439 results match your criteria crucial ingredient


Spectroscopic evaluation on pseudopolymorphs of sodium naproxen.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 25;261:120018. Epub 2021 May 25.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland.

This paper demonstrates the assessment of vibrational spectroscopy methods such as middle infrared, near infrared and Raman spectroscopy (FTIR, FT-NIR, Raman) for the identification of pseudopolymorphic forms of a model active pharmaceutical ingredient (API) - sodium naproxen (NpxNa). NpxNa, in the form of three different pseudopolymorphs, was investigated by methods dedicated for solid state characterization: DSC (differential scanning calorimetry), XPRD (powder X-ray diffraction), SEM (scanning electron microscopy) and Karl Fischer titration. Novelty in the results sourced in the usage of the method not applied so far to identify pseudopolymorphic forms of NpxNa, that is, FTIR and FT-NIR. Read More

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Genome-Wide Identification of Tannase Genes and Their Function of Wound Response and Astringent Substances Accumulation in Juglandaceae.

Front Plant Sci 2021 17;12:664470. Epub 2021 May 17.

State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, China.

Tannins are important polyphenol compounds with different component proportions in different plant species. The plants in the Juglandaceae are rich in tannins, including condensed tannins and hydrolyzable tannins. In this study, we identified seven tannase genes () responsible for the tannin metabolism from walnut, pecan, and Chinese hickory, and three nut tree species in the Juglandaceae, which were divided into two groups. Read More

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Prediction Performance and Economic Efficiency of Soft Sensors for in-Line Water Content Monitoring in Fluidized Bed Granulation: PP-Based Model vs. NIRS-Based Model.

Chem Pharm Bull (Tokyo) 2021 ;69(6):548-556

Department of Systems Science, Kyoto University.

Soft sensors play a crucial role as process analytical technology (PAT) tools. They are classified into physical models, statistical models, and their hybrid models. In general, statistical models are better estimators than physical models. Read More

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January 2021

Silver Nanoparticles Conjugated with Contact Lens Solutions May Reduce the Risk of Keratitis.

Pathogens 2021 May 11;10(5). Epub 2021 May 11.

Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Departamento de Obstetricia, Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología, Medicina Legal y Forense y Parasitología, Universidad de La Laguna, Av. Astrofísico Francisco Sánchez S/N, 38203 Tenerife, Spain.

keratitis (AK), a severe sight-threatening corneal infection, has become a significant medical problem, especially among contact lens wearers. The disease manifests as eye pain, congestion, blurred vision, lachrymation, and ring-shaped infiltrates of the cornea, and can lead to permanent blindness. Inappropriate habits of contact lens users may result in an increased risk of AK infection. Read More

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The active ingredients and mechanisms of Longchai Jiangxue Formula in treating PV, based on UPLC/Q-TOF-MS/MS, systematic pharmacology, and molecular biology validation.

Biomed Pharmacother 2021 May 28;140:111767. Epub 2021 May 28.

Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address:

Background: Polycythemia vera (PV) is a refractory hematological disease that lack of effective therapy. Chinese traditional medicine Longchai Jiangxue formula (LCJX) has showed the powerful effects on PV. However, the active ingredients and mechanisms of this formula have not been elucidated. Read More

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The Composition of Root-Associated Bacteria and Fungi of and Their Relationship With the Bioactive Ingredients.

Front Microbiol 2021 11;12:642730. Epub 2021 May 11.

State Key Laboratory of Crop Stress Biology in Arid Areas, College of Life Science, Northwest A&F University, Xianyang, China.

(Fisch.) Bge. var. Read More

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Comparison of Membrane Depth Determination Techniques for Active Ingredient Skin Penetration Studies Using Microdialysis.

Skin Pharmacol Physiol 2021 May 21:1-11. Epub 2021 May 21.

Cosmetic Functionals, Merck KGaA, Darmstadt, Germany.

Introduction: The skin is a major physical barrier to the environment, and thus, percutaneous delivery of active ingredients to the dermal target site faces a unique set of hurdles. The efficacy of these active ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically.

Objective: The aim of this study was to understand if different physicochemical properties influence the skin penetration of active ingredients and the depth to which they penetrate into the dermis. Read More

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Can torrefaction be a suitable method of enhancing shredder fines recycling?

Waste Manag 2021 Jun 14;128:211-220. Epub 2021 May 14.

Stena Recycling International AB, Fiskhamnsgatan 8B, Göteborg, Sweden.

Effective recycling of metallic waste and end-of-life vehicles (ELVs) is of crucial importance. Currently used separation and sorting techniques result in the formation of fine residue (usually below 10-20 mm) called shredder fines. Shredder fines contain the so-called 'fluff' (i. Read More

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[Critical quality attribute assessment of big brand traditional Chinese medicine: modular identification of Tongren Niuhuang Qingxin Pills based on efficacy with chemical properties].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1606-1615

School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Engineering Research Center of Chinese Medicine Production and New Drug Development, Ministry of Education Beijing 102488,China.

Identification of critical quality attribute(CQA) is crucial in quality control of Tongren Niuhuang Qingxin Pills(TRNHQXP). In this study, 661 active components in TRNHQXP were selected by liquid chromatography-mass spectrometry(LC-MS) and network pharmacology based on reported data and TCMSP, BATMAN-TCM, and TCMID databases, as well as mass spectrometry data, and 1 413 targets of the active components were obtained through SwissTargetPrediction. The 152 potential targets obtained from the intersection of predicted targets with 456 stroke targets underwent functional enrichment analysis by Metascape. Read More

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A Generalized Asymmetric Dual-Front Model for Active Contours and Image Segmentation.

IEEE Trans Image Process 2021 19;30:5056-5071. Epub 2021 May 19.

The Voronoi diagram-based dual-front scheme is known as a powerful and efficient technique for addressing the image segmentation and domain partitioning problems. In the basic formulation of existing dual-front approaches, the evolving contour can be considered as the interfaces of adjacent Voronoi regions. Among these dual-front models, a crucial ingredient is regarded as the geodesic metrics by which the geodesic distances and the corresponding Voronoi diagram can be estimated. Read More

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Potential Mechanism of on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics.

Drug Des Devel Ther 2021 4;15:1915-1930. Epub 2021 May 4.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

Background: , a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammation, hyperlipidemia, atherosclerosis and Alzheimer's disease.

Aim Of The Study: To elucidate the mechanism by which modulates lipid metabolism and explore the medicinal effects of at a holistic level.

Materials And Methods: The potential active ingredients of and targets involved in regulating lipid metabolism were identified using a network pharmacology approach. Read More

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Effects of Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies.

Molecules 2021 04 30;26(9). Epub 2021 Apr 30.

College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Korea.

Skin moisturization is very crucial for maintaining the flexibility, viscoelasticity, and differentiation of the epidermis and its deprivation causes several diseases from dry skin to dermatitis. , a miracle plant having diverse medicinal properties including skin moisturization effects. This study investigated for the first time the molecular mechanism targeting skin moisturization effects of the flower and its major active constituent. Read More

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Nano-scale selective and sensitive optical sensor for metronidazole based on fluorescence quenching: 1H-Phenanthro[9,10-d]imidazolyl-calix[4]arene fluorescent probe.

Anal Chim Acta 2021 Jun 9;1162:338494. Epub 2021 Apr 9.

Selçuk University, Department of Chemistry, 42150, Konya, Turkey. Electronic address:

It is crucial to determine and control the metronidazole (MET) ingredient in food and pharmaceuticals for human health and food safety. Even though many sensors have been previously reported to detect MET, there is still a need for a highly selective and sensitive, easy, fast, cost-effective sensor in this area. Herein, we report a fluorescent calix[4]arene derivative (PIMC) for highly selective and sensitive and facile and rapid MET detection based on fluorescence (FL) quenching. Read More

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Effects of salt concentration on the quality of paocai, a fermented vegetable product from China.

J Sci Food Agric 2021 Apr 28. Epub 2021 Apr 28.

National Engineering Research Center of Seafood, Collaborative Innovation Center of Provincial and Ministerial Co-Construction for Deep Processing, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian, China.

Background: Paocai is a traditional Chinese fermented vegetable food. As the most important ingredient, salt has crucial effects on the bacterial community and volatile compounds of paocai. To demonstrate the effects of salt on the fermentation of paocai, the bacterial composition and volatile compounds were investigated using high-throughput sequencing and gas chromatography-mass spectrometry (GC-MS). Read More

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Repository scale classification and decomposition of tandem mass spectral data.

Sci Rep 2021 Apr 15;11(1):8314. Epub 2021 Apr 15.

Computational Biology Department in the School of Computer Science, Carnegie Mellon University, Pittsburgh, USA.

Various studies have shown associations between molecular features and phenotypes of biological samples. These studies, however, focus on a single phenotype per study and are not applicable to repository scale metabolomics data. Here we report MetSummarizer, a method for predicting (i) the biological phenotypes of environmental and host-oriented samples, and (ii) the raw ingredient composition of complex mixtures. Read More

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Heterogeneous Adsorption and Local Ordering of Formate on a Magnetite Surface.

J Phys Chem Lett 2021 Apr 14;12(15):3847-3852. Epub 2021 Apr 14.

DESY NanoLab, Deutsches Elektronen-Synchrotron (DESY), Notkestraße 85, 22607 Hamburg, Germany.

We report a novel heterogeneous adsorption mechanism of formic acid on the magnetite (111) surface. Our experimental results and density functional theory (DFT) calculations give evidence for dissociative adsorption of formic acid in quasibidentate and chelating geometries. The latter is induced by the presence of iron vacancies at the surface, making oxygen atoms accessible for hydrogen atoms from dissociated formic acid. Read More

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Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer.

Biomed Pharmacother 2021 Jul 10;139:111579. Epub 2021 Apr 10.

ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy. Electronic address:

Alzheimer's disease (AD) is the most common type of dementia worldwide, characterized by the deposition of neurofibrillary tangles and amyloid-β (Aβ) peptides in the brain. Additionally, increasing evidence demonstrates that a neuroinflammatory state and oxidative stress, iron-dependent, play a crucial role in the onset and disease progression. Besides conventional therapies, the use of natural-based products represents a future medical option for AD treatment and/or prevention. Read More

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Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin.

Phytomedicine 2021 Jun 24;86:153527. Epub 2021 Feb 24.

College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address:

Background: SiNiSan (SNS) is an ancient Chinese herbal prescription, and the current clinical treatment of irritable bowel syndrome (IBS) is effective. In the previous study of the research team, the multi-functional co-synergism of SNS against IBS was presented. Some potential drug targets and candidate ligands were predicted. Read More

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Enzymatically Extracted Apple Pectin Possesses Antioxidant and Antitumor Activity.

Molecules 2021 Mar 6;26(5). Epub 2021 Mar 6.

Department of Biotechnology and General Technology of Foods, Faculty of Food Technology, University of Agriculture in Krakow, ul. Balicka 122, 30-149 Kraków, Poland.

The biological activity of apple pectin extracted conventionally or enzymatically using endo-xylanase and endo-cellulase, was tested in vitro. The analyses were performerd in tetraplicates and the statistical significance of the differences were assessed using ANOVA, Tukey post hoc and LSD (the least significant difference) tests. Multivariate regression analysis was applied to determine the structural components that have a crucial importance for antioxidant and antitumor properties of pectins. Read More

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Antimicrobial Use Surveillance Indicators for Finfish Aquaculture Production: A Review.

Front Vet Sci 2021 11;8:595152. Epub 2021 Mar 11.

Human-Environment-Animal Transdisciplinary Antimicrobial Resistance Research Group, School of Public Health, University of Alberta, Edmonton, AB, Canada.

Quantification and tracking of antimicrobial use (AMU) are key factors for the development of responsible antimicrobial stewardship programs and comparison between countries. Global finfish aquaculture growth and increased AMU creates the potential for exchange of antimicrobial resistance between aquatic and terrestrial environments, making AMU surveillance imperative for this industry. The objective of this review is to collate current literature on AMU surveillance indicators and their application to commercial finfish aquaculture production. Read More

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Engaging Community and Academic Partners to Explore Adolescent Emotional Well-Being.

J Health Care Poor Underserved 2021 ;32(1):506-522

In an under-resourced area of the South Bay of Los Angeles, partnerships were formed between community advocates with extensive research experience, less experienced academic investigators, and an urban public high school without partnered research experience. This article outlines the process of developing these partnerships through a community-academic research conference addressing a priority area identified by the local community to define and understand the importance and relevance of adolescent emotional well-being. Teen participants from the high school identified support from the community as the most crucial ingredient for achieving adolescent emotional well-being. Read More

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January 2021

Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis.

Biomed Pharmacother 2021 Jun 4;138:111413. Epub 2021 Mar 4.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Background: Monosodium urate (MSU)-mediated inflammatory response is a crucial inducing factor in gouty arthritis. Here, we explored the underlying mechanism of total glucosides of paeony (TGP) in MSU-induced inflammation of THP-1 macrophages in gouty arthritis.

Methods: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to detect cell viability. Read More

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Influence of enzyme concentrations in enzymatic bioprocessing of red rice bran: A detailed study on nutraceutical compositions, antioxidant and human LDL oxidation inhibition properties.

Authors:
I Sapna A Jayadeep

Food Chem 2021 Jul 9;351:129272. Epub 2021 Feb 9.

Department of Grain Science and Technology, CSIR - Central Food Technological Research Institute, Mysore 570020, Karnataka, India. Electronic address:

Enzymes and their concentrations are crucial factors in improving the release of nutraceuticals bounded to rice bran's cell wall matrix. This study aims to investigate the optimal concentrations of Viscozyme and Fiberzyme at 3-30 beta-glucanase units/2 g in improving the release of phenolics, tocopherols, tocotrienols, and γ-oryzanol fractions and enhancing the bioactivities of red rice bran. At specific concentrations, Fiberzyme increased ferulic (301%) and caffeic acid (691%) in soluble phenolics, p-coumaric acid (98%), and catechin (161%) in bound phenolics as well as γ-oryzanol fractions(32%-134%) and increased ferric reducing power (90%), DPPH (41%), and hydroxyl (25%) radical scavenging activities. Read More

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Curcumin Modulates the Crosstalk Between Macrophages and Bone Mesenchymal Stem Cells to Ameliorate Osteogenesis.

Front Cell Dev Biol 2021 9;9:634650. Epub 2021 Feb 9.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Bone healing is thought to be influenced by the cross-talk between bone forming and immune cells. In particular, macrophages play a crucial role in the regulation of osteogenesis. Curcumin, the major bioactive polyphenolic ingredient of turmeric, has been shown to regulate inflammatory response and osteogenic activities. Read More

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February 2021

Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy.

J Diabetes Res 2021 5;2021:8891093. Epub 2021 Feb 5.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072 Sichuan, China.

Background: Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus and is a major cause of end-stage kidney disease. Cordyceps sinensis (Cordyceps, Dong Chong Xia Cao) is a widely applied ingredient for treating patients with DN in China, while the molecular mechanisms remain unclear. This study is aimed at revealing the therapeutic mechanisms of Cordyceps in DN by undertaking a network pharmacology analysis. Read More

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February 2021

Green synthesis of lignin nanorods/g-CN nanocomposite materials for efficient photocatalytic degradation of triclosan in environmental water.

Chemosphere 2021 Jun 28;272:129801. Epub 2021 Jan 28.

Department of Medicinal and Applied Chemistry, College of Life Sciences, Kaohsiung Medical University (KMU), Kaohsiung City, 807, Taiwan; Research Center for Environmental Medicine, College of Medicine, Kaohsiung Medical University (KMU), Kaohsiung City, 807, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital (KMUH), Kaohsiung City, 807, Taiwan. Electronic address:

Triclosan (TCS) is a common anti-microbial ingredient in pharmaceutical and personal care products. The usage of TCS was banned by the United States Food and Drug Administration (in 2016) due to its potential health risks. However, TCS has been frequently detected in the aquatic environment. Read More

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Genotype and Successive Harvests Interaction Affects Phenolic Acids and Aroma Profile of Genovese Basil for Pesto Sauce Production.

Foods 2021 Jan 30;10(2). Epub 2021 Jan 30.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

Basil ( L.) is an essential ingredient of the Mediterranean cuisine due to its distinctive aroma. Genovese basil leaves are used to prepare "pesto", a condiment that has always caught the interest of consumers and producers. Read More

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January 2021

Lyophilized Drug-Loaded Solid Lipid Nanoparticles Formulated with Beeswax and Theobroma Oil.

Molecules 2021 Feb 9;26(4). Epub 2021 Feb 9.

College of Pharmacy, QU Health, Qatar University, Doha, Qatar.

Solid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or controlled release of the API, respectively. In both aspects, the responses of the lipid matrix to external challenges is crucial. Here, we evaluate the effects of lyophilization on key responses of 1:1 beeswax-theobroma oil matrix SLNs using three model drugs: amphotericin B (AMB), paracetamol (PAR), and sulfasalazine (SSZ). Read More

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February 2021

Experimental and molecular docking investigation of the inclusion complexes between 20(S)-protopanaxatriol and four modified β-cyclodextrins.

Carbohydr Res 2021 Feb 4;500:108256. Epub 2021 Feb 4.

College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650500, PR China. Electronic address:

20(S)-Protopanaxatriol (PPT) is a type of ginsenoside isolated from panax notoginseng or ginseng, which is an essential ingredient in functional food, healthcare products and traditional medicine. However, the research and development of PPT are restricted due to its poor solubility. To circumvent the associated problems, a novel bridged-bis [6-(2,2'-(ethylenedioxy) bis (ethylamine))-6-deoxy-β-CD] (H4) was successfully synthesized. Read More

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February 2021

Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2.

Int J Biol Macromol 2021 Apr 4;176:1-12. Epub 2021 Feb 4.

Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, China; Hunan Key Laboratory of Animal Models for Human Diseases, Hunan Key Laboratory of Medical Genetics & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410013, China. Electronic address:

SARS-CoV-2 is the etiological agent responsible for the ongoing pandemic of coronavirus disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive target for antiviral inhibitors due to its indispensable role in viral replication and gene expression of viral proteins. The search of compounds that can effectively inhibit the crucial activity of 3CLpro, which results to interference of the virus life cycle, is now widely pursued. Read More

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