3,220 results match your criteria crs group


Update on Minimalist Running Shoes.

J Spec Oper Med 2021 ;21(3):107-110

This article provides updated information comparing minimalist running shoes (MRS) to conventional running shoes (CRS). Our previous review found that, compared with running in CRS, transitioning to MRS resulted in lower energy cost and less ground contact occurring at the forefoot, resulting in lower impact forces. There was some increased risk of injury with MRS, although data were conflicting. Read More

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September 2021

Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial.

J Antimicrob Chemother 2021 Sep 16. Epub 2021 Sep 16.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa.

Background: Rifampicin doses of 40 mg/kg in adults are safe and well tolerated, may shorten anti-TB treatment and improve outcomes, but have not been evaluated in children.

Objectives: To characterize the pharmacokinetics and safety of high rifampicin doses in children with drug-susceptible TB.

Patients And Methods: The Opti-Rif trial enrolled dosing cohorts of 20 children aged 0-12 years, with incremental dose escalation with each subsequent cohort, until achievement of target exposures or safety concerns. Read More

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September 2021

Treatments for seizures in catamenial (menstrual-related) epilepsy.

Cochrane Database Syst Rev 2021 Sep 16;9:CD013225. Epub 2021 Sep 16.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: This is an updated version of a Cochrane Review previously published in 2019. Catamenial epilepsy describes worsening seizures in relation to the menstrual cycle and may affect around 40% of women with epilepsy. Vulnerable days of the menstrual cycle for seizures are perimenstrually (C1 pattern), at ovulation (C2 pattern), and during the luteal phase (C3 pattern). Read More

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September 2021

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma.

Clin Cancer Res 2021 Sep 15. Epub 2021 Sep 15.

Radiation Oncology, University of Pennsylvania.

Purpose: B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cells (CART-BCMA) are a promising treatment for relapsed/refractory multiple myeloma (r/rMM). We evaluated the safety and feasibility of bridging radiation (RT) in subjects treated on a phase 1 trial of CART-BCMA.

Experimental Design: Twenty-five r/rMM subjects were treated in 3 cohorts with two doses of CART-BCMA cells +/- cyclophosphamide. Read More

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September 2021

Contribution of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Videos on YouTube to the Learning Curve in COVID-19 Pandemic Process.

Cureus 2021 Aug 2;13(8):e16820. Epub 2021 Aug 2.

General Surgery, Ankara City Hospital, Ankara, TUR.

Introduction: YouTube is a free video-sharing platform, which is watched by residents or specialists in order to catch up on their skills, see new techniques, and have information. In this study, our purpose is to evaluate whether or not these videos are an appropriate educational source for surgeons by analyzing their quality and content, in an environment of reduced elective operations due to the COVID-19 pandemic.

Methods: YouTube video search was performed by entering keywords such as CRS and HIPEC, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, cytoreductive surgery, and HIPEC. Read More

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ERAS program adherence-institutionalization, major morbidity and anastomotic leakage after elective colorectal surgery: the iCral2 multicenter prospective study.

Surg Endosc 2021 Sep 14. Epub 2021 Sep 14.

Minimally Invasive Surgery Unit, Policlinico tor Vergata University Hospital, Rome, Italy.

Background: Enhanced recovery after surgery (ERAS) programs influence morbidity rates and length of stay after colorectal surgery (CRS), and may also impact major complications and anastomotic leakage rates. A prospective multicenter observational study to investigate the interactions between ERAS program adherence and early outcomes after elective CRS was carried out.

Methods: Prospective enrolment of patients submitted to elective CRS with anastomosis in 18 months. Read More

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September 2021

Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.

FASEB J 2021 Oct;35(10):e21907

Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

This study investigated the effect of apela on renal function and anti-inflammatory effect on whole body and kidney tissue in mice with type I cardiorenal syndrome (CRS). The murine type I CRS model was established and apela was subcutaneously infused for two weeks. Cardiac and renal functions were evaluated by echocardiography and blood biochemistry, respectively. Read More

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October 2021

Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma.

Cochrane Database Syst Rev 2021 Sep 13;9:CD013365. Epub 2021 Sep 13.

Cochrane Haematology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of the lymphatic system. About 30% to 40% of people with DLBCL experience relapse and 10% are refractory to first-line treatment usually consisting of R-CHOP chemotherapy. Of those eligible for second-line treatment, commonly consisting of salvage chemotherapy followed by autologous stem-cell transplantation (ASCT), around 50% experience relapse. Read More

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September 2021

Prognosis of poorly cohesive gastric cancer after complete cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (CYTO-CHIP study).

Br J Surg 2021 Sep 9. Epub 2021 Sep 9.

Department of Surgical Oncology, CHU Lyon Sud, Hospices Civils de Lyon, Lyon, France.

Background: The incidence of gastric poorly cohesive carcinoma (PCC) is increasing. The prognosis for patients with peritoneal metastases remains poor and the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is controversial. The aim was to clarify the impact of gastric PCC with peritoneal metastases treated by CRS with or without HIPEC. Read More

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September 2021

Computer Assisted Analysis of Oral Antifungal Therapy in Chronic Rhinosinusitis With Airway Mycosis: A Retrospective Cohort Analysis.

Antimicrob Agents Chemother 2021 Sep 7:AAC0169721. Epub 2021 Sep 7.

Departments of Medicine and Pathology & Immunology, the Biology of Inflammation Center.

Background: Environmental fungi are etiologically related to chronic rhinosinusitis (CRS) with airway mycosis, but their infectious role remains uncertain in part because of potentially inadequate methods of disease quantitation.

Objective: To determine objective radiographic and symptomatic outcomes of oral antifungal therapy in adult patients with CRS and airway mycosis using computer assisted analysis.

Methods: We conducted a retrospective study of 65 patients with CRS and culture-proven airway mycosis in a single center referral-based academic practice, comparing paired sinus CT scans and symptom scores prior to and during chronic oral antifungal therapy using computer assisted analysis of sino-mucosal area (CAASMA). Read More

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September 2021

Effect of Xinyi Biyan Pill in Adjuvant Treatment of Patients with Chronic Rhinosinusitis and Its Influence on Serum Inflammatory Factors and Immune Function.

Evid Based Complement Alternat Med 2021 27;2021:2228803. Epub 2021 Aug 27.

Department of ENT & HN Surgery, Shao Yifu Hospital Affiliated to Medical College of Zhejiang University, Hangzhou, Zhejiang 310000, China.

Objective: To explore the effect of Xinyi Biyan Pill in adjuvant treatment of patients with chronic rhinosinusitis (CRS) and its influence on serum inflammatory factors and immune function.

Methods: From January 2017 to April 2020, 112 CRS patients admitted to this hospital were randomly divided into the control group ( = 52) and the study group ( = 60). The control group was treated with endoscopic sinus surgery (ESS), after the operation, levofloxacin capsules were taken orally, budesonide nasal spray was given, and the nasal cavity was flushed with normal saline; on the basis of that mentioned above, the study group was treated with Xinyi Biyan Pill orally after the surgery. Read More

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Prevalence and risk of residual viremia after ART in low- and middle-income countries: A cross-sectional study.

Medicine (Baltimore) 2021 Sep;100(35):e26817

Chulalongkorn University, Bangkok, Thailand.

Abstract: In order to design effective strategies to eradicate the HIV, an understanding of persistent viral reservoirs is needed. Many studies have demonstrated HIV residual viremia prevalence in high income countries, data from low- and middle-income countries (LMIC) are limited. We assessed the prevalence, and factors associated with residual viremia in people with HIV (PWH), who were virally-suppressed on antiretroviral therapy (ART) in LMIC. Read More

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September 2021

Severe asthma in Kuwait population: Phenotype-based approach.

Respir Med 2021 Aug 27;187:106586. Epub 2021 Aug 27.

Al-Rashed Allergy Center, Ministry of Health, Kuwait. Electronic address:

Background: There is increasing recognition of marked phenotypic heterogeneity within severe asthma patients.

Methods: Severe asthma patients on GINA step 4 or 5 treatment, followed up at Al-Rashed Allergy center Kuwait, were evaluated for: demographics (gender, age, age of asthma onset), comorbidities (allergic rhinitis (AR), chronic rhinosinusitis (CRS), chronic rhinosinusitis with nasal polyposis (CRSwNP), obesity), blood biomarkers (total serum Immunoglobulin E (IgE), peripheral eosinophils), and sensitization to inhalants allergens.

Results: A total of 169 patients were candidates for biological treatment. Read More

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Risk Factors and Outcomes of Acute Cardio-renal Syndrome in a Tertiary Care Setting in South India.

J Assoc Physicians India 2021 Aug;69(8):11-12

Department of Cardiology, Madras Medical Mission, Chennai, Tamil Nadu.

Aims And Objectives: To study the incidence,risk factors and in hospital mortality of Type I Cardiorenal syndrome(CRS1). To study the incidence of hyperkalemia in patients receiving Acei, ARB's or MRA Materials and Methods: Prospective observational cohort study done between June and December 2015 in Madras Medical Mission, Chennai. Consecutive patients admitted with ACS/ADHF were studied and clinical, biochemical and laboratory data was collected. Read More

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Association between air pollution and chronic rhinosinusitis: a nested case-control study using meteorological data and national health screening cohort data.

Rhinology 2021 09 2. Epub 2021 Sep 2.

Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Background: Inconsistent results about the effect of air pollution on chronic rhinosinusitis (CRS) have been reported. This study aimed to evaluate the impact of meteorological conditions/air pollution on the prevalence of CRS in adult Koreans.

Methodology: The data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 through 2015 were used. Read More

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September 2021

A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma.

Nat Commun 2021 08 31;12(1):5189. Epub 2021 Aug 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.

Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12-37) in the validation dataset. Read More

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Evidence-Based Recommendations for Nurse Monitoring and Management of Immunotherapy-Induced Cytokine Release Syndrome: A Systematic Review from the Children's Oncology Group.

J Pediatr Oncol Nurs 2021 Aug 30:10434542211040203. Epub 2021 Aug 30.

16121University of Michigan School of Nursing, Ann Arbor, MI, USA.

Children with B-precursor acute lymphoblastic leukemia and B-cell lymphoma, particularly those with relapsed or refractory disease, are increasingly enrolled on phase II and phase III clinical trials studying immunotherapies. These therapeutic agents may be associated with a high risk of cytokine release syndrome (CRS), and nurses lack standardized guidelines for monitoring and managing patients with CRS. Six studies and one clinical practice guideline were included in this systematic review that examined the evidence of CRS following administration of chimeric antigen receptor T-cell therapy or the bi-specific T-cell engager antibody, blinatumomab. Read More

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[Analysis of local reactions and efficacy of CD19 chimeric antigen receptor-modified T cells therapy in recurrent/refractory B-cell lymphoma with >7.5 cm lesions].

Zhonghua Xue Ye Xue Za Zhi 2021 Jul;42(7):570-576

Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.

To observe the local reactions and efficacy of CD19 CAR-T therapy in recurrence/refractory B-cell non-Hodgkin's lymphoma (R/R NHL) patients with >7.5 cm lesions. 32 R/R NHL patients with >7. Read More

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Misdiagnosis of appendiceal neoplasms as ovarian tumors: Impact of prior gynecologic surgery on definitive cytoreduction and HIPEC.

Eur J Surg Oncol 2021 Aug 24. Epub 2021 Aug 24.

Colon and Rectal Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital, NY, 10021, USA. Electronic address:

Background: Female patients with pelvic/adnexal masses often undergo gynecologic operations due to presumed ovarian origin. The diagnosis of an appendiceal tumor is often only made postoperatively after suboptimal cytoreduction has been performed. We hypothesized that an index gynecological procedure increases the morbidity of definitive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in patients with appendiceal mucinous tumors. Read More

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In vitro evaluation of a novel oxygen-generating biomaterial for chronic rhinosinusitis therapy.

Int Forum Allergy Rhinol 2021 Aug 26. Epub 2021 Aug 26.

Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Hypoxia due to closure at the ostiomeatal complex is widely considered one of the major pathogenic mechanisms leading to chronic inflammation in chronic rhinosinusitis (CRS). The objective of this study was to develop and characterize an oxygen-generating biomaterial (OGB) as an innovative treatment strategy for CRS.

Methods: An OGB was fabricated by coating hydrophobic beeswax (BW, 15mg or 30mg) on the surface of calcium peroxide - catalase complex (CPO-CA, 30mg) and characterized using scanning electron microscopy (SEM). Read More

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Does the primary tumour location affect the prognosis of patients with colorectal cancer peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?

World J Surg Oncol 2021 Aug 26;19(1):253. Epub 2021 Aug 26.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: The impact of primary tumour location on the prognosis of patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is rarely discussed, and the evidence is still limited.

Methods: Patients with PM arising from CRC treated with CRS and HIPEC at the China National Cancer Center and Huanxing Cancer Hospital between June 2017 and June 2019 were systematically reviewed. Clinical characteristics, pathological features, perioperative parameters, and prognostic data were collected and analysed. Read More

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The CellBox-2 Mission to the International Space Station: Thyroid Cancer Cells in Space.

Int J Mol Sci 2021 Aug 16;22(16). Epub 2021 Aug 16.

Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.

A spaceflight to the International Space Station (ISS) is a dream of many researchers. We had the chance to investigate the effect of real microgravity (CellBox-2 Space mission) on the transcriptome and proteome of FTC-133 human follicular thyroid cancer cells (TCC). The cells had been sent to the ISS by a Falcon 9 rocket of SpaceX CRS-13 from Cape Canaveral (United States) and cultured in six automated hardware units on the ISS before they were fixed and returned to Earth. Read More

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Evaluation of the Effectiveness of Brazilian Community Restaurants for the Dimension of Low-Income People Access to Food.

Nutrients 2021 Jul 31;13(8). Epub 2021 Jul 31.

Escola de Nutrição, Universidade Federal da Bahia, Salvador 40110-909, Brazil.

This study aimed to evaluate the effectiveness of community restaurants (CRs), managed by the Government of the State of Bahia/Brazil, for the dimension of access to food. The study used secondary data obtained from the public opinion survey Profile of users of community restaurants in Salvador. The nutritional information was accessed through the analysis of CRs' menus. Read More

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Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management.

J Pers Med 2021 Jul 28;11(8). Epub 2021 Jul 28.

Cardiovascular Imaging Group (CVIG), Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Cardiorenal syndrome (CRS) concerns the interconnection between heart and kidneys in which the dysfunction of one organ leads to abnormalities of the other. The main clinical challenges associated with cardiorenal syndrome are the lack of tools for early diagnosis, prognosis, and evaluation of therapeutic effects. Ultrasound, computed tomography, nuclear medicine, and magnetic resonance imaging are increasingly used for clinical management of cardiovascular and renal diseases. Read More

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Left Atrium Assessment by Speckle Tracking Echocardiography in Cryptogenic Stroke: Seeking Silent Atrial Fibrillation.

J Clin Med 2021 Aug 9;10(16). Epub 2021 Aug 9.

Medicine Department, Universidad Autónoma de Barcelona, 08035 Barcelona, Spain.

Silent atrial fibrillation (AF) may be the cause of some cryptogenic strokes (CrS). The aim of the study was to analyse atrial size and function by speckle tracking echocardiography in CrS patients to detect atrial disease. Patients admitted to the hospital due to CrS were included prospectively. Read More

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Development of Time-Resolved Fluorescence Immunochromatographic Assays for Simultaneously Detecting Tylosin and Tilmicosin in Milk in Group-Screening Manner.

Foods 2021 Aug 9;10(8). Epub 2021 Aug 9.

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Tylosin and tilmicosin (T&T) residues in livestock products have received extensive attention from consumers. Time-resolved fluorescence immunochromatographic assay (TRFICA), as a fast, efficient and sensitive immunoassay method, has played an increasingly important role in the food safety field. Therefore, herein a quantitative and visual TRFICA was established for simultaneously detecting T&T in milk in a group-screening manner. Read More

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Heat Shock Proteins: Connectors between Heart and Kidney.

Cells 2021 Jul 30;10(8). Epub 2021 Jul 30.

Center of Natural and Human Sciences (CCNH), Laboratory of Cardiovascular Immunology, Federal University of ABC, Santo André 09210-580, Brazil.

Over the development of eukaryotic cells, intrinsic mechanisms have been developed in order to provide the ability to defend against aggressive agents. In this sense, a group of proteins plays a crucial role in controlling the production of several proteins, guaranteeing cell survival. The heat shock proteins (HSPs), are a family of proteins that have been linked to different cellular functions, being activated under conditions of cellular stress, not only imposed by thermal variation but also toxins, radiation, infectious agents, hypoxia, etc. Read More

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Impact of Insurance Status on Oncologic and Perioperative Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy.

Ann Surg Oncol 2021 Aug 25. Epub 2021 Aug 25.

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: A growing body of research has shown that underinsured patients are at increased risk of worse health outcomes compared with insured patients. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is largely performed at highly specialized cancer centers and may pose challenges for the underinsured. This study investigates surgical outcomes following CRS-HIPEC for insured and underinsured patients with peritoneal carcinomatosis. Read More

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Deep Learning-Based Algorithm for the Detection and Characterization of MRI Safety of Cardiac Implantable Electronic Devices on Chest Radiographs.

Korean J Radiol 2021 Aug 19. Epub 2021 Aug 19.

Department of Radiology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Objective: With the recent development of various MRI-conditional cardiac implantable electronic devices (CIEDs), the accurate identification and characterization of CIEDs have become critical when performing MRI in patients with CIEDs. We aimed to develop and evaluate a deep learning-based algorithm (DLA) that performs the detection and characterization of parameters, including MRI safety, of CIEDs on chest radiograph (CR) in a single step and compare its performance with other related algorithms that were recently developed.

Materials And Methods: We developed a DLA (X-ray CIED identification [XCID]) using 9912 CRs of 958 patients with 968 CIEDs comprising 26 model groups from 4 manufacturers obtained between 2014 and 2019 from one hospital. Read More

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Optimal level of positive end-expiratory pressure during nasal continuous airway pressure for severe bronchiolitis: a prospective study.

Transl Pediatr 2021 Jul;10(7):1843-1850

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Background: Nasal continuous positive airway pressure (nCPAP) has been increasingly applied in the pediatric setting. However, there is no uniform standard for setting and titrating positive end-expiratory pressure (PEEP) level, which is paramount to the effectiveness of the treatment. This study aimed to investigate the optimal parameters for nCPAP in the treatment of severe bronchiolitis based on clinical efficacy and pulmonary function parameters. Read More

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