germany. Electronic address:

Automatic approach biases toward smoking-related cues have been implicated in the development and maintenance of addictive behaviors. Studies aiming at modifying such biases have shown promise in changing maladaptive approach tendencies for smoking cues and reducing smoking behavior. However, training effects tend to be small and partly inconsistent. Read More

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Evidence of Barrier Deficiency in Rosacea and the Importance of Integrating OTC Skincare Products into Treatment Regimens.

J Drugs Dermatol 2021 Apr;20(4):384-392

Background: Rosacea, an inflammatory skin disease that leads to an impaired skin barrier function commonly involves the face. Symptoms of rosacea can be bothersome and include pain, stinging, burning, itching, and facial flushing. This review explored skin barrier impairment in rosacea and reduced symptomatology when using over the counter (OTC) skincare products. Read More

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Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin.

Phytomedicine 2021 Jun 24;86:153527. Epub 2021 Feb 24.

College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address:

Background: SiNiSan (SNS) is an ancient Chinese herbal prescription, and the current clinical treatment of irritable bowel syndrome (IBS) is effective. In the previous study of the research team, the multi-functional co-synergism of SNS against IBS was presented. Some potential drug targets and candidate ligands were predicted. Read More

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Application of microbial 3-ketosteroid Δ-dehydrogenases in biotechnology.

Biotechnol Adv 2021 Jul-Aug;49:107751. Epub 2021 Apr 4.

Laboratory of Biophysical Chemistry, University of Groningen, 9747 AG Groningen, the Netherlands. Electronic address:

3-Ketosteroid Δ-dehydrogenase catalyzes the 1(2)-dehydrogenation of 3-ketosteroid substrates using flavin adenine dinucleotide as a cofactor. The enzyme plays a crucial role in microbial steroid degradation, both under aerobic and anaerobic conditions, by initiating the opening of the steroid nucleus. Indeed, many microorganisms are known to possess one or more 3-ketosteroid Δ-dehydrogenases. Read More

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Effects of Dietary Strategies on Exercise-Induced Oxidative Stress: A Narrative Review of Human Studies.

Antioxidants (Basel) 2021 Mar 31;10(4). Epub 2021 Mar 31.

Centre of Sports Science, Department for Nutrition, Exercise and Health, University of Vienna, 1150 Vienna, Austria.

Exhaustive exercise can induce excessive generation of reactive oxygen species (ROS), which may enhance oxidative stress levels. Although physiological levels are crucial for optimal cell signaling and exercise adaptations, higher concentrations have been demonstrated to damage macromolecules and thus facilitate detrimental effects. Besides single dosages of antioxidants, whole diets rich in antioxidants are gaining more attention due to their practicality and multicomponent ingredients. Read More

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Structural Polymorphism of Sorafenib Tosylate as a Key Factor in Its Solubility Differentiation.

Pharmaceutics 2021 Mar 13;13(3). Epub 2021 Mar 13.

Department of Pharmacognosy, Faculty of Pharmacy, Poznań University of Medical Sciences, Święcickiego 4, 60-781 Poznań, Poland.

The presence of active pharmaceutical ingredients (APIs) in the forms of different polymorphic states can induce differences in their physicochemical properties. In the case of poorly soluble APIs, like the oncological drug sorafenib tosylate, small variations in solubility may result in large bioavailability differences. The control of its therapeutic dose is crucial from the effective pharmacotherapy point of view and the reduction of side effects. Read More

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A Comprehensive Workflow for the Analysis of Bio-Macromolecular Supplements: Case Study of 20 Whey Protein Products.

J Diet Suppl 2021 Mar 25:1-19. Epub 2021 Mar 25.

Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, MS, USA University.

The presence of bio-macromolecules as major ingredients is a primary factor in marketing many biologically derived macromolecular supplements. Workflows for analyzing these supplements for quality assurance, adulteration, and other supply-chain difficulties must include a qualitative assessment of small-molecule and macromolecular components; however, no such integrated protocol has been reported for these bio-macromolecular supplements. Twenty whey protein supplements were analyzed using an integrated workflow to identify protein content, protein adulteration, inorganic elemental content, and macromolecular and small-molecule profiles. Read More

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Nano-architectural assembly of soy proteins: A promising strategy to fabricate nutraceutical nanovehicles.

Chuan-He Tang

Adv Colloid Interface Sci 2021 May 16;291:102402. Epub 2021 Mar 16.

The Research Group of Food Colloids and Nanotechnology, School of Food Science and Engineering, South China University of Technology, Guangzhou, China. Electronic address:

Use of protein-based nanovehicles has been well recognized to be one of the most effective strategies to improve water dispersibility, stability and bioavailability of nutraceuticals or bioactive ingredients. Thanks to their health-benefiting effects and unique assembly behavior, soy proteins seem to be the perfect food proteins for fabricating nanovehicles in this regard. This review presents the state-of-art knowledge about the assembly of soy proteins into nano-architectures, e. Read More

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Biomedical applications of electrospun nanofibers in the management of diabetic wounds.

Drug Deliv Transl Res 2021 Mar 21. Epub 2021 Mar 21.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.

Diabetes mellitus (DM) is a complex disease that affects almost all the body's vital organs. Around 415 million people have been diagnosed with DM worldwide, and most of them are due to type 2 DM. The incidence of DM is estimated to increase by 642 million individuals by 2040. Read More

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