13,395 results match your criteria crs


Long-acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study.

Int Forum Allergy Rhinol 2021 Sep 17. Epub 2021 Sep 17.

Lyra Therapeutics, Inc, Watertown, MA.

Background: Topical steroids are first-line treatment for chronic rhinosinusitis (CRS), but fail to provide adequate symptom control for all patients. Designed for medical treatment failures, LYR-210 is an implantable matrix that locally elutes mometasone furoate to inflamed sinonasal tissue for up to 24 weeks in CRS patients. In an open-label phase 1 study, LYR-210 demonstrated clinically relevant improvement in the 22-item Sino-Nasal Outcome Test (SNOT-22). Read More

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September 2021

Janus Kinase Inhibitors and Cell Therapy.

Front Immunol 2021 31;12:740847. Epub 2021 Aug 31.

Department of Medicine, Bone Marrow Transplantation and Cell Therapy Program, Columbia University Irving Medical Center, New York, NY, United States.

Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and immune-effector cell therapy (IECT) continue to have a critical role in the treatment of patients with high risk malignancies and hematologic conditions. These therapies are also associated with inflammatory conditions such as graft--host disease (GVHD) and cytokine release syndrome (CRS) which contribute significantly to the morbidity and mortality associated with these therapies. Recent advances in our understanding of the immunological mechanisms that underly GVHD and CRS highlight an important role for Janus kinases (JAK). Read More

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Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis.

Front Immunol 2021 31;12:733019. Epub 2021 Aug 31.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

The mechanisms that lead to disease onset and propagation in patients with chronic rhinosinusitis (CRS) are not fully elucidated. Maresins (MaR) are a family of essential fatty acid-derived lipid mediators that play a central role in the regulation of inflammation with several studies demonstrating that these mediators display protective activities in airway inflammation. Therefore, in the present studies we evaluated whether concentrations of these mediators were altered in both peripheral blood and nasal secretions from CRS patients. Read More

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The Clinical Respiratory Score: Investigating the Reliability of an Asthma Scoring Tool across a Multidisciplinary Team.

J Asthma 2021 Sep 16:1-10. Epub 2021 Sep 16.

Texas Childrens Hosp, Pediatric emergency medicine, United States.

Background: Asthma scoring tools are used by emergency department (ED) teams to communicate severity of illness. Although most have been validated, none has been found to be sufficiently valid to allow for use across a multidisciplinary team managing pediatric asthma exacerbations.

Objective: We sought to evaluate the inter-rater reliability of the Clinical Respiratory Score (CRS) among all members of an ED care team. Read More

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September 2021

Update on Minimalist Running Shoes.

J Spec Oper Med 2021 ;21(3):107-110

This article provides updated information comparing minimalist running shoes (MRS) to conventional running shoes (CRS). Our previous review found that, compared with running in CRS, transitioning to MRS resulted in lower energy cost and less ground contact occurring at the forefoot, resulting in lower impact forces. There was some increased risk of injury with MRS, although data were conflicting. Read More

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January 2021

Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial.

J Antimicrob Chemother 2021 Sep 16. Epub 2021 Sep 16.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa.

Background: Rifampicin doses of 40 mg/kg in adults are safe and well tolerated, may shorten anti-TB treatment and improve outcomes, but have not been evaluated in children.

Objectives: To characterize the pharmacokinetics and safety of high rifampicin doses in children with drug-susceptible TB.

Patients And Methods: The Opti-Rif trial enrolled dosing cohorts of 20 children aged 0-12 years, with incremental dose escalation with each subsequent cohort, until achievement of target exposures or safety concerns. Read More

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September 2021

Treatments for seizures in catamenial (menstrual-related) epilepsy.

Cochrane Database Syst Rev 2021 Sep 16;9:CD013225. Epub 2021 Sep 16.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: This is an updated version of a Cochrane Review previously published in 2019. Catamenial epilepsy describes worsening seizures in relation to the menstrual cycle and may affect around 40% of women with epilepsy. Vulnerable days of the menstrual cycle for seizures are perimenstrually (C1 pattern), at ovulation (C2 pattern), and during the luteal phase (C3 pattern). Read More

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September 2021

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma.

Clin Cancer Res 2021 Sep 15. Epub 2021 Sep 15.

Radiation Oncology, University of Pennsylvania.

Purpose: B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cells (CART-BCMA) are a promising treatment for relapsed/refractory multiple myeloma (r/rMM). We evaluated the safety and feasibility of bridging radiation (RT) in subjects treated on a phase 1 trial of CART-BCMA.

Experimental Design: Twenty-five r/rMM subjects were treated in 3 cohorts with two doses of CART-BCMA cells +/- cyclophosphamide. Read More

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September 2021

Functional impact of genomic complexity on the transcriptome of Multiple Myeloma.

Clin Cancer Res 2021 Sep 15. Epub 2021 Sep 15.

Oncology and Onco-Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan

Purpose: Multiple Myeloma (MM) is a biologically heterogenous plasma-cell disorder. In this study we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNAs), and chromosomal rearrangements (CRs). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments. Read More

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September 2021

Characterization of HLH-Like Manifestations as a CRS Variant in Patients Receiving CD22 CAR T-Cells.

Blood 2021 Sep 15. Epub 2021 Sep 15.

National Institute of Health, Bethesda, Maryland, United States.

CAR T-cell toxicities resembling hemophagocytic lymphohistiocytosis (HLH) occur in a subset of patients with cytokine release syndrome (CRS). As a variant of conventional CRS, a comprehensive characterization of CAR T-cell associated HLH (carHLH) and investigations into associated risk factors are lacking. In the context of 59 patients infused with CD22 CAR T-cells where a substantial proportion developed carHLH, we comprehensively describe the manifestations and timing of carHLH as a CRS variant and explore factors associated with this clinical profile. Read More

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September 2021

Contribution of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Videos on YouTube to the Learning Curve in COVID-19 Pandemic Process.

Cureus 2021 Aug 2;13(8):e16820. Epub 2021 Aug 2.

General Surgery, Ankara City Hospital, Ankara, TUR.

Introduction: YouTube is a free video-sharing platform, which is watched by residents or specialists in order to catch up on their skills, see new techniques, and have information. In this study, our purpose is to evaluate whether or not these videos are an appropriate educational source for surgeons by analyzing their quality and content, in an environment of reduced elective operations due to the COVID-19 pandemic.

Methods: YouTube video search was performed by entering keywords such as CRS and HIPEC, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, cytoreductive surgery, and HIPEC. Read More

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Sequential different B cell antigen-targeted CAR T-cell therapy for pediatric refractory/relapsed Burkitt Lymphoma.

Blood Adv 2021 Sep 14. Epub 2021 Sep 14.

Department of Hematology/Oncology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China, China.

Single antigen-targeted chimeric antigen receptor (CAR) T-cell therapy may be insufficient to induce a durable response in pediatric aggressive B-cell lymphomas. The clinical trial (ChiCTR1800014457) examined the feasibility of sequential different B cell antigen-targeted CAR T-cell therapy for pediatric refractory/relapsed Burkitt lymphoma. Twenty-three patients received the first CD19 CAR T-cell infusion. Read More

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September 2021

ERAS program adherence-institutionalization, major morbidity and anastomotic leakage after elective colorectal surgery: the iCral2 multicenter prospective study.

Surg Endosc 2021 Sep 14. Epub 2021 Sep 14.

Minimally Invasive Surgery Unit, Policlinico tor Vergata University Hospital, Rome, Italy.

Background: Enhanced recovery after surgery (ERAS) programs influence morbidity rates and length of stay after colorectal surgery (CRS), and may also impact major complications and anastomotic leakage rates. A prospective multicenter observational study to investigate the interactions between ERAS program adherence and early outcomes after elective CRS was carried out.

Methods: Prospective enrolment of patients submitted to elective CRS with anastomosis in 18 months. Read More

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September 2021

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis.

Cell Death Differ 2021 Sep 13. Epub 2021 Sep 13.

CAST - Center for Advanced Studies and Technology, Department of Neurosciences Imaging and Clinical Sciences, University of G. D'Annunzio of Chieti-Pescara, Chieti, Italy.

Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can provoke life-threatening inflammatory pathologies collectively known as cytokine release syndrome (CRS), exemplified by key clinical phenotypes unearthed during the SARS-CoV-2 pandemic. The underlying pathophysiology of CRS remains elusive. Read More

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September 2021

Chimeric antigen receptor T cells self-neutralizing IL6 storm in patients with hematologic malignancy.

Cell Discov 2021 Sep 14;7(1):84. Epub 2021 Sep 14.

The First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei, Anhui, China.

IL6 is one of the most elevated cytokines during chimeric antigen receptor (CAR) T cell cytokine release syndrome (CRS), and IL6R blockade by Tocilizumab has successfully relieved the most life-threatening aspects of CRS in patients. In addition, latest studies demonstrated the essential role of IL1 in driving CART induced neurotoxicity in mouse models. Here we present a clinical investigation (ChiCTR2000032124; ChiCTR2000031868) of anti-CD19 and anti-BCMA CART (41BBζ) secreting an anti-IL6 scFv and IL1 receptor antagonist (IL1RA) in treating patients with hematologic malignancy. Read More

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September 2021

Computed Tomography Analysis of the Anterosuperior Portion of the Bulla Lamella in Chinese Subjects and Its Surgical Significance in Endoscopic Frontal Sinusotomy.

ORL J Otorhinolaryngol Relat Spec 2021 Sep 10:1-7. Epub 2021 Sep 10.

Department of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, Beijing, China.

Introduction: The anterosuperior portion of the bulla lamella can extend into the frontal sinus and form the supra bulla frontal cell (SBFC) and supraorbital ethmoid cell (SOEC). This can affect the frontal drainage pathway and make surgery more challenging.

Objectives: The aim of the study was to compare the anatomical characteristics of SBFC and SOEC in Chinese chronic rhinosinusitis (CRS) patients and explore the relationship between the cells and frontal sinusitis (FS). Read More

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September 2021

The Role of Cell-Free Plasma DNA in Patients with Cardiorenal Syndrome Type 1.

Cardiorenal Med 2021 Sep 9:1-8. Epub 2021 Sep 9.

IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.

Background: Recent research highlighted the potential role of circulating cell-free DNA (cfDNA), resulted by apoptosis or cell necrosis, as a prognostic marker in the setting of different clinical conditions. Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Apoptosis of renal epithelial cells is proposed as a mechanism involved in CRS type 1. Read More

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September 2021

Dehydrozingerone ameliorates Lipopolysaccharide induced acute respiratory distress syndrome by inhibiting cytokine storm, oxidative stress via modulating the MAPK/NF-κB pathway.

Phytomedicine 2021 Aug 27;92:153729. Epub 2021 Aug 27.

CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India; Centre for Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India. Electronic address:

Background: Inflammation-mediated lung injury is a major cause of health problems in many countries and has been the leading cause of morbidity/mortality in intensive care units. In the current COVID-19 pandemic, the majority of the patients experienced serious pneumonia resulting from inflammation (Acute respiratory distress syndrome/ARDS). Pathogenic infections cause cytokine release syndrome (CRS) by hyperactivation of immune cells, which in turn release excessive cytokines causing ARDS. Read More

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Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.

FASEB J 2021 Oct;35(10):e21907

Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

This study investigated the effect of apela on renal function and anti-inflammatory effect on whole body and kidney tissue in mice with type I cardiorenal syndrome (CRS). The murine type I CRS model was established and apela was subcutaneously infused for two weeks. Cardiac and renal functions were evaluated by echocardiography and blood biochemistry, respectively. Read More

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October 2021

Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma.

Cochrane Database Syst Rev 2021 Sep 13;9:CD013365. Epub 2021 Sep 13.

Cochrane Haematology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of the lymphatic system. About 30% to 40% of people with DLBCL experience relapse and 10% are refractory to first-line treatment usually consisting of R-CHOP chemotherapy. Of those eligible for second-line treatment, commonly consisting of salvage chemotherapy followed by autologous stem-cell transplantation (ASCT), around 50% experience relapse. Read More

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September 2021

Association of Quality of Life Measures and Otolaryngologic Care in Cystic Fibrosis Patients.

Ann Otol Rhinol Laryngol 2021 Sep 11:34894211045636. Epub 2021 Sep 11.

Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Objectives: Appropriate management of chronic rhinosinusitis (CRS) among patients with cystic fibrosis (CF) is important in improving quality of life. Otolaryngologists play a critical role in reducing CRS symptom burden. This study seeks to evaluate the role of patient-reported quality-of-life measures in guiding interventions for CF-related sinus disease. Read More

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September 2021

Application of extracorporeal therapies in critically ill COVID-19 patients.

J Zhejiang Univ Sci B 2021 Sept 15;22(9):701-717

Department of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.

The coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread widely all over the world. A high proportion of patients become severely or critically ill, and suffer high mortality due to respiratory failure and multiple organ dysfunction. Read More

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September 2021

Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei of Appendiceal Origin: A Single Center Experience.

Front Surg 2021 26;8:715119. Epub 2021 Aug 26.

Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Pseudomyxoma peritonei (PMP) originating from appendiceal mucinous neoplasm is a rare peritoneal malignancy characterized by the progressive intraperitoneal accumulation of mucus leading to death if left untreated. In recent years, cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) offered increased survival rates. This study aims to identify the clinical, pathological, and surgical features influencing safety and survival outcomes of patients undergoing CRS and HIPEC for PMP of appendiceal origin. Read More

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A Multidisciplinary Approach in Prenatal Diagnosis of TSC With Cardiac Rhabdomyoma as the Initial Symptom.

Front Pediatr 2021 27;9:628238. Epub 2021 Aug 27.

Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, China.

The long-term prognosis of a fetus with cardiac rhabdomyoma (CR) depends on the correlation with tuberous sclerosis complex (TSC). In recent years, the numerous variations of uncertain significance (VUS) of TSC genes produced by high-throughput sequencing have made counseling challenging, studies until now have tended to side-step the tricky topics. Here, we integrated detailed parental phenotype, echocardiography, neuro MRI, and genetic information to conduct a comprehensive evaluation of 61 CR fetuses. Read More

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Clozapine resistant schizophrenia: Newer avenues of management.

World J Psychiatry 2021 Aug 19;11(8):429-448. Epub 2021 Aug 19.

Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

About 40%-70% of the patients with treatment-resistant schizophrenia have a poor response to adequate treatment with clozapine. The impact of clozapine-resistant schizophrenia (CRS) is even greater than that of treatment resistance in terms of severe and persistent symptoms, relapses and hospitalizations, poorer quality of life, and healthcare costs. Such serious consequences often compel clinicians to try different augmentation strategies to enhance the inadequate clozapine response in CRS. Read More

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The association of active and passive tobacco smoke exposure with chronic rhinosinusitis symptom severity: A cross-sectional study.

Int Forum Allergy Rhinol 2021 Sep 12. Epub 2021 Sep 12.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Background:  Chronic rhinosinusitis (CRS) causes a great deal of morbidity. There are a multitude of causal factors, though their precise contribution to symptom severity has yet to be defined.  We hypothesized that exposure to both primary and secondhand tobacco smoke would correlate with more severe symptoms of CRS. Read More

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September 2021

Relationship between socioeconomic status, exposure to airborne pollutants, and chronic rhinosinusitis disease severity.

Int Forum Allergy Rhinol 2021 Sep 12. Epub 2021 Sep 12.

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA.

Background: Air pollution directly interacts with airway mucosa, yet little is known about how pollutants affect upper airway inflammation. Studies have shown increased incidence of chronic rhinosinusitis (CRS), rhinitis, and asthma in areas with higher traffic pollution, and these neighborhoods are often associated with lower socioeconomic status (SES). The Area Deprivation Index (ADI) assesses neighborhood-level SES by zip code. Read More

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September 2021

Endoscopic sinus surgery for chronic rhinosinusitis: 22-item Sino-Nasal Outcome Test 5-year results.

Int Forum Allergy Rhinol 2021 Sep 12. Epub 2021 Sep 12.

Departments of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA.

Background: Currently, limited data exist as to long-term disease-specific outcomes after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). In this report, we present outcomes data collected over 5 years in a large prospective cohort of patients who underwent surgical treatment for CRS.

Methods: Patients who completed the 22-item Sino-Nasal Outcome Test (SNOT-22) before ESS were asked to complete the same survey at yearly intervals for 5 years thereafter. Read More

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September 2021

Dose escalation of subcutaneous epcoritamab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an open-label, phase 1/2 study.

Lancet 2021 Sep 8. Epub 2021 Sep 8.

Lunenburg Lymphoma Phase I/II Consortium-HOVON/LLPC, Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.

Background: Patients with relapsed or refractory B-cell non-Hodgkin lymphoma have few treatment options. We aimed to establish the safety and recommended phase 2 dose of epcoritamab, a novel bispecific antibody that targets CD3 and CD20 and induces T-cell-mediated cytotoxic activity against CD20+ malignant B cells.

Methods: For the dose-escalation part of this phase 1/2 study, we enrolled adults (aged ≥18 years) with relapsed or refractory CD20+ B-cell non-Hodgkin lymphoma at ten sites across four countries (Denmark, the Netherlands, the UK, and Spain). Read More

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September 2021

Diverse effects of clarithromycin and proposal of its clinical application for treating COVID-19 as a repurposing drug.

Trop Biomed 2021 Sep;38(3):343-352

Laboratory of Histopathology & Cytopathology, Department of Laboratory Sciences, Gunma University, Graduate School of Health Sciences, 39-22, 3-chome, Showa-machi, Maebashi, Gunma 371-8514, Japan.

Outbreak of SARS-CoV-2 has been declared a pandemic, which is a serious threat to human health. The disease was named coronavirus disease 2019 (COVID-19). Until now, several vaccines and a few drugs have been approved for the prevention and treatment for COVID-19. Read More

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September 2021